- 2023年
- 1. Deguchi S, Iwakami A, Tujigiwa M, Otake H, Mano Y, Yamamoto N, Nakazawa
Y, Nagai N. Recovery from Indomethacin-Induced Gastrointestinal Bleeding
by Treatment with Teprenone. J. Pharm. Health Care Sci.In press.
2. Masuda S, Deguchi S, Ogata F, Yoshitomi J, Otake H, Kanai K, Kawasaki
N, Nagai N. Nasal Absorption Enhancement of Mometasone Furoate Nanocrystal
Dispersions. Int. J. Nanomedicine.In press.
3. Kawaguchi M, Matsumoto K, Yoshitomi J, Otake H, Sato K, Taga A, Sasabe
T, Nobuhara K, Matsubara A, Nagai N. Poly(oxyethylene)/poly(oxypropylene)
butyl ether prolongs the repellent effect of N,N-diethyl-3-toluamide on
the skin. PLoS One, 18, e0292447, (2023).
4. Otaka Y, Kanai K, Okada D, Nagai N, Yamashita Y, Ichikawa Y, Tajima
K. Sodium Ferrous Citrate and 5-Aminolevulinic Acid Exert a Therapeutic
Effect on Endotoxin-Induced Uveitis in Rats. Int. J. Mol. Sci., 24, 13525,
(2023).
5. Aihara K, Nakazawa Y, Takeda S, Hatsusaka N, Onouchi T, Hiramatsu N,
Nagata M, Nagai N, Funakoshi-Tago M, Yamamoto N, Sasaki H. Aquaporins contribute
to Vacuoles formation in Nile grass type II diabetic rats. Med. Mol. Morphol.,
doi: 10.1007/s00795-023-00365-w. Online ahead of print.
6. 長井紀章. 点眼剤は，どう吸収される？ 特集 みるみるわかる眼とくすり. 薬局, 74(7), 39-43, (2023).
7. Ogata F, Tabuchi A, Nagai N, Toba M, Otani M, Saenjum C, Kawasaki N.
Application of Granulated Nickel–Aluminum–Zirconium Complex Hydroxide in
the Flow Method for Recovery of Chromium(VI) Ions. Chem. Pharm. Bull.,
71, 661-664, (2023).
8. 長井紀章. 水晶体再透明化をめざした薬物療法の可能性. 日本白内障学会誌, 35, 72-74, (2023).
9. Kadowaki R, Ogata F, Fushiki A, Daimyo S, Deguchi S, Otake H, Nagata
M, Sasaki H, Kawasaki N, Nagai N. Skin absorption of felbinac solid nanoparticles
in gel formulation containing l-menthol and carboxypolymethylene. J. Pharm.
Health Care Sci., 9, 20 (2023).
10. Otaka Y, Kanai K, Mori A, Okada D, Nagai N, Yamashita Y, Ichikawa Y,
Tajima K. 5-ALA/SFC Ameliorates Endotoxin-Induced Ocular Inflammation in
Rats by Inhibiting the NF-κB Signaling Pathway and Activating the HO-1/Nrf2
Signaling Pathway. Int. J. Mol. Sci., 24, 8653 (2023).
11. Nagai N, Ogata F, Kadowaki R, Deguchi S, Otake H, Nakazawa Y, Nagata
M, Sasaki H, Kawasaki N. Orally disintegrating tablets containing famotidine
nanoparticles provide high intestinal absorbability via the energy-dependent
endocytosis pathway. Front. Bioeng. Biotechnol., 11, 1167291, (2023).
12. Otaka Y, Kanai K, Okada D, Nagai N, Yamashita Y, Ichikawa Y, Tajima
K. Effects of Oral 5-Aminolevulinic Acid on Lipopolysaccharide-Induced
Ocular Inflammation in Rats. Vet. Sci., 10, 207, (2023).
13. Ogata F, Uematsu Y, Nagai N, Kobata I, Tabuchi A, Saenjum C, Nakamura
T, Kawasaki N. Potential of waste mangosteen shell in the removal of cadmium
ions: Effects of pH, contact time, and temperature. Heliyon, 9, e14503,
(2023).
14. Doki Y, Nakazawa Y, Morishita N, Endo S, Nagai N, Yamamoto N, Tamura
H, Funakoshi-Tago M. Hesperetin treatment attenuates glycation of lens
proteins and advanced-glycation end products generation. Mol. Med. Rep.,
27, 103 (2023).
15. Otake H, Mano Y, Deguchi S, Ogata F, Kawasaki N, Nagai N. Effect of
ointment Base on the Skin Wound-Healing Deficits in Streptozotocin-Induced
Diabetic Rat. Biol. Pharm. Bull., 46, 707-712, (2023).Featured Article
- 2022年
- 1. Takeda S, Yamamoto N, Nagai N, Hiramatsu N, Deguchi S, Hatsusaka N,
Kubo E, Sasaki H. Function of mitochondrial cytochrome c oxidase is enhanced
in human lens epithelial cells at high temperatures. Mol. Med. Rep., 27,
19, (2022).
2. 長井紀章, 後藤涼花, 渡辺彩花, 油納美和, 小坂太陽, 大竹裕子, 鷲見 梓, 笹木友美子, 原 真佐夫, 原田英治. MPCポリマーの併用は市販ジクアホソルナトリウムまたはヒアルロン酸ナトリウム点眼液のドライアイ治療効果を高める.
医療薬学, 48, 545-550, (2022).
3. Nagai N, Otake H. Novel drug delivery systems for the management of
dry eye. Adv. Drug Deliv. Rev., 191, 114582, (2022).
4. Nagai N, Ogata F, Deguchi S, Fushiki A, Daimyo S, Otake H, Kawasaki
N. Design of a Transdermal Sustained Release Formulation Based on Water-Soluble
Ointment Incorporating Tulobuterol Nanoparticles. Pharmaceutics, 14, 2431,
(2022).
5. Obata T, Deguchi S, Yoshitomi J, Inaba K, Urashima Y, Kobori T, Hosomi
K, Nagai N, Nakada Y. Effect of storage temperature on the dispersibility
of commercially available 0.1% fluorometholone ophthalmic suspension. PLoS
One, 17, e0277311, (2022).
6. Choudhari M, Nayak K, Nagai N, Nakazawa Y, Khunt D, Misra M. Role of
mucoadhesive agent in ocular delivery of ganciclovir microemulsion: cytotoxicity
evaluation in vitro and ex vivo. Int. Ophthalmol. doi: 10.1007/s10792-022-02514-z,
Online ahead of print, (2022).
7. Hiramatsu N, Yamamoto N, Ohkuma M, Nagai N, Miyachi E, Yamatsuta K,
Imaizumi K. Iris-derived induced pluripotent stem cells that express GFP
in all somatic cells of mice and differentiate into functional retinal
neurons. Med. Mol. Morphol., 55, 292-303, (2022).
8. Deguchi S, Kadowaki R, Otake H, Taga A, Nakazawa Y, Misra M, Yamamoto
N, Sasaki H, Nagai N. Combination of Lanosterol and Nilvadipine Nanosuspensions
Rescues Lens Opacification in Selenite-Induced Cataractic Rats. Pharmaceutics,
14, 1520, (2022).
9. Hiramatsu N, Yamamoto N, Kato Y, Nagai N, Isogai S, Imaizumi K. Formation
of three-dimensional cell aggregates expressing lens-specific proteins
in various cultures of human iris-derived tissue cells and iPS cells. Exp.
Ther. Med., 24, 539, (2022).
10. 後藤涼花, 勢力諒太朗, 渡辺彩花, 油納美和, 大竹裕子, 櫻井俊輔, 原田英治, 長井紀章. レバミピド懸濁点眼液とMPCポリマーの併用処理によるドライアイ治療効果の有用性評価.
あたらしい眼科, 39, 982-987, (2022).
11. Goto R, Oaku Y, Sasaki F, Kubota C, Deguchi S, Kadowaki R, Abe A, Nagahama
T, Nagai N. [Effects of Skin Environmental Changes by Steam Towel, Ethanol,
l-Menthol and Carpronium on the Drug Behavior in the Minoxidil Nanoparticles-applied
Mice]. Yakugaku Zasshi, 142, 1015-1020, (2022).
12. 武田 峻, 山本直樹, 長井紀章, 出口粧央里, 平松範子, 初坂奈津子, 永田万由美, 松島博之, 久保江理, 佐々木 洋. 体温がヒト水晶体中ATP産生へ与える影響と核白内障への関与.
白内障学会誌. 34, 76-82, (2022).
13. 後藤涼花, 山田茂裕, 馬地一稀, 竹中晴菜, 平松範子, 山本直樹, 佐々木洋, 長井紀章. ストレプトゾトシン誘発糖尿病ラットの水晶体構造異常に対するニルバジピンナノ分散液の保護効果.
白内障学会誌, 34, 61-65, (2022).
14. 長井紀章. 白内障疾患部への薬物送達技術. 白内障学会誌, 34, 35-37, (2022).
15. Nagai N, Kawaguchi M, Minami M, Matsumoto K, Sasabe T, Nobuhara K,
Matsubara A. N,N-Diethyl-3-toluamide Formulation Based on Ethanol Containing
0.1% 2-Hydroxypropyl-β-cyclodextrin Attenuates the Drug’s Skin Penetration
and Prolongs the Repellent Effect without Stickiness. Molecules, 27, 3174,
(2022).
16. Oaku Y, Abe A, Sasano Y, Sasaki F, Kubota C, Yamamoto N, Nagahama T,
Nagai N. Minoxidil Nanoparticles Targeting Hair Follicles Enhance Hair
Growth in C57BL/6 Mice. Pharmaceutics, 14, 947, (2022).
17. Ogata F, Nagai N, Ito C, Kobayashi Y, Yamaguchi M, Tabuchi A, Saenjum
C, Nakamura T, Kawasaki N. Improvement in adsorption of Hg2+ from aqueous
media using sodium-type fine zeolite grains. Water Sci. Technol., 85, 2827-2839,
(2022).
18. Ogata F, Nagai N, Funaki M, Tabuchi A, Kobayashi Y, Saenjum C, Nakamura
T, Kawasaki N. Optimization of the Hydrothermal Activation Treatment with
Sodium Hydroxide Solution for the Coal Fly Ash to Zeolite and its Adsorption
Capability of Lead (Ⅱ) Ions from the Liquid Phase. Chem. Pharm. Bull. (Tokyo),
70, 400-407, (2022).
19. 長岡泰司, 横田陽匡, 花栗潤哉, 渡部昌久，朝生 浩, 花﨑浩継, 秋山彩香, 大野 皓, 高瀬公陽, 山上 聡, 櫛山暁史, 櫛山
櫻, 長井紀章, 中神啓徳, 林 宏樹, 相原 一, 本庄 恵, 蔵野 信, 矢冨 裕, 五十嵐浩二. 眼科検査・治療の低侵襲化. 糖尿病網膜症診療の低侵襲化への挑戦.
日眼会誌, 126, 358-386, (2022).
20. Goto R, Nagai N. 特集/眼科医のための薬理学イロハ 点眼薬における保存剤の功と罪. MB OCULLISTA, 107,
11-18, (2022).
21. Nagai N, Ogata F, Ike A, Shimomae Y, Osako H, Nakazawa Y, Yamamoto
N, Kawasaki N. Oral Formulation Based on Irbesartan Nanocrystals Improve
Drug Solubility, Absorbability, and Efficacy. Pharmaceutics, 14, 387, (2022).
22. Hanaruri J, Nagai N, Yokota H, Kushiyama A, Watanabe M, Yamagami S,
Nagaoka T：Fenofibrate Nano-Eydrops Ameliorate Retinal Blood Flow Dysregulation
and Neurovascular Coupling in Type 2 Diabetic Mice. Pharmaceutics, 14,
384, (2022).
- 2021年
- 1. Nakazawa Y, Nagai N. [Eye Diseases with Aging –for Keeping High QOV
(Quality of Vision)]. Yakugaku Zasshi, 141, 1305-1306, (2021).
2. Goto R, Yamada S, Otake H, Nakazawa Y, Oka M, Yamamoto N, Nagai N. Instillation
of Ophthalmic Formulation Containing Nilvadipine Nanocrystals Attenuates
Lens Opacification in Shumiya Cataract Rats. Pharmaceutics, 13, 1999, (2021).
3. Sugiyama Y, Nakazawa Y, Sakagami T, Kawata S, Nagai N, Yamamoto N, Funakoshi-Tago
M, Tamura H. Capsaicin attenuate TGFβ2-induced epithelial-mesenchymal-transition
in lens epithelial cells in vivo and in vitro. Exp. Eye Res., 22, 108840,
(2021).
4. Nakazawa Y, Petrova RS, Sugiyama Y, Nagai N, Tamura H, Donaldson PJ.
Regulation of the membrane Trafficking of the Mechanosensitive Ion Channels
TRPV1 and TRPV4 by Zonular Tension, osmotic Stress and Activators in the
Mouse Lens. Int. J. Mol. Sci., 213, 12658, (2021).
5. Kita M, Kanai K, Ono HK, Otaka Y, Okada D, Nagai N, Kudo R, Yamashita
Y, Hino S, Matsunaga T, Tajima K. Retention, Bacterial Adhesion, and Biofilm
Formation between Anionic and Zwitterionic Bandage Contact Lenses in Healthy
Dogs: A Pilot Study. Vet Sci. 8, 238, (2021).
6. Otake H, Minami M, Yamaguchi M, Akiyama S, Inaba K, Nagai N. Effect
of inner physical properties on powder adhesion in inhalation capsules
in case of a high resistance device. Exp Ther Med. 22, 1353, (2021).
7. Minami M, Otake H, Nakazawa Y, Okamoto N, Yamamoto N, Sasaki H, Nagai
N. Balance of Drug Residence and Diffusion in Lacrimal Fluid Determine
Ocular Bioavailability in In Situ Gels Incorporating Tranilast Nanoparticles.
Pharmaceutics. 13, 1425, (2021).
8. Deguchi S, Ogata F, Watanabe M, Otake H, Yamamoto N, Kawasaki N, Nagai
N. Nanocrystalline Suspensions of Irbesartan Enhance Oral Bioavailability
by Improving Drug Solubility and Leading Endocytosis Uptake into the Intestine.
Pharmaceutics. 13, 1404, (2021).
9. Hayashi T, Miyamoto T, Nagai N, Kawabata A. Development of diabetes
mellitus following hormone therapy in prostate cancer patients is associated
with early progression to castration resistance. Sci Rep. 11, 17157, (2021).
10. Kita M, Kanai K, Mitsuhashi H, Noguchi T, Nagai N, Yamaguchi M, Otaka
Y, Kudo R, Yamashita Y, Tajima K. Magnesium Hydroxide Nanoparticles Improve
the Ocular Hypotensive Effect of Twice Daily Topical Timolol Maleate in
Healthy Dogs. Vet Sci. 8, 168, (2021).
11. Vorontsova I, Hall JE, Schilling TF, Nagai N, Nakazawa Y. Differences
in a Single Extracellular Residue Underlie Adhesive Functions of Two Zebrafish
Aqp0s. Cells. 10, 2005, (2021).
12. Otake H, Goto R, Ogata F, Isaka T, Kawasaki N, Kobayakawa S, Matsunaga
T, Nagai N. Fixed-Combination Eye Drops Based on Fluorometholone Nanoparticles
and Bromfenac/Levofloxacin Solution Improve Drug Corneal Penetration. Int
J Nanomedicine. 16, 5343-5356, (2021).
13. Uematsu Y, Ogata F, Nagai N, Saenjum C, Nakamura T, Kawasaki N. In
vitro removal of paraquat and diquat from aqueous media using raw and calcined
basil seed. Heliyon. 7, e07644, (2021).
14. 長井紀章. 点眼薬の製剤設計と薬物挙動. 日本白内障学会誌, 33, 32-36, (2021).
15. Ogata F, Nagai N, Iijima S, Toda M, Otani M, Nakamura T, Kawasaki N.
Exploiting the different parameters on the adsorption of phosphate ions
and its subsequent recovery using complex nickel-aluminum-zirconium hydroxide.
Chem. Pharm. Bull (Tokyo). 69, 789-795, (2021).
16. Otake H, Yamaguchi M, Ogata F, Deguchi S, Yamamoto N, Sasaki H, Kawasaki
N, Nagai N. Energy-Dependent Endocytosis Is Responsible for Skin Penetration
of Formulations Based on a Combination of Indomethacin Nanoparticles and
l-Menthol in Rat and Göttingen Minipig. Int J Mol Sci. 22, 5137, (2021).
17. 後藤涼花, 南 実沙, 宇野 樹, 山口瑞季, 稲葉一訓, 竹本晃佑, 中尾元紀, 橋本直文, 長井紀章. 自転・公転ミキサーの粉砕技術に基づく錠剤破砕と経管投与法への応用.
医療薬学, 47, 225-233 (2021).
18. Otake H, Yamaguchi M, Ogata F, Deguchi S, Yamamoto N, Sasaki H, Kawasaki
N, Nagai N. Transdermal System Based on Solid Cilostazol Nanoparticles
Attenuates Ischemia/Reperfusion-Induced Brain Injury in Mice. Nanomaterials
(Basel). 11, 1009, (2021).
19. Yamamoto N, Hiramatsu N, Ohkuma M, Hatsusaka N, Takeda S, Nagai N,
Miyachi EI, Kondo M, Imaizumi K, Horiguchi M, Kubo E, Sasaki H. Novel Technique
for Retinal Nerve Cell Regeneration with Electrophysiological Functions
Using Human Iris-Derived iPS Cells. Cells. 10, 743, (2021).
20. Deguchi S, Ogata F, Isaka T, Otake H, Nakazawa Y, Kawasaki N, Nagai
N. Prevention of Postprandial Hyperglycemia by Ophthalmic Nanoparticles
Based on Protamine Zinc Insulin in the Rabbit. Pharmaceutics. 13, 375,
(2021).
21. 中田雄一郎，山口瑞季，出口粧央里，稲葉一訓, 長井紀章. 懸濁点眼剤の物理的な安定性に及ぼす保管期間の影響. Yakugaku Zasshi.
141, 869-876, (2021).
22. Ogata F, Nagai N, Tabuchi A, Toda M, Otani M, Saenjum C, Nakamura T,
Kawasaki N. Evaluation of Adsorption Mechanism of Chromium(VI) Ion Using
Ni-Al Type and Ni-Al-Zr Type Hydroxides. Water. 13, 551, (2021).
23. Nakazawa Y, Doki Y, Sugiyama Y, Kobayashi R, Nagai N, Morisita N, Endo
S, Funakoshi-Tago M, Tamura H. Effect of Alpha-Glucosyl-Hesperidin Consumption
on Lens Sclerosis and Presbyopia. Cells. 13, 168, (2021).
24. Nagai N, Sakurai S, Seiriki R, Minami M, Yamaguchi M, Deguchi S, Harata
E. MPC Polymer Promotes Recovery from Dry Eye via Stabilization of the
Ocular Surface. Pharmaceutics. 13, 168, (2020).
25. Hiramatsu N, Nagai N, Kondo M, Imaizumi K, Sasaki H, Yamamoto N. Morphological
comparison between three-dimensional structure of immortalized human lens
epithelial cells and Soemmering's ring. Med Mol Morphol. Online ahead of
print, (2021).
26. 長井紀章. 薬物ナノ結晶を基盤とした眼内薬物送達システム. [Ocular Drug Delivery System-based on
Solid Nanoparticles]. Yakugaku Zasshi. 141, 47-53, (2021). Symposium Review.
- 2020年
- 1. Nakazawa Y, Aoki M, Doki Y, Morishita N, Endo S, Nagai N, Funakoshi-Tago
M, Tamura H. Oral consumption of α-glucosyl-hesperidin could prevent lens
hardening, which causes presbyopia. Biochem Biophys Rep. 25, pii:100885,
(2020).
2. Yamamoto N, Takeda S, Hatsusaka N, Hiramatsu N, Nagai N, Deguchi S,
Nakazawa Y, Takata T, Kodera S, Hirata A, Kubo E, Sasaki H. Effect of a
Lens Protein in Low-Temperature Culture of Novel Immortalized Human Lens
Epithelial Cells (iHLEC-NY2). Cells. 9, pii:2670, (2020).
3. Inaba K, Minami M, Yamaguchi M, Goto R, Otake H, Kotake T, Nagai N.
Effects of the Ophthalmic Additive Mannitol on Antimicrobial Activity and
Corneal Toxicity of Various Preservatives. Chem Pharm Bull (Tokyo). 68,
1069-1073, (2020).
4. Nakazawa Y, Shibata T, Nagai N, Kubo E, Tamura H, Sasaki H. Degradation
of connexin 50 protein causes waterclefts in human lens. Open Med (Wars).
15, 1163-1171, (2020).
5. Deguchi S, Ogata F, Yamaguchi M, Minami M, Otake H, Kanai K, Kawasaki
N, Nagai N. In Situ Gel Incorporating Disulfiram Nanoparticles Rescues
the Retinal Dysfunction via ATP Collapse in Otsuka Long–Evans Tokushima
Fatty Rats. Cells. 9, pii:E2171, (2020).
6. Nagai N, Isaka T, Deguchi S, Minami M, Yamaguchi M, Otake H, Okamoto
N, Nakazawa N. In Situ Gelling Systems Using Pluronic F127 Enhance Corneal
Permeability of Indomethacin Nanocrystals. Int J Mol Sci. 21, pii:E7083,
(2020).
8. 南 実沙, 山口瑞季, 山﨑由夏, 大竹裕子, 櫻井俊輔, 原田英治, 長井紀章. MPCポリマーが点眼用保存剤ベンザルコニウム塩化物の角膜傷害性及び薬物眼内移行性へ与える影響.
あたらしい眼科. 37, 1309-1314, (2020).
9. Hayashi T, Kawaguchi H, Eifuku T, Matsuoka H, Kawabata A, Nagai N. Changes
in Percutaneous Absorption of Fentanyl Patches in Rats Treated with a Sebum-Like
Secretion. Chem Pharm Bull (Tokyo). 68, 879-884, (2020).
10. Nagai N, Umachi K, Otake H, Oka M, Hiramatsu N, Sasaki H, Yamamoto
N. Ophthalmic In Situ Gelling System containing Lanosterol Nanoparticles
Delays Collapse of Lens Structure in Shumiya Cataract Rats. Pharmaceutics.
12, 629, (2020).
11. Nagai N, Minami M, Deguchi S, Otake H, Sasaki H, Yamamoto N. An In
Situ Gelling System based on Methylcellulose and Tranilast Solid Nanoparticles
Enhances Ocular Residence Time and Drug Absorption into the Cornea and
Conjunctiva. Front Bioeng Biotechnol. 8, 764, (2020).
12. 稲葉一訓, 山口瑞季, 岡 美佳子, 長井紀章. 遺伝性白内障ラットSCR に対するラノステロールの有用性に関する検討. BIO Clinica.
Vol.9 No.1, 107-109, (2020).
13. Ogata F, Nagai N, Toda M, Otani M, Saenjum C, Nakamura T, Kawasaki
N. Removal of Arsenic(III) Ion from Aqueous Media Using Complex Nickel-Aluminum
and Nickel-Aluminum-Zirconium Hydroxides. Water. 12, 1697, (2020).
14. Ogata F, Nagai N, Soeda A, Yamashiro K, Nakamura T, Saenjum C, Kawasaki
N. Removal of Sr(II) ions from aqueous solution by human hair treated with
EDTA. Bioresource Technology Reports. 9, 100393, (2020).
15. Ogata F, Nagai N, Itami R, Nakamura T, Kawasaki N. Potential of virgin
and calcined wheat bran biomass for the removal of chromium(VI) ion from
a synthetic aqueous solution. Journal of Environmental Chemical Engineering.
8, 103710, (2020).
16. Nagai N, Seiriki R, Deguchi S, Otake H, Hiramatsu N, Sasaki H, Yamamoto
N. Hydrogel Formulations Incorporating Drug Nanocrystals Enhance the Therapeutic
Effect of Rebamipide in a Hamster Model for Oral Mucositis. Pharmaceutics.
12, pii:E532, (2020).
17. 池西政幸, 石井康世, 雪矢良輔, 緒方文彦, 川﨑直人, 長井紀章, 大鳥 徹, 奥野智之. 病院内調製した鉄非含有微量元素注射製剤の品質に関する検討.
Medical Nutritionist of PEN Leaders? Vol.4 No.2 (2020年9月号).
18. Okamoto H, Yoshikawa T, Takeuchi K, Deguchi S, Hatakenaka Y, Matsuoka
H, Kawabata A, Nagai N. A Combination of Cryopreservation and Kneading
Maintains the Usability of Mohs Paste. Chem Pharm Bull (Tokyo). 68, 516-519,
(2020).
19. 大竹裕子, 長井紀章. 薬物ナノ結晶と眼内薬物送達技術. アレルギーの臨床. 40(5), 385-387 (47-49), (2020).
20. Mano Y, Otake H, Shibata T, Kubo E, Sasaki H, Nagai N. Enhancement
of Amyloid β1-43 Production in the Lens Epithelium of Japanese Type 2 Diabetic
Patients. Biomedicines. 8, pii: E87, (2020).
21. Minami M, Seiriki R, Otake H, Nakazawa Y, Kanai K, Tanino T, Nagai
N. Development of Sustained-Release Ophthalmic Formulation Based on Tranilast
Solid Nanoparticles. Materials (Basel). 13, pii: E1675, (2020).
22. Nagai N, Ogata F, Otake H, Naohito K. Oral administration System based
on Meloxicam Nanocrystals: Decreased Dose Due to High Bioavailability Attenuates
Risk of Gastrointestinal Side Effects. Pharmaceutics. 12, pii: E313, (2020).
23. Nagai N, Ishii M, Seiriki R, Ogata F, Otake H, Nakazawa Y, Okamoto
N, Kanai K, Kawasaki N. Novel Sustained-Release Drug Delivery System for
Dry Eye Therapy by Rebamipide Nanoparticles. Pharmaceutics. 12, pii: E155,
(2020).
24. Nagai N, Kawasaki N. Therapy of osteoporosis by the transdermal formulation
based on raloxifene nanoparticles in ovariectomized rat. ATLAS of Science.
https://atlasofscience.org/therapy-of-osteoporosis-by-the-transdermal-formulation-based-on-raloxifene-nanoparticles-in-ovariectomized-rat/,
(2020).
25. Nagai N, Fukuoka Y, Sato K, Otake H, Taga A, Oka M, Hiramatsu N, Yamamoto
N. The Intravitreal Injection of Lanosterol Nanoparticles Rescues Lens
Structure Collapse at an Early Stage in Shumiya Cataract Rats. Int J Mol
Sci. 21, pii: E1048, (2020).
26. 稲葉一訓, 本多公貴, 大竹裕子, 岡本紀夫, 下村嘉一, 小竹 武, 長井紀章. 点眼液の刺激性評価のためのpH変化を指標とした新規in
vitro 評価方法の提案. 医療薬学. 46, 93-99, (2020).
27. 山口瑞季, 岡美佳子, 長井紀章. ラノステロールは水晶体混濁を改善するのか？~SCRにおける有用性評価~ Precision Medicine.
3, 143-146, (2020).
28. Nakazawa Y, Aoki M, Ishiwa S, Morishita N, Endo S, Nagai N, Yamamoto
N, Funakoshi-Tago M, Tamura H. Oral intake of α‑glucosyl‑hesperidin ameliorates
selenite‑induced cataract formation. Mol Med Rep. 21, 1258-1266, (2020).
29. 南 実沙, 蛭子小春, 山崎由夏, 益田佑輔, 北口剛吉, 村田久枝, 長井紀章. 速度論解析を用いた院内製剤 L-チロキシンナトリウム注射液の安定性評価.
医療薬学. 46, 31-37, (2020).
- 2019年
- 1. Otake H, Yamamoto T, Deguchi S, Taga A, Nagai N. Retinal proteomic evaluation
of the rat following streptozotocin-injection using shotgun proteomics.
Mol Med Rep. 21, 1258-1266, (2019).
2. Nagai N, Iwai Y, Sakamoto A, Otake H, Oaku Y, Abe A, Nagahama T. Drug
Delivery System Based On Minoxidil Nanoparticles Promotes Hair Growth In
C57BL/6 Mice. Int J Nanomedicine. 14, 7921-7931, (2019).
3. Sato K, Nagai N, Yamamoto T, Mitamura K, Taga A. Identification of a
Novel Oligosaccharide in Maple Syrup as a Potential Alternative Saccharide
for Diabetes Mellitus Patients. Int J Mol Sci. 20, pii: E5041, (2019).
4. Nagai N, Sakamoto R, Yamamoto S, Deguchi S, Otake H, Tanino T. Solid
Nanocrystals of Rebamipide Promote Recovery from Indomethacin-Induced Gastrointestinal
Bleeding. Int J Mol Sci. 20, pii: E4990, (2019).
5. Ogata F, Nagai N, Nakamura T, Kawasaki N. Adsorption Capability of Fe-HT3.0
for Nitrite and Nitrate Ions in a Binary Solution System. Chem Pharm Bull
(Tokyo). 67,1168-1170, (2019).
6. 2019Medicine_innovats (Ishii M, Fukuoka Y, Deguchi S, Otake H, Tanino
T, Nagai N. Energy-Dependent Endocytosis is Involved in the Absorption
of Indomethacin Nanoparticles in the Small Intestine. Int J Mol Sci. 20,
pii: E476, (2019).
7. Nagai N, Ogata F, Yamaguchi M, Fukuoka Y, Otake H, Nakazawa Y, Kawasaki
N. Combination with l-Menthol Enhances Transdermal Penetration of Indomethacin
Solid Nanoparticles. Int J Mol Sci. 20, pii: E3644, (2019).
8. 林 友典, 高科結衣, 川口陽奈子, 永福 紡, 松岡 寛, 川畑篤史, 長井紀章. フランツ型拡散セルを用いた市販フェンタニルテープの経皮吸収性の評価：温熱条件下における薬物放出性と皮膚透過性の測定.
医療薬学. 45, 416-422, (2019).
9. 長井紀章, 福岡侑也, 真野 裕, 大竹裕子, 柴田哲平, 久保江理, 佐々木 洋. 認知症患者組織を用いた水晶体中アミロイド関連mRNA量の測定.
日本白内障学会誌. 31, 53-57, (2019).
10. 大竹裕子, 真野 裕, 長井紀章. 薬物眼内移行性の向上を目的としたナノ点眼製剤の開発. 特集2 水晶体研究会シンポジウム:私の研究を聞いて欲しい.
日本白内障学会誌. 31, 33-35, (2019).
11. 長井紀章. ラノステロールで水晶体は透明化できるのか？ 特集1 白内障学会・水晶体研究会合同シンポジウム:今話題の白内障研究, 治療を検証する.
日本白内障学会誌. 31, 17-19, (2019).
12. 福岡侑也, 大竹裕子, 長井紀章. ナノ結晶を基盤とした経口製剤化に伴うNSAIDs 消化管障害発現頻度の軽減, BIO Clinica.
34(7), 82-84 (746-748), (2019). 2017年10月号から編集部依頼により再掲載
13. Nagai N, Iwai Y, Deguchi S, Otake H, Kanai K, Okamoto N, Shimomura
Y. Therapeutic Potential of a Combination of Magnesium Hydroxide Nanoparticles
and Sericin for Epithelial Corneal Wound Healing. Nanomaterials (Basel).
9, pii: E768, (2019).
14. Nagai N, Mano Y, Otake H, Shibata T, Kubo E, Sasaki H., Changes in
mitochondrial cytochrome c oxidase mRNA levels with cataract severity in
lens epithelia of Japanese patients. Mol Med Rep. 19, 5464-5472, (2019).
15. Ogata F, Nagai N, Toda M, Otani M, Nakamura T, Kawasaki N., Evaluation
of the Interaction between Borate Ions and Nickel-Aluminum Complex Hydroxide
for Purification of Wastewater. Chem Pharm Bull (Tokyo). 67,487-492, (2019).
16. Nagai N, Ogata F, Otake H, Nakazawa Y, Kawasaki N. Energy-dependent
endocytosis is responsible for drug transcorneal penetration following
the instillation of ophthalmic formulations containing indomethacin nanoparticles.
Int J Nanomedicine. 14, 1213-1227, (2019).
17. Sato K, Kanai K, Ozaki M, Kagawa T, Kita M, Yamashita Y, Nagai N, Tajima
K. Preventive effects of tyrosol, a natural phenolic compound, on anterior
uveitis induced by anterior chamber paracentesis in healthy beagle dogs.
J Vet Med Sci. 81, 573-576, (2019).
18. Inaba K, Oie T, Otake H, Kotake T, Nagai N. Evaluation of Dissolution
Profile between Original and Generic Products of Zolpidem Tartrate by Microdialysis-HPLC.
Chem Pharm Bull (Tokyo). 67, 120-124, (2019).
19. Ogata F., Nagai N., Kishida M., Nakamura T., Kawasaki N., Interaction
between phosphate ions and Fe-Mg type hydrotalcite for purification of
wastewater. J Environ Chem Eng. 7, 102897, (2019).
20. 長井紀章. 特集 ぶどう膜炎2019. 眼科DDSの必要性―点眼若による眼内疾患治療―, 獣医眼科プラクティス. 6, 47-54,
(2019).
21. Ishii M, Fukuoka Y, Deguchi S, Otake H, Tanino T, Nagai N. Energy-Dependent
Endocytosis is Involved in the Absorption of Indomethacin Nanoparticles
in the Small Intestine. Int J Mol Sci. 20, pii: E476, (2019).
22. Nakazawa Y, Ishimori N, Oguchi J, Nagai N, Kimura M, Funakoshi-Tago
M, Tamura H. Coffee brew intake can prevent the reduction of lens glutathione
and ascorbic acid levels in HFD-fed animals. Exp Ther Med. 1420-1425, (2019).
23. Nagai N, Yamasaki Y, Nakamura T, Otake H, Okamoto N. [Effect of Methylcellulose
(Cellulose Derivatives) on Ibuprofen-crushing Efficiency in Nano Pulverizer
NP-100]. Yakugaku Zasshi. 139, 123-130, (2019).
24. Nagai N, Mano Y, otake H, Shibata T, Kubo E, Sasaki H. Changes in mitochondrial
cytochrome c oxidase mRNA levels with cataract severity in lens epithelia
of Japanese patients. Mol Med Rep. 19, 5464-5472. (2019).
25. Sato K, Iwasaki K, Nagai N, Yamashita Y, Chikazawa S, Hoshi F, Kanai
K. Comparison of early posttreatment effects of two steroidal anti-inflammatory
ophthalmic drugs on the ocular inflammatory response induced by paracentesis
in healthy canine eyes. Vet Ophthalmol. doi: 10.1111/vop.12629. (2019).
- 2018年
- 1. 石井美有, 國松紬, 蛭子小春, 大竹裕子, 長井紀章. 難溶性医薬品ナノ粒子化に伴う生体膜透過能の向上効果. 電気学会研究会誌. 12,
11-15 (2018).
2. Yamamoto T, Otake H, Hiramatsu N, Yamamoto N, Taga A, Nagai N. A Proteomic
Approach for Understanding the Mechanisms of Delayed Corneal Wound Healing
in Diabetic Keratopathy Using Diabetic Model Rat. Int J Mol Sci. 19(11),
pii: E3635 (2018).
3. Tanino T, Bando T, Nojiri Y, Okada Y, Nagai N, Ueda Y, Sakurai E. Hepatic
cytochrome P450 metabolism suppressed by mast cells in type 1 allergic
mice. Biochem Pharmacol. 158, 318-316 (2018).
4. 長井 紀章. 製剤特性に基づく点眼薬評価とナノ医薬品の応用. 医療薬学, 2018, 44(10), 481-490, 総説 奨励賞受賞記念論文.
5. Nagai N, Ogata F, Otake H, Nakazawa Y, Kawasaki N.Design of a transdermal
formulation containing raloxifene nanoparticles for osteoporosis treatmnent.
Int J Nanomedicine. 13, 5215-5229 (2018).
6. 長井 紀章. 微粒子化による非水溶性薬剤のDDS技術. PHARM STAGE. Vol.18, No.6 60-64, (2018).
7. Nakazawa Y, Pauze M, Fukuyama K, Nagai N, Funakoshi-Tgao M, Sugai T,
Tamura H. Effect of hesperetin derivatives on the development of selenite-induced
cataracts in rats. Mol Med Rep. 18(1), 1043-1050 (2018).
8. Nagai N, Ogata F, Ishii M, Fukuoka Y, Otake H, Nakazawa Y, Kawasaki
N. Involvement of Endocytosis in the Transdermal Penetration Mechanism
of Ketoprofen Nanoparticles. Int J Mol Sci. 19, pii: E2138 (2018).
9. Nagai N, Ueno A, Ishii M, Fukuoka Y, Otake H. Design of Microdialysis-CLC
Method for Measurement of Drug Behavior in Lacrimal Fluid after Instillation.
Yakugaku Zasshi. 138(8), 1111-1117 (2018).
10. Nagai N, Fukuoka Y, Ishii M, Otake H, Yamamoto T, Taga A, Okamoto N,
Shimomura Y. Instillation of Sericin Enhances Corneal Wound Healing through
the ERK Pathway in Rat Debrided Corneal Epithelium. Int J Mol Sci. 19,
pii: E1123 (2018).
11. GERD（胃食道逆流症）－病態と治療. 長井紀章NSAIDs起因性消化管障害の制御を目指した製剤工夫, BIO Clinica, 33,
61-69 (371-373) (2008). 2017年10月号から編集部依頼により転載.
12. Ogata F, Nagai N, Kariya Y, Nagahashi E, Kobayashi Y, Nakamura T, Kawasaki
N. Adsorption of Nitrite and Nitrate Ions from an Aqueous Solution by Fe-Mg-Type
Hydrotalcites at Different Molar Ratios. Chem Pharm Bull (Tokyo). 66, :458-465
(2018).Highlighted paper selected by Editor-in-Chief. Featured Article.
13 .Nagai N, Yamaoka S, Fukuoka Y, Ishii M, Otake H, Kanai K, Okamoto N,
Shimomura Y. Enhancement in Corneal Permeability of Dissolved Carteolol
by its Combination with Magnesium Hydroxide Nanoparticles. Int J Mol Sci.
19, pii: E282 (2018).
14. Ogata F, Nagai N, Ueta E, Nakamura T, Kawasaki N. Biomass Potential
of Virgin and Calcined Tapioca (Cassava Starch) for the Removal of Sr(II)
and Cs(I) from Aqueous Solutions. Chem Pharm Bull (Tokyo). 66, 295-302
(2018).
15.Deguchi S, Otake H, Nakazawa Y, Hiramatsu N, Yamamoto N, Nagai N. Ophthalmic
Formulation Containing Nilvadipine Nanoparticles Prevents Retinal Dysfunction
in Rats Injected with Streptozotocin. Int J Mol Sci. 18, pii: E2720 (2018).
16. Yoshioka C, Ito Y, Nagai N. Enhanced percutaneous absorption of cilostazol
nanocrystals using aqueous gel patch systems and clarification of the absorption
mechanism. Exp Ther Med. 15, :3501-3508 (2018).
17. Yoshioka C, Ito Y, Nagai N. An Oral Formulation of Cilostazol Nanoparticles
Enhances Intestinal Drug Absorption in Rats CLZnano oral administration.
Exp Ther Med. 15, 454-460 (2018).
18. 長井 紀章. 教育セミナー<さあ、研究を始めよう＞ 分子生物学的解析入門. 白内障学会誌, vol 30, 65-67, 2018.
- 2017年
- 1. 長井紀章. ラノステロールを用いた白内障治療の開発を目指して. 第56回 日本白内障学会総会 学会トピックス. 日本眼科學會雑誌. 121,
951 (2017).
2. Nagai N, Ogata F, Otake H, Kawasaki N, Nakazawa Y, Kanai K, Okamoto
N, Shimomura Y. Co-instillation of nano-solid magnesium hydroxide enhances
corneal permeability of dissolved timolol. Exp Eye Res. 165, 118-124 (2017).
3 .Nagai N, Yamamoto T, Mitamura K, Taga A. Proteomic profile of the lens
in a streptozotocin-induced diabetic rat model using shotgun proteomics.
Biomedical Reports. 7, 445-450 (2017).
4. NSAIDsのベネフィットとリスク. 長井紀章NSAIDs起因性消化管障害の制御を目指した製剤工夫, BIO Clinica, Vol.32
No.11, 47-49 (1099-1101) (2017) 総説.
5. Nagai N, Deguchi S, Otake H, Hiramatsu N, Yamamoto N. Therapeutic Effect
of Cilostazol Ophthalmic Nanodispersions on Retinal Dysfunction in Streptozotocin-Induced
Diabetic Rats. Int J Mol Sci. 18(9). pii: E1971 (2017).
6. Hiramatsu N, Deguchi S, Yoshioka C, Otake H, Yamamoto N, Nagai N. Evaluation
of Retinal Function in Streptozotocin-induced Diabetic Rats by Using the
Electroretinography and Immunohistochemistry Methods. Yakugaku Zasshi.
137(9), 1169-1175 (2017).
7. Nakazawa Y, Nagai N, Ishimori N, Oguchi J, Tamura H. Administration
of antioxidant compounds affects the lens chaperone activity and prevents
the onset of cataracts. Biomed Pharmacother. 95, 137-143 (2017).
8.Nagai N, Mano Y, Otake H, Shibata T, Kubo E, Sasaki H. Amyloid β1-43
Accumulates in the Lens Epithelium of Cortical Opacification in Japanese
Patients. Invest Ophthalmol Vis Sci. 58(7), 3294-3302 (2017).
9. Nagai N, Nakazawa Y, Ito Y, Kanai K, Okamoto N, Shimomura Y. A Nanoparticle-Based
Ophthalmic Formulation of Dexamethasone Enhances Corneal Permeability of
the Drug and Prolongs Its Corneal Residence Time. Biol Pharm Bull. 40(7),
1055-1062 (2017).
10. Nagai N, Ueno A, Tanino T, Oka M, Ito Y. Co-administration of Magnesium
Ion Prevents Indomethacin-Induced Intestinal Ulcerogenic Lesions in Adjuvant-Induced
Arthritis Rats. Biol Pharm Bull. 40(6), 910-915 (2017).
11. 岡美佳子，長井紀章. 白内障への薬学的アプローチ. 日本白内障学会誌. 29, 48-49, 2017.＜特集1＞.
12.長井紀章，伊藤吉將，佐々木 洋．自然発症糖尿病OLETFラットの房水中グルコース値増加は水晶体でのアミロイドβ蓄積を高める.日本白内障学会誌.
29, 86, 2017.外国誌要覧.
13.Ueno A, Yamaoka S, Ito Y, Kotake T, Nakazawa Y, Nagai N. Improvement
of Dissolution Rate and Stability in a Pirenoxine Ophthalmic Suspension
by the Bead Mill Methods. Yakugaku Zasshi. 137(5), 635-641 (2017).
14. Nagai N, Kotani S, Mano Y, Ueno A, Ito Y, Kitaba T, Takata T, Fujii
N. Ferulic Acid Suppresses Amyloid β Production in the Human Lens Epithelial
Cell Stimulated with Hydrogen Peroxide. Biomed Res Int. 2017:5343010 (2017).
15. Nagai N, Ogata F, Deguchi S, Ueno A, Kawasaki N, Ito Y. Combination
Ointment Containing Solid Tranilast Nanoparticles and Dissolved Sericin
Is Efficacious for Treating Skin Wound-Healing Deficits and Redness in
Diabetic Rats. Biol Pharm Bull. 40, :444-450 (2017).
16. Nagai N, Ito Y, Shibata T, Kubo E, Sasaki H.A positive feedback loop
between nitric oxide and amyloid β (1-42) accelerates mitochondrial damage
in human lens epithelial cells. Toxicology. 381, 19-30 (2017).The Comparative Toxicogenomics Database (CTD; http://ctdbase.org/)に登録 .
17. Ogata F, Nagai N, Kawasaki N. Adsorption Capability of Cationic Dyes
(Methylene Blue and Crystal Violet) onto Poly-γ-glutamic Acid. Chem Pharm
Bull (Tokyo). 2017;65(3):268-275. doi: 10.1248/cpb.c16-00827.表紙イラスト, Highlighted Paper selected by Editor-in-Chief, Feautured Article .
18. 長井紀章, 真野 裕, 船上仁範, 緒方文彦, 伊藤吉將, 後藤和子, 川﨑直人. 納豆菌酵素発酵代謝（NFE）エキスがSHRおよびSHR-SPラットの血圧へ与える影響.
医療薬学. 43(2), 72-79 (2017).
- 2016年
- 1. Nagai N, Tanino T, Ito Y. Pharmacokinetic Studies of Gel System Containing
Ibuprofen Solid Nanoparticles. J Oleo Sci. 65(12), 1045-1053 (2016).
2. Nagai N, Mano Y, Ito Y. An Ophthalmic Formulation of Disulfiram Nanoparticles
Prolongs Drug Residence Time in Lens. Biol Pharm Bull. 39(11), 1881-1887
(2016).
3. Nagai N, Tsukamoto A, Kotake T, Ito Y, Okamoto N, Shimomura Y. Evaluation
of Rabbit Model for Glaucoma Study: Drug Interaction in a Rabbit Model
Instilled with Ophthalmic Preparation containing Latanoprost and Timolol.
Jpn J Pharm Health Care Sci. 45(9) 645-650 (2016).
4. Nagai N. Design of Novel Ophthalmic Formulation Containing Drug Nanoparticles
and Its Usefulness as Anti-glaucoma Drugs. Yakugaku Zasshi. 136(10),1385-1390
(2016) review.
5. 長井紀章，オレオサイエンス. 16(8), 400, 2016.JOS best author award 受賞感想文.
6. Nagai N, Tsukamoto A, Kotake T, Ito Y, Okamoto N, Shimomura Y. Evaluation
of Rabbit Model for Glaucoma Study: Drug Interaction in a Rabbit Model
Instilled with Ophthalmic Preparation containing Latanoprost and Timolol.
Jpn J Pharm Health Care Sci, 45(9) 645-650 (2016).
7.Nagai N, Ito Y, Sasaki S. Hyperglycemia Enhances the Production of Amyloid
b1-42 in the Lenses of Otsuka Long-Evans Tokushima Fatty Rats, a Model
of Human Type 2 Diabetes. Invest Ophthalmol Vis Sci. 57(3), 1408-1417 (2016).
日本眼科学会雑誌 連載「外国誌要覧」にて紹介.
8. Nagai N, Ito Y, Okamoto N, Shimomura Y., Size effect of rebamipide ophthalmic
nanodispersions on its therapeutic efficacy for corneal wound healing.
Exp Eye Res. 151, 47-53 (2016).
9. 長井紀章，真野 裕，辰巳賀陽子，川﨑真緒，伊藤吉將，岡本紀夫，下村嘉一，表面麻酔剤 オキシブプロカイン塩酸塩点眼液の角膜傷害性評価. あたらしい眼科.
33(6). 863-866, (2016).
10. 長井紀章，田辺 航，辻 朗子，勝井結美，伊藤吉將 ，岡本紀夫，下村嘉一，点眼用添加物EDTAが種々保存剤の抗菌力及び角膜傷害性へ与える影響.
あたらしい眼科. 33(6). 857-861, (2016).
11. 長井紀章，伊藤吉將，白内障予防効果の向上を目指して―薬物ナノ結晶製剤の有用性―, 日本白内障学会誌, 28. 52-55, (2016).
12. Kodama N, Nagai N, Yasuhara T. New Developments to Break the Limitations
of the Integrated Program-Inclusive Reform of Teaching and Learning by
the Jigsaw Method. Yakugaku Zasshi. 136(3), 359-360 (2016).
13. Nagai N, Ogata F, Kawasaki N, Ito Y. Increased Expression of Interleukin
18 in Lenses of Ovariectomized Rat. Biol Pharm Bull. 39(1), 138-142 (2016).
14. 緒方文彦, 長井紀章, 伊藤吉將, 川﨑直人. カルシウム欠乏卵巣摘出ラットを用いた永久硬水および一時硬水の骨形成効果に関する基礎研究.
臨床環境医学. 24 (2), 94-101 (2015).
- 2015年
- 1. Nagai N, Yoshioka C, Ito Y, Funakami Y, Nishikawa H, Kawabata A. Intravenous
Administration of Cilostazol Nanoparticles Ameliorates Acute Ischemic Stroke
in a Cerebral Ischemia/Reperfusion-Induced Injury Model. Int J Mol Sci.
16(12), 29329-29344 (2015).
2. Nagai N, Iwamae A, Tanimoto S, Yoshioka C, Ito Y. Pharmacokinetics and
Antiinflammatory Effect of a Novel Gel System Containing Ketoprofen Solid
Nanoparticles. Biol Pharm Bull 38 (12), 191891924 (2015).
3. 小竹 武, 松本 優里香, 塚本 あゆみ, 井上 知美, 石渡 俊二, 草薙 みか, 坂野 千賀, 大里 恭章, 伊藤 吉將, 長井 紀章,
消炎鎮痛パップ剤の適性保管に関する研究：痔疾用軟膏剤への成分混入の危険性 (医療薬学). 41(11), 786-789 (2015).
4. Nagai N, Tanino T, Ito Y. Excessive Interleukin 18 Relate the Aggravation
of Indomethacin-Induced Intestinal Ulcerogenic Lesions in Adjuvant-Induced
Arthritis Rat. Biol Pharm Bull. 38(10), 1580-1590 (2015).
5. Nagai N, Ogata F, Kawasaki N, Ito Y, Funakami Y, Okamoto N, Shimomura
Y. Hypercalcemia Leads to Delayed Corneal Wound Healing in Ovariectomized
Rats. Biol Pharm Bull. 38(7), 1063-1069 (2015).
6. Tanino T, Nagai N, Funakami Y. Phloridzin-sensitive transport of echinacoside
and acteoside and altered intestinal absorption route after application
of Cistanche tubulosa extract. J Pharm Pharmacol. 67(10), 1457-1465 (2015).
7. Tanino T, Funakami Y, Nagai N, Kato Y. Cyclosporin A-sensitive cytotoxicity
of flurbiprofen nonstereoselectively mediated by cytochrome P450 metabolism
in three-dimensional cultured rat hepatocytes. J Pharm Pharmacol. 67(10),
1406-1415 (2015).
8. Otori T, Shimomura T, Nagai N, Figoni W, Matsuyama K, Application of
Near-infrared Spectroscopy for Evaluating Generic Formulations of the Drug
Losartan, Intl. J. Pharm.Tech. , 7(2), 9015-9027 (2015).
9. Nagai N, Yoshioka C, Tanino T, Ito Y, Okamoto N, Shimomura Y. Decrease
in Corneal Damage due to Benzalkonium Chloride by the Addition of Mannitol
into Timolol Maleate Eye Drops. J Oleo Sci, 64(7) 743-750 (2015).
10. 長井紀章，伊藤吉將，水晶体でのアミロイドβ蓄積がATP産生能へ与える影響. 京都大学原子炉実験所報告書（KUR report）( KURRI-KR)
, 46-49 (2015).
11. Nagai N, Yoshioka C, Tanabe W, Tanino T, Ito Y, Okamoto N, Shimomura
Y. Effects of Ophthalmic Formulations containing Cilostazol Nanoparticles
on Retinal Vasoconstriction in Rats Injected with Endothelin-1. Pharm Anal
Acta, 6:4 (2015).
12. Nagai N, Yoshioka C, Tanino T, Ito Y, Okamoto N, Shimomura Y. Enhanced
Production of Nitric Oxide Leads to ATP Collapse in the Retinas of Otsuka
Long-Evans Tokushima Fatty Rats, a Model of Human Diabetes. Curr Eye Res.
5, 1-11 (2015).
13. 長井紀章，真野 裕，松平有加，山岡咲絵，吉岡千晶，伊藤吉將，岡本紀夫，下村嘉一, 薬物粒子径変更に伴うブリンゾラミド懸濁性点眼液の眼内薬物移行性評価.
あたらしい眼科. 32(4), 545-549 (2015).
14. Nagai N, Ito Y, Tanino T. Effect of High Glucose Levels on Amyloid
β Production in Retinas of Spontaneous Diabetes Mellitus Otsuka Long-Evans
Tokushima Fatty Rats. Biol Pharm Bull. 38(4), 601-610 (2015).
World Biomedical Frontiersにて紹介.
http://biomedfrontiers.org/alzheimer-2015-11-3/
15. 長井紀章，吉岡千晶，森 愛里，伊藤吉將，岡本紀夫，下村嘉一, ラット角膜上皮剥離モデルを用いた種々市販緑内障治療配合剤の角膜傷害性評価.
あたらしい眼科. 32(3), 419-424 (2015).
16. Nagai N, Yoshioka C, Ito Y. Topical Therapies for Rheumatoid Arthritis
by Gel Ointments containing Indomethacin Nanoparticles in Adjuvant-Induced
Arthritis Rat. J Oleo Sci. 64(3), 337-346 (2015)..
17. Nagai N, Yamamoto T, Tanabe W, Ito Y, Kurabuchi S, Mitamura K, Taga
A. Changes in plasma glucose in Otsuka long-evans Tokushima Fatty rats
after oral administration of maple syrup. J Oleo Sci. ;64(3), 331-335 (2015).
18. Nagai N, Yoshioka C, Mano Y, Tnabe W, Ito Y, Okamoto N, Shimomura Y.
A nanoparticle formulation of disulfiram prolongs corneal residence time
of the drug and reduces intraocular pressure. Exp Eye Res. 132, 115-123
(2015).
- 2014年
- 1.Nagai N., Yoshioka C., Mano Y., Ito Y. Effect of Eye Drops Containing
Disulfiram and Low-Substituted Methylcellulose in Reducing Intraocular
Pressure in Rabbit Models. Curr Eye Res. 20, 1-11 (2014).
2. 長井紀章, 金 裕生, 松野純男, 松山賢治, 大鳥 徹. チェーン薬局を対象とした診療科別におけるジェネリック使用傾向の解析とその評価法の確立.
医薬品情報学. 2014; 16(3): 137-142..
3. Nagai N, Ito Y., A New Preparation Method for Ophthalmic Drug Nanoparticles.
Pharm Anal Acta (Pharmaceutica Analytica Acta), 5, 6, 2014 Open Access.
4 .Nagai N, Ito Y., Effect of Solid Nanoparticle of Indomethacin on Therapy
for Rheumatoid Arthritis in Adjuvant-Induced Arthritis Rat. Biol Pharm
Bull 37(7), 1109-1118 (2014).
World Biomedical Frontiersにて紹介.
http://biomedfrontiers.org/arthritis-2014-12-3/
5. 長井紀章, ミトコンドリア及び細胞膜傷害に伴う水晶体混濁機構の解明とその予防・治療薬の開発. 日本白内障学会誌. 26, 13-19,
2014.第52回 日本白内障学会学術賞受賞記念論文
6. 緒方文彦，長井紀章，伊藤吉將，川崎直人. カルシウム欠乏卵巣摘出ラットを用いた高ミネラル水の骨形成促進効果に関する基礎研究. Yakugaku
Zasshi. 143, 679-685 (2014).
7. 長井紀章，藤田裕美，伊藤吉將，岡本紀夫，下村嘉一, ウサギ赤血球を用いたベンザルコニウム塩化物の傷害性評価とセリシンによる保護効果. あたらしい眼科.
31, 729-732 (2014).
8. Lu S, Nakagomi T, Nakano-doi A, Takata M, Okamoto N, Mimura O, Ito Y,
Nagai N, Tachibana H, Matsuyama Y. Effect of Cilostazol Nanoparticles on
Endothelial Proliferation after Ischemic Stroke. Acta Med. Hyogo, 38, 75-80
(2014).
9. 長井紀章, 緒方文彦, 塚本あゆみ, 林 友典, 西浦早織, 松岡 寛, 小竹 武, 川﨑直人, 伊藤吉將. デキストリン併用投与がクレメジン®細粒経管投与時の低回収率及びチューブ詰まりに与える影響.
薬局薬学., 6, 22-27 (2014).
10. Nagai N, Ito Y, Okamoto N, Shimomura Y. A nanoparticle formulation
reduces the corneal toxicity of indomethacin eye drops and enhances its
corneal permeability. Toxicology, 319, 53-62 (2014).
11. Nagai N, Ono H, Hashino M, Ito Y, Okamoto N, Shimomura Y. Improved
corneal toxicity and permeability of tranilast by the preparation of ophthalmic
formulations containing its nanoparticles J. Oleo Sci., 63(2):177-86 (2014).
12. Nagai N, Ito Y., Excessive hydrogen peroxide enhances the attachment
of amyloid β1-42 in the lens epithelium of UPL rats, a hereditary model
for cataracts. Toxicology, 315, 55-64 (2014).
13. Nagai N, Ito Y., Therapeutic Effects of Gel Ointments containing Tranilast
Nanoparticles on Paw Edema in Adjuvant-Induced Arthritis Rats. Biol Pharm
Bull., 37 (1), 96-104 (2014).
- 2013年
- 1. Nagai N, Ito Y., Therapeutic Effects of Sericin on Diabetic Keratopathy
in OLETF Rat. World J Diabetes., 4(6), 282-289 (2013).TOPIC HIGHLIGHT,
Review.
2. 長井紀章, 緒方文彦, 船上仁範, 伊藤吉將, 川﨑直人. 卵巣摘出ラットへの低カルシウム食投与による角膜上皮傷害治癒速度の遅延. あたらしい眼科.
30 (11), 1623-1627, 2013.
3. 岡本紀夫、長井紀章、伊藤吉將、下村嘉一. アリピプラゾールによる一過性の近視化の1例.眼科臨床紀要, 6 (11), 903-905 (2013).
4. Nagai N, Ito Y, Taga A. Comparison of the enhancement of plasma glucose
levels in type 2 diabetes Otsuka Long-Evans Tokushima Fatty rats by oral
administration of sucrose or maple syrup. J Oleo Sci., 62(9), 737-743 (2013).
5. 長井紀章, 伊藤吉將, 岡本紀夫, 下村嘉一. 糖尿病モデル動物OLETFラット網膜におけるインターフェロン-gamma及び一酸化窒素の発現.
眼薬理学会, 27, 27-29 (2013). プロシーディング
6. Nagai N, Ito Y, Okamoto N, Shimomura Y, Okamura H. Changes in Interleukin
18 in the Retinas of Otsuka Long-Evans Tokushima Fatty Rats, a Model of
Human Type 2 Diabetes. J Oleo Sci., 62(7), 513-523 (2013).
7. 長井紀章, 大江恭平, 森 愛里, 伊藤吉將, 岡本紀夫, 下村嘉一. 各種保存剤を用いた市販緑内障治療（配合）点眼液における角膜傷害性のキネティクス解析.
あたらしい眼科, 30 (7), 1023-1028 (2013).
8. Ito Y, Nagai N*, Okamoto N, Shimomura Y, Nakanishi K, Tanaka R. Reduction
of Enhanced Rabbit Intraocular Pressure by Instillation of Pyroglutamic
Acid Eye Drops. Biol Pharm Bull, 36(6), 1017-1023 (2013). Highlighted paper
selected by Editor-in-Chief.
9. Nagai N., Ito Y. Effect of Magnesium Ion Supplementation on Obesity
and Diabetes Mellitus in Otsuka Long-Evans Tokushima Fatty (OLETF) Rats
Under Excessive Food Intake. J Oleo Sci, 62(6), 403-408 (2013).
10. Nagai N., Ito Y., Okamoto N., Shimomura Y. Decrease in Corneal Damage
due to Benzalkonium Chloride by the Addition of Sericin into Timolol Maleate
Eye Drops. J. Oleo Sci., 62, 159-166 (2013).
11. 長井紀章, 竹田厚志, 伊藤吉將. 糖尿病モデル動物OLETFラット水晶体におけるアミロイドbetaの蓄積, あたらしい眼科, 30,
:97-101 (2013).
12. 長井紀章, 緒方文彦, 林 友典, 西浦早織, 松岡 寛, 川﨑直人, 伊藤吉將. カリメート®散経管投与時の低回収率及びチューブ詰まりに対するデキストリンの保護効果.
医療薬学, 39, 33-38 (2013).
- 2012年
- 1. Nagai N., Takeda A., Itanami Y., Ito Y. Co-administration of Water Containing
Magnesium Ion Prevents Loxoprofen-Induced Lesions in Gastric Mucosa of
Adjuvant-Induced Arthritis Rat. Biol Pharm Bull., 35, 2230-2237 (2012).
2.長井紀章, 小西菜穂子, 新田宰久, 多賀 淳, 伊藤吉將. 微小ローラーポンプを用いた溶出試験の改良 (Improvement of dissolutiontest
using micro-controlled roller pump), Yakugaku Zasshi, 132, 1307-1316(2012).
3. 長井紀章, 竹田厚志, 村尾まゆみ, 伊藤吉將, 岡本紀夫, 下村嘉一. 糖尿病モデル動物OLETFラット網膜におけるアミロイドβの蓄積.
眼薬理, 26, 35-37. (2012) プロシーディング.
4.Nagai N., Ito Y., Okamoto N., Shimomura Y. An In Vitro Evaluation for
Corneal Damages after Instillation of Eye Drops Using Rat Debrided Corneal
Epithelium：Changes in Corneal Damage of Benzalkonium Chloride by Addition
of Thickening Agent. Yakugaku Zasshi, 132, 837-843 (2012).
5. Nagai N., Ito Y. Dysfunction in Cytochrome c Oxidase Caused by Excessive
Nitric Oxide in Human Lens Epithelial Cells Stimulated with Interferon-gamma
and Lipopolysaccharide. Curr Eye Res., 37, 889-997 (2012).
6.Kanai K, Ito Y, Nagai N, Itoh N, Hori Y, Chikazawa S, Hoshi F, HiguchiS.
Effects of instillation of eyedrops containing disulfiram and hydroxypropyl-β-cyclodextrininclusion
complex on endotoxin-induced uveitis in rats. Curr Eye Res.,37, 124-131
(2012).
7. Nagai N., Ito Y., Takeuchi N. Pharmacokinetic and Pharmacodynamic Evaluationof
the Anti-Cataract Effect of Eye Drops Containing Disulfiram and Low-SubstitutedMethylcellulose
using ICR/f Rats as a Hereditary Cataract Model. Biol PharmBull, 35, 239-245
(2012).
8. 長井紀章，大野ひかる，大和幹枝，堀野智美，北小路 学，伊藤吉將，髙田充隆. チェーン薬局に所属する薬剤師の意識とジェネリック医薬品普及に関する調査研究.
医療薬学, 38, 111-117 (2012).
- 2011年
- 1. 長井紀章，大江恭平，伊藤吉將，岡本紀夫，下村嘉一, ヒト角膜上皮細胞（HCE-T）を用いた緑内障治療薬のin vitro角膜細胞傷害性評価.
あたらしい眼科, 28, 1331-1336 (2011).
2. Nagai N., Ito Y, Takeuchi N, Correlation between hyper-sensitivity tohydrogen
peroxide and low defense against Ca2+ influx in cataractogeniclens of ICR/f
rats. Biol. Pharm. Bull., 34, 1005-1010 (2011).
3. Nagai N, Murao T, Oe K, Ito Y, Okamoto N, Shimomura Y, An In vitro evaluationfor
corneal damages by anti-glaucoma combination eye drops using humancorneal
epithelial cell (HCE-T), Yakugaku Zasshi., 131, 985-991 (2011).
4. 長井紀章, 村尾卓俊, 伊藤吉將, 岡本紀夫, 下村嘉一. 点眼薬含有添加剤ベンザルコニウム塩化物及びポリソルベート80点眼時におけるOLETFラット角膜傷害治癒の速度論的解析.
あたらしい眼科, 28, 855-859 (2011).
5. Nagai N, Murao T, Inubuse R, Konishi N, Ito Y. Quality Assessment forsustained
release pharmaceutical preparations by dissolution test usingmicrodialysis-HPLC
method. Yakugaku Zasshi, 131, 621-628 (2011).
6. 長井紀章, 村尾卓俊, 小仲陽子, 伊藤吉將, 竹内典子. 遺伝性白内障ICR/fラット水晶体への過酸化水素処理による脂質過酸化とCa2+-ATPase活性の関連性.
あたらしい眼科, 28, 527-530 (2011).
7.Kanai K, Itoh N, Ito Y, Nagai N, Hori Y, Chikazawa S, Hoshi F, Higuchi
S. Anti-inflammatory potency of oral disulfiram compared with dexamethasone
on endotoxin-induced uveitis in rats. Vet. Med. Sci., 73, :517-520 (2011).
8. Nagai N, Murao T, Ito Y, Okamoto N, Okamura H, Involvement of interleukin18
in lens opacification of Otsuka Long-Evans Tokushima Fatty Rats, a modelof
human type 2 diabetes. Curr. Eye Res., 36, 497-506 (2011).
- 2010年
- 1. Kanai K, Itoh N, Ito Y, Nagai N, Hori Y, Chikazawa S, Hoshi F, HiguchiS.
Anti-Inflammatory Potency of Oral Disulfiram Compared with Dexamethasoneon
Endotoxin-Induced Uveitis in Rats. J Vet Med Sci., (2010).
2. 小倉 岳, 片岡博文, 大坪義和, 伊藤吉將. ラタノプロスト点眼液0.005%「サワイ」の角結膜障害性の評価. あたらしい眼科. 27,1721-1726
(2010).
3. Kanai K, Itoh N, Yoshida K, Yonezawa T, Ikadai H, Hori Y, Ito Y, NagaiN,
Chikazawa S, Hoshi F, Higuchi S. Inhibitory effect of oral disulfiramon
endotoxin-induced uveitis in rats. Curr. Eye Res., 35, 892-899 (2010).
4. Ito Y, Nagai N, Shimomura Y. Reduction in intraocular pressure by the
instillation of eye drops containing disulfiram included with 2-hydroxypropyl-beta-cyclodextrin
in rabbit. Biol. Pharm. Bull., 33, 1574-1578 (2010).
5. 長井紀章, 村尾卓俊, 伊藤吉將, 岡本紀夫. 点眼薬含有添加剤であるポリソルベート80及びEDTAが角膜上皮傷害治癒へ与える影響. あたらしい眼科,
27, 1299-1302. (2010).
6. 長井紀章, 村尾卓俊, 伊藤吉將, 岡本紀夫. セリシン添加抗緑内障薬がSC40不死化ヒト角膜上皮細胞増殖作用へ与える影響. あたらしい眼科,
27, 1295-11298 (2010).
7. Nagai N, Murao T, Okamoto N, Ito Y. Kinetic analysis of the rate of
corneal wound healing in Otsuka Long-Evans Tokushima Fatty rats, a model
of Type 2 diabetes mellitus. J. Oleo Sci., 59, 441-449 (2010).
8. Okamoto N, Ito Y, Nagai N, Murao T, Takiguchi Y, Kurimoto T, MimuraO.
Preparation of ophthalmic formulations containing cilostazol as an anti-glaucomaagent
and improvement in its permeability through the rabbit cornea. J.Oleo Sci.,
59, 423-430 (2010).
9. 長井紀章, 村尾卓俊, 伊藤吉將, 岡本紀夫, 三村 治. II型糖尿病モデル動物OLETFラットにおける角膜傷害治癒の速度論的解析.
眼薬理, 24, 52-54 (2010). プロシーディング.
10. Nagai N, Murao T, Okamoto N, Ito Y. Comparison of corneal wound healingrates
after instillation of commercially available latanoprost and travoprostin
rat debrided corneal epithelium. J. Oleo. Sci,. 59, 135-141 (2010)
11. 岡本紀夫, 伊藤吉將, 長井紀章, 細谷友雅，三村 治. 眼窩外涙腺摘出ラットドライアイモデルにおけるセサミン点眼液の効果. 眼科臨床紀要,
59, 649-652 (2010).
- 2009年
- 1. Nagai N, Murao T, Ito Y, Improvement of dissolution test using by microdialysismethod.
YAKUGAKU ZASSHI, 129, 1515-1521(2009).
2. 長井紀章, 伊藤吉將. 微小透析プローブ連結HPLCを用いた溶出試験法による後発医薬品の製剤評価法. Jasco Report, 51,14-18
(2009) Review.
3. Nagai N, Murao T, Ito Y, Okamoto N, Sasaki M. Enhancing effects of sericinon
corneal wound healing in Otsuka long-evans Tokushima Fatty rats as amodel
of human type 2 diabetes. Biol Pharm Bull. 32, 1594-1599 (2009).
4. Nagai N, Murao T, Okamoto N, Ito Y. Disulfiram reduces elevated bloodglucose
levels in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a modelof type
2 diabetes. J. Oleo Sci., 58, 485-490 (2009).
5. Nagai N, Murao T, Ito Y, Okamoto N, Sasaki M. Enhancing effect of sericinon
corneal wound healing in rat debrided corneal epihtelium. Biol. PharmBul.,
32, 933-936 (2009).
6. 長井紀章, 伊藤吉將, 臼井茂之, 平野和行. IFN-gamma及びLPSによる併用刺激処理したヒト水晶体上皮細胞株SRA 01/04における過剰産生一酸化窒素の細胞膜Ca2+-ATPase遺伝子発現に対する影響.
あたらしい眼, 26, 709-713 (2009).
7. 長井紀章, 伊藤吉將, 竹内典子, 臼井茂之, 平野和行. 遺伝性白内障ICR/fラットの水晶体混濁におけるインターロイキン18及びDNA分解酵素の関与.
あたらしい眼科, 26, 675-680 (2009).
8. 岡本紀夫, 大野新一郎, 伊藤吉將, 長井紀章, 高木和行, 三村 治. 自家調製トリアムシノロン水性懸濁液中の薬物の粒子径について.
眼科臨床紀要, 2, 326-330 (2009).
9. Nagai N, Fukuhata T, Ito Y, Usui S, Hirano K. Preventive effect of co-administrationof
water containing magnesium ion on indomethacin induced lesions of gastricmucosa
in adjuvant-induced arthritis rat. Biol. Pharm. Bul., 32, 116-120(2009).
10. 岡本紀夫, 伊藤吉將, 大野新一郎, 張野正誉, 長井紀章, 三村治. トラニラスト微粒子懸濁液を用いた硝子体可視化. あたらしい眼科,
26, 263-267 (2009).
11. Nagai N, Fukuhata T, Ito Y, Usui S, Hirano K. Involvement of interleukin18
in indomethacin-induced lesions of the gastric mucosa in adjuvant-inducedarthritis
rat. Toxicology, 255, 124-130 (2009).
- 2008年
- 1. Nagai N, Ito Y, Takeuchi N, Usui S, Hirano K. Comparison of the Mechanisms
of Cataract Development Involving Differences in Ca(2+) Regulation in Lenses
among Three Hereditary Cataract Model Rats. Biol. Pharm. Bull., 31, 1990-1995
(2008).
2. 長井紀章, 伊藤吉將, 岡本紀夫, 川上吉美. SV40不死化ヒト角膜上皮細胞（HCE-T）を用いた抗緑内障薬2剤併用時の角膜上皮細胞増殖抑制作用の比較.
あたらしい眼科, 25, 1135-1138 (2008).
3. 長井紀章, 伊藤吉將, 竹内典子, 亀井 鑠, 遺伝性白内障UPLラットにおける白内障発症とチトクロムcオキシダーゼの関与. 眼薬理,
22, 54-56 (2008).プロシーディング
4. 岡本紀夫, 伊藤吉將, 長井紀章, 田村啓, 大野新一郎, 栗本拓治, 川上吉美, 三村 治. ヒアルロン酸ナトリウムを分散安定化剤とするトラニラスト超微粒子懸濁液.
眼科, 50, No. 4 455-459 (2008).
5. Nagai N, Inomata M, Ito Y. Contribution of aldehyde dehydrogenase 3A1
to disulfiram penetration through monolayers consisting of cultured human
corneal epithelial cells. Biol. Pharm. Bull., 31, 1444-1448 (2008).
6. Nagai N, Ito Y, Takeuchi N. Effect of disulfiram eye drops on lipid
peroxide formation via excessive nitric oxide in lenses of hereditary cataract
ICR/f rats. Biol. Pharm. Bull., 31, 981-985 (2008).
7. Nagai N, Ito Y, Takeuchi N. Inhibitive effects of enhanced lipid peroxidation
on Ca(2+)-ATPase in lenses of hereditary cataract ICR/f rats. Toxicology,
247, 139-144 (2008).
8. 長井紀章, 伊藤吉將, 岡本紀夫, 川上吉美. 抗緑内障点眼薬の角膜障害におけるIn Vitroスクリーニング試験：SV40不死化ヒト角膜上皮細胞（HCE-T）を用いた細胞増殖抑制作用の比較.
あたらしい眼科, 25, 553-556 (2008).
9. Kashimoto R, Kurimoto T, Miyoshi T, Okamoto N, Tagami Y, Oono S, Ito
Y, Mimura O. Cilostazol promotes survival of axotomized retinal ganglion
cells in adult rats. Neurosci. Lett., 436, 116-119 (2008).
- 2007年
- 1. Jiang TY, Wang SL, Liu Y, Nie SF, Ito Y, Nagai N, Wu CF. In vitro cellculture
model for anti-cataract drug penetration studies. Pharmazie, 62,767-772
(2007).
2. Nagai N, Ito Y. Adverse effects of excessive nitric oxide on cytochromec
oxidase in lenses of hereditary cataract UPL rats. Toxicology, 242, 7-15(2007).
3. Nagai N, Ito Y, Okamura H. Involvement of Interleukin 18 in CataractDevelopment
in Hereditary Cataract UPL Rats. J. Biochem0 (Tokyo), 142,597-603 (2007).
4. Nagai N, Fukuhata T, Ito Y, Tai H, Hataguchi Y, Nakagawa K. Preventiveeffect
of water containing magnesium ion on paw edema in adjuvant-inducedarthritis
rat. Biol. Pharm. Bull., 30, 1934-1937 (2007).
5. 伊藤吉將, 岡本紀夫, 別所雅史, 川上吉美, 三村 治, 長井紀章. 旧型眼底カメラに最新デジタルカメラの取り付け例. あたらしい眼科,
24, 1125-1127 (2007).
6. Nagai N, Takeda M, Ito Y, Takeuchi N, Kamei A. Delay in ICR/fRat Lens
Opacification by the Instillation of Eye Drops Containing Disulfiramand
Hydroxypropyl-beta-cyclodextrin Inclusion Complex. Biol. Pharm. Bull.,30,
1529-1534 (2007).
7. Nagai N, Ito Y. Delay of Cataract Development in the Shumiya CataractRat
by Water Containing Enhanced Concentrations of Magnesium and Calcium.Curr.
Eye Res., 32, 439-445 (2007).
8. 福畠孝史, 長井紀章, 伊藤吉將, 太井秀行, 端口佳宏, 魚住嘉伸, 中川光司. マグネシウム含有点眼液によるラット結膜anaphylaxis反応抑制効果.
あたらしい眼科, 24, 831-834 (2007).
9. 長井紀章, 宋 永波, 福畠孝史, 伊藤吉將, 岡村春樹. 遺伝性白内障UPLラットの白内障発症におけるインターロイキン-18の関与.
あたらしい眼科, 24, 815-818 (2007).
10. Nagai N, Fukuhata T, Ito Y. Effect of Magnesium Deficiency on IntracellularATP
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Prevent Damage to Human Lens Epithelial Cells Induced by Interferon-Gammaand
Lipopolysaccharide. Biol. Pharm. Bull., 29, 2077-2081 (2006).
3. Nagai N, Ito Y, Inomata M, Shumiya S, Tai H, Hataguchi Y, NakagawaK.
Delay of cataract development in the shumiya cataract rat by the administrationof
drinking water containing high concentration of magnesium ion. Biol.Pharm.
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drops of liposomes containing disulfiram and cefmetazole on selenite-inducedcataract
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