業績

Research Papers

  1. Notch signaling enhances stemness by regulating metabolic pathways through modifying p53, NF-κB, and HIF-1α.
    H Moriyama, M Moriyama, T Ozawa, K Nakagawa, T Tsuruda and T Hayakawa.

    Stem Cell Dev. 2018 Jul 1;27(13):935-947.
  2. Identification of ACA-28, a 1′-acetoxychavicol acetate analogue compound, as a novel modulator of ERK MAPK signaling, which preferentially kills human melanoma cells.
    Satoh R, Hagihara K, Matsuura K, Manse Y, Kita A, Kunoh T, Masuko T, Moriyama M, Moriyama H, Tanabe G, Muraoka O, Sugiura R.
    Genes Cells.2017 Jul;22(7):608-618.
  3. BNIP3 upregulation via stimulation of ERK and JNK activity is required for the protection of keratinocytes from UVB-induced apoptosis.
    M Moriyama, H Moriyama, J Uda, H Kubo, A Goto, Y Nakajima, T Morita, T Hayakawa.
    Cell Death Dis. 2017 Apr 2;8(2):e2576.
  4. Beneficial Effects of the Genus Aloe on Wound Healing, Cell Proliferation, and Differentiation of Epidermal Keratinocytes.
    M Moriyama, H Moriyama, J Uda, H Kubo, Y Nakajima, A goto, J Akaki, Yoshida I, Matsumoka N, and Hayakawa T.
    Plos One. 2016 11 (10), e0164799
  5. Inhibitory effects of oligostilbenoids from the bark of Shorea roxburghii on malignant melanoma cell growth: Implications for novel topical anticancer candidates.
    H Moriyama, M Moriyama, K Ninomiya, T Morikawa, T Hayakawa. 
    Biol Pharm Bullet. 2016 39 (10), 1675-1682
  6. Oct4 plays a crucial role in the maintenance of gefitinib-resistant lung cancer stem cells.
    Kobayashi I, Takahashi F, Nurwidya F, Nara T, Hashimoto M, Murakami A, Yagishita S, Tajima K, Hidayat M, Shimada N, Suina K, Yoshioka Y, Sasaki S, Moriyama M, Moriyama H, Takahashi K.
    Biochem Biophys Res Commun. 2016 Apr 22;473(1):125-132
  7. Roles of Autophagy-related Gene in Differentiation and Maintenance of Epidermis.
    Moriyama M, Moriyama H, Hayakawa T.
    J Cosmetics Sci-Fi Soc. 2015 39(3): 192-194
  8. Role of Notch signaling in the maintenance of human mesenchymal stem cells under hypoxic conditions.
    Moriyama H, Moriyama M, Isshi H, Ishihara S, Okura H, Ichinose A, Ozawa T, 
    Matsuyama A, Hayakawa T. 

    Stem Cells Dev. 23(18):2211-24 (2014)
  9. BNIP3 plays crucial roles in the defferentiation and maintenance of epidermal keratinocytes.
    Moriyama M, Moriyama H, Uda J, Matsuyama A, Osawa M, Hayakawa T.
    J Invest Dermatol. 2014 134(6):1627-35
  10. Hypoxia increases Gefitinib-resistant lung cancer stem cells through the activation of insulin-like growth factor 1 receptor.
    Murakami A, Takahashi F, Nurwidya F, Kobayashi I, Minakata K, Hashimoto M, Nara T, Kato M, Kajima K, Shimada N, Iwakami S, Moriyama M, Moriyama H, Koizumi F, Takahashi K.
    PLOS ONE. 2014 8(6):e66274
  11. Tightly regulated and homogeneous transgene expression in human adipose-derived mesenchymal stem cells by lentivirus with tet-off system.
    Moriyama H, Moriyama M, Sawaragi K, Okura H, Ichinose A, Matsuyama A, Hayakawa T.
    PLOS ONE. 2013 8(6): e66274
  12. Human adipose tissue-derived multilineage progenitor cells exposed to oxidative stress induce neurite outgrowth in PC12 cells through p38 MAPK signaling.
    Moriyama M, Moriyama H, Ueda A, Nishibata Y, Okura H, Ichinose A, Matsuyama A, Hayakawa T.
    BMC Cell Biol. 2012 13(1): 21. Highly accessed
  13. Hypoxia induces Gefitinib resistance in non-small cell lung cancer with both mutant and wild-type epidermal growth factor receptors.
    Minakata K, Takahashi F, Nara T, Hashimoto M, Tajima K, Murakami A, Nurwidya F, Yae S, Koizumi F, Moriyama H, Seyama K, Nishio K, Takahashi K.
    Cancer Sci. 2012 103(11): 1946-54
  14. HMG-CoA reductase inhibitor augments the serum total cholesterol-lowering effect of human adipose tissue-derived multilineage progenitor cells in hyperlipidemic homozygous Watanabe rabbits.
    Saga A, Okura H, Soeda M, Tani J, Fumimoto Y, Komoda H, Moriyama M, Moriyama H, Yamashita S, Ichinose A, Daimon T, Hayakawa T, Matsuyama A.
    Biochem Biophys Res Commun. 2011 412(1): 50-4
  15. Breast tumor progression induced by loss of BTG2 expression is inhibited by targeted therapy with the ErbB/HER inhibitor lapatinib.
    Takahashi F, Chiba N, Tajima K, Hayashida T, Shimada T, Takahashi M, Moriyama H, Brachtel E, Edelman EJ, Ramaswamy S, Maheswaran S.
    Oncogene. 2011 30(27): 3084-95
  16. Transplantation of human adipose tissue-derived multilineage progenitor cells reduces serum cholesterol in hyperlipidemic Watanabe rabbits.
    Okura H, Saga A, Fumimoto Y, Soeda M, Moriyama M, Moriyama H, Nagai K, Lee CM, Yamashita S, Ichinose A, Hayakawa T, Matsuyama A.
    Tissue Eng Part C Methods. 2011 17(2): 145-54
  17. Multiple roles of Notch signaling in the regulation of epidermal development.
    Moriyama M, Durham AD, Moriyama H, Hasegawa K, Nishikawa S, Radtke F, Osawa M.
    Dev Cell. 2008 14(4): 594-604
  18. In vitro expansion of immature melanoblasts and their ability to repopulate melanocyte stem cells in the hair follicle.
    Yonetani S, Moriyama M, Nishigori C, Osawa M, Nishikawa S.
    J Invest Dermatol. 2007 128(2): 408-20
  19. Investigation of the molecular mechanism of ICAN, a novel gene amplification method.
    Uemori T, Mukai H, Takeda O, Moriyama M, Sato Y, Hokazono S, Takatsu N, Asada K, Kato I.
    J Biochem. 2007 142(2): 283-92
  20. Rapid up-regulation of c-FLIP expression by BCR signaling through the PI3K/Akt pathway inhibits simultaneously induced Fas-mediated apoptosis in murine B lymphocytes.
    Moriyama H, Yonehara S.
    Immunol Lett. 2007 109(1): 36-46
  21. Notch signaling via Hes1 transcription factor maintains survvival of melanoblasts and melanocyte stem cells.
    Moriyama M, Osawa M, Mak SS, Ohtsuka T, Yamamoto N, Han H, Delmas V, Kageyama R, Beermann F, Larue L, Nishikawa S.
    J Cell Biol. 2006 173(3): 333-9
  22. Indispensable role of Bcl2 in the development of the malanocyte stem cell.
    Mak SS, Moriyama M, Nishioka E, Osawa M, Nishikawa S.
    Dev Biol. 2006 291(1): 144-53
  23. Molecular characterization of melanocyte stem cells in their niche.
    Osawa M, Egawa G, Mak SS, Moriyama M, Freter R, Yonetani S, Beermann F, Nishikawa S.
    Development. 2005 132(24): 5589-99
  24. GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast.
    Takayama Y, Kamimura Y, Moriyama(Okawa) M, Muramatsu S, Sugino A, Araki H.
    Genes Dev. 2003 17(9): 1153-65
  25. Dominant role of the niche in melanocyte stem-cell fate determination.
    Nishimura EK, Jordan SA, Oshima H, Yoshida H, Osawa M, Moriyama M, Jackson IJ, Barrandon Y, Miyachi Y, Nishikawa S.
    Nature. 2002 416(6883): 854-60
  26. Genetic subtypes of HIV type 1 in Republic of Congo.
    Bikandou, B., Takehisa, J., Mboudjeka, I., Ido, E., Kuwata, T., Miyazaki, Y., Moriyama, H., Harada, Y., Taniguchi, Y., Ichimura, H., Ikeda, M., Ndolo, P.J., Nzoukoudi, M.Y., M’Vouenze, R., M’Pandi, M., Parra, H.J., M’Pele, P. & Hayami, M.
    AIDS Res Hum Retroviruses. 2000 16, 613-9
  27. Various types of HIV mixed infections in Cameroon.
    Takehisa, J., Zekeng, L., Ido, E., Mboudjeka, I., Moriyama, H., Miura, T., Yamashita, M., Gurtler, L.G., Hayami, M. & Kaptue, L.
    Virology. 1998 245, 1-10
  28. Infectivity and immunogenicity of SIVmac/HIV-1 chimeric viruses (SHIVs) with deletions in two or three genes (vpr, nef and vpx).
    Igarashi, T., Kuwata, T., Yamamoto, H., Moriyama, H., Ui, M., Miyazaki, Y. & Hayami, M.
    Microbiol Immunol. 1998 42, 71-4

 

Reviews, Books

  1. アロエベラ液汁による紫外線ダメージ軽減効果
    森山麻里子, 赤木淳二, 北郡秀晃, 森山博由
    Bio industry. 2018 35 (9), 27-35
  2. 混合植物エキスによる加齢に伴う表皮菲薄化のアプローチ
    岩野英生, 森山麻里子, 陳玉倩, 呂梨萍, 沈柏村, 森山博由, 澤木茂豊
    日本皮膚科学会雑誌. 2018 128 (5) 1174
  3. 薬学部実務実習生を対象にした処方解析プログラムの効果の検証について
    齋藤 玲奈, 阿登 大次郎, 清水 忠, 森山 博由, 小竹 武, 井上 知美, 小森 浩二, 三田村 しのぶ, 日高 眞理, 廣瀬 隆, 吉田 彰彦, 小牟田 豊, 東海 秀吉
    交通医学. 2018 72 (1-2) 17-17
  4. BIO R&D アロエベラ液汁の美肌効果.
    森山麻里子, 赤木淳二, 森山博由.
    Bio industry. 2016 33 (4), 54-59
  5. 間葉系幹細胞の化粧品評価への活用展望(幹細胞を用いた最新のエイジングケア研究と化粧品開発).
    森山博由, 森山麻里子, 早川堯夫.
    Cosmetic stage. 2015 9 (8), 24-28
  6. オートファジー関連分子による皮膚上皮細胞の分化調節・形態維持.
    森山博由, 森山麻里子, 早川堯夫.
    日本香粧品学会誌. 2015 39 (3), 192-195
  7. Fas/Fasリガンド
    森山博由, 米原伸.
    新用語ライブラリー 免疫 第2版  2000
  8. pDON-AIを用いた効率的な遺伝子導入.
    森山博由, 橋野仁一.
    TAKARA BIO VIEW. 1998 27 (27)
  9. ストレス負荷による老化促進モデルマウスの炎症反応系サイトカイン産生の増強.
    細川友秀, 森山博由, 西村泰光, 細野正道.
    基礎老化研究. 1997 20, 62

 

Patents

  1. 【発明の名称】脂肪組織由来体性幹細胞の製造方法
    発明者:森山 博由、森山 麻里子、早川 堯夫、松山 晃文
    公開番号:特開2014-030423
    出願番号:特願2013-144653
  2. 【発明の名称】核酸の増幅方法
    発明者:向井 博之、山本 純子、武田 理、三宅 一恵、上森 隆司、佐藤 好美、森山 麻里子、椹木 治久、萩屋 道雄、浅田 起代蔵、加藤 郁之進
    公開番号:特開2003-70490
    出願番号:特願2002-185781