業績目録(学術論文,総説,著書)(1998)         学会発表はこちら(2003〜) 

 (*Corresponding author)

1.     Tomita, S., Sekiguchi, F., Deguchi, T., Miyazaki, T., Ikeda, Y., Tsubota, M., Yoshida, S., Nguyen, H.D., Okada, T., Toyooka, N., Kawabata, A.* (2019) Critical role of Cav3.2 T-type calcium channels in the peripheral neuropathy induced by bortezomib, a proteasome-inhibiting chemotherapeutic agent, in mice. Toxicology, 413, 33-39. PubMed

2.     坪田真帆川畑篤史* (2019) 内臓痛におけるマクロファージ由来HMGB1の役割と治療標的分子としての可能性.Pain Res., in press. (Review)

3.     Miyamoto, T.*, Fukuyama, H., Hatanaka, S., Fujitani, M., Koizumi, Y., Kawabata, A. (2019) The C-reactive protein/albumin ratio is useful for predicting short-term survival in cancer and non-cancer patients. J. Palliat. Med., in press. PubMed

4.     Sekiguchi, F., Domoto, R. (co-first author), Nakashima, K., Yamasoba, D., Yamanishi, H., Tsubota, M., Wake, H., Nishibori, M., Kawabata, A.* (2018) Paclitaxel-induced HMGB1 release from macrophages and its implication for peripheral neuropathy in mice: evidence for a neuroimmune cross talk. Neuropharmacology, 141, 201-213. PubMed

5.     Nguyen, H.D., Okada, T., Kitamura, S., Yamaoka, S., Horaguchi, Y., Kasanami, Y., Sekiguchi, F., Tsubota, M., Yoshida, S., Nishikawa, H. Kawabata, A.*, Toyooka, N.* (2018) Design and synthesis of novel anti-hyperalgesic agents based on 6-prenylnaringenin as the T-type calcium channel blockers. Bioorg. Med. Chem., 26, 4410-4427. PubMed

6.     Sekiguchi, F., Fujita, T., Deguchi, T., Yamaoka, S., Tomochika, K., Tsubota, M., Ono, S., Horaguchi, Y., Ichii, M., Ichikawa, M., Ueno, Y., Koike, N., Tanino, T., Nguyen, H.D., Okada, T., Nishikawa, H., Yoshida, S., Ohkubo, T., Toyooka, N., Murata, K., Matsuda, H., Kawabata, A.* (2018) Blockade of T-type calcium channels by 6-prenylnaringenin, a hop component, alleviates neuropathic and visceral pain in mice. Neuropharmacology, 138, 232-244. PubMed

7.     Sekiguchi, F., Tsubota, M., Kawabata, A.* (2018) Involvement of voltage-gated calcium channels in inflammation and inflammatory pain. Biol. Pharm. Bull., 41, 1127-1134. PubMed  (Review)

8.     Tsubota, M., Okawa, Y., Irie, Y., Maeda, M., Ozaki, T., Sekiguchi, F., Ishikura, H., Kawabata, A.* (2018) Involvement of the cystathionine-γ-lyase/Cav3.2 pathway in substance P-induced bladder pain in the mouse, a model for nonulcerative bladder pain syndrome. Neuropharmacology, 133, 254-263. PubMed

9.     Tsubota, M., Ozaki, T. (co-first author), Hayashi, Y., Okawa, Y., Fujimura, A., Sekiguchi, F., Nishikawa, H., Kawabata, A.* (2018) Prostanoid-dependent bladder pain caused by proteinase-activated receptor-2 activation in mice: Involvement of TRPV1 and T-type Ca2+ channels. J. Pharmacol. Sci., 136, 46-49. PubMed

10. Tsujita, R., Tsubota, M. (co-first author), Hayashi, Y. (co-first author), Saeki, H., Sekiguchi, F., Kawabata, A.* (2018) Role of thrombin in soluble thrombomodulin-induced suppression of peripheral HMGB1-mediated allodynia in mice. J. Neuroimmune Pharmacol., 13, 179-188. PubMed

11. Hayashi, Y., Tsujita, R. (co-first author), Tsubota, M. (co-first author), Saeki, H., Sekiguchi, F., Honda, G., Kawabata, A.* (2018) Human soluble thrombomodulin-induced blockade of peripheral HMGB1-dependent allodynia in mice requires both the lectin-like and EGF-like domains. Biochem. Biophys. Res. Commun., 495, 634-638.  PubMed

12. Ozaki, T., Matsuoka, J., Tsubota, M., Tomita, S., Sekiguchi, F., Minami, T., Kawabata, A.* (2018) Zinc deficiency promotes cystitis-related bladder pain by enhancing function and expression of Cav3.2 in mice. Toxicology, 393, 102-112. PubMed

13. Ozaki, T., Tsubota, M., Sekiguchi, F., Kawabata, A.* (2018) Involvement of NF-κB in the upregulation of cystathionine-γ-lyase, a hydrogen sulfide-forming enzyme, and bladder pain accompanying cystitis in mice. Clin. Exp. Pharmacol. Physiol., 45, 355-361. PubMed

14. Irie, Y., Tsubota, M. (co-first author), Ishikura, H., Sekiguchi, F., Terada, Y., Tsujiuchi, T., Liu, K., Nishibori, M., Kawabata, A.* (2017) Macrophage-derived HMGB1 as a pain mediator in the early stage of acute pancreatitis in mice: targeting RAGE and CXCL12/CXCR4 axis. J. Neuroimmune Pharmacol., 12, 693-707. PubMed

15. 関口富美子川畑篤史* (2017) 硫化水素(H2S)分子によるイオンチャネル機能制御と病態への関与.硫酸と工業, 80 (5), 61-70. (Review)

16. Tsubota, M., Miyamoto, T., Hiruma, S., Saeki, H., Miyazaki, T., Sekiguchi, F., Funakami, Y., Kawabata, A.* (2017) Repeated cold stress reduces cyclophosphamide-induced cystitis/bladder pain and macrophage activity in mice. Pharmacology, 99, 286-290. PubMed

17. 坪田真帆川畑篤史* (2017) トロンボモジュリンアルファの内臓痛治療への応用.潰瘍, 44, 48-53. (Review)

18. Fukami, K., Asano, E., Ueda, M., Sekiguchi, F., Yoshida, S., Kawabata, A.* (2017) High glucose induces N-linked glycosylation-mediated functional upregulation and overexpression of Cav3.2 T-type calcium channels in neuroendocrine-like differentiated human prostate cancer cells. J. Pharmacol. Sci., 133, 57-60. PubMed

19. Miyamoto, T., Funakami, Y., Kawashita, E., Tomita, S., Nomura, A., Sugimoto, N., Saeki, H., Tsubota, M., Ichida, S., Kawabata, A.* (2017) Enhanced hyperthermic responses to lipopolysaccharide in mice exposed to repeated cold stress. Pharmacology, 99, 172-178. PubMed

20. Miyamoto, T., Funakami, Y., Kawashita, E., Nomura, A., Sugimoto, N., Saeki, H., Tsubota, M., Ichida, S., Kawabata, A.* (2017) Repeated cold stress enhances the acute restraint stress-induced hyperthermia in mice. Biol. Pharm. Bull., 40, 1-6. PubMed

21. Terada, Y., Tsubota, M., Sugo, H., Wakitani, K., Sekiguchi, F., Wada, K., Takada, M., Oita, A., Kawabata, A.* (2017) Tacrolimus triggers TRPV1-dependent relapse of pancreatitis-related pain in mice. Pharmacology, 99, 281-285. PubMed

22. Terada, Y., Wada, K.*, Matsuda, S., Kuwahara, T., Kawabata, A., Takada, M., Watanabe, T., Nakajima, S., Sato, T., Seguchi, O., Yanase, M., Fukushima, N., Nakatani, T. (2017) Circadian pharmacokinetics and limited sampling strategy of everolimus in heat transplant patients. Int. J. Clin. Pharmacol. Ther., 55 (1), 1-8. PubMed

23. Fukami, K., Sekiguchi, F., Kawabata, A.* (2016) Hydrogen sulfide and T-type Ca2+ channels in pain processing, neuronal differentiation and neuroendocrine secretion. Pharmacology, 99, 176-203. PubMed (Review)

24. 坪田真帆川畑篤史* (2016) 膵臓の疼痛における侵害受容体の関与と治療への展望.(特集:膵疾患の疼痛治療のup-to-date ―疼痛の発生メカニズムから疾患別治療まで)胆と膵, 37, 1535-1539. (Review)

25. Nishida, T., Tsubota, M. (co-first author), Kawaishi, Y., Yamanishi, H., Kamitani, N., Sekiguchi, F., Ishikura, H., Liu, K., Nishibori, M., Kawabata, A.* (2016) Involvement of high mobility group box 1 in the development and maintenance of chemotherapy-induced peripheral neuropathy in rats. Toxicology, 365, 48-58. PubMed

26. Sekiguchi, F., Kawara, Y., Tsubota, M., Kawakami, E., Ozaki, T., Kawaishi, Y., Tomita, S., Kanaoka, D., Yoshida, S., Ohkubo, T., Kawabata, A.* (2016) Therapeutic potential of RQ-00311651, a novel T-type Ca2+ channel blocker, in distinct rodent models for neuropathic and visceral pain. Pain, 157, 1655-1665. PubMed 

27. Mitani, K., Sekiguchi, F., Maeda, T., Tanaka, Y., Kawabata, A.* (2016) The prostaglandin E2/EP4 receptor/cyclic AMP/T-type Ca2+ channel pathway mediates neuritogenesis in sensory neuron-like ND7/23 cells. J. Pharmacol. Sci., 130, 177-180. PubMed

28. Sekiguchi, F., Sekimoto, T., Ogura, A., Kawabata, A.* (2016) Endogenous hydrogen sulfide enhances cell proliferation of human gastric cancer AGS cells. Biol. Pharm. Bull., 39, 887-890. PubMed

29. Yamasoba, D., Tsubota, M., Domoto, R., Sekiguchi, F., Nishikawa, H., Liu, K., Nishibori, M., Ishikura, H., Yamamoto, T., Taga, A., Kawabata, A.* (2016) Peripheral HMGB1-induced hyperalgesia in mice: redox state-dependent distinct roles of RAGE and TLR4. J. Pharmacol. Sci., 130, 139-142. PubMed

30. Aoki, Y., Tsubota, M., Nishimoto, Y., Maeda, Y., Sekiguchi, F., Kawabata, A.* (2016) Selective sensitization of C-fiber nociceptors by hydrogen sulfide. J. Pharmacol. Sci., 130, 38-41. PubMed

31. Nagai, N., Yoshioka, C., Ito, Y.*, Funakami, Y., Nishikawa, F., Kawabata, A. (2015) Intravenous administration of cilostazol nanoparticles ameliorates acute ischemic stroke in a cerebral ischemia/reperfusion-induced injury model. Int. J. Mol. Sci., 16, 29329-29344. PubMed

32. Fukami, K., Sekiguchi, F., Yasukawa, M., Asano, E., Kasamatsu, R., Ueda, M., Yoshida, S., Kawabata, A.* (2015) Functional upregulation of the H2S/Cav3.2 channel pathway accelerates secretory function in neuroendocrine-differentiated human prostate cancer cells. Biochem. Pharmacol. 97, 300-309. PubMed

33. Terada, Y., Kawabata, A.* (2015) H2S and pain: a novel aspect for processing of somatic, visceral and neuropathic pain signals. In Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide, edited by Moore, P.K. and Whiteman, M., Springer, Handbook of Experimental Pharmacology 230: 217-230. PubMed (Book Chapter / Review)

34. Fukami, K., Kawabata, A.* (2015) Hydrogen sulfide and neuronal differentiation: focus on Ca2+ channels. Nitric Oxide, 46, 50-54. PubMed (Review)

35. Murakami-Nakayama, M., Tsubota, M., Hiruma, S., Sekiguchi, F., Matsuyama, K., Kimura, T., Moriyama, M., Kawabata, A.* (2015) Polaprezinc attenuates cyclophosphamide-induced cystitis and related bladder pain in mice. J. Pharmacol. Sci., 127, 223-228. PubMed

36. Terada, Y., Fujimura, M., Nishimura, S., Tsubota, M., Sekiguchi, F., Kawabata, A.* (2015) Roles of Cav3.2 and TRPA1 channels targeted by hydrogen sulfide in pancreatic nociceptive processing in mice with or without acute pancreatitis. J. Neurosci. Res., 93, 361-369. PubMed

37. Takechi, M.*, Wada, T., Yagi, H., Masuko, T., Kawabata, A. (2015) Ouabain exerts cytoprotection by diminishing the intracellular K+ concentration increase caused by distinct stressful stimuli in human leukemic cells. J. Pharm. Pharmacol., 67, 126-132. PubMed

38. Maeda, Y., Sekiguchi, F., Yamanaka, R., Sugimoto, R., Yamasoba, D., Tomita, S., Nishikawa, H., Kawabata, A.* (2015) Mechanisms for proteinase-activated receptor 1-triggered prostaglandin E2 generation in mouse osteoblastic MC3T3-E1 cells. Biol. Chem., 396, 153-162. PubMed

39. 坪田真帆*川畑篤史 (2014) 結腸の疼痛および炎症におけるガス状情報伝達物質硫化水素の役割.Yakugaku Zasshi, 134, 1245-1252. PubMed (Review)

40. Sekiguchi, F., Miyamoto, Y., Kanaoka, D., Ide, H., Yoshida, S., Ohkubo, T., Kawabata, A.* (2014) Endogenous and exogenous hydrogen sulfide facilitates T-type calcium channel currents in Cav3.2-expressing HEK293 cells. Biochem. Biophys. Res. Commun., 445, 225-229. PubMed

41. Tanaka, J., Yamaguchi, K., Ishikura, H., Tsubota, M., Sekiguchi, F., Seki, Y., Tsujiuchi, T., Murai, A., Umemura, T., Kawabata, A.* (2014) Bladder pain relief by HMGB1 neutralization and soluble thrombomodulin in mice with cyclophosphamide-induced cystitis. Neuropharmacology, 79, 112-118. PubMed

42. Terada, Y., Fujimura, M., Nishimura, S., Tsubota, M., Sekiguchi, F., Nishikawa, H. and Kawabata, A.* (2013) Contribution of TRPA1 as a downstream signal of proteinase-activated receptor-2 to pancreatic pain. J. Pharmacol. Sci., 123, 284-287. PubMed

43. Tanaka, J., Seki, Y., Ishikura, H., Tsubota, M., Sekiguchi, F., Yamaguchi, K., Murai, A., Umemura, T. and Kawabata, A.* (2013) Recombinant human soluble thrombomodulin prevents peripheral HMGB1-dependent hyperalgesia in rats. Br. J. Pharmacol., 170, 1233-1241. PubMed

44. Sekiguchi, F. and Kawabata, A.* (2013) T-type calcium channels: functional regulation and implication in pain signaling. J. Pharmacol. Sci., 122, 244-250. PubMed (Review)

45. Nishikawa, H., Hayashi, H., Kubo, S., Tsubota-Matsunami, M., Sekiguchi, F., and Kawabata, A.* (2013) Inhibition by hydrogen sulfide of rabbit platelet aggregation and calcium mobilization. Biol. Pharm. Bull., 36, 1278-1282. PubMed

46. Nakayama, M.*, Fujiwara, M., Nakamura, T., Azuma, T., Matzno, S., Kamikonya, N., Kimura, T., Matsuyama, K., Kawabata, A. (2013) Stability of polaprezinc-containing oral rinse and its clinical effectiveness against radiotherapy-induced oral mucositis. Jpn. J. Drug Inform., 15, 133-138.

47. 中山雅裕*、中村豪志、東剛史、志方敏幸、川畑篤史、松山賢治、冨土原将之、上紺屋憲彦、木村健. (2013 ) ポラプレジンク含嗽液の新たな基材に関する検討医薬品情報学, 15, 13-17.

48. Takahashi, T., Okubo, K., Kojima, S., Nishikawa, H., Takemura, M., Tsubota-Matsunami, M., Sekiguchi, F. and Kawabata, A.* (2013) Antihyperalgesic effect of buprenorphine involves nociceptin/orphanin FQ peptide receptor activation in rats with spinal nerve injury-induced neuropathy. J. Pharmacol. Sci., 122, 51-54. PubMed

49. 川畑篤史*. (2013 ) Cav3.2 T型カルシウムチャネルを標的とした癌化学療法誘起神経障害性疼痛の治療戦略日薬理誌, 141, 81-84. PubMed (Review)

50. Sekiguchi, F., Aoki, Y., Nakagawa, M., Kanaoka, D., Nishimoto, Y., Tsubota-Matsunami, M., Yamanaka, R., Yoshida, S. and Kawabata, A.* (2013) AKAP-dependent sensitization of Cav3.2 channels via the EP4 receptor/cyclic AMP pathway mediates prostaglandin E2-induced mechanical hyperalgesia. Br. J. Pharmacol., 168, 734-745. PubMed

51. Sekiguchi, F., Matsumoto, Y., Maeda, Y., Tsubota-Matsunami, M., Nishikawa, H. and Kawabata, A.* (2012) Biological activity of Helicobactor pylori components in mammalian cells: is it independent of proteinase-activated recetpros? J. Physiol. Pharmacol., 63, 571-576. PubMed

52. Tsubota-Matsunami, M., Noguchi, Y., Okawa, Y., Sekiguchi, F. and Kawabata, A.* (2012) Colonic hydrogen sulfide-induced visceral pain and referred hyperalgesia involve activation of both Cav3.2 and TRPA1 channels in mice. J. Pharmacol. Sci., 119, 293-296. PubMed

53. Matsunami, M., Miki, T., Nishiura, K., Hayashi, Y., Okawa, Y., Nishikawa, H., Sekiguchi, F., Kubo, L., Ozaki, T., Tsujiuchi, T. and Kawabata, A.* (2012) Involvement of the endogenous hydrogen sulfide/Cav3.2 T-type Ca2+ channel pathway in cystitis-related bladder pain in mice. Br. J. Pharmacol., 167, 917-928. PubMed

54. Kawabata, A.* and Matsunami, M. (2012) Roles of the hydrogen sulfide/T-type calcium channel system in somatic and visceral pain processing. In Cell/Tissue Injury and Cytoprotection/Organoprotection in the Gastrointestinal Tract: Mechanisms, Prevention and Treatment, edited by Filaretova, L.P. and Takeuchi, K., Front. Gastrointest. Res., Basel, Karger (vol 30), pp212-218. (Book Chapter)

55. Matsunami, M., Kirishi, S., Okui, T. and Kawabata, A.* (2012) Hydrogen sulfide-induced colonic mucosal cytoprotection involves T-type calcium channel-dependent neuronal excitation in rats. J. Physiol. Pharmacol., 63, 61-68. PubMed

56. Okubo, K., Matsumura, M., Kawaishi, Y., Aoki, Y., Matsunami, M., Okawa, Y., Sekiguchi, F. and Kawabata, A.* (2012) Hydrogen sulfide-induced mechanical hyperalgesia and allodynia require activation of both Cav3.2 and TRPA1 channels in mice. Br. J. Pharmacol., 166, 1738-1743. PubMed

57. Okubo, K., Nakanishi, H., Matsunami, M., Shibayama, H. and Kawabata, A.* (2012) Topical application of disodium isostearyl 2-O-L-ascorbyl phosphate, an amphiphilic ascorbic derivative, reduces neuropathic hyperalgesia in rats. Br. J. Pharmacol., 166, 1058-1068. PubMed

58. Kurokawa, Y., Sekiguchi, F., Kubo, S., Yamasaki, Y., Matsuda, S., Okamoto, Y., Sekimoto, T., Fukatsu, A., Nishikawa, H., Kume, T., Fukushima, N., Akaike, A. and Kawabata, A.* (2011) Involvement of ERK in NMDA receptor-independent cortical neurotoxicity of hydrogen sulfide. Biochem. Biophys. Res. Commun., 414, 727-732. PubMed

59. 大久保寿政、川畑篤史* (2011) 神経障害性疼痛における硫化水素の役割.ペインクリニック, 32, 1464-1471. (Review)

60. Okubo, K., Takahashi, T., Sekiguchi, F., Kanaoka, D., Matsunami, M., Ohkubo, T., Yamazaki, J., Fukushima, N., Yoshida, S. and Kawabata, A.* (2011) Inhibition of T-type calcium channels and hydrogen sulfide-forming enzyme reverses paclitaxel-evoked neuropathic hyperalgesia in rats. Neuroscience, 188, 148-156. PubMed

61. Matsunami, M., Kirishi, S., Okui, T. and Kawabata, A.* (2011) Chelating luminal zinc mimics hydrogen sulfide-evoked colonic pain in mice: possible involvement of T-type calcium channels. Neuroscience, 181: 257-264. PubMed

62. Miki, T., Matsunami, M., Nakamura, S., Okada, H., Matsuya, H. and Kawabata, A.* (2011) ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis. Pain, 152, 1373-1381. PubMed

63. Kawabata, A.* (2011) Prostaglandin E2 and pain: an update. Biol. Pharm. Bull., 34, 1170-1173. (Review)  PubMed

64. Kawabata, A.* (2011) Lipid Mediators and Pain Signaling: Foreword. Biol. Pharm. Bull., 34, 1153. (Foreword)  PubMed

65. Sekiguchi, F., Ohi, A., Maeda, Y., Takaoka, K., Sekimoto, T., Nishikawa, H. and Kawabata, A.* (2011) Delayed production of arachidonic acid contributes to the delay of proteinase-activated receptor-1 (PAR1)-triggered prostaglandin E2 release in rat gastric epithelial RGM1 cells. J. Cell. Biochem., 112, 909-1015. PubMed

66. Nishimura, S. Ishikura, H., Matsunami, M., Shinozaki, Y., Sekiguchi, F., Naruse, M., Kitamura, T., Akashi, R., Matsumura, K. and Kawabata, A.* (2010) The proteinase/proteinase-activated receptor-2/transient receptor potential vanilloid-1 cascade impacts pancreatic pain in mice. Life Sci., 87, 643-650. PubMed

67. Moriyuki, K., Sekiguchi, F., Matsubara, K., Nishikawa, H. and Kawabata, A.* (2010) Curcumin inhibits the proteinase-activated receptor-2-triggered prostaglandin E2 production by suppressing COX-2 upregulation and Akt-dependent activation of NF-κB in human lung epithelial cells. J. Pharmacol. Sci., 114, 225-229. PubMed

68. Fukushima, O., Nishimura, S., Matsunami, M., Aoki, Y., Nishikawa, H., Ishikura, H. and Kawabata, A.* (2010) Phosphorylation of ERK in the spinal dorsal horn following pancreatic pro-nociceptive stimuli with proteinase-activated receptor-2 agonists and hydrogen sulfide in rats: evidence for involvement of distinct mechanisms. J. Neurosci. Res., 88, 3198-3205. PubMed

69. Tarui, T., Fukami, K., Nagasawa, K., Yoshida, S., Sekiguchi, F. and Kawabata, A.* (2010) Involvement of Src kinase in T-type calcium channel-dependent neuronal differentiation of NG108-15 cells by hydrogen sulfide. J. Neurochem., 114, 512-519. PubMed

70. Takahashi, T., Aoki, Y., Okubo, K., Maeda, Y., Sekiguchi, F., Mitani, K., Nishikawa, H. and Kawabata, A.* (2010) Upregulation of Cav3.2 T-type calcium channels targeted by endogenous hydrogen sulfide contributes to maintenance of neuropathic pain. Pain, 150, 183-191. PubMed

71. Takaoka, K., Sekiguchi, F., Shigi, H., Maeda, Y., Nishikawa, H. and Kawabata, A.* (2010) Opposite effects of two thiazolidinediones, ciglitazone and troglitazone, on proteinase-activated receptor-1-triggered prostaglandin E2 release. Toxicology, 268, 40-45. PubMed

72. Moriyuki, K., Sekiguchi, F., Matsubara, K., Nishikawa, H. and Kawabata, A.* (2009) PAR2-triggered prostaglandin E2 release, but not cyclooxygenase-2 upregulation, requires activation of the phosphatidylinositol 3-kinase/Akt/NFκB pathway in human alveolar epithelial cells. J. Pharmacol. Sci., 111, 269-275. PubMed

73. Kanke, T., Kabeya, M., Kubo, S., Kondo, S., Yasuoka, K., Tagashira, J., Ishiwata, H., Saka, M., Furuyama, T., Nishiyama, T., Doi, T., Hattori, Y., Kawabata, A., Cunningham, M., Plevin, R.* (2009) Novel antagonists for proteinase-activated receptor 2: inhibition of cellular and vascular responses in vitro and in vivo. Br. J. Pharmacol.,158, 361-371. PubMed

74. Taniguchi, E., Matsunami, M., Kimura, T., Yonezawa, D., Ishiki, T., Sekiguchi, F., Nishikawa, H., Maeda, Y., Ishikura, H., Kawabata, A.* (2009) Rhodanese, but not cystathionine-γ-lyase, is associated with dextran sulfate sodium-evoked colitis in mice: a sign of impaired colonic sulfide detoxification? Toxicology, 264, 96-103. PubMed

75. 川畑篤史*(2009) 気体メディエーターとしての硫化水素の神経機能.21, 12, 239-245. (Review)

76. Nishimura, S., Fukushima, O., Ishikura, H., Takahashi, T., Matsunami, M., Tsujiuchi, T., Sekiguchi, F., Naruse, M., Kamanaka, Y. and Kawabata, A.* (2009) Hydrogen sulfide as a novel mediator for pancreatic pain in rodents. Gut, 58, 762-770. PubMed Outstanding paper

77. Maeda, Y., Aoki, Y., Sekiguchi, F., Matsunami, M., Takahashi, T., Nishikawa, H. and Kawabata, A.* (2009) Hyperalgesia induced by spinal and peripheral hydrogen sulfide: evidence for involvement of Cav3.2 T-type calcium channels. Pain, 142, 127-132.  PubMed

78. Nagasawa, K., Tarui, T., Yoshida, S., Sekiguchi, F., Matsunami, M., Ohi, A., Fukami, K., Ichida, S., Nishikawa, H. and Kawabata, A.* (2009) Hydrogen sulfide evokes neurite outgrowth and expression of high-voltage-activated Ca2+ currents in NG108-15 cells: involvement of T-type Ca2+ channels. J. Neurochem., 108, 676-684. PubMed

79. Matsunami, M., Tarui, T., Mitani, K., Nagasawa, K., Fukushima, O., Okubo, K., Yoshida, S., Takemura, M. and Kawabata, A.* (2009) Luminal hydrogen sulfide plays a pronociceptive role in mouse colon. Gut, 58, 751-761. PubMed Outstanding paper

80. Hirano, K.* and Kawabata, A. (2008) Basic and translational research on proteinase-activated receptors: Preface. J. Pharmacol. Sci., 108, 406-407. PubMed (Preface)

81. Tanaka, Y., Sekiguchi, F., Hong, H. and Kawabata, A.* (2008) PAR2 triggers IL-8 release via MEK/ERK and PI3-kinase/Akt pathways in GI epithelial cells. Biochem. Biophys. Res. Commun., 377, 622-626. PubMed

82. 関口富美子川畑篤史(2008) Protease-activated receptor シグナル.救急・集中治療, 20 (9-10), 1297-1303. (Review)

83. Kawabata, A.*, Matsunami, M. and Sekiguchi, F. (2008) Gastrointestinal roles for proteinase-activated receptors in health and disease. Br. J. Pharmacol., 153, S230-S240. (Review) PubMed

84. Nagataki, M., Moriyuki, K., Sekiguchi, F. and Kawabata, A.* (2008) Evidence that PAR2-triggered prostaglandin E2 (PGE2) formation involves the ERK-cytosolic phospholipase A2-COX-1-microsomal PGE synthase-1 cascade in human lung epithelial cells. Cell Biochem. Funct., 26, 279-282. PubMed

85. Moriyuki, K., Nagataki, M., Sekiguchi, F., Nishikawa, H. and Kawabata, A.* (2008) Signal transduction for formation/release of interleukin-8 caused by a PAR2-activating peptide in human lung epithelial cells. Regul. Pept, 145, 42-48. PubMed

86. Kubo, S., Kajiwara, M. and Kawabata, A.* (2007) Dual modulation of the tension of isolated gastric artery and gastric mucosal circulation by hydrogen sulfide in rats. Inflammopharmacology, 15, 288-292.

87. Sekiguchi, F., Takaoka, K. and Kawabata, A.* (2007) Proteinase-activated receptors in the gastrointestinal system: a functional linkage to prostanoids. Inflammopharmacology, 15, 246-251. (Review)

88. Kubo, S., Kurokawa, Y., Doe, I., Masuko, T., Sekiguchi, F. and Kawabata, A.* (2007) Hydrogen sulfide inhibits activity of three isoforms of recombinant nitric oxide synthase. Toxicology, 241, 92-97.

89. 松波真帆川畑篤史*(2007) H2Sは痛みのメディエータか?.日薬理誌, 130, 436-437. (Review:最近の話題)

90. Yonezawa, D., Sekiguchi, F., Miyamoto, M., Taniguchi, E., Honjo, M., Masuko, T., Nishikawa, H. and Kawabata, A.* (2007) A protective role of hydrogen sulfide against oxidative stress in rat gastric mucosal epithelium. Toxicology, 241, 11-18.

91. Kubo, S., Doe, I., Kurokawa, Y. and Kawabata, A.* (2007) Hydrogen sulfide causes relaxation in mouse bronchial smooth muscle. J. Pharmacol. Sci., 104, 392-396.

92. Kawabata, A.* (2007) Roles for H2S in Pain Processing: Response to Cunha and Verri. Pain, 130, 302-303.

93. Ishikura, H., Nishimura, S., Matsunami, M., Tsujiuchi, T., Ishiki, T., Sekiguchi, F., Naruse, M., Nakatani, T., Kamanaka, Y. and Kawabata, A.* (2007) The proteinase inhibitor camostat mesilate suppresses pancreatic pain in rodents. Life Sci., 80, 1999-2004.

94. Kawabata, A.*, Ishiki, T., Nagasawa, K., Yoshida, S., Maeda, Y., Takahashi, T., Sekiguchi, F., Wada, T., Ichida, S. and Nishikawa, H. (2007) Hydrogen sulfide as a novel nociceptive messenger. Pain, 132, 74-81.

95. Kubo, S., Doe, I., Kurokawa, Y., Nishikawa, H. and Kawabata, A.* (2007) Direct inhibition of endothelial nitric oxide synthase by hydrogen sulfide: contribution to dual modulation of vascular tension. Toxicology, 232, 138-146.

96. Sekiguchi, F., Saito, S., Takaoka, K., Hayashi, H., Nagataki, M., Nagasawa, K., Nishikawa, H., Matsui, H. and Kawabata, A.* (2007) Mechanisms for prostaglandin E2 formation caused by proteinase-activated receptor-1 activation in rat gastric mucosal epithelial cells. Biochem. Pharmacol., 73, 103-114.

97. Kubo, S., Ishiki, T., Doe, I., Sekiguchi, F., Nishikawa, H., Kawai, K., Matsui, H. and Kawabata, A.* (2006) Distinct activity of peptide mimetic intracellular ligands (pepducins) for proteinase-activated receptor-1 in multiple cells/tissues. Ann. NY Acad. Sci., 1091, 445-459.

98. 松波真帆関口富美子川畑篤史*(2006) プロテアーゼ活性化受容体.日薬理誌, 128, 434-436. (Review:キーワード解説)

99. 川畑篤史* (2006). PARの消化管機能.日薬理誌, 128, 82-87. (Review)

100.                 Kawabata, A.*, Kawao, N., Kitano, T., Matsunami, M., Satoh, R., Ishiki, T., Masuko, T., Kanke, T. and Saito N. (2006). Colonic hyperalgesia triggered by proteinase-activated receptor-2 in mice: involvement of endogenous bradykinin. Neurosci. Lett., 402, 167-172.

101.                 Kawabata, A.*, Kawao, N., Hironaka, Y., Ishiki, T., Matsunami, M. and Sekiguchi, F. (2006). Antiallodynic effect of etidronate, a bisphosphonate, in rats with adjuvant-induced arthritis: involvement of ATP-sensitive K+ channels. Neuropharmacology, 51, 182-190.

102.                 Kawabata, A.*, Matsunami, M., Tsutsumi, M., Ishiki, T., Fukushima, O., Sekiguchi, F., Kawao, N., Minami, T., Kanke, T. and Saito, N. (2006) Suppression of pancreatitis-related allodynia/hyperalgesia by proteinase-activated receptor-2 in mice. Br. J. Pharmacol., 148, 54-60.

103.                 川畑篤史* (2006). PAR-2と痛み.日薬理誌, 127, 133-136. (Review)

104.                 Sekiguchi, F., Hasegawa, N., Inoshita, K., Yonezawa, D., Inoi, N., Kanke, T., Saito, N. and Kawabata, A.* (2006) Mechanisms for modulation of mouse gastrointestinal motility by proteinase-activated receptor (PAR)-1 and -2 in vitro. Life Sci., 78, 950-957.

105.                 Kawao, N., Nagataki, M., Nagasawa, K., Kubo, S., Cushing, K., Wada, T., Sekiguchi, F., Ichida, S., Hollenberg, M.D., MacNaughton, W.K., Nishikawa, H. and Kawabata, A.* (2005) Signal transduction for proteinase-activated receptor-2-triggered prostaglandin E2 formation in human lung epithelial cells. J. Pharmacol. Exp. Ther., 315, 576-589.

106.                 Nishikawa, H. and Kawabata, A.* (2005) PAR-2 as a target for gastric mucosal protection. Drugs of Future, 30, 793-798. (Review)

107.                 川畑篤史* (2005).知覚神経・TRPV1の急性膵炎発症への関与.G. I. Research, 13, 387-392. (Review)

108.                 西川裕之, 川畑篤史* (2005). 消化器系におけるPARの役割.Surgery Frontier , 12, 135-143. (Review)

109.                 関口富美子* (2005). Protease-activated receptors (PARs)をターゲットとしたアゴニスト/アンタゴニストの開発と消化器系疾患に対する治療応用の可能性. Yakugaku Zasshi, 125, 491-498. (Review)

110.                 Kanke, T.*, Ishiwata, H., Kabeya, M., Saka, M., Doi, T., Hattori, Y., Kawabata, A. and Plevin, R. (2005) Binding of a highly potent protease-activated receptor-2 (PAR2) activating peptide, [3H]-2-furoyl-LIGRL-NH2, to human PAR2. Br. J. Pharmacol., 145, 255-263.

111.                 Kawabata, A.*, Oono, Y., Yonezawa, D., Hiramatsu, K., Inoi, N., Sekiguchi, F., Honjo, M., Hirofuchi, M., Kanke, T. and Ishiwata, H. (2005) 2-furoyl-LIGRL-NH2, a potent agonist for proteinase-activated receptor-2, as a gastric mucosal cytoprotective agent. Br. J. Pharmacol., 144, 212-219.

112.                 Kawabata, A.* and Kawao, N. (2005) Physiology and pathophysiology of proteinase-activated receptors (PARs): PARs in the respiratory system: cellular signaling and physiological/pathological roles. J. Pharmacol. Sci., 97, 20-24. (Review)

113.                 Kanke, T.*, Takizawa, T., Kabeya, M. and Kawabata, A. (2005) Physiology and pathophysiology of proteinase-activated receptors (PARs): Proteinase-activated receptor-2 (PAR-2) as a potential therapeutic target. J. Pharmacol. Sci., 97, 38-42. (Review)

114.                 Nishikawa, H., Kawai, K., Tanaka, M., Ohtani, H., Tanaka, S., Kitagawa, C., Nishida, M., Abe, T., Araki, H. and Kawabata, A.* (2005). Protease-activated receptor-2 (PAR-2)-related peptides induce tear secretion in rats: involvement of PAR-2 and non-PAR-2 mechanisms. J. Pharmacol. Exp. Ther., 312, 324-331.

115.                 Kimura, T., Arai, M., Masuda, H. and Kawabata, A.* (2004). Impact of a pharmacist-implemented anemia management in outpatients with end-stage renal disease in Japan. Biol. Pharm. Bull., 27, 1831-1833.

116.                 Kawabata, A.*, Nakaya, Y., Ishiki, T., Kubo, S., Kuroda, R., Sekiguchi, F., Kawao, N., Nishikawa, H. (2004) Receptor-activating peptides for PAR-1 and PAR-2 relax rat gastric artery via multiple mechanisms. Life Sci., 75, 2689-2702.

117.                 Sekiguchi, F. and Kawabata, A.* (2004) Protease-activated receptors (PARs) as therapeutic targets: development of agonists/antagonists and modulation of gastrointestinal functions. Drug Design Reviews, 1, 287-296. (Review)

118.                 川畑篤史* (2004) PAR (protease-activated receptor). 生体の科学 55, 520-521. (Review)

119.                 Kawabata, A.*, Kubo, S., Ishiki, T., Kawao, N., Sekiguchi, F., Kuroda, R., Hollenberg, M.D., Kanke, T. and Saito N. (2004) Proteinase-activated receptor-2-mediated relaxation in mouse tracheal and bronchial smooth muscle: Signal transduction mechanisms and distinct agonist sensitivity. J. Pharmacol. Exp. Ther., 311, 402-410.

120.                 Kawabata, A.*, Itoh, H., Kawao, N., Kuroda, R., Sekiguchi, F., Masuko, T., Iwata, K., Ogawa, A. (2004). Activation of trigeminal nociceptive neurons by parotid PAR-2 activation in rats. NeuroReport, 15, 1617-1621.

121.                 Sekiguchi, F., Mita, Y., Kamanaka, Y., Kawao, N., Matsuya, H., Taga, C. and Kawabata, A.* (2004). The potent iNOS inhibitor ONO-1714 inhibits nNOS and exerts antinociception in rats. Neurosci. Lett., 365, 111-115.

122.                 Kawabata, A*, Kanke, T., Yonezawa, D., Ishiki, T., Saka, M., Kabeya, M., Sekiguchi, F., Kubo, S., Kuroda, R., Iwaki, M., Katsura, K. and Plevin, R (2004) Potent and metabolically stable agonists for protease-activated receptor-2: Evaluation of activity in multiple assay systems in vitro and in vivo. J. Pharmacol. Exp. Ther., 309, 1098-1107.

123.                 Kawao, N., Ikeda, H., Kitano, T., Kuroda, R., Sekiguchi, F., Kataoka, K., Kamanaka, Y. and Kawabata, A.* (2004) Modulation of capsaicin-evoked visceral pain and referred hyperalgesia by protease-activated receptors 1 and 2. J. Pharmacol. Sci., 94, 277-285.

124.                 Kawabata, A.*, Kubo, S., Nakaya, Y., Ishiki, T., Kuroda, R., Sekiguchi, F., Kawao, N. and Nishikawa, H. (2004). Distinct roles for protease-activated receptors 1 and 2 in vasomotor modulation in rat superior mesenteric artery. Cardiovasc. Res. 61, 683-692.

125.                 Kawabata, A.*, Nishikawa, H., Saitoh, H., Nakaya, Y., Hiramatsu, K., Kubo, S., Nishida, M., Kawao, N., Kuroda, R., Sekiguchi, F., Kinoshita, M., Kakehi, K., Arizono, N., Yamagishi, H. and Kawai, K. (2004) A protective role of protease-activated receptor-1 in rat gastric mucosa. Gastroenterology 126, 208-219. Breakthrough paper

126.                 Kawao, N., Hiramatsu, K., Inoi, N., Kuroda, R., Nishikawa, H., Sekiguchi, F. and Kawabata, A.* (2003) The PAR-1-activating peptide facilitates pepsinogen secretion in rats. Peptides 24, 1449-1451.

127.                 Kamanaka, Y., Kawabata, A.*, Matsuya, H., Taga, C., Sekiguchi, F. and Kawao, N. (2003) Effect of a potent iNOS inhibitor (ONO-1714) on acetaminophen-induced hepatotoxicity in the rat. Life Sci. 74, 793-802.

128.                 Kawabata, A.*, Nakaya, Y., Kuroda, R., Wakisaka, M., Masuko, T., Nishikawa, H. and Kawai, K. (2003) Involvement of EDHF in the hypotension and increased gastric mucosal blood flow caused by PAR-2 activation in rats. Br. J. Pharmacol. 140, 247-254.

129.                 黒田良太郎*川畑篤史 (2003) 痛み情報伝達経路 末梢から大脳皮質までYakugaku Zasshi 123, 533-546. (Review)

130.                 Kawabata, A.* (2003) Gastrointestinal functions of proteinase-activated receptors. Life Sci. 74, 247-254. (Review)

131.                 川畑篤史*河尾直之 (2003) Protease-activated receptors と炎症BIO Clinica 18, 551-555 (Review)

132.                 Nishikawa, H. and Kawabata, A.* (2003) Modulation of gastric functions by PARs. Drug Dev. Res. 60, 9-13. (Review)

133.                 川畑篤史* (2003) プロテアーゼ受容体PAR-2 (protease-activated receptor-2) の生理機能.日薬理誌 121, 411-420. (Review)

134.                 Kawabata, A.* (2002) Multiple roles for protease-activated receptor-2 in gastric mucosa. Inflammopharmacology 10, 343-349. (Review)

135.                 川畑篤史* (2002) Protease-activated receptor-2 (PAR-2): 神経系,消化器系および血管系における役割.日本血栓止血学会誌 13, 467-476. (Review)

136.                 川畑篤史*黒田良太郎 (2002)  胃粘膜保護薬開発のための新しい標的分子としてのプロテアーゼ受容体PAR (protease-activated receptor). 日薬理誌 120 (補冊1), 85P-87P. (Review)

137.                 Kawabata, A.*, Kuroda, R., Nishida, M., Nagata, N., Sakaguchi, Y., Kawao, N., Nishikawa, H., Arizono, N. and Kawai, K. (2002) Protease-activated receptor-2 (PAR-2) in the pancreas and parotid gland: immunolocalization and involvement of nitric oxide in the evoked amylase secretion. Life Sci. 71, 2435-2446.

138.                 Kawabata, A.*, Kawao, N., Itoh, H., Shimada, C., Takebe, K., Kuroda, R., Masuko, T., Kataoka, K. and Ogawa, S. (2002) Role of N-methyl-D-aspartate receptors and the nitric oxide pathway in nociception/hyperalgesia elicited by PAR-2 activation in mice and rats. Neurosci. Lett. 329, 349-353.

139.                 川畑篤史* (2002) PAR (protease-activated receptor). 生体の科学 53, 345.  (Mini Review)

140.                 Nishikawa, H., Kawai, K., Nishimura, S., Tanaka, S., Araki, H., Al-Ani, B., Hollenberg, M.D., Kuroda, R. and Kawabata, A.* (2002) Suppression by protease-activated receptor-2 activation of gastric acid secretion in rats. Eur. J. Pharmacol. 447, 87-90.

141.                 Gojyo, F., Sugiyo, S., Kuroda, R., Kawabata, A., Varathan, V., Shigenaga, Y. and Takemura, M.* (2002) Effects of somatosensory cortical stimulation on expression of c-Fos in rat medullary dorsal horn in response to formalin-induced noxious stimulation. J. Neurosci. Res., 68, 479-488.

142.                 Kawabata, A.* (2002) PAR-2: structure, function and relevance to human diseases of the gastric mucosa. Expert Reviews in Molecular Medicine (a Web journal published by Cambridge University Press), 16 July, http://www.expertreviews.org/02004799h.htm. (Review)

143.                 Kawao, N., Shimada, C., Itoh, H., Kuroda, R. and Kawabata, A.* (2002) Capsazepine inhibits thermal hyperalgesia but not nociception triggered by protease-activated receptor-2 in rats. Jpn. J. Pharmacol., 89, 184-187.

144.                 Kawabata, A.*, Kawao, N., Kuroda, R., Tanaka, A. and Shimada, C. (2002) The PAR-1-activating peptide attenuates carrageenan-induced hyperalgesia in rats. Peptides 23, 1181-1183.

145.                 Kawao, N., Sakaguchi, Y., Tagome, A., Kuroda, R., Nishida, S., Irimajiri, K., Nishikawa, H., Kawai, K., Hollenberg, M.D., and Kawabata, A.* (2002) Protease-activated receptor-2 in the rat gastric mucosa: immunolocalization and facilitation of pepsin/pepsinogen secretion. Br. J. Pharmacol., 135, 1292-1296.

146.                 Kawabata, A.*, Kawao, N., Kuroda, R., Itoh, H. and Nishikawa, H. (2002) Specific expression of spinal Fos after PAR-2 stimulation in mast cell-depleted rats. NeuroReport, 13, 511-514.

147.                 Kawabata, A.*, Kinoshita, M., Kuroda, R. and Kakehi, K. (2002) Capsazepine partially inhibits the neurally mediated gastric mucus secretion following activation of protease-activated receptor-2. Clin. Exp. Pharmacol. Physiol., 29, 360-361.

148.                 Morimoto, N., Nakano, M., Kinoshita, M., Kawabata, A., Morita, M., Oda, Y., Kuroda, R. and Kakehi, K.* (2001) Specific distribution of sialic acids in animal tissues as examined by LC-ESI-MS after derivatization with 1,2-diamino-4,5-methylenedioxybenzene. Anal. Chem. 73, 5422-5428.

149.                 Kawabata, A.*, Kuroda, R., Nagata, N., Kawao, N., Masuko, T., Nishikawa, H. and Kawai, K. (2001) In vivo evidence that protease-activated receptors 1 and 2 modulate gastrointestinal transit in the mouse. Br. J. Pharmacol. 133, 1213-1218.

150.                 Kawabata, A.*, Kuroda, R., Morimoto, N., Kawao, N., Masuko, T., Kakehi, K., Kataoka, K., Taneda, M., Nishikawa, H. and Araki, H. (2001) Lipopolysaccharide-induced subsensitivity of protease-activated receptor-2 in the mouse salivary glands in vivo. Naunyn-Schmiedeberg’s Arch. Pharmacol. 364, 281-284.

151.                 Kawabata, A.*, Kinoshita, M., Nishikawa, H., Kuroda, R., Nishida, M., Araki, H., Arizono, N., Oda, Y. and Kakehi, K. (2001) The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection. J. Clin. Invest. 107, 1443-1450. Breakthrough paper

152.                 Kuroda, R., Kawao, N., Yoshimura, H., Umeda, W., Takemura, M., Shigenaga, Y. and Kawabata, A.* (2001) Secondary somatosensory cortex stimulation facilitates the antinociceptive effect of the NO synthase inhibitor through suppression of spinal nociceptive neurons in the rat. Brain Res. 903, 110-116.

153.                 Kawabata, A.*, Kuroda, R., Nakaya, Y., Kawai, K., Nishikawa, H. and Kawao, N. (2001) Factor Xa-evoked relaxation in rat aorta: involvement of PAR-2. Biochem. Biophys. Res. Commun. 282, 432-435.

154.                 Kawabata, A.*, Kawao, N., Kuroda, R., Tanaka, A., Itoh, H. and Nishikawa, H. (2001) Peripheral PAR-2 triggers thermal hyperalgesia and nociceptive responses in rats. NeuroReport 12, 715-719.

155.                 Kawabata, A.*, Kuroda, R., Nakaya, Y., Kawao, N. Nishikawa, H. (2001) Ex vivo evidence that the phosphodiesterase inhibitor IBMX attenuates the up-regulation of PAR-2 in the endotoxemic rat aorta. Thromb. Res. 101, 513-515.

156.                 川畑篤史* (2001) 創薬の新たな標的分子としてのG蛋白共役型プロテアーゼ受容体PAR (protease-activated receptor)Yakugaku Zasshi 121, 1-7. (Review)

157.                 Kataoka, K.*, Asai, T., Taneda, M., Ueshima, S., Matsuo, O., Kuroda, R., Kawabata, A. and Carmeliet, P. (2000) Roles of urokinase type plasminogen activator in a brain stab wound. Brain Res. 887, 187-190.

158.                 Kawabata, A.*, Kuroda, R., Kuroki, N., Nishikawa, H. and Kawai, K. (2000) Dual modulation by thrombin of the motility of rat oesophageal muscularis mucosae via two distinct protease-activated receptors (PARs): a novel role for PAR-4 as opposed to PAR-1. Br. J. Pharmacol.  131, 578-584.

159.                 Kinoshita, M., Inagake, K., Kawabata, A., Kuroda, R., Oda, Y. and Kakehi, K.* (2000) Fluorometric determination of mucin-type glycoproteins by the galactose oxidase-peroxidase method. Anal. Biochem. 284, 87-92.

160.                 Kawabata, A., Morimoto, N., Oda, Y., Kinoshita, M., Kuroda, R. and Kakehi, K.* (2000) Determination of mucin in salivary glands using sialic acids as the marker by high performance liquid chromatography with fluorometric detection. Anal. Biochem. 283, 119-121.

161.                 Kawabata, A.*, Kuroda, R., Kuroki, N., Nishikawa, H., Kawai, K. and Araki, H. (2000) Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle. Life Sci. 67, 2521-2530.

162.                 Kawabata, A.*, Nishikawa, H., Kuroda, R., Kawai, K. and Hollenberg, M.D. (2000) Proteinase-activated receptor-2 (PAR-2): regulation of salivary and pancreatic exocrine secretion in vivo in rats and mice. Br. J. Pharmacol. 129, 1808-1814.

163.                 Kawabata, A.*, Morimoto, N., Nishikawa, H., Kuroda, R., Oda, Y. and Kakehi, K. (2000) Activation of protease-activated receptor-2 (PAR-2) triggers mucin secretion in the rat sublingual gland. Biochem. Biophys. Res. Commun. 270, 298-302.

164.                 Kuroda, R., Kawabata, A.*, Kawao, N., Umeda, W., Takemura, M. and Shigenaga, Y. (2000) Somatosensory cortex stimulation-evoked analgesia in rats: potentiation by NO synthase inhibition.  Life Sci. 66,  PL271-PL276.

165.                 Nishikawa, H., Kawabata, A.*, Kawai, K. and Kuroda, R. (2000) Guinea pig platelets do not respond to GYPGKF, a protease-activated receptor-4-activating peptide: a property distinct from human platelets.  Blood Coag. Fibrinol. 11, 111-113.

166.                 Kawabata, A.* and Kuroda, R. (2000) Protease-activated receptor (PAR), a novel family of G protein-coupled seven trans-membrane domain receptors: activation mechanisms and physiological roles. Jpn. J. Pharmacol. 82, 171-174. (Review)

167.                 Nishikawa, H., Kawabata, A.*, Kuroda, R., Nishida, M. and Kawai, K. (2000) Characterization of protease-activated receptors in rat peritoneal mast cells.  Jpn. J. Pharmacol. 82, 74-77.

168.                 Kawabata, A.*, Kuroda, R., Nishikawa, H. and Kawai, K. (1999) Modulation by protease-activated receptors of the rat duodenal motility in vitro: possible mechanisms underlying the evoked contraction and relaxation. Br. J. Pharmacol. 128, 865-872.

169.                 川畑篤史*,黒田良太郎,Hollenberg, M.D. (1999) プロテアーゼ受容体 (PAR) の生理的役割:特に消化器系機能への関与について.日薬理誌 114 (補冊1), 173P-179P. (Review)

170.                 Kawabata, A.*, Kuroda, R., Nishikawa, H., Asai, T., Kataoka, K. and Taneda, M. (1999) Enhancement of vascular permeability by specific activation of protease-activated receptor-1 in rat hindpaw: a protective role of endogenous and exogenous nitric oxide.  Br. J. Pharmacol. 126, 1856-1862.

171.                 Al-Ani, B., Saifeddine, M., Kawabata, A. and Hollenberg, M.D.* (1999) Proteinase activated receptor 2: role of extracellular loop 2 for ligand-mediated activation.  Br. J. Pharmacol. 128, 1105-1113.

172.                 Al-Ani, B., Saifeddine, M., Kawabata, A., Renaux, B., Mokashi, S. and Hollenberg, M.D.* (1999) Proteinase-activated receptor-2 (PAR2): development of a ligand binding assay correlating with activation of PAR2 by PAR1- and PAR2-derived peptide ligands.  J. Pharmacol. Exp. Ther. 290, 753-760.

173.                 Kawabata, A., Saifeddine, M., Al-Ani, B., Leblond, L. and Hollenberg, M.D.* (1999) Evaluation of proteinase-activated receptor-1 (PAR1) agonists and antagonists using a cultured cell receptor desensitization assay: Activation of PAR2 by PAR1-targeted ligands.  J. Pharmacol. Exp. Ther. 288, 358-370.

174.                 Kawabata, A.*, Kuroda, R., Minami, T., Kataoka, K. and Taneda, M. (1998) Increased vascular permeability by a specific agonist of protease-activated receptor-2 in rat hindpaw.  Br. J. Pharmacol. 125, 419-422.

175.                 Minami, T.*, Okazaki, J., Kawabata, A., Kuroda, R. and Okazaki, Y. (1998) Penetration of cisplatin into mouse brain by lipopolysaccharide.  Toxicology 130, 107-113.

176.                 Kawabata, A.*, Hata, T., Kuroda, R. (1998) Cross tolerance to environmental stress and endotoxin.  Life Sci. 62, PL327-PL333.

177.                 Kawabata, A., Murakami, E., Iwaki, M., Ogiso, T., Suzuki, S., Mishima, M., Takada, M. and Kakehi, K.* (1998) Importance of clinical activities to job satisfaction in Japanese pharmacists.  Am. J. Health-Syst. Pharm. 55, 360-363.

178.                 Minami, T.*, Okazaki, J., Kawabata, A., Kawaki, H., Okazaki, Y. and Tohno, Y. (1998)  Roles of nitric oxide and prostaglandins in the increased permeability of the blood-brain barrier caused by lipopolysaccharide. Environ. Toxicol. Pharmacol. 5, 35-41.

179.                 Kawabata, A.* and Hata, T. (1998) Disseminated intravascular coagulation (DIC)-like events produced by environmental stress and by lipopolysaccharide: Nitric oxide as a common key molecule.  In “The Biology of Nitric Oxide Part 6”, edited by S. Moncada, N. Toda, H. Maeda and E.A. Higgs, pp.220, Portland Press (London).

180.                 川畑篤史* (1998) NOS発現部位からみたNOの役割 - 3.脳幹 - 内因性鎮痛物質とNOClinical Neuroscience 16, 775-777. (Review)

 

 

1997年までの業績目録(論文)