1997年までの業績目録（論文）

1. Kawabata, A., Saifeddine, M., Al-Ani, B. and Hollenberg, M.D., (1997) Protease-activated receptors: development of agonists selective for receptors triggered by either thrombin (PAR1) or trypsin (PAR2). Proc. West. Pharmacol. Soc. 40, 49-51.

2. Hollenberg, M.D., Saifeddine, M., Al-Ani, B. and Kawabata, A. (1997) Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity and receptor selectivity of receptor-activating peptides. Can. J. Physiol. Pharmacol. 75, 832-841.

3. Kawabata, A. (1996) Evidence that endogenous nitric oxide modulates plasma fibrinogen levels in mice. Br. J. Pharmacol. 117, 236-237.

4. Kawabata, A., Iwatsubo, K., Takaya, S. and Takagi, H. (1996) Central antinociceptive effect of L-orinithine, a metabolite of L-arginine, in rats and mice. Eur. J. Pharmacol. 296, 23-31.

5. Kawabata, A., Muguruma, H., Tanaka, M. and Takagi, H. (1996) Kyotorphin synthetase activity in rat adrenal glands and spinal cord. Peptides 17, 407-411.

6. Kawabata, A. (1996) 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one reverses the inhibition by sodium nitroprusside of thrombin-induced platelet aggregation in the rat. Thromb. Res. 82, 543-545.

7. Kawabata, A. and Hata, T. (1996) Attenuation by prolonged nitric oxide synthase inhibition of the enhancement of fibrinolysis caused by environmental stress in the rat. Br. J. Pharmacol. 119, 346-350.

8. Minami, T., Okazaki, J., Kawabata, A., Kawaki, H. and Okazaki, Y. (1996) Lipopolysaccharide-induced platinum accumulation in the cerebral cortex after cisplatin administration in mice: involvement of free radicals. Environ.Toxicol.Pharmacol. 2, 321-326.

9. 川畑篤史，高木博司 (1996) NOの疼痛制御における役割の多様性．医学のあゆみ　別冊「NOのすべて」，平田結喜緒　編　pp.68-73, 医歯薬出版（東京）．（総説）

10. Kawabata, A., Watanabe, H. and Takagi, H. (1995) Supraspinally applied nitric oxide donors exert a dual action on thermal nociception in mice. Pharm. Sci. 1, 189-192.

11. Kawabata, A., Tanaka, M., Muguruma, H. and Takagi, H. (1995) N^G-nitro-L-arginine methyl ester and -methyl-L-ornithine inhibit kyotorphin synthetase from rat brain. Peptides 16, 1317-1319.

12. Kawabata, A. (1995) Effect of aminoguanidine on the survival in mice treated with lipopolysaccharide. Pharm. Sci. 1, 455-457.

13. 高木博司，川畑篤史 (1995) NOと痛み．「NO」, 戸田　昇　編，pp.157-169, メジカルビュー社（東京）．（著書）

14. 川畑篤史，高木博司 (1995) 痛みの情報伝達・制御とNO．実験医学13, 66-71.（総説）

15. Kawabata, A., Kasamatsu, K., Umeda, N. and Takagi, H. (1994) The noradrenaline precursor L-threo-3,4-dihydroxyphenylserine exhibits antinociceptive activity via central -adrenoceptors in the mouse. Br. J. Pharmacol. 111, 503-508.

16. Kawabata, A., Manabe, S., Manabe, Y. and Takagi, H. (1994) Effect of topical administration of L-arginine on formalin-induced nociception in the mouse: a dual role of peripherally formed NO in pain modulation. Br. J. Pharmacol. 112, 547-550.

17. Kawabata, A., Manabe, S. and Takagi, H. (1994) Comparison of antinociception induced by supraspinally administered L-arginine and kyotorphin. Br. J. Pharmacol. 112, 817-822.

18. Kawabata, A. and Takagi, H. (1994) The dual role of L-arginine in nociceptive processing in the brain: involvement of nitric oxide and kyotorphin. In "Nitric Oxide - roles in neuronal communication and neurotoxicity", edited by H. Takagi, N. Toda and R.D. Hawkins, pp.115-125, Japan Scientific Societies Press and CRC Press (Tokyo and Boca Raton, Florida).　（著書）

19. 川畑篤史，高木博司 (1994) NOと痛み．神経研究の進歩　38, 940-947.（総説）

20. Kawabata, A., Kasamatsu, K. and Takagi, H. (1993) L-Tyrosine-induced antinociception in the mouse: involvement of central -opioid receptor and bulbo-spinal noradrenergic systems. Eur. J. Pharmacol. 233, 255-260.

21. Kawabata, A. and Hata, T. (1993) Characterization of platelet hypofunctions in rats under SART stress (repeated cold stress). Thromb. Res. 69, 197-207.

22. Kawabata, A., Umeda, N. and Takagi, H. (1993) L-Arginine exerts a dual role in nociceptive processing in the brain: involvement of the kyotorphin-Met-enkephalin pathway and NO-cyclic GMP pathway. Br. J. Pharmacol. 109, 73-79.

23. Kawabata, A. and Hata, T. (1993) Possible involvement of oxygen-derived free radicals in abnormal hemostasis induced by SART stress (repeated cold stress) in laboratory animals. Thromb. Res. 72, 321-331.

24. Hata, T., Kawabata, A. and Itoh, E. (1992) Platelet hypoaggregability in rats exposed to SART stress (repeated cold stress). Thromb. Res. 65, 617-629.

25. Kawabata, A., Fukuzumi, Y., Fukushima, Y. and Takagi, H. (1992) Antinociceptive effect of L-arginine on carrageenin-induced hyperalgesia in rats: possible involvement of central opioidergic systems. Eur. J. Pharmacol. 218, 153-158.

26. Kawabata, A., Nishimura, Y. and Takagi, H. (1992) L-Leucyl-L-arginine, naltrindole and D-arginine block antinociception elicited by L-arginine in mice with carrageenin-induced hyperalgesia. Br. J. Pharmacol. 107, 1096-1101.

27. Hata, T., Itoh, E., Kamanaka, Y., Kawabata, A. and Honda, S. (1991) Plasma catecholamine levels in SART-stressed rats and effects of drugs on stress-induced alteration in plasma and brain catecholamine levels. J. Auton. Pharmacol. 11, 15-25.

28. Hata, T., Itoh, E. and Kawabata, A. (1991) Changes in CNS levels of serotonin and its metabolite in SART-stressed (repeatedly cold-stressed) rats. Jpn. J. Pharmacol. 56, 101-104.

29. Hata, T., Kawabata, A. and Itoh, E. (1991) Blood coagulation and fibrinolysis in SART-stressed (repeated cold-stressed) rats and drug effect on the altered hemostatic parameters. Jpn. J. Pharmacol. 56, 403-412.

30. Nishimura, Y., Hata, T., Kawabata, A., Itoh, E. and Kita, T. (1989) Impairment of passive avoidance performance in SART-stressed mice and the action of drugs. Jpn. J. Pharmacol. 49, 111-117.

31. Hata, T., Itoh, E., Oyama, R., Kawabata, A. and Kita, T. (1989) Subsensitivity to substance P in SART-stressed mice. Jpn. J. Pharmacol. 49, 293-296.

32. Hata, T., Nishimura, Y., Itoh, E., Kawabata, A. and Kita, T. (1989) A characteristic pattern of avoidance behavior in SART-stressed rats. Jpn. J. Pharmacol. 49, 436-440.

33. Hata, T., Kawabata, A., Itoh, E. and Kita, T. (1989) Thrombocytopenia in SART-stressed animals - Comparison to other types of stress. Jpn. J. Psychosom. Med. 29, 651-658.

34. Hata, T., Kita, T., Itoh, E. and Kawabata, A. (1988) The relationship of hyperalgesia in SART (repeated cold)-stressed animals to the autonomic nervous system. J. Auton. Pharmacol. 8, 45-52.

35. Hata, T., Kawabata, A., Kita, T., Itoh, E. and Nishimura, Y. (1988) Changes in platelet count and related parameters in SART-stressed mice and the action of administered Neurotropin. Jpn. J. Pharmacol. 47, 349-356.

36. Hata, T., Kita, T., Itoh, E., Oyama, R. and Kawabata, A. (1988) Mechanism of the analgesic effect of Neurotropin. Jpn. J. Pharmacol. 48, 165-173.

37. Hata, T., Nishimura, Y., Kita, T., Itoh, E. and Kawabata, A. (1988) The abnormal open-field behavior of SART-stressed rats and effects of some drugs on it. Jpn. J. Pharmacol. 48, 479-490.

38. Hata, T., Kita, T., Kamanaka, Y., Honda, S., Kakehi, K., Kawabata, A. and Itoh, E. (1987) Catecholamine levels in the brain of SART (repeated cold)-stressed rats. J. Auton. Pharmacol. 7, 257-266.

39. Hata, T., Nishimura, Y., Kita, T., Kawabata, A. and Itoh, E. (1987) Electrocorticogram in rats loaded with SART stress (repeated cold stress). Jpn. J. Pharmacol. 45, 365-372.

40. Kita, T., Hata, T., Higashiguchi, T., Itoh, E. and Kawabata, A. (1986) Changes of total acetylcholine content and the activities of related enzymes in SART (repeated cold)-stressed rat brain and duodenum. Jpn. J. Pharmacol. 40, 174-177.

41. Hata, T., Kita, T., Kawabata, A., Itoh, E. and Nishimura, Y. (1986) Changes of tissue blood flow in mice loaded with SART (repeated cold) stress or restraint and water immersion stressed, and the effect of administered Neurotropin. Jpn. J. Pharmacol. 41, 69-79.

42. Hata, T., Kita, T., Kawabata, A., Itoh, E. and Kawashima, Y. (1985) Effect of ginseng-20S-prosapogenin on tissue blood flow measured by the hydrogen clearance method in sympathicotonic- or parasympathicotonic-type stressed mice. J. Pharmacobio-Dyn. 8, 1069-1073.