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Laboratory of Molecular Pharmacogenomics,
School of Pharmaceutical Sciences, Kinki University

Œ¤‹†‹ĆŃPUBLICAtion

‰pŒę”­•\˜_•ś
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2018”N“x@‰pŒę”­•\˜_•ś

The molecular basis of drug discovery targeting the regulatory mechanism of MA PK signaling via the spatial regulation of RNA-binding proteins
Ryosuke Satoh
Yakugaku-Zasshi, 2018 in press
Pubmed

Distinct Roles of Two Histone Methyltransferases in Transmitting H3K36me3-Based Epigenetic Memory Across Generations in Caenorhabditis elegans
Jeremy Kreher, Teruaki Takasaki, ProfileChad Cockrum, ProfileSimone Sidoli, Benjamin A. Garcia, Ole N. Jensen, Susan Strome.
Genetics, 2018 Nov, 210(3): 969-982
Pubmed

Distinct modes of stress granule assembly mediated by the KH-type RNA-binding protein Rnc1.
Ryosuke Satoh, Nobuki Hara, Aki Kawasaki, Teruaki Takasaki, Reiko Sugiura
Genes Cells, 2018 Jul, 23(9): 778-785   
Pubmed

2017”N“x@‰pŒę”­•\˜_•ś

More than just an immunosuppressant: The emerging role of FTY720 as a novel inducer of ROS and apoptosis.
Teruaki Takasaki, Kanako Hagihara, Ryosuke Satoh, Reiko Sugiura
Oxid Med Cell Longev, 2018 Mar; 2018:4397159. doi: 10.1155/2018/4397159
Pubmed

Rae1
-mediated nuclear export of Rnc1 is an important determinant in controlling MAPK signaling.
Ryosuke Satoh, Kanako Hagihara, Reiko Sugiura
Curr Genet, 2018 Feb; 64(1): 103-108
Pubmed

A genome-wide screen for FTY720-sensitive mutants reveals genes required for ROS homeostasis.
Kanako Hagihara, Kanako Kinoshita, Kouki Ishida, Shihomi Hojo, Yoshinori Kameoka, Ryosuke Satoh, Teruaki Takasaki, Reiko Sugiura
Microb Cell, 2017 Nov; 4(12): 390-401
Pubmed

Microchip electrophoresis
utilizing an in situ photopolymerized Phos-tag binding polyacrylamide gel for specific entrapment and analysis of phosphorylated compounds.
Sachio Yamamoto, Miyuki Himeno, Masaya Kobayashi, Miki Akamatsu, Ryosuke Satoh, Mitsuhiro Kinoshita, Reiko Sugiura, Shigeo Suzuki
Analyst, 2017 Sep; 142(18): 3416-3423
Pubmed

Impaired lymphocyte trafficking in mice deficient in the kinase activity of PKN1.
Rana Mashud, Akira Nomachi, Akihide Hayakawa, Koji Kubouchi, Sally Danno, Takako Hirata, Kazuhiko Matsuo, Takashi Nakayama, Ryosuke Satoh, Reiko Sugiura, Manabu Abe, Kenji Sakimura, Shigeharu Wakana, Hiroyuki Ohsaki, Shingo Kamoshida, Hideyuki Mukai
Sci Rep, 2017 Aug; 7(1): 7663, doi: 10.1038/s41598-017-07936-9
Pubmed

Identification of ACA-28, a 1'-Acetoxychavicol Acetate analog compound, as a novel modulator of ERK MAPK signaling, which preferentially kills human melanoma cells.
Ryosuke Satoh, Kanako Hagihara, Kazuki Matsuura, Yoshiaki Manse, Ayako Kita, Tatsuki Kunoh, Takashi Masuko, Mariko Moriyama, Hiroyuki Moriyama, Genzoh Tanabe, Osamu Muraoka, Reiko Sugiura.
Genes Cells, 2017 Jul; 22(7): 608-618
Pubmed

Evaluation of a novel method for measurement of intracellular calcium ion concentration in fission yeast.
Fumihiko Ogata, Ryosuke Satoh, Ayako Kita, Reiko Sugiura, Naohito Kawasaki.
J Toxicol Sci, 2017 Apr; 42(2): 159-166
Pubmed

2016”N“x@‰pŒę”­•\˜_•ś

Chemical shift assignments of the first and second RRMs of Nrd1, a fission yeast MAPK-target RNA binding protein.
Ayaho Kobayashi, Teppei Kanaba, Ryosuke Satoh, Yutaka Ito, Reiko Sugiura, Masaki Mishima.
Biomol NMR Assign, 2017 Oct; 11(2): 123-126
Pubmed

Spatial regulation of the KH domain RNA-binding protein Rnc1 mediated by a Crm1-independent nuclear export system in Schizosaccharomyces pombe.
Ryosuke Satoh, Yasuhiro Matsumura, Akitomo Tanaka, Makoto Takada, Yuna Ito, Kanako Hagihara, Masahiro Inari, Ayako Kita, Akira Fukao, Toshinobu Fujiwara, Shinya Hirai, Tokio Tani, Reiko Sugiura.
Mol Microbiol, 2017 May; 104(3): 428-448
Pubmed

Structure-activity relationshipstudies on acremomannolipin A, the potent calcium signal modulator with a novel glycolipid structure 4: Role of acyl side chains on d-mannose.
Nozomi Tsutsui, Genzoh Tanabe, Nami Ikeda, Saika Okamura, Marika Ogawa, Kuniko Miyazaki, Ayako Kita, Reiko Sugiura, Osamu Muraoka
Eur J Med Chem, 2016 Oct; 121: 250-271
Pubmed

Skb5, an SH3 adaptor protein, regulates Pmk1 MAPK signaling by controlling the intracellular localization of the MAPKKK Mkh1.
Yuki Kanda, Ryosuke Satoh, Saki Matsumoto, Chisato Ikeda, Natsumi Inutsuka, Kanako Hagihara, Sumio Matzno, Sho Tsujimoto, Ayako Kita, Reiko Sugiura
J Cell Sci, 2016 Aug; 129(16): 3189-3202
Pubmed

2015”N“x@‰pŒę”­•\˜_•ś

PKN3 is the major regulator of angiogenesis and tumor metastasis in mice.
Hideyuki Mukai, Aiko Muramatsu, Rana Mashud, Koji Kubouchi, Sho Tsujimoto, Tsunaki Hongu, Yasunori Kanaho, Masanobu Tsubaki, Shozo Nishida, Go Shioi, Sally Danno, Mona Mehruba, Ryosuke Satoh, Reiko Sugiura
Sci Rep, 2016 Jan; 6:18979, doi: 10.1038/srep18979
Pubmed

Structure-activity relationship studies on acremomannolipin A, the potent calcium signal modulator with a novel glycolipid structure 3: Role of the length of alditol side chain.
Nozomi Tsutsui, Genzoh Tanabe, Nao Morita, Yoshitomo Okayama, Ayako Kita, Reiko Sugiura, Osamu Muraoka
Bioorg Med Chem, 2015 Jul; 23(13): 3761-3773
Pubmed

Chemical genomics approach to identify genes associated with sensitivity to rapamycin in the fission yeast Scizosaccharomyces pombe.
Akira Doi, Ayumi Fujimoto, Shun Sato, Takaya Uno, Yuki Kanda, Keita Asami, Yuriko Tanaka, Ayako Kita, Ryosuke Satoh, Reiko Sugiura
Genes Cells, 2015 Apr; 20(4): 292-309
Pubmed

Geranylgeranyltransferase Cwg2-Rho4/Rho5 module is implicated in the Pmk1 MAPK Kinase-mediated cell wall integrity pathway in fission yeast.
Akira Doi, Ayako Kita, Yuki Kanda, Takaya Uno, Keita Asami, Ryosuke Satoh, Kentaro Nakano, Reiko Sugiura
Genes Cells, 2015 Apr; 20(4): 310-323
Pubmed

2014”N“x@‰pŒę”­•\˜_•ś

Imp2, the PSTPIP homolog in fission yeast, affects sensitivity to the immunosuppressant FK506 and membrane trafficking in fission yeast.
Ayako Kita, Mari Higa, Akira Doi, Ryosuke Satoh, Reiko Sugiura
Biochem Biophys Res Commun, 2015 Feb; 457(3): 273-279
Pubmed

Spatial control of calcineurin in response to heat shock in fission yeast.
Mari Higa, Ayako Kita, Kanako Hagihara, Yuki Kitai, Akira Doi, Rie Nagasoko, Ryosuke Sato, Reiko Sugiura
Genes Cells, 2015 Feb; 20(2): 95-107
Pubmed

Negative feedback regulation of calcineurin-dependent Prz1 transcription factor by the CaMKK-CaMK1 axis in fission yeast.
Eugenia Cisneros-Barroso, Tula Yance-Chavez, Ayako Kito, Reiko Sugiura, Alba Gomez-Hierro, David Gimenez-Zaragoza, Rosa Aligue
Nucleic Acids Res, 2014 Nov; 42(15): 9573-9587
Pubmed

Efficient and cost effective production of active-form human PKB using silkworm larvae.
Ryoko Maesaki, Ryosuke Satoh, Masato Taoka, Teppei Kanaba, Tsunaki Asano, Chiharu Fujita, Toshinobu Fujiwara, Yutaka Ito, Toshiaki Isobe, Toshio Hakoshima, Katsumi Maenaka, Masaki Mishima
Sci Rep, 2014 Aug; 4:6016, doi: 10.1038/srep06016
Pubmed

FTY720 stimulated ROS generation and the Sty1/Atf1 signaling pathway in the fission yeast Schizosaccharomyces pombe.
Kanako Hagihara, Aya Mizukura, Yuki Kitai, Mariko Yao, Kouki Ishida, Tatsuki Kunoh, Ayako Kita, Takashi Masuko, Sumino Matzno, Kenji Chiba, Reiko Sugiura
Genes Cells, 2014 Apr; 19(4): 325-337
Pubmed

Structure-activity relationship studies on acremomannolipin A, the potent calcium signal modulator with a novel glycolipid structure 2: Role of the alditol side chain stereochemistry.
Nozomi Tsutsui, Genzoh Tanabe, Genki Gotoh, Nao Morita, Naohisa Nomura, Ayako Kita, Reiko Sugiura, Osamu Muraoka
Bioorg Med Chem, 2014 Feb; 22(3): 945-959
Pubmed

2013”N“x@‰pŒę”­•\˜_•ś

Functional link between Rab GTPase-mediated membrane trafficking and PI4,5P2 signaling.
Cuifang Li, Ayako Kita, Yuuka Hashimoto, Misako Ihara, Ayako Kato, Naoya Ogura, Akira Doi, Masahide Oku, Toshiki Itoh, Yasuyoshi Sakai, Reiko Sugiura
Genes Cells, 2014 Mar; 19(3): 177-197
Pubmed

Fingolimod (FTY720) Stimulates Ca2+/Calcineurin Signaling in Fission Yeast.
Kanako Hagihara, Ayako Kita, Aya Mizukura, Mariko Yao, Yuki Kitai, Tatsuki Kunoh, Takashi Masuko, Sumino Matzno, Kenji Chiba, Reiko Sugiura
PLoS ONE, 2013 Dec; 8(12): e81907
Pubmed

Stereoselective total synthesis of Acremomannolipin A and its anomer, the potent calcium signal modulators with a novel glycolipid structure: role of the stereochemistry at the anomeric center on the activity.
Nozomi Tsutsui, Genzoh Tanabe, Genki Gotoh, Ayako Kita, Reiko Sugiura, Osamu Muraoka
Tetrahedron, 2013 Nov; 69(47): 9917-9930
Link

Structure of the second RRM domain of Nrd1, a fission yeast MAPK target RNA binding protein, and implication for its RNA recognition and regulation.
Ayaho Kobayashi, Teppei Kanaba, Ryosuke Satoh, Toshinobu Fujiwara, Yutaka Ito, Reiko Sugiura, Masaki Mishima
Biochem Biophys Res Commun, 2013 Jul; 437(1): 12-17
Pubmed

Sip1, an AP-1 Accessory Protein in Fission Yeast, Is Required for Localization of Rho3 GTPase.
Yang Yu, Cuifang Li, Ayako Kita, Yuta Katayama, Koji Kubouchi, Masako Udo, Yukako Imanaka, Shiho Ueda, Takashi Masuko, Reiko Sugiura
PLoS ONE 8(7): 2013 Jul; 8(7): e68488
Pubmed

2012”N“x@‰pŒę”­•\˜_•ś

The first total synthesis of Acremomannolipin A, the potential Ca2+ signal modulator with a characteristic glycolipid structure, isolated from the filamentous fungus Acremonium strictum.
Nozomi Tsutsui, Genzoh Tanabe, Ayako Kita, Reiko Sugiura, Osamu Muraoka
Tetrahedron Lett, 2013 Feb; 54(6): 451-453
Link

Acremomannolipin A, the potential calcium signal modulator with a characteristic glycolipid structure from the filamentous fungus Acremonium strictum.
Reiko Sugiura, Ayako Kita, Nozomi Tsutsui, Osamu Muraoka, Kanako Hagihara, Nanae Umeda, Tatsuki Kunoh, Hirofumi Takada, Dai Hirose
Bioorg Med Chem Lett, 2012 Nov; 22(21): 6735-6739
Pubmed

Sip1, a Conserved AP-1 Accessory Protein, is Important for Golgi/Endosome Trafficking in Fission Yeast
Yang Yu, Ayako Kita, Masako Udo, Yuta Katayama, Mami Shintani, Kwihwa Park, Kanako Hagihara, Nanae Umeda, Reiko Sugiura
PLoS ONE, 2012 Sep; 7(9): e45324
Pubmed

Studies on the Roles of Clathrin-Mediated Membrane Trafficking and Zinc Transporter Cis4 in the Transport of GPI-Anchored Proteins in Fission Yeast.
Wurentuya Jaiseng, Yue Fang, Yan Ma, Reiko Sugiura, Takayoshi Kuno
PLoS ONE, 2012 Jul; 7(7): e41946
Pubmed

Genetic screening for regulators of Prz1, a transcriptional factor acting downstream of calcineurin in fission yeast.
Atsushi Koike, Toshiaki Kato, Reiko Sugiura, Yan Ma, Yuki Tabata, Koji Ohmoto, Susie O. Sio, Takayoshi Kuno
J Biol Chem, 2012 Jun; 287(23): 19294-19303
Pubmed

2011”N“x@‰pŒę”­•\˜_•ś

Role of the RNA-binding Protein Nrd1 in Stress Granule Formation and Its Implication in the Stress Response in Fission Yeast.
Ryosuke Satoh, Akitomo Tanaka, Ayako Kita, Takahiro Morita, Yasuhiro Matsumura, Nanae Umeda, Makoto Takada, Sachiko Hayashi, Tokio Tani, Kaori Shinmyozu, Reiko Sugiura
PLoS ONEC2012 Jan; 7(1): e29683
Pubmed

The stress granule protein Vgl1 and poly-A binding protein Pab1 are required for doxorubicin resistance in the fission yeast Schizosaccharomyces pombe.
Takahiro Morita, Ryosuke Satoh, Nanae Umeda, Ayako Kita, and Reiko Sugiura
Biochemical and Biophysical Research Communications 2012 Jan; 417(1): 399-403
Pubmed

2010”N“x@‰pŒę”­•\˜_•ś

Transient Receptor Potential (TRP) and Cch1-Yam8 Channels Play Key Roles in the Regulation of Cytoplasmic Ca2+ in Fission Yeast.
Yan Ma, Reiko Sugiura, Atsushi Koike, Hidemine Ebina, Susie O. Sio, Takayoshi Kuno
PLoS ONE, 2011 Jul; 6(7): e22421.
Pubmed

Role of RNA-Binding Proteins in MAPK Signal Transduction Pathway.
Reiko Sugiura, Ryosuke Satoh, Shunji Ishiwata, Nanae Umeda, Ayako Kita
J Signal Transduct, 2011 Apr; 2011: 109746
Pubmed

Role of the Small GTPase Rho3 in Golgi/Endosome Trafficking through Functional Interaction with Adaptin in Fission Yeast.
Ayako Kita, Cuifang Li, Yang Yu, Nanae Umeda, Akira Doi, Mitsuko Yasuda, Shunji Ishiwata, Atsushi Taga, Yoshihiro Horiuchi, Reiko Sugiura
PLoS ONE, 2011 Feb; 6(2): e16842
Pubmed

In vitro assay of the interaction between Rnc1 protein and Pmp1 mRNA by affinity capillary electrophoresis with a carboxylated capillary.
Atsushi Taga, Ryosuke Satoh, Shunji Ishiwata, Shunji Kodama, Atsushi Sato, Kentaro Suzuki, Reiko Sugiura
J Pharm Biomed Anal, 2010 Dec; 53(5): 1332-1337
Pubmed

MAP Kinase Kinase Kinase (MAPKKK)-dependent and -independent activation of Sty1 stress MAPK in fission yeast.
Xin Zhou, Yan Ma, Reiko Sugiura, Daiki Kobayashi, Masahiro Suzuki, Lu Deng, Takayoshi Kuno
J Biol Chem, 2010 Oct; 285(43): 32818-32823
Pubmed

Isolation of a fission yeast mutant that is sensitive to valproic acid and defective in the gene encoding Ric1, a putative component of Ypt/Rab-specific GEF for Ryh1 GTPase.
Yan Ma, Reiko Sugiura, Lili Zhang, Xin Zhou, Mai Takeuchi, Yi He, Takayoshi Kuno
Mol Genet Genomics, 2010 Sep; 284(3): 161-171 (Faculty of 1000 cited.)
Pubmed

2009”N“x@‰pŒę”­•\˜_•ś

The Cell Surface Protein Gene ecm33+ Is a Target of the Two Transcription Factors Atf1 and Mbx1 and Negatively Regulates Pmk1 MAPK Cell Integrity Signaling in Fission Yeast.
Hirohumi Takada, Aiko Nishida, Mitsuhiro Domae, Ayako Kita, Yuki Yamano, Atsushi Uchida, Shunji Ishiwata,Yue Fang , Xin Zhou, Takashi Masuko, Mitsuhiro Kinoshita, Kazuaki Kakehi, Reiko Sugiura
Mol Biol Cell, 2010 Feb; 21(4): 674-685
Pubmed

Deletion mutants of AP-1 adaptin subunits display distinct phenotypes in fission yeast.
Yan Ma, Mai Takeuchi, Reiko Sugiura, Susie O. Sio, Takayoshi Kuno
Genes Cells, 2009 Aug; 14(8): 1015-1028
Pubmed

The Role of the RNA-Binding Protein Nrd1 and Pmk1 MAPK in the Regulation of Myosin mRNA Stability in Fission Yeast.
Ryosuke Satoh, Takahiro Morita, Hirofumi Takada, Ayako Kita, Shunji Ishiwata, Akira Doi, Kanako Hagihara, Atsushi Taga, Yasuhiro Matsumura, Hideki Tohda, Reiko Sugiura
Mol Biol Cell, 2009 May; 20(9): 2473-2485
Pubmed

Pleiotropic phenotypes caused by an opal nonsense mutation in an essential gene encoding HMG-CoA reductase in fission yeast.
Yue Fang, Kiwamu Imagawa, Xin Zhou, Ayako Kita, Reiko Sugiura, Wurentuya Jaiseng, Takayoshi Kuno
Genes Cells, 2009 Jun; 14(6): 759-771
Pubmed

2008”N“x@‰pŒę”­•\˜_•ś

Cation Diffusion Facilitator Cis4 is Implicated in Golgi Membrane Trafficking via Regulating Zinc Homeostasis in Fission Yeast.
Yue Fang, Reiko Sugiura, Yan Ma, Tomoko Yada-Matsushima, Hirotatsu Umeno, Takayoshi Kuno
Mol Biol Cell, 2008 Apr; 19(4): 1295-1303
Pubmed

Molecular Genetic Approach to Identify Inhibitors of Signal Transduction Pathways.
Shunji Ishiwata, Takayoshi Kuno, Hirofumi Takada, Atsushi Koike Reiko Sugiura
Sourcebook of Models for Biomedical Research, 2008; 439-443
book website

2007”N“x@‰pŒę”­•\˜_•ś

Atf1 Is a Target of the MAP Kinase Pmk1 and Regulates Cell Integrity in Fission Yeast.
Hirofumi Takada, Masayuki Nishimura, Yuta Asayama, Yoshiaki Mannse, Shunji Ishiwata, Ayako Kita, Akira Doi, Aiko Nishida, Naoyuki Kai, Sayako Moriuchi, Hideki Tohda, Yuko Giga-Hama, Takayoshi Kuno, Reiko Sugiura
Mol. Biol. Cell, 2007 Dec; 18(12): 4794-4802
Pubmed

Wobble inosine tRNA modification is essential to cell cycle progression in G1/S and G2/M transitions in fission yeast.
Satoshi Tsutsumi, Reiko Sugiura, YanMa, Hideki Tokuoka, Kazuki Ohta, Rieko Ohte, Akiko Noma, Tsutomu Suzuki, Takayoshi Kuno
J Biol Chem, 2007 Nov; 282(46): 33459-33465
Pubmed

Essential roles of class E Vps proteins for sorting into multivesicular bodies in Schizosaccharomyces pombe.
Tomo Iwaki, Masayuki Onishi, Masaru Ikeuchi, Ayako Kita, Reiko Sugiura, Yuko Giga-Hama, Yasuhisa Fukui, Kaoru Takegawa
Microbiology, 2007 Aug; 153(Pt 8): 2753-2764
Pubmed

Six new amino acid-auxotrophic markersfor targeted gene integration and disruption in fission yeast.
Yan Ma, Reiko Sugiura, Mariko Saito, Atsushi Koike, Susie O. Sio, Yasuko Fujita, Kaoru Takegawa, Takayoshi Kuno
Curr Genet, 2007 Aug; 52(2): 97-105
Pubmed

Valproic Acid Affects Membrane Trafficking And Cell Wall Integrity in Fission Yeast.
Makoto Miyatake, Takayoshi Kuno, AyakoKita, Kosaku Katsura, Kaoru Takegawa, Satoshi Uno, Toshiya Nabata, and Reiko Sugiura
Genetics, 2007 Apr; 175(4): 1695-1705
Pubmed

2006”N“x@‰pŒę”­•\˜_•ś

Rho2 is a Target of the Farnesyltransferase Cpp1 and Acts Upstream of Pmk1 MAP Kinase Signaling in Fission Yeast.
Yan Ma, Takayoshi Kuno, Ayako Kita, Yuta Asayama, Reiko Sugiura
Mol Biol Cell, 2006 Dec; 17(12): 5028-5037
Pubmed

Genetic Evidence for Phospholipid-Mediated Regulation of the Rab GDP-Dissociation Inhibitor in Fission Yeast.
Yan Ma, Takayoshi Kuno, Ayako Kita, Toshiya Nabata, Satoshi Uno, Reiko Sugiura
Genetics, 2006 Sep; 174(3): 1259-1271
Pubmed

Real-Time Monitoring of Calcineurin Activity in Living Cells: Evidence for Two Distinct Ca2+-Dependent Pathways in Fission Yeast.
Lu Deng, Reiko Sugiura, Mai Takeuchi, Masahiro Suzuki, Hidemine Ebina, Tomonori Takami, Atsushi Koike, Shiori Iba, Takayoshi Kuno
Mol Biol Cell, 2006 Aug; 17(11): 4790-4800
Pubmed

Genetic and Functional Interaction between Ryh1 and Ypt3: two Rab GTPases that Function in S. pombe Secretory Pathway.
Yi He, Reiko Sugiura, Yan Ma, Ayako Kita, Lu Deng, Kaoru Takegawa, Ken Matsuoka, Hisato Shuntoh, Takayoshi Kuno
Genes Cells, 2006 Mar; 11(3): 207-221
Pubmed

2005”N“x@‰pŒę”­•\˜_•ś

sphatidylinositol-4-phosphate-5-kinase regulates fission yeast cell integrity through a phospholipase C-mediated protein kinase C-independent pathway.
Lu Deng, Reiko Sugiura, Kazuki Ohta, Kazuki Tada, Masahiro Suzuki, Masato Hirata, Shun-ichi Nakamura, Hisato Shuntoh, Takayoshi Kuno
J Biol Chem, 2005 Jul; 280(30): 27561-27568
Pubmed

The role of the regulatory subunit of fission yeast calcineurin for in vivo activity and its relevance to FK506 sensitivity.
Susie O. Sio, Takafumi Suehiro, Reiko Sugiura, Mai Takeuchi, Hideyuki Mukai, Takayoshi Kuno
J Biol Chem, 2005 Apr; 280(13): 12231-12238
Pubmed

Comparison of Toxicity and Toxicokinetics/Pharmacokinetics of an ƒż1L-adrenoceptor Agonist in Rats and Rhesus monkeys.
Matsumaru T, Reiko Sugiura, Kenji Sakai, Takashi Igarashi, Takayoshi Kuno
J Pharmacol Sci, 2005 Feb; 97(2): 273-283
Pubmed

2004”N“x@‰pŒę”­•\˜_•ś

Loss of Apm1, the AP-1 Clathrin-Adaptor mu1 Subunit, Causes Distinct Phenotypes and Synthetic Lethality with Calcineurin Deletion in Fission Yeast.
Ayako Kita, Reiko Sugiura, Hiromi Shoji, Yi He, Lu Deng, Yabin Lu, Susie O. Sio, Kaoru Takegawa, Motoyoshi Sakaue, Hisato Shuntoh, Takayosi Kuno
Mol Biol Cell, 2004 Jun; 15(6): 2920-2931
Pubmed

Lub1 Participates in Ubiquitin Homeostasis and Stress Response via Maintenance of Cellular Ubiquitin Contents in Fission Yeast.
Yasunari Ogiso, Reiko Sugiura, Tsuneyoshi Kamo, Satoshi Yanagiya, Yabin Lu, Koei Okazaki, Hisato Shuntoh, Takayosi Kuno
Mol Cell Biol, 2004 Mar; 24(6): 2324-2331
Pubmed

Upregulation of mRNA in MAPK Signaling: Transcriptional Activation or mRNA Stabilization?
Reiko Sugiura, Ayako Kita, Takayosi Kuno
Cell Cycle, 2004 Mar; 3(3): 286-288
Pubmed

Pmr1, a P-type ATPase, and Pdt1, an Nramp Homolog, Cooperatively Regulate Cell Morphogenesis in Fission Yeast: The Importance of Mn2+ Homeostasis.
Takuya Maeda, Reiko Sugiura, Ayako Kita, Mariko Saito, Lu Deng, Yi He; Yabin Lu, Yasuko Fujita, Kaoru Takegawa, Hisato Shuntoh, Takayosi Kuno
Genes Cells, 2004 Jan; 9(1): 71-82
Pubmed

2003”N“x@‰pŒę”­•\˜_•ś

Feedback regulation of MAPK signalling by an RNA-binding protein.
Reiko Sugiura, Ayako Kita, Yasuhito Shimizu, Hisato Shuntoh, Susie O. Sio, Takayosi Kuno
Nature, 2003 Aug; 424(6951): 961-965, ŠÖ˜A‹LŽ–i’Š“úC–ˆ“úC_ŒËC“úŒoj
Pubmed

Zinc Finger Protein Prz1 Regulates Ca2+ but Not Cl- Homeostasis in Fission Yeast: Identification of Distinct Branches of Calcineurin Signaling Pathway in Fission Yeast.
Sonoko Hirayama, Reiko Sugiura, Yabin Lu, Takuya Maeda, Kenji Kawagishi, Mistuhiro Yokoyama, Hideki Tohda, Yuko Giga-Hama, Hisato Shuntoh, Takayoshi Kuno
J Biol Chem, 2003 May; 278(20): 18078-18084
Pubmed

2002”N“x@‰pŒę”­•\˜_•ś

Calcineurin is implicated in the regulation of the septation initiation network in fission yeast.
Yabin Lu, Reiko Sugiura, Tomoko Yada, Hong Cheng, Susie O. Sio, Hisato Shuntoh, Takayoshi Kuno
Genes Cells, 2002 Oct; 7(10): 1009-1019
Pubmed

Role of the Rab GTP-binding protein Ypt3 in the fission yeast exocytic pathway, and its connection to calcineurin function.
Hong Cheng, Reiko Sugiura, Wenlian Wu, Masaaki Fujita, Yabin Lu, Susie O. Sio, Rena Kawai, Kaoru Takegawa, Hisato Shuntoh, Takayoshi Kuno
Mol Biol Cell, 2002 Aug; 13(8): 2963-2976
Pubmed

Genetic interaction between calcineurin and type 2 myosin and their involvement in the regulation of cytokinesis and chloride ion homeostasis in fission yeast.
Masaaki Fujita, Reiko Sugiura, Yabin Lu, Linxiao Xu, Yujie Xia, Hisato Shuntoh, Takayoshi Kuno
Genetics, 2002 Jul; 161(3): 971-981
Pubmed

Calcineurin phosphatase in signal transduction: lessons from fission yeast.
Reiko Sugiura, Susie O. Sio, Hisato Shuntoh, Takayoshi Kuno
Genes Cells, 2002 Jul; 7(7): 619-627
Pubmed

2001”N“x@‰pŒę”­•\˜_•ś

Downregulation of vascular soluble guanylate cyclase induced by high salt intake in spontaneously hypertensive rats.
Satomi Kagota, Akiko Tamashiro, Yu Yamaguchi, Reiko Sugiura, Takayoshi Kuno, Kazuki Nakamura, Masaru Kunitomo
Br J Pharmacol, 2001 Oct; 134 (4): 737-744
Pubmed

Its8, a fission yeast homolog of Mcd4 and Pig-n, is involved in GPI anchor synthesis and shares an essential function with calcineurin in cytokinesis.
Tomoko Yada, Reiko Sugiura, Ayako Kita, Yuumi Itoh, Yabin Lu, Yeongjin Hong, Taroh Kinoshita, Hisato Shuntoh, Takayoshi Kuno
J Biol Chem, 2001 Apr; 276 (17): 13579-13586
Pubmed

Molecular genetic analysis of the calcineurin signaling pathways.
Reiko Sugiura-R; Susie O. Sio, Hisato Shuntoh, Takayoshi Kuno
Cell Mol Life Sci, 2001 Feb; 58(2): 278-288
Pubmed

2000”N“x@‰pŒę”­•\˜_•ś

Phosphatidylinositol-4-phosphate 5-kinase Its3 and calcineurin Ppb1 coordinately regulate cytokinesis in fission yeast.
Yingjie Zhang, Reiko Sugiura, Yabin Lu, Masako Asami, Takuya Maeda, Toshiki Itoh, Tadaomi Takenawa, Hisato Shuntoh, Takayoshi Kuno
J Biol Chem, 2000 Nov; 275(45): 35600-35606
Pubmed

Tol1, a fission yeast phosphomonoesterase, is an in vivo target of lithium and its deletion leads to sulfite auxotrophy.
Rumi Miyamoto, Reiko Sugiura, Shinya Kamitani, Tomoko Yada, Yabin Lu, Susie O. Sio, Masahiro Asakura, Akio Matsuhisa, Hisato Shuntoh, Takayoshi Kuno
J Bacteriol, 2000 Jul; 182(13): 3619-3625
Pubmed

1999”N“x@‰pŒę”­•\˜_•ś

The MAPK kinase Pek1 acts as a phosphorylation-dependent molecular switch.
Reiko Sugiura, Takashi Toda, Susheela Dhut, Hisato Shuntoh, Takayoshi Kuno
Nature, 1999 Jun; 399(6735): 479-483
Pubmed

1998”N“x@‰pŒę”­•\˜_•ś

pmp1+, a suppressor of calcineurin deficiency, encodes a novel MAP kinase phosphatase in fission yeast.
Reiko Sugiura, Takashi Toda, Hisato Shuntoh, Mitsuhiro Yanagida, Takayoshi Kuno
EMBO J, 1998 Jan; 17(1): 140-148
Pubmed

1996”N“x@‰pŒę”­•\˜_•ś

The fission yeast pmk1+ gene encodes a novel mitogen-activated protein kinase homolog which regulates cell integrity and functions coordinately with the protein kinase C pathway.
Takashi Toda, Susheela Dhut, Giulio Superti-Furga, Yukiko Gotoh, Eisuke Nishida, Reiko Sugiura, Takayoshi Kuno
Mol Cell Biol, 1996 Dec; 16(12): 6752-6764
Pubmed

Cloning and characterization of hsc1+, a heat shock cognate gene of the fission yeast Schizosaccharomyces pombe.
Ken-ichi Oishi, Reiko Sugiura, Hisato Shuntoh, Takayoshi Kuno
Gene, 1996 Nov; 181(1-2): 45-49
Pubmed


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y•ęƒQƒmƒ~ƒNƒX‚đ—p‚˘‚˝drug discovery
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•Ş—ôy•ęƒ‚ƒfƒ‹Œn‚đ—p‚˘‚˝ƒQƒmƒ€‘n–ň‚ĆƒQƒmƒ€–ň—Šw
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V‹KMAPKK Pek1‚Í—}§‚ĆŠˆŤ‰ť‚Ě—ź‹@”\‚đŽ‚Â•ŞŽqƒXƒCƒbƒ`‚Ě–đŠ„‚đ‚ˇ‚é
™‰Y—íŽqCt“Ą‹vlC‹v–ě‚‹`
×–EHŠw, 1999; 18(8): 1100-1101

ƒJƒ‹ƒVƒjƒ…[ƒŠƒ“
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ŽR–{‰ë@•Ňi—r“yŽĐj
1999; 144-145

PP2BiƒJƒ‹ƒVƒjƒ…[ƒŠƒ“j‚̍\‘˘‚Ć‹@”\
t“Ą‹vlC™‰Y—íŽqC‹v–ě‚‹`
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y•ę‚É‚¨‚Ż‚éƒJƒ‹ƒVƒjƒ…[ƒŠƒ“î•ń“`’BŒn
™‰Y—íŽqCt“Ą‹vlC‹v–ě‚‹`
’`”’ŽżŠjŽ_y‘f, 1998;uƒvƒƒeƒCƒ“ƒzƒXƒtƒ@ƒ^[ƒ[‚̍\‘˘‚Ć‹@”\v6ŒŽ†‘Š§C43(8): 1021-1028

•Ş—ôy•ęƒ‚ƒfƒ‹Œn‚É‚¨‚Ż‚éƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚Ě‹@”\‰đÍ
™‰Y—íŽqCt“Ą‹vlC‹v–ě‚‹`
ŽŔŒąˆăŠw, 1997; 15(6): 629-634

‚o‚o‚Q‚a‚̐ś—‹@”\
t“Ą‹vlC™‰Y—íŽqC‹v–ě‚‹`
×–EHŠw, 1997; 16(2): 201-209

V‹K‚l‚`‚o‚j
“o“c—˛C™‰Y—íŽqC‹v–ě‚‹`
ŽŔŒąˆăŠw, 1996; 14(19): 54-59

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2017”N“xś–˝‰ČŠwŒnŠw‰ď‡“Ż”NŽŸ‘ĺ‰ďiConBio2017j@2017”N12ŒŽ6`9“úi_ŒËjiƒ|ƒXƒ^[j

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RNA granule‚đ‰î‚ľ‚˝DEAD boxŒ^RNA helicase Ded1‚É‚ć‚éPKC/MAPKƒVƒOƒiƒ‹§Œä‹@\‚Ě’ńĽ
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2017”N“xś–˝‰ČŠwŒnŠw‰ď‡“Ż”NŽŸ‘ĺ‰ďiConBio2017j@2017”N12ŒŽ6`9“úi_ŒËjiƒ|ƒXƒ^[j

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Chemical genetics identifies ACA-28, a 1'-acetoxychavicol acetate analogue compound, as a novel modulator of ERK MAPK signaling, which preferentially kills human melanoma cells by inducing ERK-dependent apoptosis
Reiko Sugiura
The 3rd Japan-Taiwan Bilateral Conference on Protein Phosphatase & The 8th Japanese Conference on Protein PhosphataseiŒű“ށj
Nov 18-21, 2017(Sendai)

The DEAD box RNA helicase Ded1 negatively regulates PKC/MAPK signaling via RNA granule
Yuki Kanda, Yoshinori Nagai, Kiko Tsuchiya, Ryosuke Satoh, Teruaki Takasaki, Reiko Sugiura
The 3rd Japan-Taiwan Bilateral Conference on Protein Phosphatase & The 8th Japanese Conference on Protein Phosphataseiƒ|ƒXƒ^[j
Nov 18-21, 2017(Sendai)
—DGƒ|ƒXƒ^[ÜŽóÜ

THE DEAD BOX RNA HELICASE DED1 NEGATIVELY REGULATES PKC/MAPK SIGNALING VIA RNA GRANULES
Yuki Kanda, Saki Matsumoto, Natsumi Inutsuka, Chisato Ikeda, Yoshinori Nagai, Kiko Tsuchiya, Teruaki Takasaki, Ryosuke Satoh, Reiko Sugiura
RNA Biology 2017 ~Cutting Edge Developments in RNA Biology for the Control of Gene Expression~iƒ|ƒXƒ^[j
Nov 13-17, 2017(Okinawa)

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‘ć67‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď   2017”N10ŒŽ14“úi_ŒËjiŒű“ށj

RNA Œ‹‡ƒ^ƒ“ƒpƒNŽż‚ĚŽžŠÔE‹óŠÔ“I§Œä‚đ‰î‚ľ‚˝MAPKƒVƒOƒiƒ‹’˛ß‹@\
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‘ć67‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď   2017”N10ŒŽ14“úi_ŒËjiŒű“ށj

Endosulfineƒzƒ‚ƒƒOIgo1‚ŞŽ_‰ťƒXƒgƒŒƒX‚ɂǂ̂悤‚ɉž“š‚ˇ‚é‚Ě‚Š
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‘ć67‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď   2017”N10ŒŽ14“úi_ŒËjiŒű“ށj

S1PŽó—e‘Ě’˛ßÜFTY720‚đ‰î‚ˇ‚éƒVƒOƒiƒ‹“`’B‹@\‚̉đ–ž
-FTY720“Y‰Á‚Ě‚ŕ‚˝‚炡Ca2+/ROS/FeƒVƒOƒiƒ‹‚̕ωť‚ƐV‚˝‚Ȑś—ŠˆŤ-
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‘ć67‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď   2017”N10ŒŽ14“úi_ŒËjiŒű“ށj

RNAŒ‹‡ƒ^ƒ“ƒpƒNŽżRnc1‚Ě‹óŠÔ§Œä‹@\‚ĆMAPKƒVƒOƒiƒ‹‚ĚŠÖ‚í‚č
˛“Ą—ş‰îAŒ´LŽ÷A”‹Œ´‰Á“ŢŽqA‚č‹PPA™‰Y—íŽq
y•ęˆâ“`ŠwƒtƒH[ƒ‰ƒ€‘ć50‰ńŒ¤‹†•ń‰ď   2017”N9ŒŽ11`13“úi“Œ‹žjiŒű“ށj

y•ęˆâ“`Šw‚Ě‘n–ň‚ւ̉ž—pFERK MAPKƒVƒOƒiƒ‹Œo˜HiƒpƒXƒEƒFƒCj •W“I–ňACA-28‚Ě”­ŒŠ‚ƐV‚˝‚Č‚Ş‚ńŽĄ—Ð헪
™‰Y—íŽqA˛“Ą—ş‰îAź‰Yˆę‹MA”‹Œ´‰Á“ŢŽqA_“c—E‹PA‚č‹PP
y•ęˆâ“`ŠwƒtƒH[ƒ‰ƒ€‘ć50‰ńŒ¤‹†•ń‰ď   2017”N9ŒŽ11`13“úi“Œ‹žjiŒű“ށj   

MAPKƒVƒOƒiƒ‹—}§ˆöŽq‚Ĺ‚ ‚éRNAŒ‹‡ƒ^ƒ“ƒpƒNŽżRnc1‚ĆƒXƒgƒŒƒXč÷—ą‚Ć‚ĚŠÖŒW
Œ´LŽ÷A˛“Ą—ş‰îA”‹Œ´‰Á“ŢŽqA‚č‹PPA™‰Y—íŽq
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Ca2+ƒzƒƒIƒXƒ^ƒVƒX‚đ‰î‚ˇ‚éƒI[ƒgƒtƒ@ƒW[ˆâ“`Žq‚ĆMAPKƒVƒOƒiƒ‹Œo˜H‚ĚŠÖ‚í‚č
“ˆ“cŠG—A”‹Œ´‰Á“ŢŽqA‚č‹PPA˛“Ą—ş‰îA™‰Y—íŽq
y•ęˆâ“`ŠwƒtƒH[ƒ‰ƒ€‘ć50‰ńŒ¤‹†•ń‰ď  2017”N9ŒŽ11`13“úi“Œ‹žjiƒ|ƒXƒ^[j

DEAD boxŒ^RNAƒwƒŠƒP[ƒXDed1‚É‚ć‚éMAPKƒVƒOƒiƒ‹—}§‹@\
‰iˆä‘P‹IA_“c—E‹PAź–{ŽŃŠóAŒ˘’ˉĎŔA’r“c’q—˘A“y‰Žˆ¨ŽqA˛“Ą—ş‰îA‚č‹PPA™‰Y—íŽq
y•ęˆâ“`ŠwƒtƒH[ƒ‰ƒ€‘ć50‰ńŒ¤‹†•ń‰ď   2017”N9ŒŽ11`13“úi“Œ‹žjiƒ|ƒXƒ^[j

Ž_‰ťƒXƒgƒŒƒX‚ɉž“š‚ľ‚˝Endosulfineƒzƒ‚ƒƒOIgo1‚Ě–đŠ„
“cŒ´Ę‰ÔA”‹Œ´‰Á“ŢŽqAÎ“chŠîAœAˆä—yA˛“Ą—ş‰îADieter WolfA ™‰Y—íŽq
y•ęˆâ“`ŠwƒtƒH[ƒ‰ƒ€‘ć50‰ńŒ¤‹†•ń‰ď   2017”N9ŒŽ11`13“úi“Œ‹žjiƒ|ƒXƒ^[j

ACA-28‚É‚ć‚éERK MAPKƒVƒOƒiƒ‹‚đ‰î‚ľ‚˝ƒƒ‰ƒm[ƒ}“ÁˆŮ“I×–E‘B—}§‹@\
ź‰Yˆę‹MA˛“Ą—ş‰îA”‹Œ´‰Á“ŢŽqA_“c—E‹PA‚č‹PPA™‰Y—íŽq
‹ß‹E‘ĺŠw‘ĺŠw‰@ƒTƒCƒGƒ“ƒXƒlƒbƒgƒ[ƒN2017u‘ć7‰ń‰@śƒTƒ~ƒbƒgv@2017”N9ŒŽ2“úi“ޗǁjiƒ|ƒXƒ^[{ƒVƒ‡[ƒgƒg[ƒNj

DEAD boxŒ^RNA helicase Ded1‚É‚ć‚éPKC/MAPKƒVƒOƒiƒ‹§Œä‹@\‚Ě’ńĽ
_“c—E‹PAŒ˘’ˉĎŔAź–{ŽŃŠóA’r“c’q—˘A‰iˆä‘P‹IA“y‰Žˆ¨ŽqA˛“Ą—ş‰îA‚č‹PPA™‰Y—íŽq
‹ß‹E‘ĺŠw‘ĺŠw‰@ƒTƒCƒGƒ“ƒXƒlƒbƒgƒ[ƒN2017u‘ć7‰ń‰@śƒTƒ~ƒbƒgv@2017”N9ŒŽ2“úi“ޗǁjiƒ|ƒXƒ^[{ƒVƒ‡[ƒgƒg[ƒNj

Hsp90‚ĆMAPKƒVƒOƒiƒ‹“`’BŒo˜H\ŹˆöŽq‚ĚƒNƒƒXƒg[ƒN‹@\
’r”¨‘ńŽŔA‘ĺ’J‰ÄŽŔA˛“Ą—ş‰îA‚č‹PPA™‰Y—íŽq
‹ß‹E‘ĺŠw‘ĺŠw‰@ƒTƒCƒGƒ“ƒXƒlƒbƒgƒ[ƒN2017u‘ć7‰ń‰@śƒTƒ~ƒbƒgv@2017”N9ŒŽ2“úi“ޗǁjiƒ|ƒXƒ^[j

RNAŒ‹‡ƒ^ƒ“ƒpƒNŽżPumiliio‚ĆƒCƒmƒVƒg[ƒ‹ƒŠƒ“Ž‰Žż‘ăŽÓ‚Ć‚Ě‹@”\“IŠÖŒW
ˆî‰×ł‘ĺA”‹Œ´‰Á“ŢŽqAŒ´LŽ÷A“c’†çťA˛“Ą—ş‰îA‚č‹PPA™‰Y—íŽq
‹ß‹E‘ĺŠw‘ĺŠw‰@ƒTƒCƒGƒ“ƒXƒlƒbƒgƒ[ƒN2017u‘ć7‰ń‰@śƒTƒ~ƒbƒgv@2017”N9ŒŽ2“úi“ޗǁjiƒ|ƒXƒ^[j

ƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‘jŠQ–ňFK506‚đ—˜—p‚ľ‚˝MAPKƒVƒOƒiƒ‹§ŒäƒƒJƒjƒYƒ€‚Ć‘n–ňŒ¤‹†FƒVƒOƒiƒ‹§Œä‹’“_‚Ć‚ľ‚Ä‚ĚRNAč÷—ą‚Ě–đŠ„‚Š‚çV‹KERK’˛ŽÜACA-28‚̍R‚Ş‚ńě—p‚Ü‚Ĺ
™‰Y—íŽq
‘ć24‰ńƒ}ƒNƒƒ‰ƒCƒhVě—pŒ¤‹†‰ďu‰‰@2017”N7ŒŽ21`22“úi“Œ‹žjiŒű“ށj

KHŒ^RNAŒ‹‡ƒ^ƒ“ƒpƒNŽżRnc1‚ĚRae1ˆË‘ś“I‚ČŠjŠO—A‘—‚đ‰î‚ľ‚˝MAPKƒVƒOƒiƒ‹§Œä‹@\
˛“Ą—ş‰îA”‹Œ´‰Á“ŢŽqA[”öˆŸŠě—ǁA“ĄŒ´rLA•˝ˆäWĆA’JŽž—YA™‰Y—íŽq
‘ć19‰ń“ú–{RNAŠw‰ď”N‰ď@2017”N7ŒŽ19`21“úi•xŽRjiŒű“ށj

ƒƒ^ƒƒ~ƒNƒXŒ¤‹†‚đ‚ß‚´‚ľ‚˝×–E“ŕ‹ŕ‘ŽƒCƒIƒ“”Z“x‚̐V‹K’č—Ę–@ŠJ”­
•ű•ś•FA˛“Ą—ş‰îA”‹Œ´‰Á“ŢŽqA™‰Y—íŽqAěúą’źl
‘ć44‰ń“ú–{“ŐŤŠw‰ďŠwp”N‰ď@2017”N7ŒŽ10`12“úi‰Ą•ljiƒ|ƒXƒ^[j

y•ęƒ‚ƒfƒ‹ś•¨‚ĆƒPƒ~ƒJƒ‹ƒQƒmƒ~ƒNƒX‚đ—p‚˘‚˝MAPƒLƒi[ƒ[ƒVƒOƒiƒ‹§Œä‹@\‚̉𖞂Ƒn–ň‚Ö‚Ě“WŠJ
™‰Y—íŽq
ˆă–ňŠî”ŐŒ¤ƒZƒ~ƒi[u‰‰@2017”N6ŒŽ6“úi‘ĺăjiŒű“ށj

Spatial Regulation of the KH Domain RNA-Binding Protein Rnc1 Mediated by a Crm1-Independent Nuclear Export System
Ryosuke Satoh, Kanako Hagihara, Masahiro Inari, Akira Fukao, Toshinobu Fujiwara, Shinya Hirai, Tokio Tani, Reiko Sugiura
9TH INTERNATIONAL FISSION YEAST MEETING (Pombe 2017) (Œű“ށ{ƒ|ƒXƒ^[)
May 14-19, 2017 (Banff)

Skb5, an SH3 Aaptor Protein, Regulates PKC/MAPK Signaling by Controlling the Intracellular Localization of MAPKKK
Yuki Kanda, Ryosuke Satoh, Saki Matsumoto, Chisato Ikeda, Natsumi Inutsuka, Kanako Hagihara, Sho Tsujimoto, Ayako Kita, Reiko Sugiura
9TH INTERNATIONAL FISSION YEAST MEETING (Pombe 2017) (ƒ|ƒXƒ^[)
May 14-19, 2017 (Banff)

Selective Killing of Human Melanoma Cancer Cells by a Novel Small Molecule Compound Identified by a Phenotypic Screen Targeting MAPK Signalling in Fission Yeast
Ryosuke Satoh, Kazuki Matsuura, Kanako Hagihara, Ayako Kita, Genzo Tanabe, Osamu Muraoka, Teruaki Takasaki, Reiko Sugiura
9TH INTERNATIONAL FISSION YEAST MEETING (Pombe 2017) (ƒ|ƒXƒ^[)
May 14-19, 2017 (Banff)

Combating Cancer with a Powerful Chemical Genetics Approach and Model Systems
Reiko Sugiura
McGill University seminar
May 15, 2017iMontrealj

2016”N“x@Šw‰ď”­•\Eu‰‰‰ď“™

RNA granules: Signaling hubs and therapeutic targets for cancer therapy
Ryosuke Satoh, Ayako Kita, Kanako Hagihara, Reiko Sugiura
‘ć39‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ďiƒVƒ“ƒ|ƒWƒEƒ€j2016”N11ŒŽ30“ú`12ŒŽ2“úi‰Ą•ljiˆË—ŠƒVƒ“ƒ|ƒWƒEƒ€j

ƒ_ƒEƒ“ÇŠÖ˜Aˆâ“`ŽqRCAN1‚ÍŽ_‰ťƒXƒgƒŒƒX‰ž“šƒVƒOƒiƒ‹“`’BŒo˜H‚đ§Œä‚ˇ‚é
˛“Ą—ş‰îA•Ę•{—œšAŠě‘˝ˆťŽqAÎŒ´ŒcˆęA™‰Y—íŽq
‘ć39‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ďiƒVƒ“ƒ|ƒWƒEƒ€j2016”N11ŒŽ30“ú`12ŒŽ2“úi‰Ą•ljiˆË—ŠƒVƒ“ƒ|ƒWƒEƒ€j

—n‰tNMR–@‚đ—p‚˘‚˝’ˇ‹——Łî•ń‚ĚŽć“ž‚É‚ć‚éRNAŒ‹‡Ťƒ^ƒ“ƒpƒNŽżNrd1‚ĚƒhƒƒCƒ“ŠÔ”zŒü‚ĚŒˆ’č
‰iˆäŠ¸AŹ—ŃĘ•ŰA˛“Ą—ş‰îA™‰Y—íŽqAˆÉ“Ą—˛AŽO“‡ł‹K
‘ć39‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2016”N11ŒŽ30“ú`12ŒŽ2“úi‰Ą•ljiƒ|ƒXƒ^[j

S1PŽó—e‘Ě’˛ßÜFTY720‚đ‰î‚ˇ‚éˆâ“`Žq”­Œťƒvƒƒtƒ@ƒCƒŠƒ“ƒO‚Ě–Ô—…“I‰đÍ‚Ć“S‘ăŽÓ‹@\‚ĚŠÖ‚í‚č
”‹Œ´‰Á“ŢŽqAÎ“chŠîA–؉ş‰Ŕ“ߎqAŠě‘˝ˆťŽqA˛“Ą—ş‰îA‹ßd—TŽŸA‰vŽq‚Aź–ěƒ’jAç—tŒ’ŽĄA™‰Y—íŽq
‘ć39‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2016”N11ŒŽ30“ú`12ŒŽ2“úi‰Ą•ljiƒ|ƒXƒ^[j

ƒ‚ƒfƒ‹ś•¨‚đ—p‚˘‚˝MAPKƒVƒOƒiƒ‹§ŒäƒƒJƒjƒYƒ€‚̉𖞂Ƒn–ň‚ւ̉ž—p
™‰Y—íŽq
–kŠC“š‘ĺŠw‘ĺŠw‰@ˆăŠwŒ¤‹†‰Ču‰‰‰ď@2016”N11ŒŽ17“úiŽD–yjiŒű“ށj

Applying Kinase-Phosphatase Interplay in Ca2+ Signaing for Cancer Therapeutics: A pas de deux.
Reiko Sugiura
the 12th International Conference on Protein Phosphatase & International Symposium on Innovative Research for Genome-Based Drug Discovery and Cancer TherapeuticsiˆË—ŠƒVƒ“ƒ|ƒWƒEƒ€j
Oct 27-30, 2016 (Osaka)

Skb5, an SH3 adaptor protein, regulates PKC/MAPK signaling via spatial regulation of MAPKKK.
Yuki Kanda, Ryosuke Satoh, Saki Matsumoto, Chisato Ikeda, Natsumi Inutsuka, Kanako Hagihara, Sho Tsujimoto, Ayako Kita, Reiko Sugiura
the 12th International Conference on Protein Phosphatase & International Symposium on Innovative Research for Genome-Based Drug Discovery and Cancer TherapeuticsiŽáŽčŒű“Ş”­•\j
Oct 27-30, 2016 (Osaka)

Anticancer-drug screening utilizing fission yeast genetics identified Acremomannolipin A, a Calcium signalling modulator with anti-tumor activity
Ryosuke Satoh, Kazuki Matsuura, Kanako Hagihara, Nozomu Tsuchimoto, Yoshimasa Hyodo, Ayako Kita, Osamu Muraoka, Genzoh Tanabe, Reiko Sugiura
the 12th International Conference on Protein Phosphatase & International Symposium on Innovative Research for Genome-Based Drug Discovery and Cancer TherapeuticsiŽáŽčŒű“Ş”­•\j
Oct 27-30, 2016 (Osaka)

Preoin kinase N (PKN) family-dipendent regulation of hepatic cytochrome P450 2C and metabolic profile analysis in PKN mutant mice through targeted metabolomics by LC-MS/MS.
Atsushi Kawase, Nobuyuki Nimura, Marina Yamashita, Yuki Ono, Koji Kubouchi, Nanae Sawada, Hiroaki Shimada, Ryosuke Satoh, Ayako Kita, Hideyuki Mukai, Masahiro Iwaki, Reiko Sugiura
the 12th International Conference on Protein Phosphatase & International Symposium on Innovative Research for Genome-Based Drug Discovery and Cancer Therapeuticsiƒ|ƒXƒ^[j
Oct 27-30, 2016 (Osaka)

Mutaion and Inhibition of Hsp90 affects stress granule assembly and MAPK signaling. ~Implications of anti-cancer mechanisms of Geldanamycin~
Takumi Ikehata, Ryosuke Satoh, Ayako Kita, Reiko Sugiura
the 12th International Conference on Protein Phosphatase & International Symposium on Innovative Research for Genome-Based Drug Discovery and Cancer Therapeuticsiƒ|ƒXƒ^[{ƒVƒ‡[ƒgƒg[ƒNj
Oct 27-30, 2016 (Osaka)

Skb5, an SH3 domain adaptor protein, plays a regulatory role in the PKC/MAPK signaling pathway by controlling the intracellular localization of the MAPKKK Mkh1.
Chisato Ikeda, Yuki Kanda, Ryosuke Satoh, Saki Matsumoto, Natsumi Inutsuka, Kanako Hagihara, Sho Tsujimoto, Ayako Kita, Reiko Sugiura
the 12th International Conference on Protein Phosphatase & International Symposium on Innovative Research for Genome-Based Drug Discovery and Cancer Therapeuticsiƒ|ƒXƒ^[{ƒVƒ‡[ƒgƒg[ƒNj
Oct 27-30, 2016 (Osaka)
uŠvV‚Ş‚ńƒQƒmƒ€v—DGƒ|ƒXƒ^[”­•\ÜŽóÜ

Global gene expression profiling reveals unexpected spectrum of effects of a novel immune modulator FTY720. ~Possible involvement of iron homeostasis as an antitumor property of FTY720~
Kanako Hagihara, Kouki Ishida, Knako Kinoshita, Ryosuke Satoh, Ayako Kita, Reiko Sugiura
the 12th International Conference on Protein Phosphatase & International Symposium on Innovative Research for Genome-Based Drug Discovery and Cancer Therapeuticsiƒ|ƒXƒ^[{ƒVƒ‡[ƒgƒg[ƒNj
Oct 27-30, 2016 (Osaka)

Anti-cancer drug discovery using fission yeast genetics identified a novel analog of 1'-Acetoxychavicol Acetate (ACA) with a potent anti-tumor activity against human melanoma cells.
Kazuki Matsuura, Ryosuke Satoh, Kanako Hagihara, Nozomu Tsuchimoto, Yoshimasa Hyodo, Ayako Kita, Genzoh Tanabe, Osamu Muraoka, Reiko Sugiura
the 12th International Conference on Protein Phosphatase & International Symposium on Innovative Research for Genome-Based Drug Discovery and Cancer Therapeuticsiƒ|ƒXƒ^[{ƒVƒ‡[ƒgƒg[ƒNj
Oct 27-30, 2016 (Osaka)

Functional Analysis of the Puf family RNA-binding protein Pumilio in stress responses and the inositol phospholipid signaling pathway.
Masahiro Inari, Ryosuke Satoh, Yusuke Kimura, Kanako Hagihara, Yuki Kitai, Kouki Ishida, Haruka Hiroi, Ayako Kita, Dieter Wolf, Reiko Sugiura
the 12th International Conference on Protein Phosphatase & International Symposium on Innovative Research for Genome-Based Drug Discovery and Cancer Therapeuticsiƒ|ƒXƒ^[{ƒVƒ‡[ƒgƒg[ƒNj
Oct 27-30, 2016 (Osaka)
uŠvV‚Ş‚ńƒQƒmƒ€v—DGƒ|ƒXƒ^[”­•\ÜŽóÜ

Evaluation of the measurement method of intracellular calcium ion concentration in fission yeast.
Fumihiko Ogata, Ryosuke Satoh, Ayako Kita, Reiko Sugiura, Naohito Kawasaki
the 12th International Conference on Protein Phosphatase & International Symposium on Innovative Research for Genome-Based Drug Discovery and Cancer Therapeuticsiƒ|ƒXƒ^[j
Oct 27-30, 2016 (Osaka)

A Genome-wide Sreen Reveals Genes Involved in Calcium Signaling and Glycosylation for Tolerance to SKB (Sugiura Kagoubutsu B ), a Novel Glycolipid with Potent Anti-tubor Activity.
Ayako Kita, Ai Minamibayashi, Miki Yamazaki, Kanako Hagihara, Ryosuke Satoh, Reiko Sugiura
the 12th International Conference on Protein Phosphatase & International Symposium on Innovative Research for Genome-Based Drug Discovery and Cancer Therapeuticsiƒ|ƒXƒ^[j
Oct 27-30, 2016 (Osaka)

‹ß‘ĺ‚Š‚琢ŠE‚Ö”­M‚ˇ‚é‚Ş‚ńŒ¤‹†`y•ę‚đ—p‚˘‚˝’´Šî‘bŒ¤‹†‚̐Ź‰Ę‚đŠłŽŇ‚ł‚ń‚É“Í‚Ż‚é‹´“n‚ľŒ¤‹†‚đ‚ß‚´‚ľ‚Ä
™‰Y—íŽq
‹ß‹E‘ĺŠw śŠU‹łˆçŒ¤C‰ď@2016”N10ŒŽ1“úi‘ĺăjiŒű“ށj

RNAŒ‹‡’`”’ŽżRnc1‚Ě‹ÇÝ‰đÍ‚Š‚猊‚Ś‚Ä‚Ť‚˝MAPKƒVƒOƒiƒ‹‚̐§Œä‹@\
˛“Ą—ş‰îA”‹Œ´‰Á“ŢŽqAˆî‰×ł‘ĺA’r”¨‘ńŽŔAŠě‘˝ˆťŽqA™‰Y—íŽq
y•ęˆâ“`ŠwƒtƒH[ƒ‰ƒ€‘ć49‰ńŒ¤‹†•ń‰ď@2016”N9ŒŽ9“ú`11“úi_ŒËjiŒű“ށj

S1PŽó—e‘Ě’˛ßÜFTY720‚đ‰î‚ˇ‚éƒVƒOƒiƒ‹“`’B‹@\‚̉đ–ž
”‹Œ´‰Á“ŢŽqAÎ“chŠîA–؉ş‰Ŕ“ߎqAŠě‘˝ˆťŽqA˛“Ą—ş‰îA‹ßd—TŽŸA‰vŽq‚Aź–ěƒ’jAç—tŒ’ŽĄA™‰Y—íŽq
y•ęˆâ“`ŠwƒtƒH[ƒ‰ƒ€‘ć49‰ńŒ¤‹†•ń‰ď@2016”N9ŒŽ9“ú`11“úi_ŒËjiŒű“ށj

•Ş—ôy•ę‚đ—p‚˘‚˝Calcineurin‚ĆCalcipressin‚Ě‹ÇÝ§Œä‹@\‚̉đÍ
’r”¨‘ńŽŔA‰ŞŽRˆÇ“ށA˛“Ą—ş‰îA”‹Œ´‰Á“ŢŽqAŠě‘˝ˆťŽqA™‰Y—íŽq
y•ęˆâ“`ŠwƒtƒH[ƒ‰ƒ€‘ć49‰ńŒ¤‹†•ń‰ď@2016”N9ŒŽ9“ú`11“úi_ŒËjiƒ|ƒXƒ^[j

SH3ƒAƒ_ƒvƒ^[Skb5‚ÍMAPKKK‚Ě×–E“ŕ‹ÇÝ‚đ§Œä‚ˇ‚é‚ą‚Ć‚ĹPmk1 MAPKƒVƒOƒiƒ‹‚đ—}§‚ˇ‚é
’r“c’q—˘A_“c—E‹PA˛“Ą—ş‰îAź–{ŽŃŠóAŒ˘’ˉĎŔA”‹Œ´‰Á“ŢŽqAź–ěƒ’jAŠě‘˝ˆťŽqA™‰Y—íŽq
y•ęˆâ“`ŠwƒtƒH[ƒ‰ƒ€‘ć49‰ńŒ¤‹†•ń‰ď@2016”N9ŒŽ9“ú`11“úi_ŒËjiƒ|ƒXƒ^[j

RNAŒ‹‡ƒ^ƒ“ƒpƒNŽżPumilio‚ĆPI4,5P2ƒVƒOƒiƒ‹‚Ěˆâ“`Šw“IŠÖ‚í‚č
ˆî‰×ł‘ĺA˛“Ą—ş‰îA”‹Œ´‰Á“ŢŽqAœAˆä—yA–kˆä—CŽ÷AÎ“chŠîADieter WolfAŠě‘˝ˆťŽqA™‰Y—íŽq
y•ęˆâ“`ŠwƒtƒH[ƒ‰ƒ€‘ć49‰ńŒ¤‹†•ń‰ď@2016”N9ŒŽ9“ú`11“úi_ŒËjiƒ|ƒXƒ^[j

PKC/MAPKƒVƒOƒiƒ‹‚Ě‹óŠÔ“I§ŒäƒƒJƒjƒYƒ€‚Ć‘n–ň‚ւ̉ž—p
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L“‡‘ĺŠwŒ’N’ˇŽőŒ¤‹†‹’“_iHiHAj‘ć6‰ńƒ[ƒNƒVƒ‡ƒbƒv@2016”N7ŒŽ8“úiL“‡jiŒű“ށj

Spatial Regulation of RNA-binding Proteins via Stress Granule Formation by Signaling Pathways.
Ryosuke Satoh, Ayako Kita, Reiko Sugiura
The RNA Society of Japan 18th Annual Meeting & the 21th Annual Meeting of the RNA Society (RNA 2016 Kyoto)iƒ|ƒXƒ^[j
Jun 28- Jul 2, 2016 (Kyoto)

RNA granules: Signaling habs and therapeutic targets for cancer therapy.
Reiko Sugiura
The RNA Society of Japan 18th Annual Meeting & the 21th Annual Meeting of the RNA Society (RNA 2016 Kyoto)iƒ|ƒXƒ^[j
Jun 28- Jul 2, 2016 (Kyoto)

ƒVƒOƒiƒ‹“`’B‹’“_‚Ć‚ľ‚Ä‚ĚRNA granule‚Ě‹@”\‰đÍ‚Ć‘n–ň‚ւ̉ž—p
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‘ć1‰ńRNAč÷—ą/RNAƒ^ƒ“ƒpƒNŽż•Ą‡‘ĚŒ¤‹†‰ď@2016”N7ŒŽ16“ú`17“úi‰ŞčjiˆË—ŠŒű“ށj

Calcineurin—}§ˆöŽqCalcipressin‚Ěstress granuleˆÚs‚ÉŠÖ‚í‚é—Ěˆć‚ĆCalcineurinƒVƒOƒiƒ‹‚É—^‚Ś‚é–đŠ„‚Ě‰đÍ
’r”¨‘ńŽŔA‰ŞŽRˆÇ“ށA˛“Ą—ş‰îA”‹Œ´‰Á“ŢŽqAŠě‘˝ˆťŽqA™‰Y—íŽq
‘ć1‰ńRNAč÷—ą/RNAƒ^ƒ“ƒpƒNŽż•Ą‡‘ĚŒ¤‹†‰ď@2016”N7ŒŽ16“ú`17“úi‰Şčjiƒ|ƒXƒ^[j

RNAŒ‹‡ƒ^ƒ“ƒpƒNŽżPumilio‚ĆƒCƒmƒVƒg[ƒ‹ƒŠƒ“Ž‰ŽżŒo˜H‚ĚƒXƒgƒŒƒX‰ž“š‚É‚¨‚Ż‚é–đŠ„‚Ě‰đÍ
ˆî‰×ł‘ĺA˛“Ą—ş‰îA”‹Œ´‰Á“ŢŽqAœAˆä—yA–kˆä—CŽ÷AÎ“chŠîADieter WolfAŠě‘˝ˆťŽqA™‰Y—íŽq
‘ć1‰ńRNAč÷—ą/RNAƒ^ƒ“ƒpƒNŽż•Ą‡‘ĚŒ¤‹†‰ď@2016”N7ŒŽ16“ú`17“úi‰Şčjiƒ|ƒXƒ^[j

RNA granule‚̍\ŹˆöŽq‚đ‰î‚ľ‚˝PKCƒVƒOƒiƒ‹§ŒäƒƒJƒjƒYƒ€‚̉đÍ
Šě‘˝ˆťŽqA_“c—E‹PAź–{ŽŃŠóAŒ˘’ˉĎŔA’r“c’q—˘A˛“Ą—ş‰îA“yˆäÍA™‰Y—íŽq
‘ć1‰ńRNAč÷—ą/RNAƒ^ƒ“ƒpƒNŽż•Ą‡‘ĚŒ¤‹†‰ď@2016”N7ŒŽ16“ú`17“úi‰Şčjiƒ|ƒXƒ^[j

RNAŒ‹‡’`”’Žż‚ĚƒŠƒ“Ž_‰ť‚ÍStress granule‚ĚŒ`Ź‚𒲐߂ˇ‚é
˛“Ą—ş‰îA”‹Œ´‰Á“ŢŽqA’r”¨‘ńŽŔAˆî‰×ł‘ĺAŠě‘˝ˆťŽqA™‰Y—íŽq
‘ć1‰ńRNAč÷—ą/RNAƒ^ƒ“ƒpƒNŽż•Ą‡‘ĚŒ¤‹†‰ď@2016”N7ŒŽ16“ú`17“úi‰Şčjiƒ|ƒXƒ^[j

Combating Cancer with a Powerful Chemical Genetics Approach
Reiko Sugiura
‘ĺă‘ĺŠwˆăŠwŒnŒ¤‹†‰ČƒZƒ~ƒi[@2016”N5ŒŽ24“úi‘ĺăjiŒű“ށj

2015”N“x@Šw‰ď”­•\

ƒVƒOƒiƒ‹“`’B‹’“_iƒnƒuj‚Ć‚ľ‚Ä‚ĚRNAč÷—ą‚Ě–đŠ„
™‰Y—íŽq
‘ć38‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@‘ć88‰ń“ú–{ś‰ťŠw‰ď‘ĺ‰ď‡“Ż‘ĺ‰ďiƒ[ƒNƒVƒ‡ƒbƒvj2015”N12ŒŽ1“ú`4“úi_ŒËjiˆË—ŠŒű“ށj

ƒJƒ‹ƒVƒjƒ…[ƒŠƒ“ƒVƒOƒiƒ‹‚Ě‹óŠÔ“I§Œä‹@\
˛“Ą—ş‰îA”‹Œ´‰Á“ŢŽqAŠě‘˝ˆťŽqA™‰Y—íŽq
‘ć38‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@‘ć88‰ń“ú–{ś‰ťŠw‰ď‘ĺ‰ď‡“Ż‘ĺ‰ďiƒ[ƒNƒVƒ‡ƒbƒvj2015”N12ŒŽ1“ú`4“úi_ŒËjiˆË—ŠŒű“ށj

ƒCƒmƒVƒg[ƒ‹ƒŠƒ“Ž‰Žż‘ăŽÓ‚ÉŠÖ‚í‚éV‹KˆöŽqŒQ‚Ě‹@”\‰đÍ
Ź‘qŽ–çA…–ě—ĹŽqA—›‰–FAŠě‘˝ˆťŽqA˛“Ą—ş‰îAźŒű‰p—˘AˆÉ“ĄrŽ÷A™‰Y—íŽq
‘ć38‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@‘ć88‰ń“ú–{ś‰ťŠw‰ď‘ĺ‰ď‡“Ż‘ĺ‰ď@2015”N12ŒŽ1“ú`4“úi_ŒËjiƒ|ƒXƒ^[j

–Ɖu—}§–ňFTY720‚Ěˆâ“`Žq”­Œťƒvƒƒtƒ@ƒCƒŠƒ“ƒO‚̉đÍ
–kˆä—CŽ÷A”‹Œ´‰Á“ŢŽqA…ŒÉĘA”Ş•S–ƒ—˘ŽqAÎ“chŠîAŠě‘˝ˆťŽqA˛“Ą—ş‰îA‰vŽq‚Aź–ěƒ’jAç—tŒ’ŽĄA™‰Y—íŽq
‘ć38‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@‘ć88‰ń“ú–{ś‰ťŠw‰ď‘ĺ‰ď‡“Ż‘ĺ‰ď@2015”N12ŒŽ1“ú`4“úi_ŒËjiƒ|ƒXƒ^[j

PKN3ƒmƒbƒNƒAƒEƒgƒ}ƒEƒX‚đ—p‚˘‚˝V‚˝‚ČŒŒŠÇVś‚Ć‚Ş‚ń“]ˆÚƒVƒOƒiƒ‹‚̐§Œä‹@\
ŒE“ŕN“ńA’Ň–{ăāA_“c—E‹PAŹ–ě—S‹PA–ŘŒË—FŠGAŕV“c“ށXAź“cĄŽOA’֐łŠ°AMashud RanaAŒüˆäGKA™‰Y—íŽq
‘ć38‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@‘ć88‰ń“ú–{ś‰ťŠw‰ď‘ĺ‰ď‡“Ż‘ĺ‰ď@2015”N12ŒŽ1“ú`4“úi_ŒËjiƒ|ƒXƒ^[j

ƒJƒ‹ƒVƒjƒ…[ƒŠƒ“ƒVƒOƒiƒ‹‚Ě‹óŠÔ“I§Œä‹@\
˛“Ą—ş‰îAŠě‘˝ˆťŽqA™‰Y—íŽq
–˘—ˆ‘n–ňˆă—ĂƒCƒmƒx[ƒVƒ‡ƒ“ƒVƒ“ƒ|ƒWƒEƒ€uRNA‚ĆŠŕŒ¤‹†‚Ş‘ń‚­ś–˝‰ČŠw‚ĚĹ‘Oüv@2015”N11ŒŽ30“úi“Œ‘ĺăjiˆË—ŠŒű“ށj

PKN3ƒmƒbƒNƒAƒEƒgƒ}ƒEƒX‚đ—p‚˘‚˝V‚˝‚ČŒŒŠÇVś‚Ć‚Ş‚ń“]ˆÚƒVƒOƒiƒ‹‚̐§Œä‹@\
ŒE“ŕN“ńA’Ň–{ăāA_“c—E‹PAŹ–ě—S‹PA–ŘŒË—FŠGAŕV“c“ށXAź“cĄŽOA’֐łŠ°ARana MashudAŒüˆäGKA™‰Y—íŽq
–˘—ˆ‘n–ňˆă—ĂƒCƒmƒx[ƒVƒ‡ƒ“ƒVƒ“ƒ|ƒWƒEƒ€uRNA‚ĆŠŕŒ¤‹†‚Ş‘ń‚­ś–˝‰ČŠw‚ĚĹ‘Oüv@2015”N11ŒŽ30“úi“Œ‘ĺăjiƒ|ƒXƒ^[j

×–E‘BƒVƒOƒiƒ‹Pmk1 MAPKŒo˜H‚ĆƒI[ƒhƒtƒ@ƒW[ŠÖ˜AˆöŽq‚ĚŠÖŒW
Ź’rŽj‰ŘAmŒF‹v”üAűü‹´G˜aA“ě—Ńˆ¤AŒE“ŕN“ńA˛“Ą—ş‰îAŠě‘˝ˆťŽqA™‰Y—íŽq
–˘—ˆ‘n–ňˆă—ĂƒCƒmƒx[ƒVƒ‡ƒ“ƒVƒ“ƒ|ƒWƒEƒ€uRNA‚ĆŠŕŒ¤‹†‚Ş‘ń‚­ś–˝‰ČŠw‚ĚĹ‘Oüv@2015”N11ŒŽ30“úi“Œ‘ĺăjiƒ|ƒXƒ^[j

KHŒ^RNAŒ‹‡ƒ^ƒ“ƒpƒNŽżRnc1‚ÍMAPKƒVƒOƒiƒ‹‚Ɉˑś‚ľ‚ăXƒgƒŒƒXč÷—ą‚Ɉڍs‚ˇ‚é
–Ř‘ş—I‰îA˛“Ą—ş‰îAŠě‘˝ˆťŽqA™‰Y—íŽq
–˘—ˆ‘n–ňˆă—ĂƒCƒmƒx[ƒVƒ‡ƒ“ƒVƒ“ƒ|ƒWƒEƒ€uRNA‚ĆŠŕŒ¤‹†‚Ş‘ń‚­ś–˝‰ČŠw‚ĚĹ‘Oüv@2015”N11ŒŽ30“úi“Œ‘ĺăjiƒ|ƒXƒ^[j

Stress granuleŒ`Ź‚đ‰î‚ľ‚˝RNAŒ‹‡’`”’Žż‚Ě‹óŠÔ“I§Œä‚É‚¨‚Ż‚éƒVƒOƒiƒ‹“`’BŒo˜H‚Ě–đŠ„
˛“Ą—ş‰îA–Ř‘ş—I‰îAŠě‘˝ˆťŽqA™‰Y—íŽq
‘ć17‰ń“ú–{RNAŠw‰ď”N‰ď@2015”N7ŒŽ15`17“úiŽD–yjiƒ|ƒXƒ^[j

KHŒ^RNAŒ‹‡’`”’ŽżRnc1‚ÍMAPKƒVƒOƒiƒ‹‚Ɉˑś‚ľ‚ăXƒgƒŒƒXč÷—ą‚Ɉڍs‚ˇ‚é
–Ř‘ş—I‰îA˛“Ą—ş‰îAŠě‘˝ˆťŽqA™‰Y—íŽq
‘ć17‰ń“ú–{RNAŠw‰ď”N‰ď@2015”N7ŒŽ15`17“úiŽD–yjiƒ|ƒXƒ^[j

RNA Granules as Signaling Hubs.
Reiko Sugiura
8TH INTERNATIONAL FISSION YEAST MEETING (Pombe 2015)
Jun 21-16, 2015 (Kobe)iŒű“ށj

The SH3 domain protein Skb5 is a novel regulator of PKC/MAPK signaling in fission yeast.
Yuki Kanda, Sho Tsujimoto, Saki Matsumoto, Natsumi Inutsuka, Ayako Kita, Ryosuke Sato, Reiko Sugiura
8TH INTERNATIONAL FISSION YEAST MEETING (Pombe 2015)
Jun 21-16, 2015 (Kobe)iƒ|ƒXƒ^[j

Imp2, the PSTPIP homolog in fission yeast, regulates cytokinesis and membrane traffic.
Ayako Kita, Mari Higa, Akira Doi, Ryosuke Satoh, Reiko Sugiura
8TH INTERNATIONAL FISSION YEAST MEETING (Pombe 2015)
Jun 21-16, 2015 (Kobe)iƒ|ƒXƒ^[j

Genome-Wide Analysis of Gene Expression Profiles upon FTY720 Treatment.
Yuki Kitai, Kanako Hagihara, Aya Mizukura, Mariko Yao, Kouki Ishida, Ayako Kita, Ryosuke Satoh, Yuji Chikashige, Takashi Masuko, Sumio Matzno, Kenji Chiba, Reiko Sugiura
8TH INTERNATIONAL FISSION YEAST MEETING (Pombe 2015)
Jun 21-16, 2015 (Kobe)iƒ|ƒXƒ^[j

An endogenous calcineurin inhibitor DSCR1/RCAN1 regulates calcium and oxidative stress signaling.
Koji Kubouchi, Ayako Kita, Ryosuke Satoh, Rie Nagasoko, Yumi Iga, Reiko Sugiura
8TH INTERNATIONAL FISSION YEAST MEETING (Pombe 2015)
Jun 21-16, 2015 (Kobe)iƒ|ƒXƒ^[j

Functional analysis of novel regulatory factors involved in PI4P5K/PI4,5P2 signaling.
Naoya Ogura, Ryoko Mizuno, Cuifang Li, Ayako Kita, Ryosuke Satoh, Eri Nishiguchi, Toshiki Itoh, Reiko Sugiura
8TH INTERNATIONAL FISSION YEAST MEETING (Pombe 2015)
Jun 21-16, 2015 (Kobe)iƒ|ƒXƒ^[j

Chemical genomics reveals genes associated with sensitivity to rapamycin in the fission yeast Schizosaccharomyces pombe.
Takaya Uno, Akira Doi, Ayumi Fujimoto, Shun Sato, Yuuki Kanda, Keita Asami, Yuriko Tanaka, Ayako Kita, Ryosuke Satoh, Reiko Sugiura
8TH INTERNATIONAL FISSION YEAST MEETING (Pombe 2015)
Jun 21-16, 2015 (Kobe)iƒ|ƒXƒ^[j

2014”N“x@Šw‰ď”­•\

Combating Cancer with a Powerful Chemical Genomics and Model Systems `Cancer Therapeutics in Fission Yeast`
Reiko Sugiura
Ž„—§‘ĺŠwí—Ş“IŒ¤‹†Šî”ŐŒ`ŹŽx‰‡Ž–‹Ć`‘BƒVƒOƒiƒ‹‚đ•W“I‚Ć‚ľ‚˝ŠvV“I‚Ş‚ńŽĄ—Ă–@ŠJ”­‚đ‚ß‚´‚ľ‚˝“‡“IƒQƒmƒ€Œ¤‹†‚ÉŠÖ‚ˇ‚éˆă–ň˜AŒgŠî”ŐŒ`Ź`uƒLƒbƒNƒIƒtƒVƒ“ƒ|ƒWƒEƒ€v@2015”N3ŒŽ24“úi‘ĺăjiˆË—ŠƒVƒ“ƒ|ƒWƒEƒ€j

×–E‘BƒVƒOƒiƒ‹§Œä‹’“_‚Ć‚ľ‚Ä‚ĚRNAč÷—ą‚Ě–đŠ„
™‰Y—íŽq
‘ć88‰ń“ú–{–ň—Šw‰ď”N‰ď@2015”N3ŒŽ18“ú`20“úi–źŒĂ‰Žj

Pmk1 MAPKŒo˜H‚ĆƒI[ƒgƒtƒ@ƒW[ŠÖ˜AˆöŽq‚Ě‹@”\“IŠÖŒW
mŒF‹v”üA•ĐŽR—Y‘ĺAŹ’rŽj‰ŘA‚‹´G˜aA“ě—Ńˆ¤AŠě‘˝ˆťŽqA˛“Ą—ş‰îA™‰Y—íŽq
‘ć88‰ń“ú–{–ň—Šw‰ď”N‰ď@2015”N3ŒŽ18“ú`20“úi–źŒĂ‰Žj

S1PŽó—e‘Ě’˛ßÜFTY720Š´ŽóŤˆâ“`Žq‚Ě–Ô—…“I’Tő
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‘ć88‰ń“ú–{–ň—Šw‰ď”N‰ď@2015”N3ŒŽ18“ú`20“úi–źŒĂ‰Žj

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‘ć37‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2014”N11ŒŽ25“ú`27“úi‰Ą•lj

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‘ć37‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2014”N11ŒŽ25“ú`27“úi‰Ą•lj

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‘ć37‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2014”N11ŒŽ25“ú`27“úi‰Ą•lj

S1PŽó—e‘Ě’˛ßÜFTY720‚đ‰î‚ˇ‚éˆâ“`Žq”­Œťƒvƒƒtƒ@ƒCƒŠƒ“ƒO‚Ě–Ô—…“I‰đÍ
”‹Œ´‰Á“ŢŽqA…ŒÉĘA”Ş•S–ƒ—˘ŽqA–kˆä—CŽ÷AÎ“chŠîAŠě‘˝ˆťŽqA˛“Ą—ş‰îA‹ßd—TŽŸA‰vŽq‚Aź–ěƒ’jAç—tŒ’ŽĄA™‰Y—íŽq
‘ć37‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2014”N11ŒŽ25“ú`27“úi‰Ą•lj

Novel functional roles for calcineurin inhibitor DSCR1/RCAN1 in the regulation of calcium and oxdative stress signaling
Koji Kubouchi, Ayako Kita, Mari Higa, Ryosuke Satoh, Reiko Sugiura
11th International Conference on Protein Phosphatase (ICPP11)
Nov 12-14, 2014(Sendai)

”MŽhŒƒ‚ɉž“š‚ľ‚˝ƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚Ě‹ÇÝ§Œä‹@\‚̉đÍ
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‘ć126‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2014”N10ŒŽ24“úi˜a‰ĚŽRj

PKN3ˆâ“`ŽqƒmƒbƒNƒAƒEƒgƒ}ƒEƒX‚đ—p‚˘‚˝‚Ş‚ń“]ˆÚ—}§ƒƒJƒjƒYƒ€‚Ě’Tő
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‘ć126‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2014”N10ŒŽ24“úi˜a‰ĚŽRj

ƒCƒmƒVƒg[ƒ‹ƒŠƒ“Ž‰Žż‘ăŽÓ‚đ§Œä‚ˇ‚éPH domainƒ^ƒ“ƒpƒNŽż‚Ě“Ż’č‚Ć‹@”\‰đÍ
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‘ć126‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2014”N10ŒŽ24“úi˜a‰ĚŽRj

SH3ƒhƒƒCƒ“ƒ^ƒ“ƒpƒNŽżSkb5‚É‚ć‚éPKC/MAPKƒVƒOƒiƒ‹§ŒäƒƒJƒjƒYƒ€‚̉đ–ž
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‘ć126‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2014”N10ŒŽ24“úi˜a‰ĚŽRj

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™‰Y—íŽq
‘ć87‰ń“ú–{ś‰ťŠw‰ď‘ĺ‰ď@2014”N10ŒŽ15`18“úi‹ž“sj

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˛“Ą—ş‰îAˆÉ“Ą—S“ށAŠě‘˝ˆťŽqA”‹Œ´‰Á“ŢŽqA’JŽž—YA™‰Y—íŽq
‘ć87‰ń“ú–{ś‰ťŠw‰ď‘ĺ‰ď@2014”N10ŒŽ15`18“úi‹ž“sj

ƒqƒgPDK1•Ş—ôy•ęƒzƒ‚ƒƒOKsg1‚Ě×–EŒ`‘Ԑ§Œä‚ĆCa2+ƒVƒOƒiƒ‹“`’BŒo˜H‚É‚¨‚Ż‚é–đŠ„
‘ĺ‰Y“Ő‹`A“yˆäÍA‰F–ě‹MĆA˛“ĄxA_“c—E‹PAŠě‘˝ˆťŽqA”‹Œ´‰Á“ŢŽqA”ä‰Ă^—A˛“Ą—ş‰îA™‰Y—íŽq
‘ć87‰ń“ú–{ś‰ťŠw‰ď‘ĺ‰ď@2014”N10ŒŽ15`18“úi‹ž“sj

y•ęƒ‚ƒfƒ‹ś•¨‚đ—p‚˘‚˝ERK MAPKƒVƒOƒiƒ‹“`’BŒo˜H‘jŠQ–ň‚Ě’Tő
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‘ć64‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2014”N10ŒŽ11“úi‹ž“sj

AP-1ƒAƒNƒZƒTƒŠ[ƒ^ƒ“ƒpƒNŽżSip1‚ĚƒSƒ‹ƒW/ƒGƒ“ƒhƒ][ƒ€‚É‚¨‚Ż‚é×–E“ŕ–Œ—A‘—‚Ě–đŠ„
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‘ć64‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2014”N10ŒŽ11“úi‹ž“sj

y•ęƒ‚ƒfƒ‹ś•¨‚đ—p‚˘‚˝MAPKƒVƒOƒiƒ‹“`’B‘jŠQ–ň‚É‚ć‚éR‚Ş‚ńě—p‚ĚŠJ”­
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‘ć32‰ńƒoƒCƒI‹ZpƒV[ƒYŒöŠJ‰ď@2014”N9ŒŽ25“úi‘ĺăj

Role of RNA-binding protein in MAPK signaling and cell fate regulation.
Ryosuke Satoh, Yuna Ito, Ayako Kita, Kanako Hagihara, Akira Doi, Reiko Sugiura
The FEBS EMBO 2014 Conference
Aug 30-Sep 4, 2014 (Paris)

The SH3 domain protein is a novel regulator of PKC/MAPK signaling in fission yeast.
Yuki Kanda, Akira Doi, Ayako Kita, Hajime Naruse, Reiko Sugiura
The FEBS EMBO 2014 Conference
Aug 30-Sep 4, 2014 (Paris)

MAPƒLƒi[ƒ[ƒVƒOƒiƒ‹ˆË‘ś“I‚ČRNAŒ‹‡ƒ^ƒ“ƒpƒNŽżNrd1‚É‚ć‚éƒXƒgƒŒƒXč÷—ąŒ`Ź‹@\
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‘ć16‰ń“ú–{RNAŠw‰ď”N‰ď@2014”N7ŒŽ23`25“úi–źŒĂ‰Žj

S1PŽó—e‘Ě’˛ßÜFTY720‚đ‰î‚ˇ‚éV‚˝‚ČƒVƒOƒiƒ‹“`’B‹@\‚̉đ–ž
Î“chŠîA”‹Œ´‰Á“ŢŽqA…ŒÉĘA”Ş•S–ƒ—˘ŽqA‰Ş“cçšA‚’ËŽOŒbA–kˆä—CŽ÷AŠě‘˝ˆťŽqA‰vŽq‚Aź–ěƒ’jAç—tŒ’ŽĄA™‰Y—íŽq
“ú–{ƒPƒ~ƒJƒ‹ƒoƒCƒIƒƒW[Šw‰ď ‘ć9‰ń”N‰ď@2014”N6ŒŽ11`13“úi‘ĺăj

Role of RNA-binding pritein in MAPK signaling and cell fate regulation.
Ryosuke Satoh, Reiko Sugiura
Anti-Aging International Mini-Symposium 2014: Cell Signaling and Therapeutic Targets for Geriatric and Inflammatory Diseases
Jun 7, 2014 (Osaka)

2013”N“x@Šw‰ď”­•\

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‘ć6‰ń“ú–{ƒvƒƒeƒCƒ“ƒzƒXƒtƒ@ƒ^[ƒ[Œ¤‹†‰ďŠwpW‰ď@2014”N2ŒŽ20`21“úiŽOdj

S1PŽó—e‘Ě’˛ßÜFTY720‚đ‰î‚ˇ‚éƒVƒOƒiƒ‹“`’B‹@\‚̉đ–ž
”‹Œ´‰Á“ŢŽqA…ŒÉĘA”Ş•S–ƒ—˘ŽqA‰Ş“cçšA‚’ËŽOŒbA–kˆä—CŽ÷AÎ“chŠîAŠě‘˝ˆťŽqA‰vŽq‚Aź–ěƒ’jAç—tŒ’ŽĄA™‰Y—íŽq
‘ć6‰ń“ú–{ƒvƒƒeƒCƒ“ƒzƒXƒtƒ@ƒ^[ƒ[Œ¤‹†‰ďŠwpW‰ď@2014”N2ŒŽ20`21“úiŽOdj

RNAŒ‹‡’`”’ŽżHuD‚ĆmRNAŠjŠO—A‘—ˆöŽqTAP/NXF1‚É‚ć‚écapˆË‘ś“I–|–󊈐Ť‰ť‹@\
˛“Ą—ş‰îA[”öˆŸŠě—ǁA–ě–{–ž’jA“ĄŒ´rL
‘ć36‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2013”N12ŒŽ3`6“úi_ŒËj

AP-1ƒAƒNƒZƒTƒŠ[ƒ^ƒ“ƒpƒNŽżIts4/Sip1‚Ć’á•ŞŽq—ĘG ƒ^ƒ“ƒpƒNŽżRho3‚É‚ć‚éƒNƒ‰ƒXƒŠƒ“ƒAƒ_ƒvƒ^[AP-1•Ą‡‘Ě‚Ěƒƒ“ƒuƒŒƒ“ƒgƒ‰ƒtƒBƒbƒN§Œä‹@\
ŒE“ŕN“ńA˜°—zA—›‰–FAŠě‘˝ˆťŽqA•ĐŽR—Y‘ĺAV’J^–˘A™‰Y—íŽq
‘ć36‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2013”N12ŒŽ3`6“úi_ŒËj

PKC ‚¨‚ć‚ŃPKC ‰ş—ŹˆöŽq‚ĚƒŠƒ“Ž_‰ť‘Ş’č‚É‚ć‚éMAPK ƒVƒOƒiƒ‹ŠˆŤ‚̉đÍ
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‘ć36‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2013”N12ŒŽ3`6“úi_ŒËj

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‘ć36‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2013”N12ŒŽ3`6“úi_ŒËj

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‘ć36‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2013”N12ŒŽ3`6“úi_ŒËj

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‘ć36‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2013”N12ŒŽ3`6“úi_ŒËj

y•ęƒ‚ƒfƒ‹ś•¨‚đ—p‚˘‚˝MAPK ƒpƒXƒEƒFƒC‘jŠQ–ň’TőŒn‚ĚŠm—§
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‘ć124‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2013”N11ŒŽ1“úi‹ž“sj

Role of RNA-binding protein in MAPK signaling.
Ryosuke Satoh, Reiko Sugiura
The 2nd Taiwan-Japan Bilateral Conference on Protein Phosphatases
Nov 28-29, 2013 (Taiwan)

AP-1 ƒAƒNƒZƒTƒŠ[ƒ^ƒ“ƒpƒNŽżSip1 ‚Ć’á•ŞŽq—ĘG ƒ^ƒ“ƒpƒNŽżRho3 ‚É‚ć‚郁ƒ“ƒuƒŒƒ“ƒgƒ‰ƒbƒtƒBƒbƒN§Œä‹@\‚̉đ–ž
•ĐŽR—Y‘ĺA˜°—zA—›‰–FAŒE“ŕN“ńA‹v”\Ž÷AV’J^–˘AŠě‘˝ˆťŽqA™‰Y—íŽq
‘ć124‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2013”N11ŒŽ1“úi‹ž“sj

•Ş—ôy•ę—R—ˆ‚ĚMAPƒLƒi[ƒ[‚É‚ć‚čƒŠƒ“Ž_‰ť‚ł‚ę‚éRNAŒ‹‡ƒ^ƒ“ƒpƒNŽżNrd1‚̍\‘˘‰đÍ
Ayaho Kobayashi, Ryosuke Satoh, Toshinobu Fujiwara, Reiko Sugiura, Yutaka Ito, Masaki Mishima
‘ć51‰ń“ú–{ś•¨•¨—Šw‰ď”N‰ď@2013”N12ŒŽ3“ú`6“úi‹ž“sj

S1PŽó—e‘Ě’˛ßÜFTY720‚Ě×–E“ŕƒVƒOƒiƒ‹“`’BŒo˜H‚̉𖞁|FTY720‚ĆƒXƒgƒŒƒX‰ž“šƒVƒOƒiƒ‹‚Ć‚ĚŠÖŒW|
–kˆä—CŽ÷A”‹Œ´‰Á“ŢŽqA…ŒÉĘA”Ş•S–ƒ—˘ŽqA‰Ş“cçšA‚’ËŽOŒbAŠě‘˝ˆťŽqA‰vŽq‚Aç—tŒ’ŽĄA™‰Y—íŽq
‘ć63‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2013”N10ŒŽ12“úi‹ž“sj

PHƒhƒƒCƒ“‚đ—L‚ˇ‚éƒ^ƒ“ƒpƒNŽżSio1‚ĆƒCƒmƒVƒg[ƒ‹ƒŠƒ“Ž‰ŽżƒVƒOƒiƒ‹‚ĚŠÖ‚í‚čFƒCƒmƒVƒg[ƒ‹ƒŠƒ“Ž‰Žż‚ĆPHƒhƒƒCƒ“ƒ^ƒ“ƒpƒNŽż‚ɂ‚˘‚Ä
Ź‘qŽ–çA—›‰–FAŠě‘˝ˆťŽqAˆäŒ´”üšŽqA‰Á“ĄĘA’Ň–{ăāA™‰Y—íŽq
‘ć63‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2013”N10ŒŽ12“úi‹ž“sj

AP-1ƒAƒNƒZƒTƒŠ[ƒ^ƒ“ƒpƒNŽżIts4/Sip1‚Ć’á•ŞŽq—ĘGƒ^ƒ“ƒpƒNŽżRho3‚É‚ć‚éƒNƒ‰ƒXƒŠƒ“ƒAƒ_ƒvƒ^[AP-1•Ą‡‘Ě‚Ěƒƒ“ƒuƒŒƒ“ƒhƒ‰ƒtƒBƒbƒN§Œä‹@\
ŒE“ŕN“ńA˜°—zAŠě‘˝ˆťŽqA•ĐŽR—Y‘ĺAV’J^–˘A™‰Y—íŽq
‘ć63‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2013”N10ŒŽ12“úi‹ž“sj

V‹KCalciumƒVƒOƒiƒ‹’˛ß•¨Žżacremomannolipin A ‚̍\‘˘ŠˆŤ‘ŠŠÖŒ¤‹†F“œƒAƒ‹ƒR[ƒ‹\‘˘‚ŞŠˆŤ‚É‹y‚Ú‚ˇŒř‰Ę
“›ˆä–]A“c糌łŽOAŒă“ĄŒł‹CAX“c’źA–ě‘şŽ‰›A‰ŞŽR‘P’mAŠě‘˝ˆťŽqA™‰Y—íŽqA‘ş‰ŞC
‘ć63‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2013”N10ŒŽ12“úi‹ž“sj

_Œo“ÁˆŮ“IRNAŒ‹‡’`”’ŽżHuD‚Ě×–E“ŕ‹ÇÝ‚ĆcapˆË‘ś“I–|–󊈐Ť‰ť”\‚Ć‚ĚŠÖŒW
˛“Ą—ş‰îA[”öˆŸŠě—ǁA–ě–{–ž’jA“ĄŒ´rL
‘ć15‰ń“ú–{RNAŠw‰ď”N‰ďi‘ć15‰ńRNAƒ~[ƒeƒBƒ“ƒOj@2013”N7ŒŽ24“ú`26“úiźŽRj

A novel regulatory role for the calcineurin inhibitor DSCR1 (Down syndrome candidate region 1) in p38 MAPK-mediated stress signaling.
Reiko Sugiura, Nanae Umeda, Mari Higa, Yukiko Nota, Anna Ochiai, Yoshimi Kiyose, Ayako Kita
7th International Fission Yeast Meeting (Pombe2013)
Jun 24-29, 2013 (London)

The regulatory mechanism of phospholipid balance by lipid binding protein.
Cuifang Li, Ayako Kita, Yuuka Hashimoto, Misako Ihara, Ayaka Kato, Naoya Ogura, Reiko Sugiura.
7th International Fission Yeast Meeting (Pombe2013)
Jun 24-29, 2013 (London)

MAPK-dependent Rnc1 localization to stress granules.
Yuna Ito, Ryosuke Satoh, Mari Higa, Hajime Naruse, Makoto Takada, Reiko Sugiura
7th International Fission Yeast Meeting (Pombe2013)
Jun 24-29, 2013 (London)

MAPK signalling regulates stress-dependent formation of RNA-granules in fission yeast.
Mari Higa, Hajime Naruse, Yuna Ito, Akira Doi, Ryosuke Satoh, Ayako Kita, Reiko Sugiura
7th International Fission Yeast Meeting (Pombe2013)
Jun 24-29, 2013 (London)

RNAŒ‹‡’`”’ŽżNrd1‚ĚNMR–@‚É‚ć‚é\‘˘‰đÍ
Ź—ŃĘ•ŰA˛“Ą—ş‰îA“ĄŒ´rLAˆÉ“Ą—˛A™‰Y—íŽqAŽO“‡ł‹K
‘ć13‰ń“ú–{’`”’Žż‰ČŠw‰ď”N‰ď@2013”N6ŒŽ12`14“úi’šŽćj

2012”N“x@Šw‰ď”­•\

Spatial regulatory mechanism of the Pl4,5P2 signaling pathway by membrane trafficking system.
Cuifang Li, Ayako Kita, Yuuka Hashimoto, Misako Ihara, Ayako Kato, Naoya Ogura, Reiko Sugiura
10th International Conference on Protein Phosphatase
Feb 7-9, 2013 (Tokyo)

Chemical Genetic Analysis of the Ca2+/calcineurin signaling.
Yang Yu, Kanako Hagihara, Ayako Kita, Reiko Sugiura
10th International Conference on Protein Phosphatase
Feb 7-9, 2013 (Tokyo)

A role of Sip1, a calthrin adaptor ap-1 complex binding protein and Ca2+/calcineurin signaling in membrane trafficking.
Yang Yu, Ayako Kita, Masako Udo, Yuta Katayama, Mami Shintani, Kwihwa Park, Reiko Sugiura
10th International Conference on Protein Phosphatase
Feb 7-9, 2013 (Tokyo)

CƒLƒi[ƒ[ƒVƒOƒiƒ‹§ŒäˆöŽq‚Ć‚ľ‚Ä‚ĚDed1‚Ě‹@”\‰đÍ
“yˆä@Í
•˝Ź24”N“xRNA§ŒäŠw—Ěˆć”ljď‹c@2013”N1ŒŽ9“úi‹{éj

ƒPƒ~ƒJƒ‹ƒoƒCƒIƒƒW[‚ĚŽč–@‚đ—p‚˘‚˝AƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚̐V‚˝‚Č“]ŽĘ•W“Iˆâ“`Žqtcp1+‚Ě“Ż’č‚Ć”­ŒťƒƒJƒjƒYƒ€‚̉đ–ž
”Ş•S–ƒ—˘ŽqA”‹Œ´‰Á“ŢŽqA…ŒÉĘA‰Ş“cçšA‚’ËŽOŒbAŠě‘˝ˆťŽqA™‰Y—íŽq
‘ć85‰ń“ú–{ś‰ťŠw‰ď‘ĺ‰ď@2012”N12ŒŽ14`16“úi•Ÿ‰Şj

Skb5‚̓XƒLƒƒƒbƒtƒH[ƒ‹ƒhƒ^ƒ“ƒpƒNŽż‚Ć‚ľ‚āAPKC/ MAPKƒVƒOƒiƒ‹‚𕉂ɐ§Œä‚ˇ‚é
ŹŁˆęA“yˆäÍA_“c—E‹PAŠě‘˝ˆťŽqA“Ą–{–ž—R”üAŽ›˜e–GA™‰Y—íŽq
‘ć85‰ń“ú–{ś‰ťŠw‰ď‘ĺ‰ď@2012”N12ŒŽ14`16“úi•Ÿ‰Şj

MAPKƒVƒOƒiƒ‹“`’BŒo˜H‚ĆTRPƒ`ƒƒƒlƒ‹Vic2‚Ě‹@”\“IŠÖ˜A
ˆ°“cšŽ÷AŹ–ě‘ž‹MA‹v”\Ž÷A“ŕ“c“ÄŽjAŠě‘˝ˆťŽqA™‰Y—íŽq
‘ć85‰ń“ú–{ś‰ťŠw‰ď‘ĺ‰ď@2012”N12ŒŽ14`16“úi•Ÿ‰Şj

RNAŒ‹‡’`”’ŽżHuD‚Ě×–E“ŕ‹ÇÝ‚ĆcapˆË‘ś“I–|–󊈐Ť‰ť”\‚Ć‚ĚŠÖŒW
˛“Ą—ş‰îA[”öˆŸŠě—ǁA–ě–{–ž’jA“ĄŒ´rL
‘ć35‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2012”N12ŒŽ11`14“úi•Ÿ‰Şj

ƒQƒmƒ€–ň—Šw“IƒAƒvƒ[ƒ`‚đ—p‚˘‚˝MAPKƒVƒOƒiƒ‹Œo˜H\ŹˆöŽqTRP ƒ`ƒƒƒlƒ‹Vic2 ‚Ě“Ż’č‚Ć‹@”\‰đÍ
ˆ°“cšŽ÷AŹ–ě‘ž‹MA‹v”\Ž÷A“ŕ“c“ÄŽjAŠě‘˝ˆťŽqA™‰Y—íŽq
‘ć122‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2012”N11ŒŽ16“úi‘ĺăj

Skb5 ‚̓XƒLƒƒƒbƒtƒH[ƒ‹ƒhƒ^ƒ“ƒpƒNŽż‚Ć‚ľ‚āAPKC/ MAPKƒVƒOƒiƒ‹‚𕉂ɐ§Œä‚ˇ‚é
ŹŁˆęA“yˆä ÍA_“c—E‹PAŠě‘˝ˆťŽqA“Ą–{–ž—R”üAŽ›˜e–GA™‰Y—íŽq
‘ć122‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2012”N11ŒŽ16“úi‘ĺăj

ƒPƒ~ƒJƒ‹ƒoƒCƒIƒƒW[‚ĚŽč–@‚đ—p‚˘‚˝AƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚̐V‚˝‚Č“]ŽĘ•W“Iˆâ“`Žqtcp1+‚Ě“Ż’č‚Ć”­ŒťƒƒJƒjƒYƒ€‚̉đ–ž
”Ş•S–ƒ—˘ŽqA”‹Œ´‰Á“ŢŽqA…ŒÉ ĘA‰Ş“cçšA‚’ËŽOŒbAŠě‘˝ˆťŽqA™‰Y—íŽq
‘ć122‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2012”N11ŒŽ16“úi‘ĺăj

Pmk1 MAPK Œo˜H‚ĆTRP ƒ`ƒƒƒlƒ‹Vic2 ‚Ě‹@”\“IŠÖ˜A
Ź–ě‘ž‹MAˆ°“cšŽ÷A“ŕ“c“ÄŽjA‹v”\ Ž÷AŠě‘˝ˆťŽqA™‰Y—íŽq
‘ć62‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2012”N10ŒŽ20“úi•şŒÉj

DEAD Box Œ^RNA helicase Ded1 ‚ĚRNA granule ‹ÇÝ‚Ć‹@”\‚ĚŠÖ‚í‚č
’Ň–{ ăāA“yˆä ÍA”ä‰Ă^—AŹŁ ˆęAŠě‘˝ˆťŽqA”~“c“Ţ•cA™‰Y—íŽq
‘ć62‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2012”N10ŒŽ20“úi•şŒÉj

ƒNƒ‰ƒXƒŠƒ“ƒAƒ_ƒvƒ^[AP-1 •Ą‡‘ĚŒ‹‡ƒ^ƒ“ƒpƒNŽżIts4/Sip1 ‚Ě×–E“ŕ–Œ—A‘—‚É‚¨‚Ż‚é–đŠ„
•ĐŽR—Y‘ĺA˜° —zAŠě‘˝ˆťŽqA—L“­‰ëŽqA–p ‹M˜aAV’J^–˘A™‰Y—íŽq
‘ć62‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2012”N10ŒŽ20“úi•şŒÉj

PHƒhƒƒCƒ“ƒ^ƒ“ƒpƒNŽżSlp2‚É‚ć‚éƒCƒmƒVƒg[ƒ‹ƒŠƒ“Ž‰ŽżƒVƒOƒiƒ‹‚̐§Œä
—›‰–FAŠě‘˝ˆťŽqA‹´–{—CAˆäŒ´”üšŽqA‰Á“ĄĘAăˆäN”\A‰œŒöGAˆÉ“ĄrŽ÷A™‰Y—íŽq
y•ęˆâ“`ŠwƒtƒH[ƒ‰ƒ€‘ć45‰ńŒ¤‹†•ń‰ď@2012”N9ŒŽ4`6“úi‹ž“sj

ƒNƒ‰ƒXƒŠƒ“ƒAƒ_ƒvƒ^[AP-1•Ą‡‘ĚŒ‹‡ƒ^ƒ“ƒpƒNŽżIts4/Sip1‚É‚ć‚éCa2+ƒVƒOƒiƒ‹§ŒäƒƒJƒjƒYƒ€‚̉đ–ž
˜°—zAŠě‘˝ˆťŽqA—L“­‰ëŽqA–p‹M˜aA•ĐŽR—Y‘ĺAV’J^–˘A™‰Y—íŽq
y•ęˆâ“`ŠwƒtƒH[ƒ‰ƒ€‘ć45‰ńŒ¤‹†•ń‰ď@2012”N9ŒŽ4`6“úi‹ž“sj

uƒQƒmƒ€–ň—Œ¤‹†‚ވă—Ă‚ĚŠv–˝‚đ‹N‚ą‚ˇF`ˆâ“`ŽqŒŸ¸‚Š‚ç‚Ş‚ń‚Ěƒe[ƒ‰[ƒ[ƒhiŒÂ•Ęjˆă—Â܂Ł`v
™‰Y—íŽq
‘ć3‰ń“ú–{ƒQƒmƒ€–ň—ŠwŒ¤‹†‰ďu‰‰‰ď@2012”N8ŒŽ19“úi_ŒËj

MAPKƒVƒOƒiƒ‹ˆË‘ś“I‚ČRNAŒ‹‡’`”’ŽżRnc1‚ĚStress Granule‹ÇÝ
ˆÉ“Ą—S“ށA˛“Ą—ş‰îA“c’†Í—FAűü“c^‹ŐA™‰Y—íŽq
‘ć14‰ń“ú–{RNAŠw‰ď”N‰ď@2012”N7ŒŽ18`20“úiĺ‘äj

Functional genomics of calcineurin in model organism.
Reiko Sugiura
From Genomics to Proteomics`Toward Understanding Gene Function andthe Mechanism of Diseases`
Jun 27, 2012 (Osaka)

Mitogen-activated Protein Kinase Pathway Regulation: Role of RNA-Binding Proteins in MAPK Signal Transduction Pathway.
Reiko Sugiura
Special Course on Global Medical Science
Jun 21, 2012 (Kobe)

RNAŒ‹‡’`”’ŽżNrd1‚ĚNMR–@‚É‚ć‚é\‘˘‰đÍ
Ź—ŃĘ•ŰA˛“Ą—ş‰îA“ĄŒ´rLAˆÉ“Ą—˛A™‰Y—íŽqAŽO“‡ł‹K
‘ć13‰ń“ú–{’`”’Žż‰ČŠw‰ď”N‰ď@2012”N6ŒŽ12“ú`14“úi’šŽćj

MAPK Signaling and RNA-granules Formation in Fission Yeast.
Reiko Sugiura
The 22nd CDB Meeting RNA Sciences in Cell and Developmental Biology II
Jun 11-13, 2012 (Kobe)

Regulation of MAPK Signaling by Nuclear-Cytoplasmic Shuttling of the RNA-Binding Protein Rnc1 in Fission Yeast.
Ryosuke Satoh, Yasuhiro Matsumura, Akitomo Tanaka, Nanae Umeda, Makoto Takada, Yuna Ito, Ayako Kita, Kanako Hagihara, Akira Doi, Toshinobu Fujiwara, Reiko Sugiura
The 22nd CDB Meeting RNA Sciences in Cell and Developmental Biology II
Jun 11-13, 2012 (Kobe)

y•ęƒ‚ƒfƒ‹ś•¨‚đ—p‚˘‚˝MAPƒLƒi[ƒ[ƒVƒOƒiƒ‹§ŒäˆöŽq‚Ě“Ż’č‚Ć‘n–ň‚Ö‚Ě“WŠJ
™‰Y—íŽqAŠě‘˝ˆťŽqA‹v”\Ž÷A”~“c“Ţ•cA‚“cG•śA”‹Œ´‰Á“ŢŽqAŹŁˆęA“yˆäÍ
“ú–{ƒPƒ~ƒJƒ‹ƒoƒCƒIƒƒW[Šw‰ď‘ć‚V‰ń”N‰ď@2012”N6ŒŽ7`9“úi‹ž“sj

S1PŽó—e‘Ě’˛ßÜFTY720‚Ě•W“Iˆâ“`Žq‚̉đÍ‚Š‚ç“ą‚Ťo‚ł‚ę‚éƒVƒOƒiƒ‹“`’BŒo˜H‹@\
”‹Œ´‰Á“ŢŽqA…ŒÉĘA”Ş•S–ƒ—˘ŽqA‰Ş“cçšA‚’ËŽOŒbAŠě‘˝ˆťŽqAÎ“nr“ńA‰vŽq‚Aç—tŒ’ŽĄA™‰Y—íŽq
“ú–{ƒPƒ~ƒJƒ‹ƒoƒCƒIƒƒW[Šw‰ď‘ć‚V‰ń”N‰ď@2012”N6ŒŽ7`9“úi‹ž“sj

×–E“ŕ—A‘—‚ĆƒCƒmƒVƒg[ƒ‹ƒŠƒ“Ž‰ŽżƒVƒOƒiƒ‹“`’BŒo˜H‚Ě‹@”\“IŠÖŒW
—›‰–FAŠě‘˝ˆťŽqA‹´–{—CAˆäŒ´”üšŽqA‰Á“ĄĘAÎ“nr“ńA™‰Y—íŽq
‘ć54‰ń“ú–{Ž‰Žżś‰ťŠw‰ď@2012”N6ŒŽ7`8“úi•Ÿ‰Şj

u×–E“ŕƒVƒOƒiƒ‹“`’B‚É‚ć‚éŠjŽ_Œ‹‡ƒ^ƒ“ƒpƒNŽż‚̐§Œä‹@\‚̉đÍFƒAƒtƒBƒjƒeƒBƒLƒƒƒsƒ‰ƒŠ[“d‹C‰j“Ž‚̉ž—p‚Ć‘n–ň‚Ö‚Ě“WŠJv
™‰Y—íŽq
‘ć62‰ń“ú–{“d‹C‰j“ŽŠw‰ďƒVƒ“ƒ|ƒWƒEƒ€@2012”N5ŒŽ11“úi“Œ‹žj

2011”N“x@Šw‰ď”­•\

ƒNƒ‰ƒXƒŠƒ“ƒAƒ_ƒvƒ^[AP-1•Ą‡‘ĚŒ‹‡ƒ^ƒ“ƒpƒNŽżIts4‚Ěƒƒ“ƒuƒŒƒ“ƒgƒ‰ƒtƒBƒbƒN‚É‚¨‚Ż‚é–đŠ„
—L“­‰ëŽqA˜°—zAŠě‘˝ˆťŽqA–p‹M˜aA•ĐŽR—Y‘žAV’J^–˘A™‰Y—íŽq
“ú–{–ňŠw‰ď‘ć132”N‰ď@2012”N3ŒŽ28`31“úi–kŠC“šj

RNAŒ‹‡’`”’ŽżNrd1‚ĚStress GranulesŒ`Ź‚ĆƒXƒgƒŒƒX‰ž“š‚É‚¨‚Ż‚é“­‚Ť
“c’†Í—FA˛“Ą—ş‰îAX“c‹M‘ĺAź‘şNOAűü“c^‹ŐAˆÉ“Ą—S“ށAŠě‘˝ˆťŽqAÎ“nr“ńA”‹Œ´‰Á“ŢŽqA™‰Y—íŽq
“ú–{–ňŠw‰ď‘ć132”N‰ď@2012”N3ŒŽ28`31“úi–kŠC“šj

SIPŽó—e‘Ě’˛ß–ňFTY720‚Ě•W“Iˆâ“`Žq‚Ě“Ż’č‚Ćˆâ“`Žq”­Œť‹@\‚̉đ–ž
…ŒÉĘA”‹Œ´‰Á“ŢŽqAŠě‘˝ˆťŽqAA“c^—A”Ş•S–ƒ—˘ŽqA‰Ş“cçšA‚’ËŽOŒbA˛“Ą—ş‰îA‰vŽq‚A™‰Y—íŽq
“ú–{–ňŠw‰ď‘ć132”N‰ď@2012”N3ŒŽ28`31“úi–kŠC“šj

R‚Ş‚ńÜ‰˜ő–hŽ~—pƒSƒ€đu‚ŕ‚ę‚ܐđv‚ĚŒŸ“˘
Î“nr“ńA‘˝‰ę~A“Ą“cGŽ÷Aź“cĄŽOAŠě‘˝ˆťŽqA™‰Y—íŽq
“ú–{–ňŠw‰ď‘ć132”N‰ď@2012”N3ŒŽ28`31“úi–kŠC“šj

V‹KCalcineurinƒVƒOƒiƒ‹hR•¨Ž‘AcremomannolipinA‚̍\‘˘
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“ú–{–ňŠw‰ď‘ć132”N‰ď@2012”N3ŒŽ28`31“úi–kŠC“šj

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Novel functional roles for calcineurin inhibitor RCAN1.
Reiko Sugiura
The First Japan-Taiwan Bilateral Conference on Protein Phosphatases
Dec 2, 2011 (Okazaki)

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‘ć120‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2011”N11ŒŽ11“úi‹ž“sj

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‘ć120‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2011”N11ŒŽ11“úi‹ž“sj

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‘ć61‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2011”N10ŒŽ22“úi_ŒËj

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‘ć61‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2011”N10ŒŽ22“úi_ŒËj

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‘ć61‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2011”N10ŒŽ22“úi_ŒËj

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‘ć61‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2011”N10ŒŽ22“úi_ŒËj

A powerful genetic strategy to screen for inhibitors of MAPK signaling and its application to genomic drug discovery.
Reiko Sugiura
A New Wave of Chemical Genomics `From Biological Invertigation to Drug Discovery`
Sep 24, 2011 (Osaka)

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‘ć21‰ń“ú–{ˆă—Ă–ňŠw‰ď”N‰ď@2011”N10ŒŽ1`2“úi_ŒËj

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‘ć21‰ń“ú–{ˆă—Ă–ňŠw‰ď”N‰ď@2011”N10ŒŽ1`2“úi_ŒËj

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‘ć21‰ń“ú–{ˆă—Ă–ňŠw‰ď”N‰ď@2011”N10ŒŽ1`2“úi_ŒËj

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™‰Y—íŽq
‘ć84‰ń“ú–{ś‰ťŠw‰ď‘ĺ‰ď@2011”N9ŒŽ21“ú`24“úi‹ž“sj

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‘ć84‰ń“ú–{ś‰ťŠw‰ď‘ĺ‰ď@2011”N9ŒŽ21“ú`24“úi‹ž“sj

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‘ć73‰ńy•ęŒ¤‹†‰ď@2011”N9ŒŽ13“úi_ŒËj

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y•ęˆâ“`ŠwƒtƒH[ƒ‰ƒ€‘ć44‰ńŒ¤‹†•ń‰ď@2011”N9ŒŽ5`7“úi‹ăBj

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ƒNƒ‰ƒXƒŠƒ“ƒAƒ_ƒvƒ^[AP-1•Ą‡‘ĚŒ‹‡ƒ^ƒ“ƒpƒNŽżIts4‚Ěƒƒ“ƒuƒŒƒ“ƒgƒ‰ƒbƒtƒBƒbƒN‚É‚¨‚Ż‚é–đŠ„
˜°—zAŠě‘˝ˆťŽqA‚“cG•śA—L“­‰ëŽqA–p‹M˜aA™‰Y—íŽq
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y•ęˆâ“`ŠwƒtƒH[ƒ‰ƒ€‘ć44‰ńŒ¤‹†•ń‰ď@2011”N9ŒŽ5`7“úi‹ăBj

MADS-boxŒ^“]ŽĘˆöŽqMbx1‚̐V‹Kmembrane transporter dom1{‚đ‰î‚ľ‚˝Ca2{ƒzƒƒIƒXƒ^ƒVƒX§Œä‹@\‚̉đ–ž
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y•ęˆâ“`ŠwƒtƒH[ƒ‰ƒ€‘ć44‰ńŒ¤‹†•ń‰ď@2011”N9ŒŽ5`7“úi‹ăBj

RNA•Ş‰đƒVƒXƒeƒ€‚ĆPKC/MAPKƒVƒOƒiƒ‹“`’BŒo˜H‚ĚŠÖ‚í‚č
“yˆäÍAŠě‘˝ˆťŽqA”ä‰Ă^—A”~“c“Ţ•cAŹŁˆęA˛“Ą—ş‰îA’JŽž—YA—юѐçŽqA™‰Y—íŽq
RNAƒtƒƒ“ƒeƒBƒAƒ~[ƒeƒBƒ“ƒO2011@2011”N8ŒŽ30“ú`9ŒŽ1“úiˆ¤’mj

A Powerful Genetic Strategy to Screen for Inhibitors of MAP kinase Signalling.
Reiko Sugiura
THE SIXTH INTERNATIONAL FISSION YEAST MEETING (Pombe2011)
Jun 25-30, 2011 (Boston)

The cell surface protein Ecm33 negatively regulates Pmk1 MAPK signaling via Ca2+ homeostasis
Mitsuhiro Domae, Hirohumi Takada, Ayako Kita, Yuki Yamano, Atsushi Uchida, Reiko Sugiura
THE SIXTH INTERNATIONAL FISSION YEAST MEETING (Pombe2011)
Jun 25-30, 2011 (Boston)

Spatial regulatory mechanism of the PI4,5P2 signaling pathway by membrane trafficking system
Cuifang Li, Ayako Kita, Yuuka Hashimoto, Misako Ihara, Nanae Umeda, Shunji Ishiwata, Reiko Sugiura
THE SIXTH INTERNATIONAL FISSION YEAST MEETING (Pombe2011)
Jun 25-30, 2011 (Boston)

MAP kinase signaling regulates stress granule formation via the RNA-binding protein Nrd1.
Ryosuke Satoh, Takahiro Morita, Yasuhiro Matumura, Akitomo Tanaka, Makoto Takada, Nanae Umeda, Ayako Kita, Shunji Ishiwata, Akira Doi, Kanako Hagihara, Atushi Taga, Tokio Tani, Sachiko Hayashi, Reiko Sugiura
THE SIXTH INTERNATIONAL FISSION YEAST MEETING (Pombe2011)
Jun 25-30, 2011 (Boston)

The MADS-box transcription factor Mbx1 controls Ca2+ homeostasis via the regulation of dom1+.
Atsushi Uchida, Yuki Yamano, Sayako Moriuchi, Yuta Asayama, Mari Higa, Naoyuki Yamagishi, Masaki Ashida, Ayako Kita, Shunji Ishiwata, Reiko Sugiura
THE SIXTH INTERNATIONAL FISSION YEAST MEETING (Pombe2011)
Jun 25-30, 2011 (Boston)

A Rule for Its4, a Clathrin Adaptor Ap-1 Complex Binding Protein, in Membrane Trafficking
Yang Yu, Ayako Kita, Hirohumi Takada, Masako Udo, Kwihwa Park, Reiko Sugiura
THE SIXTH INTERNATIONAL FISSION YEAST MEETING (Pombe2011)
Jun 25-30, 2011 (Boston)

Role of RNA-Binding Proteins in MAPK Signal Transduction Pathway.
Ryosuke Satoh, Yasuhiro Matsumura, Kanako Hagihara, Akira Doi, Nanae Umeda, Hirofumi Takada, Ayako Kita, Reiko Sugiura
RNA 2011 Sixteenth Annual Meeting of the RNA Society (RNA 2011 Kyoto)
Jun 14-18, 2011 (Kyoto)

MAP kinase signaling-dependent regulation of stress granule formation mediated by the RNA-binding protein Nrd1 in fission yeast.
Ryosuke Satoh, Takahiro Morita, Hirofumi Takada, Nanae Umeda, Ayako Kita, Shunji Ishiwata, Akira Doi, Kanako Hagihara, Yasuhiro Matsumura, Akitomo Tanaka, Makoto Takada, Atsushi Taga, Tokio Tani, Sachiko Hayashi, Reiko Sugiura
RNA 2011 Sixteenth Annual Meeting of the RNA Society (RNA 2011 Kyoto)
Jun 14-18, 2011 (Kyoto)

2010”N“x@Šw‰ď”­•\

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“ú–{–ňŠw‰ď‘ć131”N‰ď@2011”N3ŒŽ28“ú`31“úiĂ‰Şj

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“ú–{–ňŠw‰ď‘ć131”N‰ď@2011”N3ŒŽ28“ú`31“ú@iĂ‰Şj

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“ú–{–ňŠw‰ď‘ć131”N‰ď@2011”N3ŒŽ28“ú`31“ú@iĂ‰Şj

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Î“nr“ń, ‘˝‰ę~, ˛–ě—T”V, Ź—ѐł—˛, Œ´“cŽm˜N, Źň—Sˆę,X‰K‹ž, źŽR’C”ü, rˆä^”üŽq, “ĄŒ´‹Ő, ‹T–{_Ži, ă“c˜ał, ŽOăł, ‘ĺ‹÷“Ţ“Ţ, ’r“c‹v—Y, ˆîˆäŒbŽq, ‰Í“ŕşl, Šě‘˝ˆťŽq, űü“c[—˛, ™‰Y—íŽq
“ú–{–ňŠw‰ď‘ć131”N‰ď@2011”N3ŒŽ28“ú`31“ú@iĂ‰Şj

ƒLƒƒƒsƒ‰ƒŠ[“d‹C‰j“Ž‚đ—p‚˘‚éŒÂX‚Ě’ŽËÜ—eŠí‚Š‚ç‚Ě˜R‰t—Ę’áƒRƒXƒgŠČˆŐ‘Ş’č–@‚ĚŠJ”­
‘˝‰ę~AÎ“nr“ńA“Ą“cGŽ÷Aź“cĄŽOAŠě‘˝ˆťŽqA™‰Y—íŽq
“ú–{–ňŠw‰ď‘ć131”N‰ď@2011”N3ŒŽ28“ú`31“ú@iĂ‰Şj

A Powerful Genetic Strategy to Screen for Inhibitors of MAP kinase Signalling and Its Application to Genomic Drug Discovery.
Reiko Sugiura
1st International Symposium on Carcinogenic Spiral & 9th International Conference on Protein Phosphatase@Feb 1-3, 2011 (Tokyo)

Stress-Activated Protein Kinase Signaling Regulates Ca2+-Calcineurin Signaling.
Daiki Kanbayashi, Aiko Nishida, Ayako Kita, Reiko Sugiura
1st International Symposium on Carcinogenic Spiral & 9th International Conference on Protein Phosphatase@Feb 1-3, 2011 (Tokyo)

MADS-Box Transcription Factor Mbx1 Is Involved in the Regulation of Calcineurin Signaling through Ca2+-Homeostasis Modulation.
Yuki Yamano, Atsushi Uchida, Sayako Moriuchi, Yuta Asayama, Naoyuki Yamagishi, Masaki Ashida, Ayako Kita, Syunji Ishiwata, Reiko Sugiura
1st International Symposium on Carcinogenic Spiral & 9th International Conference on Protein Phosphatase Feb 1-3, 2011 (Tokyo)

The Actin Binding Protein Cis3/PSTPIP Is Involved in the Regulation of the Pmk1 MAPK Signaling Pathway and Cytokinesis.
Akihiro Takeda, Satoru Takamura, Tomoyuki Takabe, Keiko Sugimoto, Yuka Shimamura, Ayako Kita, Shunji Ishiwata, Reiko Sugiura
1st International Symposium on Carcinogenic Spiral & 9th International Conference on Protein Phosphatase Feb 1-3, 2011 (Tokyo)

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‘ć33‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@‘ć83‰ń“ú–{ś‰ťŠw‰ď‘ĺ‰ď‡“Ż‘ĺ‰ď@2010”N12ŒŽ7“ú`10“úi_ŒËj

MADS-boxŒ^“]ŽĘˆöŽqMbx1‚͐V‹Kmembrane transporter dom1+‚đ‰î‚ľ‚ÄCa2+ƒzƒƒIƒXƒ^ƒVƒX‚đ§Œä‚ˇ‚é
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‘ć33‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@‘ć83‰ń“ú–{ś‰ťŠw‰ď‘ĺ‰ď‡“Ż‘ĺ‰ď@2010”N12ŒŽ7“ú`10“úi_ŒËj

DSCR1‚Ě•Ş—ôy•ęƒzƒ‚ƒƒOCbp1‚đ‰î‚ˇ‚éCNƒVƒOƒiƒ‹‚ĆMAPKƒVƒOƒiƒ‹“`’BŒo˜H‚ĚƒNƒƒXƒg[ƒN
”~“c“Ţ•cAă—Ń‘ĺ‹NAź“c—•ŽqAě–k–ƒ‹MA´ŁD”üAŠě‘˝ˆťŽqA‚“cG•śA™‰Y—íŽq
‘ć118‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2010”N11ŒŽ19“úi‘ĺăj

MAPKƒVƒOƒiƒ‹ˆË‘ś“I‚Ɉâ“`Žq”­Œť‚ސ§Œä‚ł‚ę‚é×–E•\–Ęƒ^ƒ“ƒpƒNŽżEcm33‚Ě‹@”\‰đÍ‚Ćin vivo real-time MAPKƒVƒOƒiƒ‹ƒ‚ƒjƒ^ƒŠƒ“ƒOƒVƒXƒeƒ€‚ĚŠm—§
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‘ć118‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2010”N11ŒŽ19“úi‘ĺăj

Simultaneous Binding Assay ofMicroheterogenious Proteins by Capillary Electrophoresis with Laser InducedFluorescence Detection.
Atsushi Taga, Daiki Kanbayashi, Nanae Umeda, Shuji Kodama, Atsushi Sato, Kentaro Suzuki, Masakazu Izako, Reiko Sugiura
16th International Symposium on Separation Science,
Sep 6-10, 2010, (Rome)

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‘ć60‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2010”N10ŒŽ30“úi‘ĺăj

×–E“ŕ•\–Ę’`”’ŽżEcm33‚É‚ć‚é×–E“ŕCa2+”Z“x‚̐§ŒäƒƒJƒjƒYƒ€‚̉đÍ
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‘ć60‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2010”N10ŒŽ30“úi‘ĺăj

ƒNƒ‰ƒXƒŠƒ“ƒAƒ_ƒvƒ^[•Ą‡‘Ě‚ĆRNAŒ‹‡ƒ^ƒ“ƒpƒNŽż‚̐V‚˝‚ČƒNƒƒXƒg[ƒN‹@\
—L“­‰ëŽqA˜°—zA‚“cG•śAĄ’†—R‰ÔŽqAŠě‘˝ˆťŽqAÎ“nr“ńA”~“c“Ţ•cA™‰Y—íŽq
‘ć60‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2010”N10ŒŽ30“úi‘ĺăj

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…ŒÉĘA”‹Œ´‰Á“ŢŽqAŠě‘˝ˆťŽqA˛“Ą—ş‰îAA“c^—AÎ“nr“ńA‰vŽq‚Aç—tŒŤŽĄA™‰Y—íŽq
‘ć60‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2010”N10ŒŽ30“úi‘ĺăj

RNAŒ‹‡’`”’ŽżNrd1‚ÍMAPKƒVƒOƒiƒ‹ˆË‘ś“I‚Éstress granuleŒ`Ź‚đ§Œä‚ˇ‚é
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RNAƒtƒƒ“ƒeƒBƒAƒ~[ƒeƒBƒ“ƒO@2010”N‚XŒŽ27“ú`29“úiĂ‰Şj

ƒŒ[ƒU[—ă‹NŒuŒőŒŸoƒLƒƒƒsƒ‰ƒŠ[“d‹C‰j“Ž‚đ—p‚˘‚é•s‹ĎˆęŤƒ^ƒ“ƒpƒNŽż‚ĚŒ‹‡”\•]‰ż
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“ú–{•ŞÍ‰ťŠw‰ď‘ć59”N‰ď@2010”N9ŒŽ15“ú`17“úiĺ‘äj

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“°‘OŒőGA‚“cG•śAź“c—•ŽqAŠě‘˝ˆťŽqA‰vŽq‚A™‰Y—íŽq
y•ęˆâ“`ŠwƒtƒH[ƒ‰ƒ€‘ć43‰ńŒ¤‹†•ń‰ď@2010”N9ŒŽ9“ú`11“úi“ޗǁj

RNAŒ‹‡’`”’ŽżNrd1‚ÍMAPKƒVƒOƒiƒ‹ˆË‘ś“I‚ÉStress GranuleŒ`Ź‚đ§Œä‚ˇ‚é
˛“Ą—ş‰îAX“c‹M‘ĺA‚“cG•śAŠě‘˝ˆťŽqAÎ“nr“ńA”‹Œ´‰Á“ŢŽqAź‘şNOA“c’†Í—FA’JŽž—YA—эšçŽqA‘˝‰ę~A™‰Y—íŽq
y•ęˆâ“`ŠwƒtƒH[ƒ‰ƒ€‘ć43‰ńŒ¤‹†•ń‰ď@2010”N9ŒŽ9“ú`11“úi“ޗǁj

ƒNƒ‰ƒXƒŠƒ“ƒAƒ_ƒvƒ^[AP-1•Ą‡‘ĚŒ‹‡ƒ^ƒ“ƒpƒNŽżIts4‚Ěƒƒ“ƒuƒŒƒ“ƒgƒ‰ƒtƒBƒbƒN‚É‚¨‚Ż‚é–đŠ„
˜°—zAŠě‘˝ˆťŽqA‚“cG•śA—L“­‰ëŽqA—›‰–FA™‰Y—íŽq
y•ęˆâ“`ŠwƒtƒH[ƒ‰ƒ€‘ć43‰ńŒ¤‹†•ń‰ď@2010”N9ŒŽ9“ú`11“úi“ޗǁj

MADs-boxŒ^“]ŽĘˆöŽqMbx1‚Ě•W“IˆöŽq‚Ě“Ż’č‚ĆCa2+/CalcineurinƒVƒOƒiƒ‹“`’BŒo˜H‚É‚¨‚Ż‚é–đŠ„
“ŕ“c“ÄŽjAŽR–ě—LŠóAX“ŕƒTƒ„ŽqA’ŠŽR—Y‘žA”ä‰Ă^—AŽRŠÝŽLAŠě‘˝ˆťŽqAÎ“nr“ńA™‰Y—íŽq
y•ęˆâ“`ŠwƒtƒH[ƒ‰ƒ€‘ć43‰ńŒ¤‹†•ń‰ď@2010”N9ŒŽ9“ú`11“úi“ޗǁj

MADs-boxŒ^“]ŽĘˆöŽqMbx1‚ĚExportin‚É‚ć‚é‹ÇÝ§Œä‚Ć“]ŽĘŠˆŤ‚ւ̉e‹ż
ŽR–ě—LŠóA“ŕ“c“ÄŽjAX“ŕƒTƒ„ŽqA’ŠŽR—Y‘žA”ä‰Ă^—AŽRŠÝŽLAŠě‘˝ˆťŽqAÎ“nr“ńA™‰Y—íŽq
y•ęˆâ“`ŠwƒtƒH[ƒ‰ƒ€‘ć43‰ńŒ¤‹†•ń‰ď@2010”N9ŒŽ9“ú`11“úi“ޗǁj

’á•ŞŽq—ĘGƒ^ƒ“ƒpƒNŽżRab GTPase‚đ‰î‚ľ‚˝×–E–Œ—A‘—ƒVƒXƒeƒ€‚É‚ć‚éƒCƒmƒVƒg[ƒ‹ƒŠƒ“Ž‰Žż‡Źy‘fPI(4)P5K‚̐§ŒäƒƒJƒjƒYƒ€
—›‰–FAŠě‘˝ˆťŽqA‹´–{—CAÎ“nr“ńA™‰Y—íŽq
y•ęˆâ“`ŠwƒtƒH[ƒ‰ƒ€‘ć43‰ńŒ¤‹†•ń‰ď@2010”N9ŒŽ9“ú`11“úi“ޗǁj

ƒAƒNƒ`ƒ“Œ‹‡ƒ^ƒ“ƒpƒNŽżCis3‚ĆMAPƒLƒi[ƒ[Œo˜H‚ĚƒNƒƒXƒg[ƒN‚É‚ć‚é×–EŽż•Ş—ô‚̐§Œä
•“cÍOA‚•”•üKA‚‘ş‹ĹA™–{‚Ż‚˘ŽqAŠě‘˝ˆťŽqA”~“c“Ţ•cAÎ“nr“ńA™‰Y—íŽq
y•ęˆâ“`ŠwƒtƒH[ƒ‰ƒ€‘ć43‰ńŒ¤‹†•ń‰ď@2010”N9ŒŽ9“ú`11“úi“ޗǁj

Molecular genetic approach to identify regulators of MAPK signaling.
Reiko Sugiura
IMC9 THE BIOLOGY OF FUNGI
Aug 1-6 2010 (Edinburgh, UK)

Molecular genetic approach to identify regulators of MAPK signaling.
Reiko Sugiura
IMC9 THE BIOLOGY OF FUNGI
Aug 1-6 2010 (Edinburgh, UK)

The Cell Surface Protein Ecm33 Negatively Regulates the Pmk1 Mapk Signalling Via Ca2+ Control.
Mitsuhiro Domae, Hirohumi Takada, Aiko Nishida, Yuki Yamano, Atsushi Uchida, Reiko Sugiura et al
IMC9 THE BIOLOGY OF FUNGI
Aug 1-6 2010 (Edinburgh, UK)

RNAŒ‹‡’`”’ŽżNrd1‚ÍMAPKƒVƒOƒiƒ‹ˆË‘ś“I‚Ɋ‹ŤƒXƒgƒŒƒX‰ž“š‚đ§Œä‚ˇ‚é
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‘ć1‰ńRNA Study Meeting –{‰ď@2010”N7ŒŽ29“ú`30“úi“Œ‹žj

•Ş—ôy•ę‚É‚¨‚Ż‚éRNAŒ‹‡ƒ^ƒ“ƒpƒNŽżSts5‚ÍRho/ƒvƒƒeƒCƒ“ƒLƒi[ƒ[C/MAPKƒVƒOƒiƒ‹‚đ§Œä‚ˇ‚é
‚“cG•śA‰Á“Ąˆť‰ĚAŠě‘˝ˆťŽqAÎ“nr“ńA”~“c“Ţ•cA™‰Y—íŽq
‘ć12‰ń“ú–{RNAŠw‰ď”N‰ď@2010”N7ŒŽ27“ú`20“úi“Œ‹žj

Protein Kinase C ƒVƒOƒiƒ‹“`’BŒo˜H‚̐V‹K§ŒäˆöŽq‚Ĺ‚ ‚éRNA helicase Ded1‚ĆP-body‹ÇÝ‚Ě‹@”\‰đÍ
‰Á“Ąˆť‰ĚA“yˆäÍAŠě‘˝ˆťŽqAˆŔ“cŒő“sŽqA‚“cG•śA˛“Ą—ş‰îA”~“c“Ţ•cAÎ“nr“ńA™‰Y—íŽq
‘ć12‰ń“ú–{RNAŠw‰ď”N‰ď@2010”N7ŒŽ27“ú`20“úi“Œ‹žj

Šj“ŕŠjŠO—A‘—‚đ‰î‚ľ‚˝RNAŒ‹‡ƒ^ƒ“ƒpƒNŽżRnc1‚Ě‹@”\‰đÍ
ź‘şNOA˛“Ą—ş‰îA“c’†Í—FAŠě‘˝ˆťŽqA”~“c“Ţ•cAÎ“nr“ńA‘˝‰ę~A™‰Y—íŽq
‘ć12‰ń“ú–{RNAŠw‰ď”N‰ď@2010”N7ŒŽ27“ú`20“úi“Œ‹žj

Functional Relationship between MAP kinase Signaling and Pumilio in Fission Yeast.
Kanako Hagihara, Ryousuke Satoh, Takahiro Morita, Hirohumi Yakada, Ayako Kita Shunji Ishiwata, Mari Ueda, Aya Mizukura, Nanae Umeda, Reiko Sugiura
The 19th CDB Meeting RNA Sciences in Cell and Developmental Biology
May 10-12, 2010 (Kobe)

MAP Kinase Signaling Dependent Regulation of Cell Fate Mediated by the RNA-binding protein Nrd1 in Fission yeast.
Ryosuke Satoh, Takahiro Morita, Hirohumi Takada, Ayako Kita, Shunji Ishiwata, Akira Doi, Kanako Hagihara, Yasuhiro Matsumura, Akitomo Tanaka, Atsushi Taga, Kaori Shinmyouzu, Reiko Sugiura
The 19th CDB Meeting RNA Sciences in Cell and Developmental Biology
May 10-12, 2010 (Kobe)

RNA-Binding Proteins as Regulators of MAPK Signaling.
Akira Doi, Ayako Kita, Mitsuko Yasuda, Hirohumi Takada, Ayaka Katoh, Ryosuke Satoh, Kanako Hagihara, Reiko Sugiura
The 19th CDB Meeting RNA Sciences in Cell and Developmental Biology
May 10-12, 2010 (Kobe)

RNA-Binding Proteins as Regulators of MAPK Signaling.
Akira Doi, Ayako Kita, Mitsuko Yasuda, Hirohumi Takada, Ayaka Katoh, Ryosuke Satoh, Kanako Hagihara, Reiko Sugiura
The 19th CDB Meeting RNA Sciences in Cell and Developmental Biology
May 10-12, 2010 (Kobe)

2009”N“x@Šw‰ď”­•\

RNA‚đ‰î‚ˇ‚éMAPƒLƒi[ƒ[ƒVƒOƒiƒ‹‚̐V‚˝‚Ȑ§Œä‹@\‚Ć‘n–ň‚Ö‚Ě“W–]
™‰Y—íŽq
“ú–{–ňŠw‰ď‘ć130”N‰ď@2010”N3ŒŽ28“ú`30“úi‰ŞŽRj

Protein Kinase CƒVƒOƒiƒ‹“`’BŒo˜H‚̐V‹K§ŒäˆöŽq‚Ĺ‚ ‚éRNA helicase Ded1‚ĆP-body‹ÇÝ‚Ě‹@”\“IŠÖ˜A
“yˆäÍAŠě‘˝ˆťŽqA‚“cG•śA˛“Ą—ş‰îAŽR–{‹ą•˝A–î–ě—R‰ŔAÎ“nr“ńA™‰Y—íŽq
“ú–{–ňŠw‰ď‘ć130”N‰ď@2010”N3ŒŽ28“ú`30“úi‰ŞŽRj

DSCR1iDown Syndrome Critical Region 1jƒzƒ‚ƒƒOCbp1‚ĚƒŠƒ“Ž_‰ťˆË‘ś“I‹@”\‚Ş
Ca2+/ƒJƒ‹ƒVƒjƒ…[ƒŠƒ“ƒVƒOƒiƒ‹‚É—^‚Ś‚é‰e‹ż‚̉đÍ
ě–k–ƒ‹MAă—Ń‘ĺ‹NA”~“c“Ţ•cAź“c—•ŽqA´ŁD”üAŠě‘˝ˆťŽqA™‰Y—íŽq
“ú–{–ňŠw‰ď‘ć130”N‰ď@2010”N3ŒŽ28“ú`30“úi‰ŞŽRj

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ă—Ń‘ĺ‹NAź“c—•ŽqAě–k–ƒ‹MA”~“c“Ţ•cA´ŁD”üAŠě‘˝ˆťŽqA‚“cG•śA™‰Y—íŽq
“ú–{–ňŠw‰ď‘ć130”N‰ď@2010”N3ŒŽ28“ú`30“úi‰ŞŽRj

MAPKƒVƒOƒiƒ‹ˆË‘ś“I‚Č2‚‚̓]ŽĘˆöŽqAtf1‚¨‚ć‚ŃMbx1‚É‚ć‚Á‚Ĉâ“`Žq”­Œť‚ސ§Œä‚ł‚ę‚éV‹Kˆâ“`Žq
tpa1+‚Ě‹@”\‰đÍF`in vivo real-time MAPƒLƒi[ƒ[ƒVƒOƒiƒ‹ˆË‘ś“I“]ŽĘŠˆŤ‘Ş’čƒVƒXƒeƒ€‚ĚŠm—§‚Ɖž—p`
‚“cG•śAź“c—•ŽqA“°‘OŒőGAŠě‘˝ˆťŽqAŽR–ě—FŠóA“ŕ“c“ÄŽjAÎ“nr“ńA‰€“cŒ’“WA™‰Y—íŽq
“ú–{–ňŠw‰ď‘ć130”N‰ď@2010”N3ŒŽ28“ú`30“úi‰ŞŽRj

’á•ŞŽq—ĘGƒ^ƒ“ƒpƒNŽżRab GTPase‚đ‰î‚ľ‚˝×–E–Œ—A‘—ƒVƒXƒeƒ€‚É‚ć‚éƒCƒmƒVƒg[ƒ‹ƒŠƒ“Ž‰Žż‡Źy‘fPI(4)P5K‚̐§ŒäƒƒJƒjƒYƒ€
—›‰–FAŠě‘˝ˆťŽqA‹´–{—CAÎ“nr“ńA™‰Y—íŽq
“ú–{–ňŠw‰ď‘ć130”N‰ď@2010”N3ŒŽ28“ú`30“úi‰ŞŽRj

RNAŒ‹‡ƒ^ƒ“ƒpƒNŽżNrd1‚ÍMAPƒLƒi[ƒ[ƒVƒOƒiƒ‹ˆË‘ś“I‚ɍזE‰^–˝‚đ§Œä‚ˇ‚é
˛“Ą—ş‰îAX“c‹M‘ĺA‚“cG•śAŠě‘˝ˆťŽqAÎ“nr“ńA“yˆäÍA”‹Œ´‰Á“ŢŽqAź‘şNOA“c’†Í—FA‘˝‰ę~A“Œ“c‰p‹BA™‰Y—íŽq
“ú–{–ňŠw‰ď‘ć130”N‰ď@2010”N3ŒŽ28“ú`30“úi‰ŞŽRj

ƒAƒNƒ`ƒ“Œ‹‡ƒ^ƒ“ƒpƒNŽżCis3‚ĆMAPƒLƒi[ƒ[Œo˜H‚ĚƒNƒƒXƒg[ƒN
‚•”•üKA‚‘ş‹ĹA•“cÍOA™–{‚Ż‚˘ŽqAÎ“nr“ńAŠě‘˝ˆťŽqA™‰Y—íŽq
“ú–{–ňŠw‰ď‘ć130”N‰ď@2010”N3ŒŽ28“ú`30“úi‰ŞŽRj

ƒQƒmƒ€–ň—Šw“IŽč–@‚ĆƒPƒ~ƒJƒ‹ƒoƒCƒIƒƒW[‚đ—p‚˘‚˝V‹K–Ɖu—}§–ňFTY720‚Ě•W“Iˆâ“`Žq‚Ě”­Œť‚Ć×–E“ŕƒJƒ‹ƒVƒEƒ€ƒVƒOƒiƒ‹“`’BŒo˜H‚É—^‚Ś‚é‰e‹ż‚̉đÍ
”‹Œ´‰Á“ŢŽqA…ŒÉĘAŠě‘˝ˆťŽqA˛“Ą—ş‰îAA“c^—A‰vŽq‚Aç—tŒŤŽĄA™‰Y—íŽq
“ú–{–ňŠw‰ď‘ć130”N‰ď@2010”N3ŒŽ28“ú`30“úi‰ŞŽRj

ƒAƒtƒBƒjƒeƒB[ƒLƒƒƒsƒ‰ƒŠ[“d‹C‰j“Ž‚É‚ć‚éRNA-GFP-ƒ^ƒ“ƒpƒNŽż‘ŠŒÝě—p‚ĚŠĎŽ@
‘˝‰ę~A˛“Ą—ş‰îAÎ“nr“ńAŹ‹ĘCŽkA˛“Ą–rA—é–ŘŒ’‘ž˜YA™‰Y—íŽq
“ú–{–ňŠw‰ď‘ć130”N‰ď@2010”N3ŒŽ28“ú`30“úi‰ŞŽRj

‰ťŠw”­Œő‚đ—p‚˘‚˝’ŽËÜŹ‡ƒgƒŒ[ƒjƒ“ƒOƒVƒXƒeƒ€‚ĚŠJ”­
Î“nr“ńA‘˝‰ę~A˛–ě—T”VAŹ—ѐł—˛A–ěŒŠŽR~AŒ´“cŽm˜YAŹň—SˆęA–ě‘ş^”üAX‰K‹žAźŽR’C”üAVˆä^”üŽqAX“c‹M‘ĺAŠě‘˝ˆťŽqA‚“c[—˛A™‰Y—íŽq
“ú–{–ňŠw‰ď‘ć130”N‰ď@2010”N3ŒŽ28“ú`30“úi‰ŞŽRj

ƒ`[ƒ€Šî”ŐŒ^ŠwKiTBLj‚đ“ą“ü‚ľ‚˝–ňŠw•”EˆăŠw•”˜AŒg‹łˆç
–Ř‘şŒ’AˆŔŒ´’q‹vA‘Dăm”́A’ˇˆä‹IÍAŠě‘˝ˆťŽqA–kŹ˜HŠwA‘ĺ’š“OAŠâéłGAź”ö—
“ú–{–ňŠw‰ď‘ć130”N‰ď@2010”N3ŒŽ28“ú`30“úi‰ŞŽRj

‹ß‹E‘ĺŠw–ňŠw•”‚É‚¨‚Ż‚é–Í‹[ŠłŽŇ—{Ź‚ĚŽć‚č‘g‚Ý
‘ĺ’š“OA–Ř‘şŒ’AˆŔŒ´’q‹vA–kŹ˜HŠwA‘Dăm”́AÎ“nr“ńA’J–ěŒörA‘şă‰xŽqA”ŞŒŹ_ŽqA‚“c[—˛
“ú–{–ňŠw‰ď‘ć130”N‰ď@2010”N3ŒŽ28“ú`30“úi‰ŞŽRj

RNA-BINDING PROTEINS AS REGURATORS OF MAPK SIGNALING.
Reiko Sugiura
The 5th International Fission Yeast Meeting (Pombe 2009)
Oct 26-31, 2009 (Tokyo)

A Role of Its4, A Clathrin-Associated Adaptor-Protein-1 Complex (AP-1) binding protein, in membrane trafficKING of Fission Yeast.
Yang Yu, Ayako Kita, Hirofumi Takada, Cuifang Li, Reiko Sugiura
The 5th International Fission Yeast Meeting (Pombe 2009)
Oct 26-31, 2009 (Tokyo)

A NOVEL CELL SURFACE PROTEIN TPA1 ACTS AS A NEGATIVE REGULATOR OF THE PMK1 MAPK SIGNALING.
Hirofumi Takada, Aiko Nishida, Mitsuhiro Domae, Ayako Kita, Shunji Ishiwata, Yuki Yamano, Atsushi Uchida, Reiko Sugiura
The 5th International Fission Yeast Meeting (Pombe 2009)
Oct 26-31, 2009 (Tokyo)

MAPK SIGNALING-DEPENDENT REGULATION OF CELL FATE MEDIATED BY THE RNA-BINDING PROTEIN Nrd1.
Ryosuke Satoh, Ayako Kita, Shunji Ishiwata, Akira Doi, Kanako Hagihara, Yasuhiro Matsumura, Hideki Tohda, Reiko Sugiura
The 5th International Fission Yeast Meeting (Pombe 2009)
Oct 26-31, 2009 (Tokyo)

Observation of Interaction between RNA and GFP-Protein by Affinity Capillary Electrophoresis.
Atsushi Taga, Ryosuke Satoh, Shunji Ishiwata, Shuji Kodama, Atsushi Sato, Kentaro Suzuki, Reiko Sugiura
ISPPP 2009 - International Symposium on the S eparation of Proteins, Peptides and Polynucleotides , October 25-28, 2009, Florida, USA

ƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚Ě“ŕˆöŤ§ŒäˆöŽqDSCR1ƒzƒ‚ƒƒO‚̐V‚˝‚Č•W“I•ŞŽq‚Ě“Ż’č
ă—Ń‘ĺ‹NAź“c—•ŽqAě–k–ƒ‹MA”~“c“Ţ•cAŠě‘˝ˆťŽqA‚“cG•śA™‰Y—íŽq
‘ć59‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2009”N10ŒŽ24“úi‘ĺăj

V‹K–Ɖu—}§–ňFTY720‚Ě•W“Iˆâ“`Žq‚Ě“Ż’č‚Ć×–E“ŕCa2+ƒVƒOƒiƒ‹“`’BŒo˜H‚É‚¨‚Ż‚é–đŠ„‚Ě‰đÍ
”‹Œ´‰Á“ŢŽqAŠě‘˝ˆťŽqA‰vŽq‚Aç—tŒŤŽĄA˛“Ą—ş‰îA™‰Y—íŽq
‘ć59‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2009”N10ŒŽ24“úi‘ĺăj

MADS-boxŒ^“]ŽĘˆöŽqMbx1‚Ě‹ÇÝ§ŒäƒƒJƒjƒYƒ€‚ŞCa2+ƒzƒƒIƒXƒ^ƒVƒX‚É—^‚Ś‚é‰e‹ż‚̉đÍ
“ŕ“c“ÄŽjAŽR–ě—FŠóAX“ŕƒTƒ„ŽqA’ŠŽR—Y‘žAŠě‘˝ˆťŽqAÎ“nr“ńA™‰Y—íŽq
‘ć59‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2009”N10ŒŽ24“úi‘ĺăj

V‹KƒNƒ‰ƒXƒŠƒ“ƒAƒ_ƒvƒ^[AP-1•Ą‡‘ĚŒ‹‡ƒ^ƒ“ƒpƒNŽżIts4‚Ěƒƒ“ƒuƒŒƒ“ƒ“ƒgƒ‰ƒbƒtƒBƒbƒN‚É‚¨‚Ż‚é–đŠ„
˜°—zAŠě‘˝ˆťŽqA‚“cG•śA—›‰–FA™‰Y—íŽq
‘ć59‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2009”N10ŒŽ24“úi‘ĺăj

ƒmƒbƒNƒAƒEƒgƒRƒŒƒNƒVƒ‡ƒ“‚đ—p‚˘‚˝MAPƒLƒi[ƒ[ƒVƒOƒiƒ[ƒ€\ŹˆöŽq‚Ě“Ż’č‚Ć‹@”\‰đÍ
‹g‘ş”ü–ëAŠě‘˝ˆťŽqAˆäă‚ä‚Š‚čA™‰Y—íŽq
‘ć59‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2009”N10ŒŽ24“úi‘ĺăj

MAPK/Atf1iCREBjƒVƒOƒiƒ‹‚̐V‚˝‚Č•W“Iˆâ“`Žqtpa1+‚Ěƒvƒƒ‚[ƒ^[‰đÍ‚ĆMAPKƒVƒOƒiƒ‹“`’BŒo˜H‚É‚¨‚Ż‚é–đŠ„
“°‘OŒőGA‚“cG•śAź“c—•ŽqAŠě‘˝ˆťŽqA‰vŽq‚A™‰Y—íŽq
‘ć59‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2009”N10ŒŽ24“úi‘ĺăj

ƒNƒ‰ƒXƒŠƒ“ƒAƒ_ƒvƒ^[•Ą‡‘ĚƒĘ1ƒTƒuƒ†ƒjƒbƒgApm1‚̐§ŒäˆöŽq‚Ć‚ľ‚Ä‚Ě’á•ŞŽq—ĘGƒ^ƒ“ƒpƒNŽżRho3‚Ě”­ŒŠ‚ĆƒSƒ‹ƒWEƒGƒ“ƒhƒ][ƒ€‚É‚¨‚Ż‚é“­‚Ť
—›‰–FAŠě‘˝ˆťŽqAˆŔ“cŒő“sŽqA˜°—zAŽR–{‹ą•˝A‘˝‰ę~AÎ“nr“ńA™‰Y—íŽq
‘ć59‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2009”N10ŒŽ24“úi‘ĺăj

MAPƒLƒi[ƒ[‚É‚ć‚郊ƒ“Ž_‰ťˆË‘ś“I‚ČRNAŒ‹‡ƒ^ƒ“ƒpƒNŽżNrd1‚Ě×–E‰^–˝§Œä‹@\
˛“Ą—ş‰îAX“c‹M‘ĺA‚“cG•śAŠě‘˝ˆťŽqAÎ“nr“ńA“yˆäÍA”‹Œ´‰Á“ŢŽqAź‘şNOA‘˝‰ę~A“Œ“c‰p‹BA™‰Y—íŽq
‘ć82‰ń“ú–{ś‰ťŠw‰ď‘ĺ‰ď@2009”N10ŒŽ21“ú`24“úi_ŒËj

MAPƒLƒi[ƒ[ƒVƒOƒiƒ‹“`’B‚É‚ć‚émRNAŒ‹‡ƒ^ƒ“ƒpƒNŽż‚̐§Œä
™‰Y—íŽq
‘ć82‰ń“ú–{ś‰ťŠw‰ď‘ĺ‰ď@2009”N10ŒŽ21“ú`24“úi_ŒËj

•Ş—ôy•ę‚É‚¨‚Ż‚éRNAŒ‹‡ƒ^ƒ“ƒpƒNŽżNrd1‚É‚ć‚éMAPƒLƒi[ƒ[ƒVƒOƒiƒ‹ˆË‘ś“I‚Č×–E‰^–˝§Œä‹@\
˛“Ą—ş‰îAX“c‹M‘ĺA‚“cG•śAŠě‘˝ˆťŽqAÎ“nr“ńA“yˆä ÍA”‹Œ´‰Á“ŢŽqAź‘şNOA‘˝‰ę~A“Œ“c‰p‹BA™‰Y—íŽq
‘ć11‰ń“ú–{RNAŠw‰ď”N‰ďi‘ć11‰ńRNAƒ~[ƒeƒBƒ“ƒOj@2009”N7ŒŽ27“ú`29“úiVŠƒj

2008”N“x@Šw‰ď”­•\

ƒAƒNƒ`ƒ“Œ‹‡ƒ^ƒ“ƒpƒNŽżCis3‚ĚMAPƒLƒi[ƒ[‚É‚ć‚郊ƒ“Ž_‰ť§Œä
‚‘ş‹ĹA•“cÍOA‚•”•üKAÎ“nr“ńAŠě‘˝ˆťŽqA™‰Y—íŽq
‘ć129‰ń“ú–{–ňŠw‰ď”N‰ď@2009”N3ŒŽ26“ú`28“úi‹ž“sj

RNAŒ‹‡’`”’ŽżSts5‚ĆƒŠƒ“Ž_‰ťƒVƒOƒiƒ‹“`’B‚Ě‹@”\“IŠÖŒW
ŽđˆäŠě—TA‚“cG•śAb”ă’źŽuAŠě‘˝ˆťŽqAÎ“nr“ńA™‰Y—íŽq
‘ć129‰ń“ú–{–ňŠw‰ď”N‰ď@2009”N3ŒŽ26“ú`28“úi‹ž“sj

’á•ŞŽq—ĘGƒ^ƒ“ƒpƒNŽżRho2‚đ‰î‚ˇ‚éƒVƒOƒiƒ‹“`’BŒo˜H‚̐V‚˝‚Ȑ§ŒäƒƒJƒjƒYƒ€
’|“‡šDA“c’†ääťŽqA‹ß“Ą‘ĺ‹MAŠě‘˝ˆťŽqAÎ“nr“ńA™‰Y—íŽq
‘ć129‰ń“ú–{–ňŠw‰ď”N‰ď@2009”N3ŒŽ26“ú`28“úi‹ž“sj

RNAŒ‹‡ƒ^ƒ“ƒpƒNŽżNrd1‚É‚ć‚é×–E‰^–˝ƒXƒCƒbƒ`ƒ“ƒO‚̐§Œä‹@\
˛“Ą—ş‰îAX“c‹M‘ĺA‚“cG•śA”‹Œ´‰Á“ŢŽqA“yˆäÍAŠě‘˝ˆťŽqAÎ“nr“ńA™‰Y—íŽq
‘ć31‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ďE‘ć81‰ń“ú–{ś‰ťŠw‰ď‘ĺ‰ď ‡“Ż‘ĺ‰ďiBMB2008j2008”N12ŒŽ9“ú`12“úi_ŒËj

Rho/CƒLƒi[ƒ[ƒVƒOƒiƒ‹“`’BŒo˜H‚É‚¨‚˘‚Ä‹@”\‚ˇ‚éV‹Kˆâ“`ŽqSts5‚Ě“­‚Ť
b”ă’źŽuA‚“cG•śAŽđˆäŠě—TAŠě‘˝ˆťŽqAÎ“nr“ńA™‰Y—íŽq
‘ć114‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2008”N11ŒŽ14“úi_ŒËj

’á•ŞŽq—ĘGƒ^ƒ“ƒpƒNRho2‚đ‰î‚ˇ‚éƒVƒOƒiƒ‹“`’B‹@\‚̉đ–ž
’|“‡šDA“c’†ääťŽqA‹ß“Ą‘ĺ‹MAŠě‘˝ˆťŽqAÎ“nr“ńA™‰Y—íŽq
‘ć114‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2008”N11ŒŽ14“úi_ŒËj

“]ŽĘˆöŽqAtf1‚Íglycogen synthase kinase‚É‚ć‚čƒŠƒ“Ž_‰ť‚ł‚ę‚é
Î“nr“ńA•ŸŽRłlAź“c—•ŽqA‚“cG•śA˛“Ą—ş‰îAŠě‘˝ˆťŽqA™‰Y—íŽq
‘ć114‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2008”N11ŒŽ14“úi_ŒËj

Molecular Genetic Analysis of the Calcineurin-mediated Signaling Pathways.
Reiko Sugiura
8th International Conference on Protein Phosphatases, Maebashi, 12-14 Nov. 2008

Cbp1, an Endogenous Inhibitor of Calcineurin Signaling, Acts as a Negative Regulator of Atf1, a Downstream Transcription Factor of the Stress-activated MAP Kinase Pathway.
Aiko Nishida, Daiki Kanbayashi, Hirofumi Takada, Ayako Kita, Shunji Ishiwata, Reiko Sugiura
8th International Conference on Protein Phosphatases, Maebashi, 12-14 Nov. 2008

The Atf1 Transcription Factor Is a Target of the Mitogen-activated Protein Kinase Pmk1 and Regulates the Expression of the tpa1+ Gene, which Encodes a Novel Cell Surface Protein in Fission Yeast.
Hirofumi Takada, Aiko Nishida, Ayako Kita, Shunji Ishiwata, Takashi Masuko, Kazue Masuko, Reiko Sugiura
8th International Conference on Protein Phosphatases, Maebashi, 12-14 Nov. 2008

Cross-talk between Calcineurin Signaling and the MADS-box Transcription Factor Mbx1 in the Ca2+ Homeostasis in Fission Yeast.
Sayako Moriuchi, Yuki Yamano, Yuta Asayama, Ayako Kita, Shunji Ishiwata, Reiko Sugiura
8th International Conference on Protein Phosphatases, Maebashi, 12-14 Nov. 2008

The Actin Binding Protein Cis3/PSTPIP Plays a Role in Activation of MAPK Signaling Pathways.
Satoru Takamura, Akihiro Takeda, Ayako Kita, Shunji Ishiwata, Reiko Sugiura
8th International Conference on Protein Phosphatases, Maebashi, 12-14 Nov. 2008

The regulatory mechanism of cell-fate switching by MAPK signaling and the RNA-binding protein Nrd1.
Ryosuke Sato, Takahiro Morita, Hirofumi Takada, Kanako Hagihara, Akira Doi, Ayako Kita, Shunji Ishiwata, Reiko Sugiura
8th International Conference on Protein Phosphatases, Maebashi, 12-14 Nov. 2008

ƒAƒNƒ`ƒ“Œ‹‡ƒ^ƒ“ƒpƒNŽżCis3/PSTPIP‚ĚMAPƒLƒi[ƒ[ƒVƒOƒiƒ‹ŠˆŤ‰ť‚É‚¨‚Ż‚é–đŠ„
•“cÍOA‚‘ş‹ĹAÎ“nr“ńAŠě‘˝ˆťŽqA™‰Y—íŽq
‘ć58‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2008”N10ŒŽ25“úi_ŒËj

Glycogen synthase kinase‚É‚ć‚é“]ŽĘˆöŽqAtf1‚ĚƒŠƒ“Ž_‰ť§Œä
•ŸŽRłlAÎ“nr“ńAź“c—•ŽqA‚“cG•śA˛“Ą—ş‰îAŠě‘˝ˆťŽqA™‰Y—íŽq
‘ć58‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2008”N10ŒŽ25“úi_ŒËj

MADS-boxŒ^“]ŽĘˆöŽqMbx1‚ĆCa2+/ƒJƒ‹ƒVƒjƒ…[ƒŠƒ“ƒVƒOƒiƒ‹“`’BŒo˜H‚ĚƒNƒƒXƒg[ƒN‹@\
ŽR–ě—FŠóAX“ŕƒTƒ„ŽqA’ŠŽR—Y‘žAŠě‘˝ˆťŽqAÎ“nr“ńA™‰Y—íŽq
‘ć58‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2008”N10ŒŽ25“úi_ŒËj

ƒJƒ‹ƒVƒjƒ…[ƒŠƒ“—}§ˆöŽqCbp1 ‚É‚ć‚éƒXƒgƒŒƒX‰ž“šMAPK ƒVƒOƒiƒ‹‚̐§Œä
ă—Ń‘ĺ‹NAź“c—•ŽqA‚“cG•śAŠě‘˝ˆťŽqAÎ“nr“ńA™‰Y—íŽq
‘ć58‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2008”N10ŒŽ25“úi_ŒËj

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The Atf1 Transcription Factor acts as a critical signaling node that links cell integrity signal and stress responses mediated by two distinct MAPK pathways.
Hirofumi Takada, Aiko Nishida, Yuta Asayama, Naoyuki Kai, Akira Doi, Ayako Kita, Shunji Ishiwata, Reiko Sugiura
The 21st Naito Conference-Nuclear Dynamics and RNA [I], Yamanashi Jun. 2008

2007”N“x@Šw‰ď”­•\

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ƒQƒmƒ€–ň—Šw“IƒAƒvƒ[ƒ`‚É‚ć‚éMAPKŒo˜H‚̐§ŒäˆöŽq‚Ě“Ż’č‚Ć‹@”\‰đÍ
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y•ęˆâ“`ŠwƒtƒH[ƒ‰ƒ€‘ć40‰ńŒ¤‹†•ń‰ď@2007”N9ŒŽ11“ú`13“úi‘ĺăj

•Ş—ôy•ęƒ‚ƒfƒ‹ś•¨‚đ—p‚˘‚˝ƒNƒ‰ƒXƒŠƒ“ƒAƒ_ƒvƒ^[•Ą‡‘Ě‚Ć’á•ŞŽq—ĘGƒ^ƒ“ƒpƒNŽżRho3‚Ě‹@”\“IŠÖŒW
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y•ęˆâ“`ŠwƒtƒH[ƒ‰ƒ€‘ć40‰ńŒ¤‹†•ń‰ď@2007”N9ŒŽ11“ú`13“úi‘ĺăj

Development of a Novel Type Capillary for Protein Analysis by Capillary Electrophoresis.
Atsushi Taga, Yoshitaka Honda, Atsushi Sato, Hiroyuki Terashima, Kentaro Suzuki, Shuji Kodama, Shunji Ishiwata, Takahiro Morita, Reiko Sugiura
Euroanalysis XIV Antwerp, Belgium, 9-14 Sep. 2007

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‘ć9‰ń“ú–{RNAŠw‰ď”N‰ďi‘ć9‰ńRNAƒ~[ƒeƒBƒ“ƒOj2007”N7ŒŽ28“ú`31“úi–źŒĂ‰Žj

•Ş—ôy•ęƒ‚ƒfƒ‹ś•¨‚đ—p‚˘‚˝Pumilio‚Ćcell integrityƒVƒOƒiƒ‹‚Ě‹@”\“IŠÖŒW
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‘ć9‰ń“ú–{RNAŠw‰ď”N‰ďi‘ć9‰ńRNAƒ~[ƒeƒBƒ“ƒOj2007”N7ŒŽ28“ú`31“úi–źŒĂ‰Žj

RNAŒ‹‡ƒ^ƒ“ƒpƒNŽżRnc1‚ĚŠj“ŕEŠjŠOˆÚs‚É‚ć‚鐧Œä‹@\‚̉đÍ
ç“cKŽuA“‡—Ç‘žA“V’J”ü—éA“‡Œ´‡ˆęAŠě‘˝ˆťŽqAÎ“nr“ńA™‰Y—íŽq
‘ć9‰ń“ú–{RNAŠw‰ď”N‰ďi‘ć9‰ńRNAƒ~[ƒeƒBƒ“ƒOj2007”N7ŒŽ28“ú`31“úi–źŒĂ‰Žj

Molecular genetic screen to identify novel components of the pmk1 MAPK signaling.
Sayako Moriuchi, Yuta Asayama, Yan Ma, Ayako Kita, Takayoshi Kuno, Reiko Sugiura
XX‡Vrd International Conference on Yeast Genetics and Molecular Biology, Melbourne, Australia 1-6 July 2007

The identical and phenotypic characterization of an endogenous calcineurin inhibitor Cbp1 in fission yeast.
Aiko Nishida, Kousaku Katsura, Hirofumi Takada, Akira Doi, Ayako Kita, Shunji Ishiwata, Takayoshi Kuno, Reiko Sugiura
XX‡Vrd International Conference on Yeast Genetics and Molecular Biology, Melbourne, Australia 1-6 July 2007

A powerful genetic strategy to screen for inhibitors of MAP kinase signaling.
Hirofumi Takada, Yoshiaki Manse, Akira Doi, Naoyuki Kai, Yoshihiro Sakai, Ayako Kita, Shunji Ishiwata, Takayoshi Kuno, Reiko Sugiura
XX‡Vrd International Conference on Yeast Genetics and Molecular Biology, Melbourne, Australia 1-6 July 2007

Apm1, theƒĘ1 subunit of the Clathrin-Associated Adaptor Protein-1 Complex, Shares an essential function with Calcineurin in fission yeast.
Sachiko Tomita, Ayako Kita, Hirofumi Takada, Mariko Tanaka, Saori Takeshima, Satoru Takamura, Shunji Ishiwata, Takayoshi Kuno, Reiko Sugiura
XX‡Vrd International Conference on Yeast Genetics and Molecular Biology, Melbourne, Australia 1-6 July 2007

Valproic acid affects membrane trafficking in fission yeast.
Ayako Kita, Makoto Miyatake, Takayoshi Kuno, Kosaku Katsura, Kaoru Takegawa, Satoshi Uno, Toshiya Nabata, Reiko Sugiura
XX‡Vrd International Conference on Yeast Genetics and Molecular Biology, Melbourne, Australia 1-6 July 2007

Functional interaction between Pumilio family and cell integrity signaling in fission yeast.
Ryosuke Sato, Takahiro Morita, Sara Watanabe, Hirofumi Takada, Ayako Kita, Shunji Ishiwata, Reiko Sugiura
XX‡Vrd International Conference on Yeast Genetics and Molecular Biology, Melbourne, Australia 1-6 July 2007

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‘ć127‰ń“ú–{–ňŠw‰ď”N‰ď@2007”N3ŒŽ28“ú`30“úi•xŽRj

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ź‘şŤ”VA‚“cG•śA“Ú“cËŽqAäݐŁ‹MşAă“c“OAŠě‘˝ˆťŽqAÎ“nr“ńA™‰Y—íŽq
‘ć127‰ń“ú–{–ňŠw‰ď”N‰ď@2007”N3ŒŽ28“ú`30“úi•xŽRj

ƒ‚ƒfƒ‹ś•¨‚đ—p‚˘‚˝–Ɖu—}§–ňŠ´ŽóŤ•ĎˆŮ‘Ě‚ĚŒ´ˆöˆâ“`Žqits4+‚Ě×–E“ŕ—A‘—‚É‚¨‚Ż‚é“­‚Ť
‚“cG•śAäݐŁ‹MşA“Ú“cËŽqAĄ’†—R‰ÔŽqA“c’†ääťŽqA“yˆäÍAź‘şŤ”VAŠě‘˝ˆťŽqAÎ“nr“ńA™‰Y—íŽq
‘ć127‰ń“ú–{–ňŠw‰ď”N‰ď@2007”N3ŒŽ28“ú`30“úi•xŽRj

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‘ć127‰ń“ú–{–ňŠw‰ď”N‰ď@2007”N3ŒŽ28“ú`30“úi•xŽRj

2006”N“x@Šw‰ď”­•\

•Ş—ôy•ęƒ‚ƒfƒ‹Œn‚đ—p‚˘‚˝ƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚Ě“ŕˆöŤƒCƒ“ƒqƒrƒ^[Cbp1‚Ě×–E“ŕƒVƒOƒiƒ‹“`’B‚É‚¨‚Ż‚é“­‚Ť
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‘ć110‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2006”N11ŒŽ10“úi‹ž“sj

•Ş—ôy•ęƒ‚ƒfƒ‹Œn‚đ—p‚˘‚˝ˆŸ‰”ƒgƒ‰ƒ“ƒXƒ|[ƒ^[‚Ě‹@”\‰đÍ
”~–ě—S’BA–[ŒŽA™‰Y—íŽqA‹v–ě‚‹`
‘ć110‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2006”N11ŒŽ10“úi‹ž“sj

•Ş—ôy•ęƒ‚ƒfƒ‹Œn‚đ—p‚˘‚˝ƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚É‚ć‚萧Œä‚ł‚ę‚ézinc fingerŒ^“]ŽĘˆöŽqPrz1‚Ě‹@”\‰đÍ
“c”¨—R‹IA™‰Y—íŽqA‘ĺ–{_ŽkA‘Oě‹M‘ăA‹v–ě‚‹`
‘ć110‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2006”N11ŒŽ10“úi‹ž“sj

•Ş—ôy•ęƒ‚ƒfƒ‹Œn‚đ—p‚˘‚˝ƒNƒ‰ƒXƒŠƒ“ƒAƒ_ƒvƒ^[•Ą‡‘Ě‚Ě‹@”\‰đÍ
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‘ć110‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2006”N11ŒŽ10“úi‹ž“sj

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‘ć110‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2006”N11ŒŽ10“úi‹ž“sj

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‘ć110‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2006”N11ŒŽ10“úi‹ž“sj

ƒQƒmƒ€–ň—Šw“IƒAƒvƒ[ƒ`‚É‚ć‚éMAPKŒo˜H‚̐§ŒäˆöŽq‚Ě“Ż’čFGeranyl geranyl transferase‚Í’á•ŞŽq—ĘGƒ^ƒ“ƒpƒNŽżRho‚đ‰î‚ľ‚ÄMAPKƒVƒOƒiƒ‹‚đ§Œä‚ˇ‚é
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‘ć110‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2006”N11ŒŽ10“úi‹ž“sj

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‘ć110‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2006”N11ŒŽ10“úi‹ž“sj

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‘ć110‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2006”N11ŒŽ10“úi‹ž“sj

•Ş—ôy•ę‚É‚¨‚Ż‚éPhosphoinositide dependent kinase (PDK) 1ƒzƒ‚ƒƒO‚Ě‹@”\‰đÍ
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‘ć56‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2006”N10ŒŽ28“úi‹ž“sj

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RNAŒ‹‡ƒ^ƒ“ƒpƒNŽżNrd1‚̓AƒNƒ`ƒ“×–EœŠiŒn‚đ§Œä‚ˇ‚é
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‘ć56‰ń“ú–{–ňŠw‰ď‹ß‹EŽx•”‘‰ďE‘ĺ‰ď@2006”N10ŒŽ28“úi‹ž“sj

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‘ć109‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2006”N6ŒŽ16“úi‰ŞŽRj

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‘ć109‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2006”N6ŒŽ16“úi‰ŞŽRj

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‘ć109‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2006”N6ŒŽ16“úi‰ŞŽRj

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“c’†ääťŽqA’|“‡šDAŠě‘˝ˆťŽqA‚“cG•śAç“cKŽuA‹v–ě‚‹`AÎ“nr“ńA™‰Y—íŽq
‘ć109‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2006”N6ŒŽ16“úi‰ŞŽRj

Molecular Genetic Approach to Identify Regulators of MAPK Signalling.
Reiko Sugiura
International Symposium of Kobe University 21st Century COE Program on Signal Transduction in Memory of Prof. Yasutomi Nishizuka
February 9-11 Kobe, 2006

2005”N“x@Šw‰ď”­•\

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™‰Y—íŽq
‘ć49‰ń“ú–{–ňŠw‰ďŠÖ“ŒŽx•”‘ĺ‰ďƒVƒ“ƒ|ƒWƒEƒ€@2005”N10ŒŽ8“úi“Œ‹žj

2‚Â‚Ě•Ş—ôy•ęRabƒtƒ@ƒ~ƒŠ[ Gƒ^ƒ“ƒpƒNŽżCRyh1‚ĆYpt3‚Ěˆâ“`Šw“I‚Š‚‹@”\“IŠÖ˜A
‰˝ˆŐA™‰Y—íŽqA”n‰AŠě‘˝ˆťŽqAűšLui‰¤‚Ö‚ń‚ɘHjAt“Ą‹vlA‹v–ě‚‹`
‘ć107‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2005”N6ŒŽ24“úi‹ŕ‘ňj

•Ş—ôy•ę‚Ěphosphatidylinositol-4-phosphate-5-kinase‚ÍPhospholipase C‚đ‰î‚ˇ‚é‚ŞProtein Kinase C‚đ‰î‚ł‚Č‚˘ƒVƒOƒiƒ‹“`’BŒo˜H‚É‚ć‚č×–E“‡Ť‚đ§Œä‚ˇ‚é
Lu DengA™‰Y—íŽqA‘ž“c˜aŽ÷A‘˝“cˆęŽ÷A—é–ؐłLAt“Ą‹vlA‹v–ě‚‹`
‘ć107‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2005”N6ŒŽ24“úi‹ŕ‘ňj

•Ş—ôy•ęƒ‚ƒfƒ‹ś•¨‚đ—p‚˘‚˝’á•ŞŽq—ĘGƒ^ƒ“ƒpƒNŽżRabƒtƒ@ƒ~ƒŠ[‚ĆGDI‚Ě‹@”\‰đÍ
”n‰ALu DengA‰˝ˆŐA™‰Y—íŽqA‹v–ě‚‹`
‘ć107‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2005”N6ŒŽ24“úi‹ŕ‘ňj

2004”N“x@Šw‰ď”­•\

•Ş—ôy•ęPlc1‚đ‰î‚ľ‚˝ƒCƒmƒVƒg[ƒ‹ƒŠƒ“Ž‰ŽżƒVƒOƒiƒ‹“`’BŒo˜H‚̉đÍ
‘ž“c˜aŽ÷ALu DengA™‰Y—íŽqA—é–ؐłGA•˝“c‰ëlA’†‘şrˆęAt“Ą‹vlA‹v–ě‚‹`
‘ć27‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2004”N12ŒŽ8`11“úi_ŒËj

•Ş—ôy•ępmc1+‹y‚Ńprz1+‚ĚƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‰ž“š‹@\‚̉đÍ
‚ŒŠ’m“żA™‰Y—íŽqA‘Oě‹M‘ăA’|“ŕ^ˆßA–ź”¨rĆA‹v–ě‚‹`
‘ć27‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2004”N12ŒŽ8`11“úi_ŒËj

in vivo‚É‚¨‚Ż‚éƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚ĚŠˆŤ‰ť‚Ć—}§‚ɂ͐§ŒäƒTƒuƒ†ƒjƒbƒg‚Ş•K—v‚Ĺ‚ ‚é
––L‹MŽjASusie O SioA™‰Y—íŽqA’|“ŕ^ˆßAŒüˆäGKA‹v–ě‚‹`
‘ć27‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2004”N12ŒŽ8`11“úi_ŒËj

•Ş—ôy•ęWASPƒzƒ‚ƒƒOWsp1‚̓Jƒ‹ƒVƒjƒ…[ƒŠƒ“‚Ć‹@”\“I‚ÉŠÖ˜A‚ˇ‚é
‹{–{ˆč‹|AÎ‘q—˘“ށA傖źG•ôA‰Ş–{–ƒ—˜A™‰Y—íŽqA‹v–ě‚‹`At“Ą‹vl
‘ć27‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2004”N12ŒŽ8`11“úi_ŒËj

•Ş—ôy•ęV‹K‰h—{ƒ}[ƒJ[ˆâ“`Žq‚Ě’P—Ł‚đ–ÚŽw‚ľ‚˝•ĎˆŮ‘ĚƒXƒNƒŠ[ƒjƒ“ƒO
Ä“Ą^—ŽqAŹ’r“ÖŽ‘A™‰Y—íŽqA‹v–ě‚‹`
‘ć27‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2004”N12ŒŽ8`11“úi_ŒËj

•Ş—ôy•ęƒ‚ƒfƒ‹‚đ—p‚˘‚˝PI4P5K‰ßč”­Œť‘Ě‚Ě×–E‘B—}§‚𑊕₡‚éˆöŽq‚Ě‹@”\‰đÍ
‘吟^‹MA™‰Y—íŽqAV‘ş˜a‹vA‘˝“cˆęéAt“Ą‹vlA‹v–ě‚‹`
‘ć106‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2004”N11ŒŽ5“úi‹ž“sj

PI(4)P5ƒLƒi[ƒ[‚Ć‹@”\“I‚ÉŠÖ˜A‚ˇ‚éˆöŽq‚Ě“Ż’č‚Ć‹@”\‰đÍ
‘˝“cˆęéA™‰Y—íŽqAŒKŒ´ç‰ŔA‘吟^‹MAt“Ą‹vlA‹v–ě‚‹`
‘ć106‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2004”N11ŒŽ5“úi‹ž“sj

•Ş—ôy•ęƒ‚ƒfƒ‹Œn‚đ—p‚˘‚˝ƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚Ě“ŕˆöŤƒCƒ“ƒqƒrƒ^[Cbp1‚Ě‹@”\‰đÍ
œAˆŔ^ŽŔA‚“cŽA‚ŒŠ’m“żAŠě‘˝ˆťŽqA‹v–ě‚‹`A™‰Y—íŽq
‘ć106‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2004”N11ŒŽ5“úi‹ž“sj

•Ş—ôy•ęƒ‚ƒfƒ‹Œn‚đ—p‚˘‚˝MAPƒLƒi[ƒ[Œo˜H‚É‚¨‚˘‚Ä‹@”\‚ˇ‚éˆöŽq‚Ě“Ż’č
ŻŽq—T”üA’ËŒ´ŒcŽqA‚ŒŠ’m“żA–ź”¨rĆAŠě‘˝ˆťŽqA‹v–ě‚‹`A™‰Y—íŽq
‘ć106‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2004”N11ŒŽ5“úi‹ž“sj

•Ş—ôy•ęƒ‚ƒfƒ‹Œn‚đ—p‚˘‚˝×–EŽż•Ş—ô‚É•K{‚ĚˆöŽq‚Ĺ‚ ‚éƒZƒvƒ`ƒ“‚Ě‹@”\‰đÍ
–ź”¨rĆA‚‘şˆşŽqA‘˝“cˆęéAŻŽq—T”üAŠě‘˝ˆťŽqA‹v–ě‚‹`A™‰Y—íŽq
‘ć106‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2004”N11ŒŽ5“úi‹ž“sj

An RNA-binding protein-mediated feedback regulation of MAPK signalling.
Reiko Sugiura
The fifth UK Japan Cell Cycle Workshop, April 16th, 2004

RNA‚đ‰î‚ˇ‚éƒ}ƒbƒvƒLƒi[ƒ[ƒVƒOƒiƒ‹‚̐V‚˝‚Ȑ§Œä‹@\
™‰Y—íŽq
‘ć28‰ń_ŒË‘ĺŠwˆăŠw•”ƒoƒCƒIƒTƒCƒGƒ“ƒXŒ¤‹†‰ď@2004”N3ŒŽ24“úi_ŒËj

RNA‚đ‰î‚ˇ‚éƒ}ƒbƒvƒLƒi[ƒ[ƒVƒOƒiƒ‹‚̐V‚˝‚Ȑ§Œä‹@\
™‰Y—íŽqAŠě‘˝ˆťŽqAt“Ą‹vlA‹v–ě‚‹`
ƒVƒ“ƒ|ƒWƒEƒ€FuƒVƒOƒiƒ‹“`’BŒ¤‹†‚ĚĹ‘OüF‘n–ň‚Ö‚Ě“WŠJ‚đ‚ß‚´‚ľ‚āv
‘ć77‰ń“ú–{–ň—Šw‰ď”N‰ď@2004”N3ŒŽ8-10“úi‘ĺă)

Calcineurin pathway in the fission yeast Schizosaccharomycespombe.
Takayoshi Kuno, Hisato Shuntoh, Yabin Lu, Ayako Kita, Reiko Sugiura
6th International Conference@on Protein Phosphatases & International Symposium on Nano-Biotechnology
February 18-20, Okayama, 2004

2003”N“x@Šw‰ď”­•\

•Ş—ôy•ę‚É‚¨‚Ż‚éƒĘ-adaptin‚ĆƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚Ě‹@”\“IŠÖ˜A
Šě‘˝ˆťŽqA™‰Y—íŽqAŻŽq—T”üA–ź”¨rĆA‹{•MAă–{’q‰ŘA˜CˆŸŕ_At“Ą‹vlA‹v–ě‚‹`
‘ć26‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2003”N12ŒŽ10`13“úi_ŒËj

•Ş—ôy•ę‚Ěƒ†ƒrƒLƒ`ƒ“ƒzƒƒIƒXƒ^ƒVƒX‚ÉŠÖ—^‚ˇ‚élub1+‚Ě‹@”\‰đÍ
–ö’JŒŤŽuAŹ–Ř‘]‘אŹA™‰Y—íŽqA‹{•MA”n‰A˜CˆŸŕ_At“Ą‹vlA‹v–ě‚‹`
‘ć26‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2003”N12ŒŽ10`13“úi_ŒËj

•Ş—ôy•ęplc1+ˆâ“`Žq‚Ě‹@”\‰đÍ
Lu DengA™‰Y—íŽqA‘ž“c˜aŽ÷A‘吟–ƒ‹MA‘˝“cˆęéA‰˝ˆŐA˜CˆŸŕ_At“Ą‹vlA‹v–ě‚‹`
‘ć26‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2003”N12ŒŽ10`13“úi_ŒËj

ƒJƒ‹ƒVƒEƒ€‚É’´Š´ŽóŤ‚đŽŚ‚ˇ•Ş—ôy•ę•ĎˆŮ‘Ě‚Ě’P—Ł‚Ćˆâ“`Žq‚Ě“Ż’č
‰˝ˆŐA™‰Y—íŽqALu DengA”n‰A‚ˆä‹KŽqAŹ–Ř‘]‘אŹA˜CˆŸŕ_At“Ą‹vlAâăŒłËA‹v–ě‚‹`
‘ć26‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2003”N12ŒŽ10`13“úi_ŒËj

ƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚Ć•Ş—ôy•ęƒNƒ‰ƒXƒŠƒ“d˝‚Ć‚Ěˆâ“`Šw“I‚¨‚ć‚Ń‹@”\“IŠÖ˜A
’Ň‰Şˆę–çA“Ą“cšşA™‰Y—íŽqA––L‹MŽjAâ–{‹IŽqA’|“ŕ^ˆßA˜CˆŸŕ_At“Ą‹vlA‹v–ě‚‹`
‘ć26‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2003”N12ŒŽ10`13“úi_ŒËj

•Ş—ôy•ęƒ‚ƒfƒ‹Œn‚đ—p‚˘‚˝ƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚Ě“ŕˆöŤƒCƒ“ƒqƒrƒ^[Cbp1‚Ě‹@”\‰đÍ
´…NlA™‰Y—íŽqAœAˆŔ^ŽŔAŠě‘˝ˆťŽqA‚ŒŠ’m“żA“Ą“cšşA˜CˆŸŕ_At“Ą‹vlA‹v–ě‚‹`
‘ć26‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2003”N12ŒŽ10`13“úi_ŒËj

ƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚É‚ć‚萧Œä‚ł‚ę‚ézinc fingerŒ^“]ŽĘˆöŽqPrz1‚Ě‹@”\‰đÍ
ěŠÝŒ’“ńA™‰Y—íŽqAÖ“Ą^—ŽqA‹{–{ˆč‹|A’|“ŕ˛_A˜CˆŸŕ_At“Ą‹vlA‹v–ě‚‹`
‘ć26‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2003”N12ŒŽ10`13“úi_ŒËj

•Ş—ôy•ęƒ‚ƒfƒ‹Œn‚đ—p‚˘‚˝MAPƒLƒi[ƒ[Œo˜H‚É‚¨‚˘‚Ä‹@”\‚ˇ‚éˆöŽq‚Ě“Ż’č
”n‰A™‰Y—íŽqAŠě‘˝ˆťŽqAŻŽq—T”üA‚ŒŠ’m“żA’|“ŕ^ˆßA‰Ş‘şŒŠA˜CˆŸŕ_At“Ą‹vlA‹v–ě‚‹`
‘ć104‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2003”N11ŒŽ7“úi‘ĺăj

•Ş—ôy•ęƒ‚ƒfƒ‹Œn‚đ—p‚˘‚˝R‚Ä‚ń‚Š‚ń–ňƒoƒ‹ƒvƒŽ_’´Š´ŽóŤ•ĎˆŮ‘̂̉đÍ‚¨‚ć‚Ń‚ť‚ĚŒ´ˆöˆâ“`Žq‚Ě“Ż’č
‹{•MA™‰Y—íŽqA–ź”¨rĆAŠě‘˝ˆťŽqA´…NlAœAˆŔ^”üA‚ˆä‹KŽqA˜CˆŸŕ_At“Ą‹vlA‹v–ě‚‹`
‘ć104‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2003”N11ŒŽ7“úi‘ĺăj

•Ş—ôy•ę‚É‚¨‚Ż‚éƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚Ćƒ~ƒIƒVƒ“‚Ěˆâ“`Šw“IŠÖŒW‚ĆŽűkŠÂŒ`Ź‚É‚¨‚Ż‚é–đŠ„
“Ą“cšşA™‰Y—íŽqALu YabinALinxiao XuAYujie XiaAt“Ą‹vlA‹v–ě‚‹`
‘ć76‰ń“ú–{–ň—Šw‰ď”N‰ď@2003”N3ŒŽ24“úi•Ÿ‰Ş)

2002”N“x@Šw‰ď”­•\

ƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚Ć‹@”\“I‚ÉŠÖ˜A‚ˇ‚é•Ş—ôy•ęWASPiWiskott-Aldrich Syndrome proteinjƒzƒ‚ƒƒOWsp1‚Ě‹@”\‰đÍ
’|“ŕ‹v”üŽqA™‰Y—íŽqAě–{çÎAŽRŠÝO“TA‹{–{ˆč‹|AŹź“ń•vAă–{’q‰ŘA˜CˆŸŕ_A‹v–ě‚‹`At“Ą‹vl
‘ć102‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2002”N11ŒŽ15“úi‰ŞŽRj

ƒXƒgƒŒƒX—U“ąŤR‚Ş‚ńÜ‘ϐŤ‚É‚¨‚Ż‚éƒvƒƒeƒAƒ\[ƒ€Šj’~Ď‚ĚŠÖ—^
Ź–Ř‘]‘אŹA•y“cÍOA’ß”ö—˛A‹v–ě‚‹`
‘ć102‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2002”N11ŒŽ15“úi‰ŞŽRj

Functional interaction between Its5/Ypt3 and calcineurin in the regulation of fission yeast exocytic pathway.
Hong Cheng, Reiko Sugiura, Masaaki Fujita, Yabin Lu, Susie O. Sio, , Kaoru Takegawa, Hisato Shuntoh, Takayoshi Kuno
The Second International Fission Yeast Meeting, March 25-30, Kyoto, 2002

Functional analysis of Its1, a clathrin-associated adaptor protein complex (AP-2) beta subunit in fission yeast.
Chika Sakamoto, Reiko Sugiura, Hong Cheng, Yabin Lu, Takayoshi Kuno, Kaoru Takegawa, Hisato Shuntoh
The Second International Fission Yeast Meeting, March 25-30, Kyoto, 2002

Functional Analysis of Calcineurin-Mediated Signalling Pathway Using Fission Yeast as a Model System
Reiko Sugiura, Hong Cheng, Hisato Shuntoh, Takayoshi Kuno.
5th International Conference on Protein Phosphatases, Protein Phosphatases in Cellular Signaling Systems, March 13-15, Okazaki, 2002

•Ş—ôy•ęzinc fingerŒ^“]ŽĘˆöŽqPrz1‚̓Jƒ‹ƒVƒjƒ…[ƒŠƒ“‚Ěƒ^[ƒQƒbƒg‚Ěˆę‚‚ł ‚é
•˝ŽR‰€ŽqA™‰Y—íŽqAěŠÝŒ’“ńA˜CˆŸŕ_A‰ĄŽRŒőGAt“Ą‹vlA‹v–ě‚‹`
‘ć101‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@2002”N6ŒŽ21“úiäj

•Ş—ôy•ęIts1/clathrin-associated protein (AP-2) beta-adaptin‚ĚŒ‡‘š‚Í‘˝Ę‚Č•\ŒťŒ^‚đˆř‚Ť‹N‚ą‚ˇ
t“Ą‹vlAă–{’q‰ŘA’ögA™‰Y—íŽqA˜CˆŸŕ_Aě–{çÎA’|“ŕ‹v”üŽqAŽRŠÝO“TA‹v–ě‚‹`
‘ć75‰ń“ú–{–ň—Šw‰ď”N‰ď@2002”N3ŒŽ13`15“úiŒF–{j

2001”N“x@Šw‰ď”­•\

Genetic and biochemical analysis of calcineurin-mediated signaling pathway using fission yeast as a model system.
Reiko Sugiura, Hong Cheng, Tomoko Yada, Hisato Shuntoh, Susie Sio, Takayoshi Kuno
20th International Conference on Yeast Genetics and Molecular Biology, Prague, Czech Republic, 2001

ƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚Ćƒ~ƒIƒVƒ“‚Ěˆâ“`Šw“IŠÖŒW
Xu LinxiaoA™‰Y—íŽqACheng HongA•˝ŽR‰€ŽqA–kě‰p”üAă’JW–çA–î“c•üŽqALu YabinAt“Ą‹vlA‹v–ě‚‹`
‘ć74‰ń“ú–{–ň—Šw‰ď”N‰ď@2001”N3ŒŽ21`23“úi‰Ą•lj

ƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚Ćˆâ“`“I‚ÉŠÖ˜A‚ˇ‚éV‹Kˆâ“`Žqits4+‚̉đÍ
–ě‘ş‰p–žA™‰Y—íŽqA‰Şč‘ž˜YAŠě‘˝ˆťŽqAˆÉ“Ą—D”üA“Ą“cšşAă–{’q‰ŘAt“Ą‹vlA‹v–ě‚‹`
‘ć74‰ń“ú–{–ň—Šw‰ď”N‰ď@2001”N3ŒŽ21`23“úi‰Ą•lj

2000”N“x@Šw‰ď”­•\

Genetic and biochemical analysis of calcineurin-mediated signaling pathway using fission yeast as a model system.
Reiko Sugiura, Hisato Shuntoh, Takayoshi Kuno
4th International Conference on Protein Phosphatases, "Role of Protein Phosphatases in Intracellular Signaling Systems", Sendai, 2000

•Ş—ôy•ęƒ‚ƒfƒ‹Œn‚đ—p‚˘‚˝ƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚Ě‹@”\‰đÍiƒVƒ“ƒ|ƒWƒEƒ€j
t“Ą‹vlA™‰Y—íŽqA˜C@ˆŸŕ_A‹v–ě‚‹`
‘ć73‰ń“ú–{ś‰ťŠw‰ď‘ĺ‰ď@2000”N10ŒŽ11`14“úi‰Ą•lj

•Ş—ôy•ęƒ‚ƒfƒ‹Œn‚đ—p‚˘‚˝ƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚Ě•W“I•ŞŽq‚Ě“Ż’č‚Ć‹@”\‰đÍiƒ[ƒNƒVƒ‡ƒbƒvj
™‰Y—íŽqAt“Ą‹vlA‹v–ě‚‹`
‘ć23‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2000”N12ŒŽ13`16“úi_ŒËj

•Ş—ôy•ęƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚Ć‹@”\“I‚ÉŠÖ˜A‚ˇ‚ébeta-adaptin‚Ě’P—Ł‚Ć‹@”\‰đÍ
ă–{’q‰ŘAt“Ą‹vlA˜CˆŸŕ_A™‰Y—íŽqA‹v–ě‚‹`
‘ć33‰ńy•ęˆâ“`ŠwƒtƒH[ƒ‰ƒ€Œ¤‹†•ń‰ď@2000”N8ŒŽ‚V`‚X“úi“Œ‹žj

ƒ†ƒrƒLƒ`ƒ“|ƒvƒƒeƒAƒ\|ƒ€Œn‚đ‰î‚ľ‚˝ƒXƒgƒŒƒX‰ž“š‹@\‚ÉŠÖ—^‚ˇ‚éuts2+‚Ě’P—Ł‚ƉđÍ
‰Á–Ý—ǁAˆÉ“Œ@Œ°AŹň‰ë]A™‰Y—íŽqAt“Ą‹vlAŽs‹´łŒőA‹v–ě‚‹`
‘ć33‰ńy•ęˆâ“`ŠwƒtƒH[ƒ‰ƒ€Œ¤‹†•ń‰ď@2000”N8ŒŽ‚V`‚X“úi“Œ‹žj

ƒ†ƒrƒLƒ`ƒ“|ƒvƒƒeƒAƒ\|ƒ€Œn‚đ‰î‚ľ‚˝ƒXƒgƒŒƒX‰ž“š‹@\‚ÉŠÖ—^‚ˇ‚éuts2+‚Ě’P—Ł‚ƉđÍ
‰Á–Ý—ǁA™‰Y—íŽqA‹v‰ä@“ցA‘OěŸ‰pA‹{–{—Ż”üA‰ŞčF‰fAt“Ą‹vlAŽs‹´łŒőA‹v–ě‚‹`
‘ć23‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2000”N12ŒŽ13`16“úi_ŒËj

ƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚Ć‹@”\“I‚ÉŠÖ˜A‚ˇ‚é•Ş—ôy•ębeta-adaptinˆâ“`Žqits1+‚̉đÍ
ă–{’q‰ŘAt“Ą‹vlA˜CˆŸŕ_A™‰Y—íŽqA‰Şč‘ž˜YAˆÉ“Ą—D”üA—с@•Ű‰Aě–{çÎA’|“ŕ‹v”üŽqA‹v–ě‚‹`
‘ć23‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2000”N12ŒŽ13`16“úi_ŒËj

•Ş—ôy•ęPI(4)P5K Its3‚̓Jƒ‹ƒVƒjƒ…[ƒŠƒ“Ppb1‚Ć‹¤“Ż“I‚ɍזEŽż•Ş—ô‚đ§Œä‚ˇ‚é
‘O“c‘ń–çA’Ł‰pž^A™‰Y—íŽqA˜CˆŸŕ_A’ögAˆÉ“ĄrŽ÷A’|“ę’‰bAt“Ą‹vlA‹v–ě‚‹`
‘ć23‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2000”N12ŒŽ13`16“úi_ŒËj

ƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚ĆGPI anchor‡Źy‘f‚Ěˆâ“`Šw“I‹y‚Ń‹@”\“IŠÖ˜A
–î“c•üŽqA™‰Y—íŽqAŠě‘˝ˆťŽqA“Ą“cšşAă’JW–çA–kě‰p”üA•˝ŽR‰€ŽqA™—Ń‹ăŒŐAt“Ą‹vlA‹v–ě‚‹`
‘ć23‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@2000”N12ŒŽ13`16“úi_ŒËj

1999”N“x@Šw‰ď”­•\

Dual Functions of a novel MAPKK, Pek1 as a phosphorylation-dependent molecular switch.
Reiko Sugiura, Takashi Toda, Susheela Dhut, Hisato Shuntoh, Takayoshi Kuno
First International Fission Yeast Meeting, Edinburgh, UK 1999

ƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚Ć‹@”\“I‚ÉŠÖ˜A‚ˇ‚é•Ş—ôy•ębeta-adaptin‚Ě’P—Ł‚Ć‹@”\‰đÍ
ă–{’q‰ŘAt“Ą‹vlA‘şă‚Š‚¨‚éA‰ÁX”ü—œšA—]‹˝‰Ŕ‘ăŽqAŒŕ•ś˜@A‰Ä‰Fž^A˜CˆŸŕ_A™‰Y—íŽqA‹v–ě‚‹`@@@
‘ć96‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@1999”N11ŒŽ5“úi‹ž“sŽsj

–Ɖu—}§–ňiFK506j‚ÉŠ´ŽóŤ‚Ĺ‚ ‚é•Ş—ôy•ę•ĎˆŮ‘́iits8j‚Ě•ĎˆŮˆâ“`Žq‚Ě’P—Ł‹y‚Ń‹@”\‰đÍ
–î“c•üŽqA™‰Y—íŽqA’Ł‰pž^AH“Ą—˜ĘA”’ěƒA’ögA‰Şč‘ž˜YAt“Ą‹vlA‹v–ě‚‹`
‘ć96‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@1999”N11ŒŽ5“úi‹ž“sj

•Ş—ôy•ęV‹Kˆâ“`Žq (uts2+)‚̓†ƒrƒLƒ`ƒ“|ƒvƒƒeƒAƒ\[ƒ€Œo˜H‚đ‰î‚ľ‚˝ƒXƒgƒŒƒX‰ž“š‚ÉŠÖ—^‚ˇ‚é
‰Á–Ý—ǁA™‰Y—íŽqAŹŽÄ‚ä‚Š‚čA™—Ń‹ăŒŐA‘OěŸ‰pAŹň‰ë]AˆÉ“ŒŒ°AŽs‹´łŒőAt“Ą‹vlA‹v–ě‚‹`@
‘ć96‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@1999”N11ŒŽ5“úi‹ž“sj

•Ş—ôy•ę‚ĚƒŠƒ`ƒEƒ€•W“I•ŞŽq‚Ě“Ż’č‚Ć‚ť‚Ěˆâ“`ŽqƒmƒbƒNƒAƒEƒg
‹{–{—Ż”üA™‰Y—íŽqAă’JW–çA–î“c•üŽqA˜CˆŸŕ_ASusie O. SioA’Š‘qš”ŽAź‹v–žśA
t“Ą‹vlA‹v–ě‚‹`@@@
‘ć96‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@1999”N11ŒŽ5“úi‹ž“sj

1998”N“x@Šw‰ď”­•\

Isolation of Multicopy Suppressors of Calcineurin Deficiency in Fission Yeast.
Takayoshi Kuno, Reiko Sugiura, Hisato Shuntoh
3rd International Conference on Cellular Regulation by Protein Phosphatases. Hiroshima, Japan, 1998

pmp1+, a suppressor of calcineurin deficiency, encodes a novel MAP kinase phosphatase in fission yeast.
Reiko Sugiura, Takashi Toda, Hisato Shuntoh, Mitsuhiro Yanagida, Takayoshi Kuno
Conference on Signalling Network for Cellular Regulation, Kobe, Japan, 1998

ƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚Ě•ŞŽqˆâ“`ŠwiƒVƒ“ƒ|ƒWƒEƒ€j
t“Ą‹vlA™‰Y—íŽqA‹v–ě‚‹`
‘ć71‰ń“ú–{ś‰ťŠw‰ď‘ĺ‰ď@1998”N10ŒŽ14`17“úi–źŒĂ‰Žj

ƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚ƐV‹KMAPƒLƒi[ƒ[ƒzƒXƒtƒ@ƒ^[ƒ[‚ĚCl-ƒzƒƒIƒXƒ^ƒVƒX‚É‚¨‚Ż‚é‹Ś“Ż“I–đŠ„
™‰Y—íŽqAt“Ą‹vlA“Ą“c“N’jAH“Ą—˜ĘA‹v–ě‚‹`
‘ć71‰ń“ú–{–ň—Šw‰ď”N‰ď@1998”N3ŒŽ23`26“úi‹ž“sj

•Ş—ôy•ęƒJƒ‹ƒVƒjƒ…[ƒŠƒ“ŠÖ˜Aˆâ“`Žqits2+‚Ě’P—Ł‚ƉđÍ
Žá‰h“ż•FAt“Ą‹vlA™‰Y—íŽqA™—с@A’Ł‰pž^A‹v–ě‚‹`
‘ć71‰ń“ú–{–ň—Šw‰ď”N‰ď@1998”N3ŒŽ23`26“úi‹ž“sj

•Ş—ôy•ęMAP kinase kinase Pek1‚É‚ć‚éPmk1 MAP kinaseŒo˜H‚ĚŠˆŤ‰ť‚Ć—}§
™‰Y—íŽqA“o“c—˛At“Ą‹vlA‹v–ě‚‹`
‘ć31‰ńy•ęˆâ“`ŠwƒtƒH[ƒ‰ƒ€Œ¤‹†•ń‰ď@1998”N8ŒŽ5`7“úi‘ĺăj

•Ş—ôy•ęMAP kinase kinase Pek1‚É‚ć‚éPmk1 MAP kinaseŒo˜H‚ĚŠˆŤ‰ť‚Ć—}§
™‰Y—íŽqAt“Ą‹vlA“o“c—˛ASusie O. SioA‘OěŸ‰pA‹v–ě‚‹`
‘ć21‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@1998”N12ŒŽ16`19“úi‰Ą•lj

Ž‡ŠOüƒXƒgƒŒƒX‰ž“š‹@\‚Ě•ŞŽqˆâ“`Šw“I‰đÍ
‰Á–Ý—ǁAˆÉ“Œ@Œ°A™‰Y—íŽqA‹v‰ä“ցAt“Ą‹vlA™—Ń‹ăŒŐAH“Ą—˜ĘA‹{–{—Ż”üAŽs‹´łŒőA‹v–ě‚‹`@@@
‘ć21‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@1998”N12ŒŽ16`19“úi‰Ą•lj

•Ş—ôy•ę1,3-beta-ƒOƒ‹ƒJƒ“‡Źy‘f‚Ěˆâ“`Šw“I‰đÍ
t“Ą‹vlAŽá‰h“ż•FA™‰Y—íŽqA˜CˆŸŕ_AŒŕ•ś˜@A‰Ä‰Fž^A’Ł‰pž^A–î“c•üŽqA‹v–ě‚‹`
‘ć21‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@1998”N12ŒŽ16`19“úi‰Ą•lj

1997”N“x@Šw‰ď”­•\

pmp1+, a suppressor of calcineurin deficiency, encodes a novel MAP kinase phosphatase in fission yeast
Reiko Sugiura, Takashi Toda, Hisato Shuntoh, Mitsuhiro Yanagida, Takayoshi Kuno
The 3rd UK-Japan Cell Cycle Workshop The Cell Cycle: Regulation and Mechanism, Kyoto, Japan, 1997

×–E‘B‚ĆŒ`‘ÔŒ`Ź‚É‚¨‚Ż‚éƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚Ě–đŠ„iƒVƒ“ƒ|ƒWƒEƒ€j
t“Ą‹vlA™‰Y—íŽqA‹v–ě‚‹`
‘ć70‰ń“ú–{ś‰ťŠw‰ď‘ĺ‰ď@1997”N6ŒŽ22`25“úi‹ŕ‘ňj

ƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚Ć‹@”\“I‚ÉŠÖ˜A‚ˇ‚é•Ş—ôy•ę‚Ě’á•ŞŽq—ĘGTPŒ‹‡’`”’Žżˆâ“`Žqits5+‚Ě’P—Ł‚ƉđÍ
Œŕ•ś˜@A™‰Y—íŽqAt“Ą‹vlA‹v–ě‚‹`
‘ć91‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@1997”N6ŒŽ20“úiL“‡j

•Ş—ôy•ęchloride ion’´Š´ŽóŤ•ĎˆŮŠ”‚Ě•Ş—Ł‚ƉđÍ
™‰Y—íŽqA‰Ä‰Fž^A´ě‹v”üŽqAt“Ą‹vlA‹v–ě‚‹`
‘ć91‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@1997”N6ŒŽ20“úiL“‡j

PI4P 5kinase‚Ć‹@”\“I‚ÉŠÖ˜A‚ˇ‚éˆâ“`Žq‚Ě’P—Ł‚Ć“Ż’č
ŽĹč˝ŽiA™‰Y—íŽqAt“Ą‹vlA‹v–ě‚‹`
‘ć20‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@1997”N12ŒŽ16`19“úi‹ž“sj

1996”N“x@Šw‰ď”­•\

Isolation and Characterization of Calcineurin-related Genes in Fission Yeast.
Hisato Shuntoh, Reiko Sugiura, Takayoshi Kuno
Tokyo Metropolitan Institute for Neuroscience Symposium 1996 "Protein Phosphatases & Cellular Regulation", Tokyo, Japan, 1996

ƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚đ‰î‚ˇ‚é×–E“ŕƒVƒOƒiƒŠƒ“ƒO|•Ş—ôy•ę•ĎˆŮ‘Ě‚đ—p‚˘‚˝‰đÍiƒVƒ“ƒ|ƒWƒEƒ€j
t“Ą‹vlA™‰Y—íŽqAˆ˘˛”ü‰ëŽqAŽá‰h“ż•FA—с@’ź”VAŒŕ@‰_˜@A‹g“c—FŒbA´ě‹v”üŽqAˆÉ“Œ@Œ°A•˝ˆä‚Ý‚Ç‚čA‹v–ě‚‹`
‘ć90‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@1996”N10ŒŽ25“úi’Áj

ƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚Ć‹@”\“I‚ÉŠÖ˜A‚ˇ‚éˆâ“`Žq‚Ě“Ż’č‚ƉđÍ
t“Ą‹vlAˆ˘˛”ü‰ëŽqA™‰Y—íŽqAŽá‰h“ż•FAŞˆäkŽĄA‘ĺÎŒ’ˆęAŽR–{^—R”üA‹v–ě‚‹`
‘ć69‰ń“ú–{–ň—Šw‰ď”N‰ď@1996”N3ŒŽ20`23“úi’ˇčj

•Ş—ôy•ę‚ĚCl-ƒzƒƒIƒXƒ^ƒVƒX‚É‚¨‚Ż‚éƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚ƐV‹KMAPƒLƒi[ƒ[‚̝hR“I–đŠ„
™‰Y—íŽqAt“Ą‹vlAźŒ´dŽĄA‰Ä‰Fž^A‰Ąˆä“ÖŽqA‘OěŸ‰pAŽR–{^—R”üA‹v‰ä“ցA“o“c—˛A–ö“c[OA‹v–ě‚‹`
‘ć90‰ń“ú–{–ň—Šw‰ď‹ß‹E•”‰ď@1996”N10ŒŽ25“úi’Áj

•Ş—ôy•ę‚ĚCl-ƒzƒƒIƒXƒ^ƒVƒX‚É‚¨‚Ż‚éƒJƒ‹ƒVƒjƒ…[ƒŠƒ“‚ƐV‹KMAPƒLƒi[ƒ[‚̝hR“I–đŠ„
™‰Y—íŽqAt“Ą‹vlA“o“c—˛A–ö“c[OA‹v–ě‚‹`
‘ć29‰ńy•ęˆâ“`ŠwƒtƒH[ƒ‰ƒ€Œ¤‹†•ń‰ď@1996”N12ŒŽ5`7“úiŒF–{j

1995”N“x@Šw‰ď”­•\

•Ş—ôy•ęƒ‚ƒfƒ‹Œn‚É‚¨‚Ż‚é–Ɖu—}§–ňFK506’´Š´ŽóŤ•ĎˆŮ‘̂̉đÍiƒVƒ“ƒ|ƒWƒEƒ€j
t“Ą‹vlA™‰Y—íŽqAˆ˘˛”ü‰ëŽqAˆÉ“Ą˝ŽqA—é–؍ŽšA‘ĺÎŒ’ˆęAźŽRł„A‹v–ě‚‹`
‘ć68‰ń“ú–{–ň—Šw‰ď”N‰ď@1995”N3ŒŽ21`24“úi–źŒĂ‰Žj

•Ş—ôy•ędsp1+ˆâ“`Žq‚ƁAmkk1+ˆâ“`Žq‚̓Jƒ‹ƒVƒjƒ…[ƒŠƒ“ˆâ“`Žq”j‰ó‚Ě‚ŕ‚˝‚炡‚‰–Š´ŽóŤ‚ɑ΂ˇ‚é‘˝ƒRƒs[ƒTƒvƒŒƒbƒT[‚Ĺ‚ ‚čAdsp1+‚͍זEŽż•Ş—ô§Œä‚É‚ŕŠÖ—^‚ˇ‚é
™‰Y—íŽqAt“Ą‹vlAˆ˘˛”ü‰ëŽqAŽR–{^—R”üA“o“c—˛A–ö“c[OA‹v–ě‚‹`
‘ć18‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@1995”N12ŒŽ6`9“úi–źŒĂ‰Žj

•Ş—ôy•ęb-adaptin homologˆâ“`Žq‚Ě•ĎˆŮ‚Í–Ć‰u—}§–ňŠ´ŽóŤ‚đˆř‚Ť‹N‚ą‚ˇ
t“Ą‹vlA™‰Y—íŽqAˆ˘˛”ü‰ëŽqAŞˆäkŽĄAŽá‰h“ż•FA‘ĺÎŒ’ˆęA‹v–ě‚‹`
‘ć18‰ń“ú–{•ŞŽqś•¨Šw‰ď”N‰ď@1995”N12ŒŽ6`9“úi–źŒĂ‰Žj

•ŞŽqˆă—ÁEƒQƒmƒ€‘n–ňŠwŒ¤‹†Žş

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