2023
Morikawa T : Pharmaceutical food science: search for bio-functional molecules obtained from natural resources to prevent and ameliorate lifestyle disease．Chem. Pharm. Bull., 71, 756–765 (2023)
Matsuda H, Morikawa T, Nakamura S, Muraoka O, Yoshikawa M : New biofunctional effects of oleanane-type triterpene saponins．J. Nat. Med., 77, 644–664 (2023)
Shimoda H, Takeda S, Miyasaka K, Yoneda A, Manse Y, Morikawa T : Diverse effects of single molecules of rice-dirived functional lipids, glucosylceramides, ceramides, and β-sitosterol glucoside, on epidermal and lung functions.Glycative Stress Res., 10, 94–109 (2023)
Sakamoto Y, Inoue Y, Nakanishi Y, Ninomiya K, Yoshikawa M, Muraoka O, Manse Y, Morikawa T : Hepatoprotective principles from the rhizomes of Picrorhiza kurroa．Biol. Pharm. Bull., 46, 848–855 (2023)
山口朋子、羅 鳳琳、橋本統星、赤木淳二、萬瀬貴昭、二宮清文、森川敏生: 肥満症に用いられる3種の漢方薬の女性ホルモン様作用と脂肪蓄積抑制効果．診療と新薬, 60, 179–187 (2023)
Matsuda H, Nagatomo A, Hatakeyama M, Manse Y, Yoshikawa M, Morikawa T : Suppressive effects of Bombycis Feces (bombyx feces) and Bombyx Batryticatus (stiff silkworm) extracts on blood glucose level elevation in disaccharides-loaded rats．Tradit. Kampo Med.，10，132–141 (2023)，
Fenglin Luo, Yoshiaki Manse, Saowanee Chaipech, Yutana Pongpiriyadacha Osamu Muraoka and Toshio Morikawa. Structures of mammeasins P and Q, coumarin-related polysubstituted benzofurans from the Thai medicinal plant Mammea siamensis (Miq.) T. Anders.: anti-proliferative activity of coumarin constituents against human prostate carcinoma cell line LNCaP. Pharmaceuticals, 16, 231 (2023).
Fenglin Luo, Yoshiaki Manse, Satoshi Ishikawa, Sakura Nishi, Anshin Chen, Tao Wang, Toshio Morikawa. Aromatase inhibitors isolated from a flowering tea, snow Chrysanthemum (the capitula of Coreopsis tinctoria Nutt.). J. Nat. Med. (2023).
Takeda, Shogo, Akari Yoneda, Kenchi Miyasaka, Yoshiaki Manse, Toshio Morikawa, and Hiroshi Shimoda. Comparative study on epidermal moisturizing effects and hydration mechanisms of rice-derived glucosylceramides and ceramides. Int. J. Mol. Sci., 24, 83 (2023).
2022
Katsuki Takashima, Miyu Teramachi, Shinsuke Marumoto, Fumihiro Ishikawa, Yoshiaki Manse, Toshio Morikawa, Genzoh Tanabe. Structure-activity relationship study of 4,5-didehydroguadiscine, an aporphine alkaloid showing potent melanogenesis-inhibitory activity in B16 melanoma cells. Bioorg. Med. Chem. Lett., 78, 129034 (2022).
下田博司，森川敏生.コメ由来グルコシルセラミドおよびセラミドの機能性.Food Style 21,26,50-55（2022).
Akifumi Nagatomo, Kiyofumi Ninomiya, Shinsuke Marumoto, Chie Sakai, Shuta Watanabe, Wakana Ishikawa, Yoshiaki Manse, Takashi Kikuchi, Takeshi Yamada, Reiko Tanaka, Osamu Muraoka, Toshio Morikawa. A Gedunin-Type Limonoid, 7-Deacetoxy-7-Oxogedunin, from Andiroba (Carapa guianensis Aublet) Reduced Intracellular Triglyceride Content and Enhanced Autophagy in HepG2 Cells. Int. J. Mol. Sci., 23, 13141 (2022).
Kenchi Miyasaka, Yoshiaki Manse, Akari Yoneda, Shogo Takeda, Norihito Shimizu, Wakana Yamada, Toshio Morikawa, Hiroshi Shimoda. Anti-melanogenic effects of glucosylceramides and elasticamide derived from rice oil by-products in melanoma cells, melanocytes, and human skin. J. Food Biochem., 46, e14353 (2022).
Fenglin Luo, Yoshiaki Manse, Saowanee Chaipech, Yutana Pongpiriyadacha, Osamu Muraoka, Toshio Morikawa. Phytochemicals with Chemopreventive Activity Obtained from the Thai Medicinal Plant Mammea siamensis (Miq.) T. Anders.: Isolation and Structure Dtermination of New Prenylcoumarins with Inhibitory Activity against Aromatase. Int. J. Mol. Sci., 23, 11233 (2022).
田上貴臣，石田晃太，石原理恵，伊藤美千穂，大井逸輝，岡坂 衛，河端昭子，酒井英二，蔦原稜太，西尾雅世，松田久司，森川敏生，山本 豊，横倉胤夫，エンメイソウについて：HPLCによるエンメイン分析法の検討と市場品の分析，生薬学雑誌，76, 37-44 (2022).
Toshio Morikawa, Bio-Functional Natural Products in Edible Resources for Human Health and Beauty. Molecules, 27, 5060 (2022).
Yoshiaki Manse, Yusuke Sakamoto, Taiki Miyachi, Mitsuyo Nire, Yoshinori Hashimoto, Sawanee Chaipech, Yutana Pongpiriyadacha, Toshio Morikawa, Antiallergic Properties of Biflavonoids Isolated from the Flowers of Mesua ferrea Linn. Separations, 9, 127 (2022).
Kosuke Kitahata, Kazuhiko Matsuo, Masako Sato, Yoko Susami, Yuta Hara, Toshio Morikawa, Naoki Oiso, Akira Kawada, Atsushi Otsuka, Takashi Nakayama, Anti-allergic effect of ascorbic acid derivative DDH-1 in a mouse model of atopic dermatitis. Exp. Dermatol., 31, 1234-1242 (2022).
Akifumi Nagatomo, Naoki Inoue, Takuya Konno, Yin Xu, Chinatsu Sakamoto, Mayuko Sone, Aya Shibasaka, Osamu Muraoka, Kiyofumi Ninomiya, Masayuki Yoshikawa, Yoshiaki Manse, Toshio Morikawa, Ursane-type triterpene oligoglycosides with anti-hepatosteatosis and anti-hyperlipidemic activity from the leaves of Ilex paraguariensis A. St.-Hil. J. Nat. Med., 76, 654-669 (2022).
森川敏生．食用資源が有する機能性成分の探索と今後の可能性：ローズヒップの体脂肪低減効果．JATAFF ジャーナル，10, 43-47 (2022).
Souichi Nakashima, Yoshimi Oda, Moeko Morita, Ayako Ohta, Toshio Morikawa, Hisashi Matsuda, Seikou Nakamura. Analysis of active compounds using target protein cofilin—cucurbitacins in cytotoxic plant Bryonia cretica. Toxins, 14, 212 (2022).
Hiroshi Shimoda, Toshio Morikawa. Tomato seed saponins promise to cure dermatitis. Research Outreach, 128, 122-125 (2022).
2021
中嶋聡一，諸頭佑香，米山眞穂，森川敏生，松田久司，中村誠宏．糖化タンパク質がメラニンの生成に与える影響．FRAGRANCE JOURNAL, 49, 46-47 (2021).
Wei Zhang, Kun Ren, Shuangfeng Wu, Jingyan Guo, Shumeng Ren, Yingni Pan, Dongmei Wang, Toshio Morikawa, Huiming Hua, Xiaoqiu Liu. Cytotoxicity evaluation and metabolism of hepatotoxicity components of Euodiae Fructus in L02 cells.J. Chromatogr. B.1186, 123040 (2021).
森川敏生．花を食べるー食用素材として花部が利用される植物に含まれる機能性成分の探索．FFI JOURNAL, 226, 323-332 (2021).Review
Shogo takeda, Kenchi Miyasaka, Sarita Shrestha, Yoshiaki Manse, Toshio Morikawa, Hiroshi Shimoda. Lycoperoside H, a tomato seed saponin, improve epidermal dehydration by increasing ceramide in the stratum corneum and steroidal anti-inflammatory effect. Molecules, 26, 5860 (2021).News Release
Yongli Guo, Qingling Cui, Shumeng Ren, Deguo Hao, Toshio Morikawa, Dongmei Wang, Xiaoqiu Liu, Yingni Pan. The hepatoprotective efficacy and biological mechanisms of three phenylethanoid glycosides from cistanches herba and their metabolites based on intestinal bacteria and network pharmacology. J. Nat. Med.,75, 784-797 (2021).
Toshio Morikawa, Kiyofumi Ninomiya, Genzoh Tanabe, Hisashi Matsuda, Masayuki Yoshikawa, Osamu Muraoka. A review of antidiabetic active thiosugar sulfoniums, salacinol and neokotalanol, from plants of the genus Salacia. J. Nat. Med., 75, 449-466 (2021).
Wei Zhang, Kun Ren, Shumeng Ren, Shuang Lv, Yingni Pan, Dongmei Wang, Toshio Morikawa, Xiaoqiu Liu. UPLC-Q-Exactive-MS analysis for the hepatotoxicity components of Evodiae Fructus based on spectrum-toxicity relationship. J. Chromatogr. B., 1176,122772 (2021).
Toshio Morikawa, Yoshiaki Manse, Fenglin Luo, Haruko Fukui, Yamato Inoue, Tsuyoshi Kaieda, Kiyofumi Ninomiya, Osamu MMuraoka, Masayuki Yoshikawa. Indole Glycosides from Calanthe discolor with Proliferative Activity on Human Hair Follicle Dermal Papilla Cells. Chem. Pharm. Bull., 69, 464-471 (2021).Featured Article
Masakazu Kobayashi, Junji Akaki, Kiyofumi Ninomiya, Masayuki Yoshikawa, Osamu Muraoka, Toshio Morikawa, Masato Odawara. Dose-Dependent Suppression of Postprandial Hyperglycemia and Improvement of Blood Glucose Parameters by Salacia chinensis Extract: Two Randomized, Double-Blind, Placebo-Controlled Studies. J. Med. Food, 24 (1),10-17 (2021).
Yoshiaki Manse, Fenglin Luo, Kazuhiro Kato, Akane Okazaki, Eriko Okada-Nishida, Mitsuhiro Yanagita, Sho Nakamura, Toshio Morikawa. Ent-kaurane-type diterpenoids from Isodonis Herba activate human hair follicle dermal papilla cells proliferation via the Akt/GSK-3β/β-catenin transduction pathway. J. Nat. Med. in Online.News Release
Fumihiro Ishikawa, Aiko Hirano, Yuuto Yoshimori, Kana Nishida, Shinya Nakamura, Kasuki Takashima, Shinsuke Marumoto, Kiyofumi Ninomiya, Isao Nakanishi, Weijia Xie, Toshio Morikawa, Osamu Muraoka, Genzoh Tanabe. Ligand compatibility of salacinol-type α-glucosidase inhibitors toward the GH31 family. RSC Adv., 11, 3221-3225 (2021).2021 RSC Advances Hot Article Collection
Katsuki Takashima, Mika sakano, Eri Kinouchi, Shinya Nakamura, Shinsuke Marumoto, Fumihiro Ishikawa, Kiyofumi Ninomiya, Isao Nakanishi, Toshio Morikawa. Elongation of the side chain by linear alkyl groups increases the potency of salacinal, a potentα-glucosidase inhibitor from the Ayurvedic traditional medicine "Salacia", against human intestinal maltase. Bioorg. Med. Chem. Lett., 33, 127751 (2021).
Fenglin Luo, Hidemi Sugita, Kenichi Muraki, Shunsuke Saeki, Saowanee Chaipech, Yunata Pongpiriyadacha, Osamu Muraoka, Toshio Morikawa. Anti-proliferative activities of coumarins from the Thai medicinal plant Mammea siamensis (Miq.) T. Anders. against human digestive tract carcinoma cell lines. Fitoterapia, 148, 104780 (2021).
2020
Tsuyoshi Takara, Kazuo Yamamoto, Naoko Szuki, Shinichiro Yamashita, Shinichiro Lio, Hayata Noguchi, Toshihiro Kakinuma, Saya Yamamoto, Toshio Morikawa, Shogo Takeda, Hiroshi Shimoda. Moriche Palm (Aguaje) Extract improves indefinite complaints in Japanese females: a randomized, placebo-controlled, double-blind trial. Functional Foods in Health and Disease 2020, 10 (9), 379-396 (2020).
Toshio Morikawa, Satoru Tamura, Tao Wang, Discovery and Total Synthesis of Bio-functional Natural Products From Traditional Medicinal Plants. Front. Chem., 8, 650 (2020). Editorial.
Wei Zhang, Jingyan Guo, Dongmei Wang, Shumeng Ren, Huiming Hua, Toshio Morikawa, Yingni Pan, Xiaoqiu Liu. Effect of CYP3A inducer/inhibitor on pharmacokinetics of five alkaloids in Evodiae Fructus. Chem.-Biol. Interact.,327, 109146 (2020).
ToshioMorikawa, Naoki Inoue, Yusuke Nakanishi, Yoshiaki Manse, Hideyuki Matsuura, Kenji Okino, Shinya Hamasaki, Masayuki Yoshikawa, Osamura Muraoka. Collagen synthesis-promoting and collagenase inhibitory activities of constituents isolated from the rhizomes of Picrorhiza kurroa Royle ex Benth. Fitoterapia, 143, 104584 (2020).
Toshio Morikawa, Fenglin Luo, Yoshiaki Manse, Hidemi Sugita, Shunsuke Saeki, Saowanee Chaipech, Yutana Pongpiriyadacha, Osamu Muraoka, Kiyofumi Ninomiya. Geranylated Coumarins From Thai Medicinal Plant Mammea siamensis With Testosterone 5α-Reductase Inhibitory Activity. Front. Chem., 8, 199 (2020).
Toshio Morikawa, Yusuke Nakanishi, Naoki Inoue, Yoshiaki Manse, Hideyuki
Matsuura, Shinya Hamasaki, Masayuki Yoshikawa, Kiyofumi Ninomiya. Acylated
iridoid glycosides with hyaluronidase inhibitory activity from the rhizomes
of Picrorhiza kurroa Royle ex Benth. Phytochemistry, 169, 112185 (2020).
2019
Toshio Morikawa, Akifumi Nagatomo, Takahiro Oka, Yoshinobu Miki, Norihisa Taira, Megumi Shibano-Kitahara, Osamu Muraoka, Kiyofumi Ninomiya. Glucose tolerance-improving activity of helichrysoside in mice and its structural requiremtns for promoting glucose and lipid metabolism.Int. J. Mol. Sci., 20, 6322 (2019).
Toshio Morikawa, Haihui Xie, Yingni Pan, Kiyofumi Ninomiya, Dan Yuan, Xiaoguang
Jia, Masayuki Yoshikawa, Seikou Nakamura, Hisashi Matsuda, Osamu Muraoka,
A review of biologically active natural products from a desert plant Cistanche
tubulosa. Chem. Pharm. Bull., 67, 675-689 (2019). Review
Toshio Morikawa, Current Topics "Recent Research in Bioactive Natural Products from Traditional Medicinal Plants”. Chem. Pharm. Bull., 67, 632-633 (2019). Foreword.Cover Page
Toshio Morikawa, Shuhei Okugawa, Yoshiaki Manse, Osamu Muraoka, Masayuki
Yoshikawa, Kiyofumi Ninomiya, Quantitative Determination of PrincipalAporphine and Benzylisoquinoline Alkaloids Due to Blooming State in Lotus
Flower (Flower Buds of Nelumbo nucifera) and Their Hyaluronidase Inhibitory
Activity. Nat. Prod. Commun., June 2019, 1-7 (2019).
Masakazu Kobayashi, Junji Akaki, Yasuyo Yamaguchi, Hiroo Yamasaki, Kiyofumi
Ninomiya, Yutana Pongpiriyadacha, Masayuki Yoshikawa, Osamu Muraoka, Toshio
Morikawa. Salacia chinensis stem extract and its thiosugar sulfonium constituent,
neokotalanol, improves HbA1c levels in ob/ob mice. J. Nat. Med., 73, 584-588
(2019).
2018
森川敏生，赤木淳二，Pongpiriyadacha Yutana，吉川雅之，二宮清文，村岡 修．サラシア属植物に含有されるポリフェノール成分の LCMS 定量分析． 日食化誌，25, 130-138 (2018).
Toshio Morikawa, Akifumi Nagatomo, Kayako Kitazawa, Osamu Muraoka, Takashi Kikuchi, Takeshi Yamada, Reiko Tanaka, Kiyofumi Ninomiya. Collagen synthesis-promoting effects of andiroba oil and its limonoid constituents in normal human dermal fibroblasts. J. Oleo Sci ., 67, 1271-1277 (2018).
Genzoh Tanabe, Sanami Teramae, Yousuke Kunikata, Shinsuke Marumoto, Shuhei Okugawa, Fumihiro Ishikawa, Wejia Xie, Toshio Morikawa, Osamu Muraoka. Synthesis of salacinol-d4 as an internal standard for mass-spectrometric quantitation of salacinol, a potent alpha-glucosidase inhibitor found in a traditional Ayurvedic medicine "Salacia". Heterocycles ., 97, 314-332 (2018).
Genzoh Tanabe, Yoshiaki Manse, Teppei Ogawa, Naoki Sonoda, Shinsuke Marumoto, Fumihiro Ishikawa, Kiyofumi Ninomiya, Saowanee Chaipech, Yutana Pongpiriyadacha, Osamu Muraoka, Toshio Morikawa. Total synthesis of gamma-alkylidenebutenolides, potent melanogenesis inhibitors from Thai medicinal plant Melodorum fruticosum. J. Org. Chem., 83, 8250-8264 (2018).
Norihisa Taira, Yushi Katsuyama, Masato Yoshioka, Osamu Muraoka, Toshio Morikawa. Structural requirements of alkylglyceryl-L-ascorbic acid derivatives for melanogenesis inhibitory activity. Int. J. Mol. Sci ., 19, 1144 (2018).
Toshio Morikawa, Yoshiaki Manse, Mika Koda, Saowanee Chaipech, Yutana Pongpiriyadacha, Osamu Muraoka, Kiyofumi Ninomiya. Two new aromatic glycosides, elengiosides A and B, from the flowers of Mimusops elengi., J. Nat. Med ., 72, 542-550 (2018).
Toshio Morikawa, Ikuko Hachiman, Kiyofumi Ninomiya, Hiroki Hata, Kaoru Sugawara, Osamu Muraoka, Hisashi Matsuda. Degranulation inhibitors from the arils of Myristica fragrans in antigen-stimulated rat basophilic leukemia cells. J. Nat. Med., 72, 464-473 (2018).
Toshio Morikawa, Katsuya Imura, Yoshinori Akagi, Osamu Muraoka, Kiyofumi Ninomiya. Ellagic acid glycosides with hepatoprotective activity from traditional Tibetan medicine Potentilla anserina. J. Nat. Med., 72, 317-325 (2018).
Fumihiro Ishikawa, Kazumi Jinno, Eri Kinouchi, Kiyofumi Ninomiya, Shinsuke Marumoto, Weijia Xie, Osamu Muraoka, Toshio Morikawa, Genzoh Tanabe. Diastereoselective synthesis of salacinol-type a-glucosidase inhibitors.J. Org. Chem., 83, 185-193 (2018).
2017
Yoshiaki Manse, Kiyofumi Ninomiya, Akane Okazaki, Eriko Okada-Nishida, Takahiro Imagawa, Mami Imamura-Mizushima, Yuki Yamano, Kinji Kaname, Sho Nakamura, Toshio Morikawa: Melanogenesis inhibitory activity of diterpenoid and triterpenoid constituents from the aerial part of Isodon trichocarpus.Nat. Prod. Commun., 12, 1185-1188 (2017).
Toshio Morikawa, Hisashi Matsuda, Masayuki Yoshikawa: A review of anti-inflammatory terpenoids from the incense gum resins frankincense and myrrh.J.Oleo. Sci., 66, 805-814 (2017).Review
Genzoh Tanabe, Nozomi Tsutsui, Kanae Shibatani, Shinsuke Marumoto, Fumihiro Ishikawa, Kiyofumi Ninomiya, Osamu Muraoka, Toshio Morikawa: Total synthesis of the aromatase inhibitors, mammeasins C and D, from Thai medicinal plant Mammea siamensis.Tetrahedron, 73, 4481-4486 (2017).
森川敏生：薬学領域からの機能性食品素材開発-サラシアの抗糖尿病効果-．大阪府薬雑誌，68，51-58 (2017).
Kiyofumi Ninomiya, Saowanee Chaipech,YusukeKunikata, Ryohei Yagi, Yutana Pongpiriyadacha, Osamu Muraoka, Toshio Morikawa: Quantitative determination of stilbenoids and dihydroisocoumarins in Shorea roxburghii and evaluation of their hepatoprotective activity.Int. J. Mol. Sci., 18, 451 (2017).
矢作忠弘，石内勘一郎，渥美聡孝，三宅克典，森永 紀，伏見裕利，大山雅義，森川敏生，田中 謙，有田正規，牧野利明：歴代教科書・解説書に見られる生薬の効能に関する記載のデータベース化（２）．生薬学雑誌，71, 20-36 (2017).
矢作忠弘，石内勘一郎，渥美聡孝，三宅克典，森永 紀，伏見裕利，大山雅義，森川敏生，田中 謙，有田正規，牧野利明：歴代教科書・解説書に見られる生薬の効能に関する記載のデータベース化（１）．生薬学雑誌，71, 1-19 (2017).
2016
Toshio Morikawa, Niichiro Kitagawa, Chiaki Motai, Kiyofumi Ninomiya, Shuhei Okugawa, Ayaka Nishida, Masayuki Yoshikawa, Osamu Muraoka: The antiproliferative effect of chakasaponins I and II, floratheasaponin A, and epigallocatechin 3-O-gallate isolated from Camellia sinensis on human digestive tract carcinoma cell lines.Int. J.Mol. Sci., 17, 1979 (2016).
Yoshiaki Manse, Kiyofumi Ninomiya, Ryosuke Nishi, Iyori Kamei, Yushi Katsuyama, Takahiro Imagawa, Saowanee Chaipech, Osamu Muraoka, Toshio Morikawa: Melanogenesis inhibitory activity of a 7-O-9'-linked neolignan from Alpinia galanga fruit. Bioorg.Med. Chem., 24, 6215-6224 (2016).
Hiroyuki Moriyama, Mariko Moriyama, Kiyofumi Ninomiya, Toshio Morikawa, Takao Hayakawa: Inhibitory effects of oligostilbenoids from the bark of Shorea roxburghii on malignant melanoma cell growth: inplications for novel topical anticancer candidate.Biol. Pharm. Bull., 39, 1675-1682 (2016).
Toshio Morikawa, Ikuko Hachiman, Kazuhiko Matsuo, Eriko Nishida, Kiyofumi Ninomiya, Takao Hayakawa, Osamu Yoshie, Osamu Muraoka, Takashi Nakayama: Neolignans from the arils of Myristica fragrans as potent antagonists of CC chemokine receptor 3. J.Nat. Prod., 79, 2005-2013 (2016).
Hisashi Matsuda, Seikou Nakamura, Toshio Morikawa, Osamu Muraoka, Masayuki Yoshikawa: New biofunctional effects of the flower buds of Camellia sinensis and its bioactive acylated oleanane-type triterpene oligoglycoside.J. Nat. Med., 70, 689-701 (2016).
Genzoh Tanabe, Weijia Xie, Gorre Balakishan, Mumen F. A. Amer, Nozomi Tsutsui, Haruka Takemura, Shinya Nakamura, Junji Akaki, Kiyofumi Ninomiya, Toshio Morikawa, Isao Nakanishi, Osamu Muraoka: Hydrophobic substituents increase the potency of salacinol, a potent alpha-glucosidase inhibitor from Ayurvedic traditional medicine 'Salacia'.Bioorg. Med. Chem., 24, 3705-3715 (2016).
Niichiro Kitagawa, Kiyofumi Ninomiya, Shuhei Okugawa, Chiaki Motai, Yusuke Nakanishi, Masayuki Yoshikawa, Osamu Muraoka, Toshio Morikawa: Quantitative determination of principal alkaloid and flavonoid constituents in Wintersweet, the flower buds of Chimonanthus praecox.Nat. Prod. Commun., 11, 953-956 (2016).
Toshio Morikawa, Niichiro Kitagawa, Genzoh Tanabe, Kiyofumi Ninomiya, Shuhei Okugawa, Chiaki Motai, Iyori Kamei, Masayuki Yoshikawa, I-Jung Lee, Osamu Muraoka: Quantitative determination of alkaloids in Lotus Flower (flower buds of Nelumbo nucifera) and their melanogenesis inhibitory activity.Molecules, 21, 930 (2016).
Kiyofumi Ninomiya, Chiaki Motai, Eriko Nishida, Niichiro Kitagawa, Kazuya Yoshihara, Takao Hayakawa, Osamu Muraoka, Xuezheng Li, Seikou Nakamura, Masayuki Yoshikawa, Hisashi Matsuda, Toshio Morikawa: Acylated oleanane-type triterpene saponins from the flowers of Bellis perennis show anti-proliferative activities against human digestive tract carcinoma cell lines.J. Nat. Med., 70, 435-451 (2016).
Kiyofumi Ninomiya, Kanae Shibatani, Mayumi Sueyoshi, Saowanee Chaipech, Yutana Pongpiriyadacha, Takao Hayakawa, Osamu Muraoka, Toshio Morikawa: Aromatase inhibitory activity of geranylated coumarins, mammeasins C and D, isolated from the flowers of Mammea siamensis.Chem. Pharm. Bull., 64, 880-885 (2016).
Kazuhiko Matsuo, Keiichi Koizumi, Mitsugu Fujita, Toshio Morikawa, Michiko Jo, Naotoshi Shibahara, Ikuo Saiki, Osamu Yoshie, Takashi Nakayama: Efficient use of a crude drug/herb library reveals Ephedra Herb as a specific antagonist for TH2-specific chemokine receptors CCR3, CCR4, and CCR8. Front.Cell Develop. Biol., 4, 54 (2016).
Kiyofumi Ninomiya, Seiya Miyazawa, Kaiten Ozeki, Natsuko Matsuo, Osamu Muraoka, Takashi Kikuchi, Takeshi Yamada, Reiko Tanaka, Toshio Morikawa: Hepatoprotective limonoids from Andiroba (Carapa guianensis).Int. J. Mol. Sci., 17, 591 (2016).
小林正和，赤木淳二，山田康代，山崎寛生，森川敏生，二宮清文，吉川雅之，村岡 修：サラシアエキス末配合食品の長期摂取時および過剰摂取時の安全性の検討．Jpn. Pharmacol. Ther.，44, 399-408 (2016).
Kiyofumi Ninomiya, Taku Matsumoto, Saowanee Chaipech, Sohachiro Miyake, Yushi Katsuyama, Akihiro Tsuboyama, Yutana Pongpiriyadacha, Takao Hayakawa, Osamu Muraoka, Toshio Morikawa: Simultaneous quantitative analysis of 12 methoxyflavones with melanogenesis inhibitory activity from the rhizomes of Kaempferia parviflora.J.Nat. Med., 70, 179-189 (2016).
Toshio Morikawa, Kiyofumi Ninomiya, Hiroyuki Kuramoto, Iyori Kamei, Masayuki Yoshikawa, Osamu Muraoka: Phenylethanoid and phenylpropanoid glycosides with melanogenesis inhibitory activity from the flowers of Narcissus tazetta var. chinensis.J. Nat. Med., 70, 89-101 (2016).
2015
中村恭子，赤木淳二，石伏史明，谷 恭輔，森川敏生，Pongpiriyadacha Yutana，村岡 修，早川堯夫，角谷晃司：rDNA ITS 領域の塩基配列による Salacia chinsnsis の鑑別．生薬学雑誌，69, 53-58 (2015).
Toshio Morikawa, Kiyofumi Ninomiya, Junji Akaki, Namiko Kakihara, Hiroyuki Kuramoto, Yurie Matsumoto, Takao Hayakawa, Osamu Muraoka, Li-Bo Wang, Li-JUn Wu, Seikou Nakamura, Masayuki Yoshikawa, Hisashi Matsuda: Dipeptidyl peptidase-IV inhibitory activity of dimeric dihydrochalcone glycosides from flowers of Helichrysum arenarium.J. Nat. Med., 69, 494-506 (2015).J. Nat. Med. Award 2015
Gnezoh Tanabe, Youta Sugano, Miki Shirato, Naoki Sonoda, Nozomi Tsutsui, Toshio Morikawa, Kiyofumi Ninomiya, Masayuki Yoshikawa, Osamu Muraoka: Total synthesis of 4,5-dihydroguadiscine: a potent melanogenesis inhibitor from the Brazillian medicinal herb, Hornschuchia obliqua.J. Nat. Prod., 78, 1536-1542 (2015).
Takanoibu Inoue, Yuuki Matsui, Takashi Kikuchi, Takeshi Yamada, Yasuko In, Osamu Muraoka, Chie Sakai, Kiyofumi Ninomiya, Toshio Morikawa, Reiko Tanaka: Carapanolides M-S from seeds of andiroba (Carapa guianensis, Meliaceae) and triglyceride metabolism-promoting activity in high glucose-pretreated HepG2 cells.Tetrahedron, 71, 2753-2760 (2015).
Toshio Morikawa, Junji Akaki, Kiyofumi Ninomiya, Eri Kinouchi, Genzoh Tanabe, Yutana Pongpiriyadacha, Masayuki Yoshikawa, Osamu Muraoka: Salacinol and related analogs: new leads for type 2 diabetes therapeutic candidates from the Thai traditional natural medicine Salacia chinensis.Nutrients, 7, 14801-1493 (2015).
Asami Sakamoto, Yuji Tanaka, Takeshi Yamada, Takashi Kikuchi, Osamu Muraoka, Kiyofumi Ninomiya, Toshio Morikawa,* Reiko Tanaka: Andirolides W-Y from the flower oil of andiroba (Carapa guianensis, Meliaceae).Fitoterapia, 100, 81-87 (2015).
2014
Toshio Morikawa, Junji Akaki, Kiyofumi Ninomiya, Eri Kinouchi, Genzoh Tanabe, Masayuki Yoshikawa, Salacinol and related analogs, new leads for type 2 diabetes therapeutic candidates from Thai traditional natural medicine Salacia chinensis.Nutrients, 6, 4147 (2014). Mini-Review
Junji Akaki, Toshio Morikawa, Sohachiro Miyake, Kiyofumi Ninomiya, Mayumi Okada, Genzoh Tanabe, Yutana Pongpiriyadacha, Masayuki Yoshikawa, Osamu Muraoka: Evaluationof Salacia species as anti-diabetic natural resources based on quantitative analysis of eight sulphonium constituents: a new class of alpha-glucosidase inhibitors.Phytochem. Anal., 25, 544-550 (2014).
Toshio Morikawa, Kiyofumi Ninomiya, Mio Imamura, Junji Akaki, Shota Fujikura, Yingni Pan, Dan Yuan, Masayuki Yoshikawa, Xiaoguang Jia, Zheng Li, Osamu Muraoka: Acylated phenylethanoid glycosides, echinacoside and acteoside from Cistanche tubulosa, improve glucose tolerance in mice.J. Nat. Med., 68, 561-566 (2014).
Toshio Morikawa, Yusuke Nakanishi, Kiyofumi Ninomiya, Hisashi Matsuda, Souichi Nakashima, Hisako Miki, Yu Miyashita, Masayuki Yoshikawa, Takao Hayakawa, Osamu Muraoka: Dimeric pyrrolidinoindoline-type alkaloids with melanogenesis inhibitory activity in flower buds of Chimonanthus praecox.J. Nat. Med., 68, 539-549 (2014).
Toshio Morikawa, Kiyofumi Ninomiya,KatsuyaImura, Takahira Yamaguchi, Yoshinori Akagi, Masayuki Yoshikawa, Takao Hayakawa, Osamu Muraoka: Hepatoprotective triterpenes from traditional Tibetan medicine Potentilla anserina.Phytochemistry, 102, 169-181 (2014).
2013
Toshio Morikawa, I-Jung Lee, Shuhei Okugawa, Sohachiro Miyake, Yoshinobu Miki, Kiyofumi Ninomiya, Niichiro Kitagawa, Masayuki Yoshikawa, Osamu Muraoka: Quantitative analysis of catechin, flavonoid, and saponin constituents in "Tea Flower", the flower buds of Camellia sinensis, from different regions in Taiwan.Nat. Prod.Commun., 8, 1553-1557 (2013).
Weijia Xie, Genzoh Tanabe, Jinyi Xu, Toshio Morikawa, Masayuki Yoshikawa, Osamu Muraoka: Research progress of synthesis and structure-activity relationship studies on sulfonium-type alpha-glucosidase inhibitors isolated from Salacia genus plants.Mini-Rev. Org. Chem., 10, 141-150 (2013).
Toshio Morikawa, Kiyofumi Ninomiya, Sohachiro Miyake, Yoshinobu Miki, Masaki Okamoto, Masayuki Yoshikawa, Osamu Muraoka: Flavonol glycosides with lipid accumulation inhibitory activity and simultaneous quantitative analysis of 15 polyphenols and caffeine in the flower buds of Camellia sinensis from different regions by LCMS.Food Chem., 140, 353-360 (2013).
Toshio Morikawa, Kiyofumi Ninomiya, FengmingXu, Naomichi Okumura, Hisashi Matsuda, Osamu Muraoka, Takao Hayakawa, Masayuki Yoshikawa: Acylated dolabellane-type diterpenes from Nigella sativa seeds with triglyceride metabolism-promoting activity in high glucose-pretreated HepG2 cells.Phytochemistry Lett., 6, 198-204 (2013).
2012
Toshio Morikawa, Mayumi Sueyoshi, SAowanee Chaipech, Hisashi MAtsuda, Yukiko Nomura, Mikuko Yabe, Tomoko Matsumoto, Kiyofumi Ninomiya, Masayuki Yoshikawa, Yutana Pongipiriyadacha, Takao Hayakawa, Osamu Muraoka: Suppressive effects of coumarins from Mammea siamensis on inducible nitric oxide synthase expression in RAW264.7 cell.Bioorg. Med. Chem., 20, 4968-4977 (2012).
Genzoh Tanabe, Shinya Nakamura, Nozomi Tsutsui, Gorre Balakishan, Weijia Xie, Satoshi Tsuchiya, Junji Akaki, Toshio Morikawa, Kiyofumi Ninomiya, Masayuki Yoshikawa, Isao Nakanishi, Osamu Muraoka: In silico desing, synthesis and evaluation of 3'-O-benzylated analogs of salacinol, a potent alpha-glucosidase inhibitor isolated from an Ayurvedic traditional medicine "Salacia".Chem. Comm., 48, 8646-8648 (2012).
Toshio Morikawa, Sohachiro Miyake, Yoshinobu Miki, Kiyofumi Ninomiya, Masayuki Yoshikawa, Osamu Muraoka: Quantitative analysis of acylated oleanane-type triterpene saponins, chakasaponins I-III and floratheasaponins A-F, in the flower buds of Camellia sinensis from different regional origins.J. Nat. Med., 66, 608-613 (2012).
Toshio Morikawa, Saowanee Chaipech, Hisashi Matsuda, Makoto Hamao, Yohei Umeda, Hiroki Sato, Haruka Tamura, Kiyofumi Ninomiya, Masayuki Yoshikawa, Yutana Pongpiriyadacha, Takao Hayakawa, Osamu Muraoka: Anti-hyperlipidemic constituents from the bark of Shorea roxburghii.J. Nat. Med., 66, 516-524 (2012).
Saowanee Chaipech, Toshio Morikawa, Kiyofumi Ninomiya, Masayuki Yoshikawa, Yutana Pongiriyadacha, Takao Hayakawa, Osamu Muraoka: New flav-3-en-3-ol glycosides, kaempferiaosides C and D, and acetophenone glycosides, kaempferiaosides E and F, from the rhizomes of Kaempferia parviflora.J. Nat. Med., 66, 486-492 (2012).
Toshio Morikawa, Kiyofumi Ninomiya, Yi Zhang, Tomomi Yamada, Seikou Nakamura, Hisashi Matsuda, Osamu Muraoka, Takao Hayakawa, Masayuki Yoshikawa: Flavonol glycosides with lipid accumulation inhibitory activity fromSedum sarmentosum.Phytochemistry Lett., 5, 53-58 (2012).
Toshio Morikawa, Saowanee Chaipech, Hisashi Matsuda, Makoto Hamao, Yohei Umeda, Hiroki Sato, Haruka Tamura, Haruka Kon'i, Kiyofumi Ninomiya, Masayuki Yoshikawa, Yutana Pongpiriyadacha, Takao Hayakawa, Osamu Muraoka: Antidiabetogenic oligstilbenoids and 3-ethyl-4-phenyl-3,4-dihydroisocoumarins from the bark of Shorea roxburghii.Bioorg. Med. Chem., 20, 832-840 (2012).
Saowanee Chaipech, Toshio Morikawa, Kiyofumi Ninomiya, Masayuki Yoshikawa, Yutana Pongpiriyadacha, Takao Hayakawa, Osamu Muraoka: Structures of two new phenolic glycosides, kaempferiaosides AandB, and hepatoprotective constituents from the rhizomes of Kaempferia parviflora.Chem. Pharm. Bull., 60, 62-69 (2012).
Toshio Morikawa, Katsuya Imura,SohachiroMiyake, Kiyofumi Ninomiya, Hisashi Matsuda, Chihiro Yamashita, Osamu Muraoka, Takao Hayakawa, Masayuki Yoshikawa: Promoting the effect of chemical constituents from the flowers of Poacynum hendersonii on adipogenesis in 3T3-L1 cells.J. Nat. Med., 66, 39-48 (2012).
2011
Toshio Morikawa, Xuezheng Li, Eriko Nishida, Seikou Nakamura, Kiyofumi Ninomiya, Hisashi Matsuda, Makoto Hamao, Osamu Muraoka, Takao Hayakawa, Masayuki Yoshikawa: Medicinal flowers. XXXII. structures of oleanane-type triterpene saponins, perennisosides VIII, IX, X, XI, and XII, from the flowers of Bellis perennis.Chem.Pharm. Bull., 59, 889-895 (2011).
Weijia Xie, Genzoh Tanabe, Junji Akaki, Toshio Morikawa, Kiyofumi Ninomiya, Toshie Minematsu, Masayuki Yoshikawa, Xiaoming Wu, Osamu Muraoka: Isolation, structure identification and SAR studies on thiosugar sulfonium salts, neosalaprinol and neoponkoranol, as potent alpha-glucosidase inhibitors.Bioorg. Med. Chem., 19, 2015-2022 (2011).
Osamu Muraoka, Toshio Morikawa, Sohachiro Miyake, Junji Akaki, Kiyofumi Ninomiya, Yutana Pongpiriyadacha, Masayuki Yoshikawa: Quantitative analysis of neosalacinol and neokotalanol, another two potent alpha-glucosidase inhibitors fromSalacia species, by LC-MS with ion pair chromatography. J. Nat. Med., 65, 142-148 (2011).
Toshio Morikawa, Hideo Oominami, Hisashi Matsuda, Masayuki Yoshikawa: New terpenoids, olibanumols D-G, from traditional Egyptian medicine olibanum, the gum-resin ofBoswallia carterii.J. Nat. Med., 65, 129-134 (2011).
2010
Toshio Morikawa, Hideo Oominami, Hisashi Matsuda, Masayuki Yoshikawa: Four new ursane-type triterpenes, olibanumols K, L, M, and N, from traditional Egyptian medicine olibanum, the gum-resin ofBoswellia carterii.Chem. Pharm. Bull., 58, 1541-1544 (2010).
Toshio Morikawa, Yingni Pan, Kiyofumi Ninomiya, Katsuya Imura, Dan Yuan, Masayuki Yoshikawa, Takao Hayakawa, Osamu Muraoka: Iridoid and acyclic monoterpene glycosides, kankanosides L, M, N, O, and P from Cistanche tubulosa.Chem. Pharm. Bull., 58, 1403-1407 (2010).
Toshio Morikawa, Fengming Xu, Hisashi Matsuda, Masayuki Yoshikawa: Structures of novel norstilbene dimer, longusone A, and stilbene dimers, longusols A, B, and C, with antiallergic and radical scavenging activities from Egyptial natural medicine Cyperus longus.Chem. Pharm. Bull., 58, 1379-1385 (2010).
Toshio Morikawa, Yuanyuan Xie, Kiyofumi Ninomiya, Masaki Okamoto, Osamu Muraoka, Dan Yuan, Masayuki Yoshikawa, Takao Hayakawa: Inhibitory effects of acylated sesquiterpene oligoglycosides from the pericarps of Sapindus rarak on tumor necrosis factor-alpha-induced cytotoxicity.Chem. Pharm. Bull., 58, 1276-1280 (2010).
小林正和，赤木淳二，山下耕作，森川敏生，二宮清文，吉川雅之，村岡 修：サラシアエキス配合食品の食後血糖上昇抑制効果，薬理と治療，38, 545-550 (2010).
Shinya Nakamura, Kazunori Takahira, Genzoh Tanabe, Toshio Morikawa, Mika Sakano, Kiyofumi Ninomiya,Masayuki Yoshikawa, Osamu Muraoka, Iso Nakanishi: Docking and SAR studies of salacinol derivatives as alpha-glucosidase inhibitors.Bioorg. Med. Chem. Lett., 20, 4420-4423 (2010).
森川敏生：TNF-alpha感受性低減作用を指標とした香辛料由来生物活性成分の探索－タイ天然薬物Piper chabaの肝保護作用成分－，薬学雑誌，130, 785-791 (2010).Review
森川敏生，村岡 修，吉川雅之：食品薬学：薬食同源の視点から薬用食品を科学する－デイジーフラワーの中性脂質上昇抑制作用サポニン成分－，薬学雑誌，130, 673-678 (2010).Review
Hisashi Matsuda, Souichi Nakashima, Osama Bashir Abdel-Halim, Toshio Morikawa, Masayuki Yoshikawa: Cucurbitane-type triterpenes with anti-proliferative effects on U937 from an Egyptian natural medicine, Bryonia cretica: styructures of new triterpene glycosides, bryoniaosides A and B. Chem.Pharm. Bull., 58, 747-751 (2010).
Osamu Muraoka, Weijia Xie, Satomi Osaki, Ayumi Kagawa, Genzoh Tanabe, Mumen F. A. Amer, Toshie Minematsu, Toshio Morikawa, Masayuki Yoshikawa: Characteristic alkaline catalyzed degradation of kotalanol, a potent alpha-glucosidase inhibitor isolated from Ayurvedic traditional medicine Salacia reticulata, leading to anhydroheptitols: another structural proof.Tetrahedron, 66, 3717-3722 (2010).
Osamu Muraoka, Toshio Morikawa, Sohachiro Miyake, Junji Akaki, Kiyofumi Ninomiya, Masayuki Yoshikawa: Quantitative determination of potent alpha-glucosidase inhibitors, salacinol and kotalanol, in Salacia species using liquid chromatography-mass spectrometry.J. Pharm. Biomed. Anal., 52, 770-773 (2010).
Toshio Morikawa, Xuezheng Li, Eriko Nishida, Seikou Nakamura, Kiyofumi Ninomiya, Hisashi Matsuda, Yoshimi Oda, Osamu Muraoka, Masayuki Yoshikawa: Medicinal flowers part 29 Acylated oleanane-type triterpene bisdesmosides: perennisaponins G, H, I, J, K, L, and M with pancreatic lipase inhibitory activity from the flowers of Bellis perennis.Helv. Chim. Acta, 93, 573-586 (2010).
Toshio Morikawa, Yingni Pan, Kiyofumi Ninomiya, Katsuya Imura, Hisashi Matsuda, Masayuki Yoshikawa, Dan Yuan, Osamu Muraoka: Acylated phenylethanoid oligoglycosides with hepatoprotective activity from the desert plant Cistanche tubulosa.Bioorg. Med. Chem., 18, 1882-1890 (2010).
2009
Toshio Morikawa, Itadaki Yamaguchi, Hisashi Matsuda, Masayuki Yoshikawa: A new amide, piperchabamide F, and two new phenylpropanoid glycosides, piperchabaosides A and B, from the fruit of Piper chaba.Chem. Pharm. Bull., 57, 1292-1295 (2009).
Hisashi Matsuda, Kiyofumi Ninomiya, Toshio Morikawa, Daisuke Yasuda, Itadaki Yamaguchi, Msayuki Yoshikawa: Hepatoprotective amide constituents from the fruit of Piper chaba: structural requirements, mode of action, and new amide.Bioorg.Med. Chem., 17, 7313-7323 (2009).
Masayuki Yoshikawa, Toshio Morikawa, Hideo Oominami, Hisashi Matsuda: Absolute stereostructures of olibanumols A, B, C, H, I, and J from olibanum, gum-resin of Boswellia carterii, and inhibitors of nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages.Chem. Pharm. Bull., 57, 957-964 (2009).
Toshio Morikawa, Yuanyuan Xie, Yasunobu Asao, Masaki Okamoto, Chihiro Yamashita, Osamu Muraoka, Hisashi Matsuda, Yutana Pongpiriyadacha, Dan Yuan, Masayuki Yoshikawa: Oleanane-type triterpenenoligoglycosides with pancreatic lipase inhibitory activity from the pericarps of Sapindus rarak.Phytochemistry, 70, 1166-1172 (2009).
Toshio Morikawa, Wang Li-Bo, Kiyofumi Ninomiya, Seikou Nakamura, Hisashi Matsuda, Osamu Muraoka, Wu Li-Jun, Masayuki Yoshikawa: Medicinal flowers. XXX. eight new glycosides, everlastosides F-M, from the flowers of Helichrysum arenarium.Chem. Pharm. Bull., 57, 853-859 (2009).
Osamu Muraoka, Toshio Morikawa, Yi Zhang, Kiyofumi Ninomiya, Seikou Nakamura, Hisashi Matsuda, Masayuki Yoshikawa: Novel megastigmanes with lipid accumulation inhibitory and lipid metabolism-promoting activities in HepG2 cells from Sedum sarmentosum.Tetrahedron, 65, 4142-4148 (2009).
Li-Bo Wang, Toshio Morikawa, Seikou Nakamura, Kiyofumi Ninomiya, Hisashi Matsuda, Osamu Muraoka, Li-Jun Wu, Masayuki Yoshikawa: Medicinal flowers. XXVIII. structures of five new glycosides, everlastsides A, B, C, D, and E, from the flowers of Helichrysum arenarium.Heterocycles, 78, 1235-1242 (2009).
Toshio Morikawa, Haihui Xie, Tao Wang, Hisashi Matsuda, Masayuki Yoshikawa: Acylated flavonol bisdesmosides, sinocrassosides A3-A7 and B3, with aminopeptidase N inhibitory activity fromSinocrassula indica.Chem. Biodiv., 6, 411-420 (2009).
Toshio Morikawa, Li-Bo Wang, Seikou Nakamura, Kiyofumi Ninomiya, Eri Yokoyama, Hisashi Matsuda, Osamu Muraoka, Li-Jin Wu, Masayuki Yoshikawa: Medicinal flowers. XXVII. new flavanone and chalcone glycosides, arenariumosides I, II, III, and IV, and tumor necrosis factor-alfa inhibitors from Everlasting, flowers of Helichrysum arenarium.Chem. Pharm. Bull., 57, 316-367 (2009).
Yasunobu Asao., Toshio Morikawa, Yuanyuan Xie, Masaki Okamoto, Makoto Hamao, Hisashi Matsuda, Osamu Muraoka, Dan Yuan, Masayuki Yoshikawa: Structures of acetylated oleanane-type triterpene saponins, rarasaponins IV, V, and VI, and anti-hyperlipidemic constituents from the pericarps of Sapindus rarak.Chem. Pharm.Bull., 57, 198-203 (2009).
2008
Seikou Nakamura, Yoshie Okazaki, Kiyofumi Ninomiya, Toshio Morikawa, Hisashi Matsuda, Masayuki Yoshikawa: Medicinal flowers. XXIV. chemical structures and hepatoprotective effects of constituents from flowers of Hedychium coronarium.Chem. Pharm. Bull., 56, 1704-1709 (2008).
Yuanyuan Xie, Toshio Morikawa, Kiyofumi Ninomiya, Katsuya Imura, Osamu Muraoka, Dan Yuan, Masayuki Yoshikawa: Medicinal Flowers. XXIII. new taraxastane-type triterpene, punicanolic acid, with tumor necrosis factor-alfa inhibitory activity from the flowers of Punica granutum.Chem. Pharm. Bull., 56, 1628-1631 (2008).
Toshio Morikawa, Haihui Xie, Tao Wang, Hisashi Matsuda, Masayuki Yoshikawa: Bioactive constituents from Chinese natural medicines. XXXII. aminopeptidase N and aldose reductase inhibitors from Sinocrassula indica: structures of sinocrassosides B4, B5, C1, and D1-D3.Chem. Pharm. Bull., 56, 1438-1444 (2008).
Koyofumi Ninomiya, Toshio Morikawa, Haihui Xie, Hisashi Matsuda, Masayuki Yoshikawa: Bioactive constituents from Chinese natural medicines. XXXI. hepatoprotective principles from Sinocrassula indica: structures of sinocrassosides A8, A9, A10, A11, and A12.Heterocycles, 75, 1983-1995 (2008).
Toshiko Morikawa, Kanako Funakoshi, Kiyofumi Ninomiya, Daisuke Yasuda, Katsutoshi Miyagawa, Hisashi Matsuda, Masayuki Yoshikawa: Medicinal foodstuffs. XXXIV. structures of new prenylchalcones and prenylflavanones with TNF-alfa and aminopeptidase N inhibitory activities from Boesenbergia rotunda.Chem. Pharm.Bull., 56, 956-962 (2008).
Masayuki Yoshikawa, Toshio Morikawa, Kanako Funakoshi, Momotaro Ochi, Yutana Pongpiriyadacha, Hisashi Matsuda: Medicinal foodstuffs. XXXIII. gastroprotective principles from Boesenbergia rotunda (Zingiberaseae)-absolute stereostructures of Diels-Alder type addition prenylchalcones-.Heterocycles, 75, 1639-1650 (2008).
Toshio Morikawa, Xuezheng Li, Eriko Nishida, Yuki Ito, Hisashi Matsuda, Seikou Nakamura, Osamu Muraoka, Masayuki Yoshikawa: Perennisosides I-VII, acylated triterpene saponins with antihyperlipidemic activities from the flowers of Bellis perennis.J. Nat. Prod., 71, 828-835 (2008).
Masayuki Yoshikawa, Xuezheng Li, Eriko Nishida, Seikou Nakamura, Hisashi Matsuda, Osamu Muraoka, Toshio Morikawa: Medicinal Flowers. XXI. Structures of Perennisaponins A, B, C, D, E, and F, acylated oleanane-type triterpene oligoglycosides, from the flowers of Bellis perennis.Chem. Pharm. Bull., 56, 559-568 (2008).
Hisashi Matsuda, Kiyofumi Ninomiya, Toshio Morikawa, Daisuke Yasuda, Itadaki Yamaguchi, Masayuki Yoshikawa: Protective effects of amide constituents from the fruit of Piper chaba on D-galactosamine/TNF-alfa-induced cell death in mouse hepatocytes.Bioorg. Med. Chem. Lett., 18, 2038-2042 (2008).
2007
Toshio Morikawa, Hisashi Matsuda, Li N., Li X., Masayuki Yoshikawa: Bioactive saponins and glycosides. XXIX. Acylated oleanane-type triterpene saponins: Theasaponins A6, A7, and B5, from the seeds of Camellia sinensis.Helv. Chim. Acta, 90, 2342-2348 (2007).
Seukou Nakamura, Xuezheng Li, Hisashi Matsuda, Kiyofumi Ninomiya, Toshio Morikawa, Kikuji Yamaguti, Masayuki Yoshikawa: Bioactive constituents from Chinese natural medicines. XXVI. Chemical structures and hepatoprotective effects of constituents from roots of Rhodiola sachalinensis.Chem. Pharm. Bull.., 55, 1505-1511 (2007).Cover Page
Masayuki Yoshikawa, Tao Wang,Toshio Morikawa, Haihui Xie, Hisashi Matsuda: Bioactive constituents from Chinese natural medicines. XXIV. Hypoglycemic effects of Sinocrassula indica in sucrose-loaded rats and genetically diabetic KK-Ay mice and structures of new acylated flavonol glycosides, sinocrassosides A1, A2, B1, and B2.Chem. Pharm. Bull., 55, 1308-1315 (2007).
Kiyofumi Ninomiya, Toshio Morikawa, Yi Zhang, Seukou Nakamura, Hisashi Matsuda, Osamu Muraoka, Masayuki Yoshikawa: Bioactive constituents from Chinese natural medicines. XXIII. Absolute structures of new megastigmane glycosides, sedumosides A4, A5, A6, H, and I, and hepatoprotective megastigmanes from Sedum sarmentosum.Chem. Pharm. Bull., 55, 1185-1191 (2007).
Yi Zhang, Toshio Morikawa, Seukou Nakamura, Kiyofumi Ninomiya, Hisashi Matsuda, Osamu Muraoka, Masayuki Yoshikawa: Bioactive constituents from Chinese natural medicines. XXV. New flavonol bisdesmosides, sarmenosides I, II, III, and IV, with hepatoprotective activity from Sedum sarmentosum.Heterocycles., 71, 1565-1576 (2007).
Kiyofumi Ninomiya, Hisashi Matsuda, Mizuho Kubo, Toshio Morikawa, Norihisa Nishida, Masayuki Yoshikawa: Potent anti-obese principle from Rosa canina: structural requirements and mode of action of trans-tiliroside.Bioorg. Med. Chem.Lett., 17, 3059-3064 (2007).
Ning Li, Toshio Morikawa, Hisashi Matsuda, Kiyofumi Ninomiya, Xian Li, Masayuki Yoshikawa: New flavanone oligoglycosides, theaflavanosides I, II, III, and IV, with hepatoprotective activity from the seeds of tea plant (Camellia sinensis).Heterocycles, 71, 1193-1201 (2007).
Masayuki Yoshikawa, Toshio Morikawa, Yi Zhang, Seikou Nakamura, Osamu Muraoka, Hisashi Matsuda: Megastigmanes and their glucosides from the whole plant of Sedum sarmentosum.J. Nat. Prod., 70, 575-583 (2007).
Masayuki Yoshikawa, Toshio Morikawa, Yasunobu Asao, Emi Fujiwara, SEikou Nakamura, Hisashi Matsuda: MEdicinal flowers. XV. The structures of noroleanane- and oleanane-type triterpene oligoglycosides with gastroprotective and platelet aggregation activities from flower buds of Camellia japonica.Chem. Pharm. Bull., 55, 606-612 (2007).
Toshio Morikawa: Search for bioactive constituents from several medicinal foods: hepatoprotective, antidiabetic, and antiallergic activities.J. Nat. Med., 61, 112-126 (2007).Review
Toshio Morikawa, Yi Zhang, Seikou Nakamura, Hisashi Matsuda, Osamu Muraoka, Masayuki Yoshikawa: Bioactive constituents from Chinese natural medicines. XXII. Absolute structures of new megastigmane glycosides, sedumosides E1, E2, E3, F1, F2, and G, from Sedum sarmentosum (Crassulaceae).Chem. Pharm. Bull., 55, 435-441 (2007).
Masayuki Yoshikawa, Toshio Morikawa, Hisanori Kobayashi, Akihiko Nakamura, Koudai Matsuhira, Seikou Nakamura, Hisashi Matsuda: Bioactive saponins and glycosides. XXVII. Structures of new cucurbitane-type triterpene glycosides and antiallergic constituents from Citrullus colocynthis.Chem. Pharm. Bull., 55, 428-434 (2007).
Masayuki Yoshikawa, Seikou Nakamura, Kenichi Ozaki, Akira Kumahara, Toshio Morikawa, Hisashi Matsuda: Structures of steroidal alkaloid oligoglycosides, robeneosides A and B, and antidiabetogenic constituents from the Brazilian medicinal plant Solanum lycocarpum. J. Nat. Prod., 70, 210-214 (2007).
Masayuki Yoshikawa, Fengming Xu, Toshio Morikawa, Yutana Pongpiriyadacha, Seikou Nakamura, Yasunobu Asao, Akira Kumahara, Hisashi Matsuda: Medicinal foodstuffs. XII. New spirostane-type steroid saponins with antidiabetogenic activity from Borassus flabellifer.Chem. Pharm. Bull., 55, 308-316 (2007).
Toshio Morikawa, Seikou Nakamura, Yasuyo Kato, Osamu Muraoka, Hisashi Matsuda, Masayuki Yoshikawa: Bioactive saponins and glycosides. XXVIII. New triterpene saponins, foliatheasaponins I, II, III, IV, and V, from Tencha (the leaves of Camellia sinensis).Chem. Pharm. Bull., 55, 293-298 (2007).
Hisashi Matsuda, Sachiko Sugimoto, Toshio Morikawa, Koudai Matsuhira, Eri Mizuguchi, Seikou Nakamura, Masayuki Yoshikawa: Bioactive constituents from Chinese natural medicines. XX. Inhibitors of antigen-induced degranulation in RBL-2H3 cells from the seeds of Psoralea corylifolia.Chem. Pharm. Bull., 55, 106-110 (2007).
Masayuki Yoshikawa, Toshio Morikawa, Seikou Nakamura, Ning Li, Xian Li, Hisashi Matsuda: Bioactive saponins and glycosides. XXV. Acylated oleanane-type triterpene saponins from the seeds of tea plant (Camellia sinensis).Chem. Pharm. Bull., 55, 57-63 (2007).
2006
Masayuki Yoshikawa, Toshio Morikawa, Junji Tanaka, Hiroshi Shimoda: Medicinal food stuffs. XXXII. Novel sesquiterpene glycoside sulfate, fukinoside A, with antiallergic activity from Japanese butterbur (Petasites japonicus).Heterocycles, 68, 2335-2342 (2006).
Toshio Morikawa, Fengming Xu, Hisashi Matsuda, Masayuki Yoshikawa: Structures of new flavonoids, erycibenins D, E, and F, and NO production inhibitors from Erycibe expansa originating in Thailand.Chem. Pharm. Bull., 54, 1530-1534 (2006).
Masayuki Yoshikawa, Hisashi Matsuda, Toshio Morikawa, Haihui Xie, Seikou Nakamura, Osamu Muraoka: Phenylethanoid oligoglycosides and acylated oligosugars with vasorelaxant activity from Cistanche tubulosa.Bioog. Med. Chem., 14, 7468-7475 (2006).Most Cited Paper 2006-2009 Award
Toshio Morikawa, Hisashi Matsuda, Ning Li, Seikou Nakamura, Xian Li, Masayuki Yoshikawa: Bioactive saponins and glycosides. XXVI. New triterpene saponins, theasaponins E10, E11, E12, E13, and G2, from the seeds of tea plant (Camellia sinensis).Heterocycles, 68, 1139-1148 (2006).
Toshio Morikawa, Haihui Xie, Hisashi Matsuda, Masayuki Yoshikawa: Glucosyloxybenzyl 2-isobutylmalates from the tubers of Gymnadenia conopsea.J.Nat. Prod., 69, 881-886 (2006).
Toshio Morikawa, Osama Bashir Abdel-Halim, Hisashi Matsuda, Shin Ando, Osamu Muraoka, Masayuki Yoshikawa: Pseudoguaiane-type sesquiterpenes and inhibitors on nitric oxide production from Dichrocephala integrifolia.Tetrahedron, 62, 6435-6442 (2006).
Haihui Xie, Toshio Morikawa, Hisashi Matsuda, Seikou Nakamura, Osamu Muraoka, Masayuki Yoshikawa: Monoterpene constituents from Cistanche tubulosa -chemical structures of kankanosides A-E and kankanol.Chem. Pharm. Bull., 54, 669-675 (2006).Cover Page
Toshio Morikawa, Haihui Xie, Hisashi Matsuda, Tao Wang, Masayuki Yoshikawa: Bioactive constituents from Chinese natural medicines. XVII. Constituents with radical scavenging effect and new glucosyloxybenzyl 2-isobutylmalates from Gymnadenia conopsea.Chem. Pharm. Bull., 54, 506-513 (2006).
Hiroshi Shimoda, Junji Tanaka, Emi Yamada, Toshio Morikawa, Naoki Kasajima, Masayuki Yoshikawa: Anti type I Allergic property nof japanese butterbur extract and its mast cell degranulation inhibitory ingredients.J. Agric. Food Chem., 54, 2915-2920 (2006).
Toshio Morikawa, Ning Li, Akifumi Nagatomo, Hisashi Matsuda, Xian Li, Masayuki Yoshikawa: Triterpene saponins with gastroprotective effects from tea seed (the seeds of Camellia sinensis).J. Nat. Prod., 69, 185-190 (2006).
Masayuki Yoshikawa, Norihisa Nishida, Kiyofumi Ninomiya, Teruki Ohgushi, Mizuho Kubo, Toshio Morikawa, Hisashi Matsuda: Inhibitory effects of coumarin and acetylene constituents from the roots of Angelica furcijuga on D-galactosamine/lipopolysaccharide-induced liver injury in mice and on nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages.Bioorg.Med. Chem., 14, 456-463 (2006).
Hisashi Matsuda, Shin Ando, Tomoko Kato, Toshio Morikawa, Masayuki Yoshikawa: Inhibitors from the rhizomes of Alpinia officinarum on production of nitric oxide in lipopolysaccharide-activated macrophages and the structural requirements of diarulheptanoids for the activity.Bioorg. Med. Chem., 14, 138-142 (2006).
2005
Hisashi Matsuda, Masayuki Yoshikawa, Toshio Morikawa, Genzoh Tanabe, Osamu Muraoka: Antidiabetogenic constituents from Salacia species.J. Trad. Med., 22, 145-153 (2005).Review
Masayuki Yoshikawa, Toshio Morikawa, Ning Li, Akifumi Nagatomo, Xian Li, Hisashi Matsuda: Bioactive saponins and glycosides. XXIII. Triterpene saponins with gastroprotective effect from the seeds of Camellia sinensis-theasaponins E3, E4, E5, E6, and E7-.Chem. Pharm. Bull., 53, 1559-1564 (2005).
Hisashi Matsuda, Shin Ando, Toshio Morikawa, Shinya Kataoka, Masayuki Yoshikawa: Structure-activity relationships of 1'S-1'-acetoxychavicol acetate for inhibitory effect on NO production in lipopolysaccharide-activated mouse peritoneal macrophages.Bioorg. Med. Chem. Lett., 15, 1949-1953 (2005).
Shin Ando, Hisashi Matsuda, Toshio Morikawa, Masayuki Yoshikawa: 1'S-1'-Acetoxychavicol acetate as a new type inhibitor of interferon-b production in lipopolysaccharide-activated mouse peritoneal macrophages.Bioorg. Med. Chem., 13, 3289-3294 (2005).
Haihui Xie, Tao Wang, Hisashi Matsuda, Toshio Morikawa, Masayuki Yoshikawa, Tadato Tani: Bioactive constituents from Chinese natural medicines. XV. Inhibitory effect on aldose reductase and structures of saussureosides A and B from Saussurea medusa.Chem. Pharm. Bull., 53, 1416-1422 (2005).
Masayuki Yoshikawa, Toshio Morikawa, Kaori Yamamoto, Yasuyo Kato, Akifumi Nagatomo, Hisashi Matsuda: Floratheasaponins A-C, acylated oleanane-type triterpene oligoglycosides with anti-hyperlipidemic activities from flowers of the tea plant (Camellia sinensis).J. Nat. Prod., 68, 1360-1365 (2005).
Toshio Morikawa, Shin Ando, Hisashi Matsuda, Shinya Kataoka, Osamu Muraoka, Masayuki Yoshikawa: Inhibitors of nitric oxide production from the rhizomes of Alpinia galanga: Structures of new 8-9' linked neolignans and sesquineolignan.Chem.Pharm. Bull., 53, 625-630 (2005).
Hisashi Matsuda, Toshio Morikawa, Teruki Ohgushi, Tomoko Ishiwada, Norihisa Nishida, Masayuki Yoshikawa: Inhibitors of nitric oxide production from the flowers of Angelica furcijuga: Structures of hyuganosides IV and V.Chem. Pharm. Bull., 53, 387-392 (2005).
2004
Hisashi Matsuda, Toshio Morikawa, Fengming Xu, Kiyofumi Ninomiya, Masayuki Yoshikawa: New Isoflavones and Pterocarpane with Hepatoprotective Activity from the Stems of Erycibe expansa,Planta Med,, 70, 1201-1209 (2004).
Hisashi Matsuda, Supinya Tewtrakul, Toshio Morikawa, Akihiko Nakamura, Masayuki Yoshikawa: Anti-Allergic Principles from Thai Zedoary: Structural Requirements of Curcuminoids for Inhibition of Degranulation and Effect on the Release of TNF-a and IL-4 in RBL-2H3 Cells.Bioorg. Med. Chem., 12, 5891-5898 (2004).
Toshio Morikawa, Hisashi Matsuda, Norihisa Nishida, Teruki Ohgushi, Masayuki Yoshikawa: Structures of New Aromatics Glycosides from a Japanese Folk Medicine, the Roots of Angelica furcijuga.Chem. Pharm. Bull., 52, 1387-1390 (2004).
Toshio Morikawa, Hisashi Matsuda, Teruki Ohgushi, Tomoko Ishiwada, Masayuki Yoshikawa: Absolute Stereostructures of Acylated Khellactone-Type Coumarins from Angellica furcijuga.Heterocycles, 63, 2211-2215 (2004).
Hisashi Matsuda, Toshio Morikawa, Haihui Xie, Masayuki Yoshikawa: Antiallergic Phenanthrenes and Stilbenes from the Tubers of Gymnadenia conopsea.Planta Med., 70, 847-855 (2004).
Hisashi Matsuda, Toshio Morikawa, Shin Ando, Hideo Oominami, Toshiyuki Murakami, Ikuko Kimura, Masayuki Yoshikawa: Absolute Stereostructures of Polypodane-Type Triterpenes, Myrrhanol A and Myrrhanone A, from Guggul-Gum Resin (the Resin of Balsamodendron mukul).Chem. Pharm. Bull., 52, 1200?1203 (2004).
Toshio Morikawa, Bohang Sun, Hisashi Matsuda, Li Jun Wu, Shoichi Harima, Masayuki Yoshikawa: Bioactive Constituents from Chinese Natural Medicines. XIV. New Glycosides of β-carboline-Type Alkaloids, Neolignan, and Phynylpropanoid rom Stellaria dichotoma L. var. lnaceolata and Their Antiallergic Activities.Chem. Pharm.Bull., 52, 1194-1199 (2004).
Bohang Sun, Toshio Morikawa, Hisashi Matsuda, Supinya Tewtrakul, Li Jun Wu, Shoichi Harima, Masayuki Yoshikawa: Structures of New β-Carboline-Type Alkaloids with Antiallergic Effects from Stellaria dichotoma.J. Nat. Prod., 67, 1464-1469 (2004).
Hisashi Matsuda, Supinya Tewtrakul, Toshio Morikawa, Masayuki Yoshikawa: Anti-Allergic Activity of Stilbenes from Korean Rhubarb (Rheum undulatum L.): Structure Requirements for Inhibition of Antigen-Induced Degranulation and Their Effects on the Release of TNF-α and IL-4 in RBL-2H3 Cells.Bioorg. Med. Chem., 12, 4871-4876 (2004).
Osama Bashir Abdel-Halim, Toshio Morikawa, Shin Ando, Hisashi Matsuda, Masayuki Yoshikawa: New Crinine-Type Alkaloids with Inhibitory Effect on Induction of Inducible Nitric Oxide Synthase from Crinum yemense.J. Nat. Prod., 67, 1119-1124 (2004).
Hisashi Matsuda, Toshio Morikawa, Shin Ando, Hideo Oominami, Toshiyuki Murakami, Ikuko Kimura, Masayuki Yoshikawa: Absolute Stereostructures of Polypodane- and Octanordammarane-Type Triterpenes with Nitric Oxide Production Inhibitory Activity from Guggul-Gum Resins.Bioorg. Med. Chem., 12, 3037-3046 (2004).
Fengming Xu, Toshio Morikawa, Hisashi Matsuda, Kiyofumi Ninomiya, Masayuki Yoshikawa: Structures of New Sesquiterpenes and Hepatoprotective Constituents from the Egyptian Herbal Medicne Cyperus longus.J. Nat. Prod., 67, 569-576 (2004).
Kiyofumi Ninomiya, Hisashi Matsuda, Hiroshi Shimoda, Norihisa Nishida, Naoki Kasajima, Tomoe Yoshino, Toshio Morikawa, Masayuki Yoshikawa: Carnosic Acid, A New Class of Lipid Absorption Inhibitor from Sage.Bioorg. Med. Chem. Lett., 14, 1943-1946 (2004).
Toshio Morikawa, Fengming Xu, Kiyofumi Ninomiya, Hisashi Matsuda, Masayuki Yoshikawa: Nigellamines A3, A4, A5, and C, New Dolabellane-Type Diterpene Alkaloids, with Lipid Metabolism-Promoting Activities from the Egyptian Medicinal Food Black Cumin.Chem. Pharm. Bull., 52, 494-497 (2004).
Toshio Morikawa, Fengming Xu, Yousuke Kashima, Hisashi Matsuda, Kiyofumi Ninomiya, Masayuki Yoshikawa: Novel Dolabellane-Type Diterpene Alkaloids with Lipid Metabolism Promoting Activities from the Seeds of Nigella sativa.Org. Lett., 6, 869-872 (2004).
Toshio Morikawa, Hisashi Matsuda, Itadaki Yamaguchi, Yutana Pongpiriyadacha, Masayuki Yoshikawa: New Amides and Gastroprotective Constituents from the Fruit of Piper chaba.Planta Med., 70, 152-159 (2004).
2003
Hisashi Matsuda, Toshio Morikawa, Mamiko Oda, Yasunobu Asao, Masayuki Yoshikawa: Potent Anti-Metastatic Activity of Dimeric Sesquiterpene Thioalkaloids from the Rhizome of Nuphar pumilum.Bioorg. Med. Chem. Lett., 13, 4445-4449 (2003).
吉川雅之，Yutana Pongpiriyadacha，來住明宣，蔭浦禎士，王 涛，森川敏生，松田久司：タイ産Salacia chinensisの生物活性：α-グルコシダーゼ阻害活性を指標とした品質評価，薬学雑誌，123，871-880 (2003).
Hisashi Matsuda, Toshio Morikawa, Hiromi Managi, Masayuki Yoshikawa: Antiallergic Principles from Alpinia galanga: Structural Requirements of Phenylpropanoids for Inhibition of Degranulation and Release of TNF-alfa and IL-4 in RBL-2H3 Cells.Bioorg. Med. Chem. Lett., 13, 3197-3202 (2003).
Toshio Morikawa, Akinobu Kishi, Yutana Pongpiriyadacha, Hisashi Matsuda, Masayuki Yoshikawa: Structures of New Friedelane-Type Triterpenes and Eudesmane-Type Sesquiterpene and Aldose Reductase Inhibitors from Salacia chinensis.J. Nat. Prod., 66, 1191-1196 (2003).
Akinobu Kishi, Toshio Morikawa, Hisashi Matsuda, Masayuki Yoshikawa: Structures of New Friedelane- and Norfriedelane-Type Triterpenes and Polyacylated Eudesmane-Type Sesquiterpene from Salacia chinensis LINN. (S. prinoides DC., Hippocrateaceae) and Radical Scavenging Activities of Principal Constituents.Chem.Pharm. Bull., 51, 1051-1055 (2003).
Masayuki Yoshikawa, Toshio Morikawa, Yousuke Kashima, Kiyofumi Ninomiya, Hisashi Matsuda: Structures of New Dammarane-Type Triterpene Saponins from the Flower Buds of Panax notoginseng and Hepatoprotective Effects of Principal Ginseng Saponins.J. Nat. Prod., 66, 922-927 (2003).
Masayuki Yoshikawa, Toshio Morikawa, Fengming Xu, Shin Ando, Hisashi Matsuda: (7R,8S) and (7S,8R) 8?5' Linked Neolignans from Egyptian Herbal Medicine Anastatica hierochuntica and Inhibitory Activities of Lignans on Nitric Oxide Production.Heterocycles, 60, 1787-1792 (2003).
Hisashi Matsuda, Yutana Pongpiriyadacha, Toshio Morikawa, Momotaro Ochi, Masayuki Yoshikawa: Gastroprotective Effects of Phenylpropanoids from the Rhizomes of Alpinia galanga in Rats: Structural Requirements and Mode of Action.Eur. J. Pharmacol., 471, 59-67 (2003).
Jing Tao, Toshio Morikawa, Hisashi Matsuda, Masayuki Yoshikawa: Bioactive Constituents from Chinese Natural Medicines. XI. Inhibitors on NO Production and Degranulation in RBL-2H3 from Rubia yunnanensis: Structures of Rubianosides II, III, and IV, Rubianol-g, and Rubianthraquinone.Chem. Pharm. Bull., 51, 654-662 (2003).
Toshio Morikawa, Jing Tao, Shin Ando, Hisashi Matsuda, Masayuki Yoshikawa: Absolute Stereostructures of New Arborinane-Type Triterpenoids and Inhibitors of Nitric Oxide Production from Rubia yunnanensis.J. Nat. Prod., 66, 638-645 (2003).
Yutana Pongpiriyadacha, Hisashi Matsuda, Toshio Morikawa, Yasunobu Asao, Masayuki Yoshikawa: Protective Effects of Polygodial on Gastric Mucosal Lesions Induced by Necrotizing Agents in Rats and the Possible Mechanisms of Action.Biol.Pharm. Bull., 26, 651-657 (2003).
Hisashi Matsuda, Toshio Morikawa, Shin Ando, Iwao Toguchida, Masayuki Yoshikawa: Structural Requirements of Flavonoids for Nitric Oxide Production Inhibitory Activity and Mechanism of Action.Bioorg. Med. Chem., 11, 1995-2000 (2003).Most Cited Paper 2003-2006 Award
Hisashi Matsuda, Yutana Pongpiriyadacha, Toshio Morikawa, Akinobu Kishi, Shinya Kataoka, Masayuki Yoshikawa: Protective Effects of Steroid Saponins from Paris polyphylla var. yunnanensis on Ethanol- or Indomethacin-Induced Gastric Mucosal Lesions in Rats: Structural Requirement for Activity and Mode of Action.Bioorg. Med.Chem. Lett., 13, 1101-1106 (2003).
Masayuki Yoshikawa, Fengming Xu, Toshio Morikawa, Kiyofumi Ninomiya, Hisashi Matsuda: Anastatins A and B, New Skeletal Flavonoids with Hepatoprotective Activities from the Desert Plant Anastatica hierochuntica.Bioorg. Med. Chem. Lett., 13, 1045-1049 (2003).
Hisashi Matsuda, Toshio Morikawa, Tomoko Ishiwada, Hiromi Managi, Masatomo Kagawa, Yoshihiko Higashi, Masayuki Yoshikawa: Medicinal Flowers. VIII. Radical Scavenging Constituents from the Flowers of Prunus mume: Structure of Prunose III.Chem. Pharm. Bull., 51, 440-443 (2003).
Hisashi Matsuda, Iwao Toguchida, Kiyofumi Ninomiya, Tadashi Kageura, Toshio Morikawa, Masayuki Yoshikawa: Effects of Sesquiterpenes and Amino Acid?Sesquiterpene Conjugates from the Roots of Saussurea lappa on Inducible Nitric Oxide Synthase and Heat Shock Protein in Lipopolysaccharide-Activated Macrophages.Bioorg. Med. Chem., 11, 709-715 (2003).Most Cited Paper 2003-2006Award
Hiroshi Shimoda, Kiyofumi Ninomiya, Norihisa Nishida, Tomoe Yoshino, Toshio Morikawa, Hisashi Matsuda, Masayuki Yoshikawa: Anti-hyperlipidemic Sesquiterpenes and New Sesquiterpene Glycosides from the Leaves of Artichoke (Cynara scolymus L.): Structure Requirement and Mode of Action. Bioorg. Med. Chem. Lett., 13, 223-228 (2003).
Toshio Morikawa, Jing Tao, Kazuho Ueda, Hisashi Matsuda, Masayuki Yoshikawa: Medicinal Foodstuffs. XXXI. Structures of New Aromatic Constituents and Inhibitors of Degranulation in RBL-2H3 Cells from a Japanese Folk Medicine, the Stem Bark of Acer nikoense.Chem. Pharm. Bull., 51, 62-67 (2003).
Toshio Morikawa, Jing Tao, Iwao Toguchida, Hisashi Matsuda, Masayuki Yoshikawa: Structures of New Cyclic Diarylheptanoids and Inhibitors of Nitric Oxide Production from Japanese Folk Medicine Acer nikoense.J. Nat. Prod., 66, 86-91 (2003).
2002
Masayuki Yoshikawa, Toshio Morikawa, Kyoko Nakano, Yutana Pongpiriyadacha, Toshiyuki Murakami, Hisashi Matsuda: Characterization of New Sweet Triterpene Saponins from Albizia myriophylla.J. Nat. Prod., 65, 1638-1642 (2002).
Jing Tao, Toshio Morikawa, Iwao Toguchida, Shin Ando, Hisashi Matsuda, Masayuki Yoshikawa: Inhibitors of Nitric Oxide Production from the Bark of Myrica rubra: Structures of New Biphenyl Type Diarylheptanoid Glycosides and Taraxerane Type Triterpene.Bioorg. Med. Chem., 10, 4005-4012 (2002).
Toshio Morikawa, Fengming Xu, Hisashi Matsuda, Masayuki Yoshikawa: Structures and Radical Scavenging Activities of Novel Norstilbene Dimer, Longusone A, and New Stilbene Dimers, Longusols A, B, and C, from Egyptian Herbal Medicines Cyperus longus.Heterocycles, 57, 1983-1988 (2002).
Toshio Morikawa, Hisashi Matsuda, Iwao Toguchida, Kazuho Ueda, Masayuki Yoshikawa: Absolute Stereostructures of Three New Sesquiterpenes from the Fruit of Alpinia oxyphylla with Inhibitory Effects on Nitric Oxide Production and Degranulation in RBL-2H3 Cells.J. Nat. Prod., 65, 1468-1474 (2002).
Hisashi Matsuda, Toshio Morikawa, Masayuki Yoshikawa: Antidiabetogenic Constituents from Several Natural Medicines.Pure Appl. Chem., 74, 1301-1308 (2002).
Hisashi Matsuda, Toshio Morikawa, Kazuho Ueda, Hiromi Managi, Masayuki Yoshikawa: Structural Requirements of Flavonoids for Inhibition of Antigen-Induced Degranulation, TNF-a and IL-4 Production from RBL-2H3 Cells.Bioorg. Med. Chem., 10, 3123-3128 (2002).
Masayuki Yoshikawa, Toshiyuki Murakami, Tomoko Ishiwada, Toshio Morikawa, Masatomo Kagawa, Yoshihiko Higashi, Hisashi Matsuda: New Flavonol Oligoglycosides and Polyacylated Sucrose with Inhibitory Effects on Aldose Reductase and Platelet Aggregation from the Flowers of Prunus mume.J. Nat. Prod., 65, 1151-1155 (2002).
Toshio Morikawa, Hisashi Matsuda, Yasuko Sakamoto, Kazuho Ueda, Masayuki Yoshikawa: New Farnesane-Type sesquiterpenes, Hedychiols A and B 8,9-Diacetate, and Inhibitors of Degranulation in RBL-2H3 Cells from the Rhizome of Hedychium coronarium.Chem. Pharm. Bull., 50, 1045-1049 (2002).
Hisashi Matsuda, Toshio Morikawa, Iwao Toguchida, Shoichi Harima, Masayuki Yoshikawa: Medicinal Flowers. VI. Absolute Stereostructures of Two New Flavanone Glycosides and a Phenylbutanoid Glycoside from the Flowers of Chrysanthemum indicum L.: Their Inhibitory Activities for Rat Lens Aldose Reductase. Chem. Pharm. Bull ., 50, 972-975 (2002).
Hisashi Matsuda, Toshio Morikawa, Yasuko Sakamoto, Iwao Toguchida, Masayuki Yoshikawa: Labdane-type Diterpenes with Inhibitory Effects on Increase in Vascular Permeability and Nitric Oxide Production from Hedychium coronarium. Bioorg. Med. Chem ., 10, 2527-2534 (2002).
Hisashi Matsuda, Toshio Morikawa, Iwao Toguchida, Masayuki Yoshikawa: Structural Requirements of Flavonoids and Related Compounds for Aldose Reductase Inhibitory Activity.Chem. Pharm. Bull., 50, 788-795 (2002).
Toshio Morikawa, Hisashi Matsuda, Kiyofumi Ninomiya, Masayuki Yoshikawa: Medicinal Foodstuffs. XXIX. Potent Protective Effects of Sesquiterpenes and Curcumin from Zedoariae Rhizoma on Liver Injury Induced by D-Galactosamine/Lipopolysaccharide or Tumor Necrosis Factor-alpha.Biol. Pharm. Bull., 25, 627-631 (2002).
Masayuki Yoshikawa, Toshio Morikawa, Hisashi Matsuda, Genzoh Tanabe, Osamu Muraoka: Absolute Stereostructure of Potent alpha-Glucosidase Inhibitor, Salacinol, with Unique Thiosugar Sulfonium Sulfate Inner Salt Structure from Salacia reticulata.Bioorg. Med. Chem., 10, 1547-1554 (2002).
Hisashi Matsuda, Yutana Pongpiriyadacha, Toshio Morikawa, Yousuke Kashima, Kyoko Nakano, Masayuki Yoshikawa: Protective Effects of Polygodial and Related Compounds on Ethanol-Induced Gastric Mucosal Lesions in Rats: Structural Requirements and Mode of Action.Bioorg. Med. Chem. Lett., 12, 477-482 (2002).
Hisashi Matsuda, Toshio Morikawa, Jing Tao, Kazuho Ueda, Masayuki Yoshikawa: Bioactive Constituents of Chinese Natural Medicines. VII. Inhibitors of Degranulation in RBL-2H3 Cells and Absolute Stereostructures of Three New Diarylheptanoid Glycosides from the Bark of Myrica rubra.Chem. Pharm. Bull., 50, 208-215 (2002).
Hisashi Matsuda, Toshio Morikawa, Yasuko Sakamoto, Iwao Toguchida, Masayuki Yoshikawa: Antiinflammatory Principles and Three New Labdane-type Diterpenes, Hedychilactones A, B, and C, from the Rhizome of Hedychium coronarium KOENG.Heterocycles, 56, 45-50 (2002).
2001
Hisashi Matsuda, Toshio Morikawa, Iwao Toguchida, Kiyofumi Ninomiya, Masayuki Yoshikawa: Medicinal Foodstuffs. XXVIII. Inhibitors of Nitric Oxide Production and New Sesquiterpenes, Zedoarofuran, 4-Epicurcumenol, Neocurcumenol, Gajutsulactones A and B, and Zedoarolides A and B, from Zedoariae Rhizoma. Chem. Pharm. Bull ., 49, 1558-1556 (2001).
Masayuki Yoshikawa, Toshio Morikawa, kenichi Yashiro, Toshiyuki Murakami, Hisashi Matsuda: Bioactive Saponins and Glycosides. XIX. Notoginseng (3): Immunological Adjuvant Activity of Notoginsenosides and Related Saponins: Structures of Notoginsenosides-L, -M, and -N from the Roots of Panax notoginseng (BURK.) F. H. CHEN..Chem. Pharm. Bull., 49, 1452-1456 (2001).
Hisashi Matsuda, Toshio Morikawa, Kiyofumi Ninomiya, Masayuki Yoshikawa: Absolute Stereostructure of Carabrane-Type Sesquiterpene and Vasorelaxant Active Sesquiterpenes from Zedoariae Rhizoma.Tetrahedron, 57, 8443-8453 (2001).
Hisashi Matsuda, Toshio Morikawa, Hiroki Ueda, Masayuki Yoshikawa: Medicinal Foodstuffs. XXVII. Saponin Constituents of Gotu Kola (2): Structures of New Ursane-ane Oleanane-Type Triterpene Oligoglycosides, Centellasaponins B, C, and D, from Centella asiatica Cultivated in Sri Lanka.Chem. Pharm. Bull., 49, 1368-1371 (2001).
Masayuki Yoshikawa, Toshio Morikawa, Emi Fujiwara, Teruki Ohgushi, Yasunobu Asao, Hisashi Matsuda: New Noroleanane-Type Triterpene Saponins with Gastroprotective Effect and Platelet Aggregation Activity from the Flowers of Camellia japonica: Reviced Structures of Camellenodiol and Camelledionol.Heterocycles, 55, 1653-1657 (2001).
Osamu Muraoka, Genzoh Tanabe, Manabu Fujimoto, Michinori Kubo, Toshie Minematsu, Hisashi Matsuda, Toshio Morikawa, Iwao Toguchida, Masayuki Yoshikawa: Absolute Stereostructures of Novel Norcadinane- and Trinoreudesmane-Type Sesquiterpenes with Nitric Oxide Production Inhibitory Activity from Alpinia oxyphylla.Bioorg. Med. Chem. Lett., 11, 2217-2220 (2001).
Hisashi Matsuda, Toshio Morikawa, Hiroki Ueda, Masayuki Yoshikawa: Medicinal Foodstuffs. XXVI. Inhibitors of Aldose Reductase and New Triterpene and Its Oligoglycoside, Centellasapogenol A and Centellasaponin A, from Centella asiatica (Gotu Kola).Heterocycles, 55, 1499-1504 (2001).
Hisashi Matsuda, Hiroshi Shimoda, Toshio Morikawa, Masayuki Yoshikawa: Phtoestrogens from the Roots of Polygonum cuspidatum (Polygonaceae): Structural Requirement of Hydroxyanthraquinones for Estrogenic Activity.Bioorg.Med. Chem. Lett., 11, 1839-1842 (2001).
Tadashi Kageura, Hisashi Matsuda, Toshio Morikawa, Iwao Toguchida, ShoichiHarima, Mamiko Oda, Masayuki Yoshikawa: Inhibitors from Rhubarb on Lipopolysaccharide?Induced Nitric Oxide Production in Macrophages: Structural Requirements of Stilbenes for the Activity,Bioorg. Med. Chem., 9, 1887-1893 (2001).
Hisashi Matsuda, Tadashi Kageura, Mamiko Oda, Toshio Morikawa, Yasuko Sakamoto, Masayuki Yoshikawa: Effects of Constituents from the Bark of Magnolia obovata on Nitric Oxide Production in Lipopolysaccharide-Activated Macrophages. Chem. Pharm. Bull ., 49, 716-720 (2001).
Hisashi Matsuda, Toshio Morikawa, Kiyofumi Ninomiya, Masayuki Yoshikawa: Hepatoprotective Constituents from Zedoariae Rhizoma: Absolute Stereostructures of Three New Carabrane-Type Sesquiterpenes, Curcumenolactones A, B, and C. Bioorg. Med. Chem ., 9, 909-916 (2001).
Hisashi Matsuda, Toshio Morikawa, Iwao Toguchida, Kiyofumi Ninomiya, Masayuki Yoshikawa: Inhibitors of Nitric Oxide Production and New Sesquiterpenes, 4-Epicurcumenol, Neocurcumenol, Gajutsulactones A and B, and Zedoarolides A and B from Zedoariae Rhizoma.Heterocycles, 55, 841-846 (2001).
Hisashi Matsuda, Toshio Morikawa, Iwao Toguchida, Ji-Young Park, Shoichi Harima, Masayuki Yoshikawa: Antioxidant Constituents from Rhubarb: Structural Requirements of Stilbenes for the Activity and Structures of Two Anthraquinone Giucosides,Bioorg. Med. Chem., 9, 41-50 (2001).
2000
Hisashi Matsuda, Tadashi Kageura, Yasunao Inoue, Toshio Morikawa, Masayuki Yoshikawa: Absolute Stereostructures and Syntheses of Saussureamines A, B, C, D, and E, Amino Acid?Sesquiterpene Conjugates with Gastroprotective Effect, from the Roots of Saussurea lappa,Tetrahedron, 56, 7763-7777 (2000).
Masayuki Yoshikawa, Hiroshi Shimoda, Toshiaki Uemura, Toshio Morikawa, Yuzo Kawahara, Hisashi Matsuda: Alcohol Absorption Inhibitors from Bay Leaf (Laurus nobilis): Structure-Requirements of Sesquiterpenes for the Activity,Bioorg. Med. Chem ., 8, 2071-2077 (2000).
Hisashi Matsuda, Tadashi Kagerura, Iwao Toguchida, Hiroki Ueda, Toshio Morikawa, Masayuki Yoshikawa. Inhibitory Effects of Sesquiterpenes from Bay Leaf on Nitric Oxide Production in Lipopolysaccharide-Activated Macrophages: Structure Requirement and Role of Heat Shock Protein Induction. Life Sci ., 66, 2151-2157 (2000).
Masayuki Yoshikawa, Toshio Morikawa, Iwao Toguchida, Shoichi Harima, Hisashi Matsuda: Medicinal Flowers. II. Inoacetate, E, F, and F Monoacetate from the Flowers of Chrysanthemum indicum L.,Chem. Pharm. Bull., 48, 651-656 (2000).
Hisashi Matsuda, Tadashi Kageura, Toshio Morikawa, Iwao Toguchida, Shoichi Harima, Masayuki Yoshikawa: Effect of Stilbene Constituents from Rhubarb on Nitric Oxide Production in Lipopolysaccharide-Activated Macrophages,Bioorg. Med. Chem. Lett., 10, 323-327 (2000).
1999
Masayuki Yoshikawa, Toshio Morikawa, Toshiyuki Muramkami, Iwao Toguchida,
Shoichi Harima, Hisashi Matsuda: Medicinal Flowers. I. Aldose Reductase
Inhibitors and Three New Eudesmane-Type Sesquiterpenes, Kikkanols A, B,
and C, from the Flowers of Chrysanthemum indicum L.,Chem. Pharm. Bull., 47, 340-345 (1999).
1998
Masayuki Yoshikawa, Toshiyuki Murakami, Toshio Morikawa, Hisashi Matsuda: Absolute Stereostructures of Carabrane-Type Sesquiterpenes, Curcumenone, 4S-Dihydrocurcumenone, and Curcarabranols A and B: Vasorelaxant Activity of Zedary Sesquiterpenes,Chem. Pharm. Bull., 46, 1186-1188 (1998).
Hisashi Matsuda, Kiyofumi Ninomiya, Toshio Morikawa, Masayuki Yoshikawa: Inhibitory Effect and Action Mechanism of Sesquiterpenes from Zedoariae Rhizoma on D-Galactosamine / Lipopolysaccharide-Induced Liver Injury,Bioorg. Med. Chem. Lett., 8, 339-344 (1998).
Hisashi Matsuda, Kiyofumi Ninomiya, Toshio Morikawa, and Masayuki Yoshikawa: Inhibitory Effect and Action Mechanism of Sesquiterpenes from Zedoariae Rhizoma on D-Galactosamine / Lipopolysaccharide-Induced Liver Injury.Bioorg. Med. Chem.Lett., 8, 339-344 (1998).
1997
Masayuki Yoshikawa, Hiromi Shimada, Toshio Morikawa, Satoshi Yoshizumi,
Narumi Matsumura, Toshiyuki Murakami, Hisashi Matsuda, Kazuyuki Hori, Johji
Yamahara: Medicinal Foodstuffs. VII. On the Saponin Constituents with Glucose
and Alcohol Absorption-Inhibitory Activity from a Food Garnish "Tonburi",
the Fruit of Japanese Kochia scoparia (L.) SCHRAD.: Structures of Scoparianosides
A, B, and C,Chem.Pharm. Bull., 45, 1300-1305 (1997).
Masayuki Yoshikawa, Yue Dai, Hiromi Shimada, Toshio Morikawa, Narumi Matsumura,
Satoshi Yoshizumi, Hisashi Matsuda, Hideaki Matsuda, Michinori Kubo: Studies
on Kochiae Fructus. II. On the Saponin Constituents from the Fruit of Chinese
Kochia scoparia (Chenopodiaceae): Structures of Kochianosides I, II, III,
and IV,Chem.Pharm. Bull., 45, 1052-1055 (1997).
Hisashi Matsuda, Toshiyuki Murakami, Kiyofumi Ninomiya, Masahiro Inadzuki,
and Masayuki Yoshikawa: New Hepatoprotective Saponins, Bupleurosides III,
VI, IX, and XIII, from Chinese Bupleuri Radix: Structure-Requirements for
the Cytoprotective Activity in Primary Cultured Rat Hepatocytes.Bioorg. Med. Chem. Lett., 7, 2193-2198 (1997).
Hisashi Matsuda, Yuhao Li, Toshiyuki Murakami, Kiyofumi Ninomiya, Nobuharu
Araki, Masayuki Yoshikawa, and Johji Yamahara: Antiinflammatory Effects
of Escins Ia, Ib, IIa, and IIb from Horse Chestnut, theSeedsof Aesculus hippocastanum L.Bioorg.Med. Chem. Lett., 7, 1611-1616 (1997).
Masayuki Yoshikawa, Toshiyuki Murakami, Kazuhiro Hirano, Masahiro Inadzuki,
Kiyofumi Ninomiya, and Hisashi Matsuda: Scorzonerosides A, B, and C, Novel
Triterpene Oligoglycosides with Hepatoprotective Effect from Chinese Bupleuri
Radix, the Roots of Bupleurum scorzonerifolium WILLD.Tetrahedron Lett., 38, 7395-7398 (1997).
Hisashi Matsuda, Yuhao Li, Toshiyuki Murakami, Kiyofumi Ninomiya, Johji
Yamahara, and Masayuki Yoshikawa: Effects of Escins Ia, Ib, IIa, and IIb
from Horse Chestnut, the Seeds of Aesculus hippocastanum L., on Acute Inflammation
in Animals.Biol.Pharm. Bull., 20, 1092-1095 (1997).
吉川雅之, 村上敏之, 植田知彦, 吉積智司, 二宮清文, 村上啓寿, 松田久司, 斉藤雅之, 藤井 互, 田中隆治, 山原條二: 漢薬の生物活性成分
(第3報) キグシ (Hoveniae Semen Seu Fructus) のアルコール性筋弛緩抑制及び肝保護作用成分：新規 Dihydroflavonol,
hovenitin I, II, III の絶対構造．薬学雑誌, 117, 108-118 (1997).