業績Achievements
原著論文
- Fukao, A., Aoyama, T. and Fujiwara, T
The molecular mechanism of translational control via the communication between the microRNA pathway and RNA-binding proteins.
RNA Biology 12 922-926. (2015)
- Lupberger J., Casanova C., Fischer B., Weiss A., Fofana I., Fontaine N., Fujiwara T., Renaud M., Kopp A., Schuster C., Brino L., Baumert TF.,Thoma C.
PI4K-beta and MKNK1 are regulators of hepatitis C virus IRES-dependent translation.
Sci Rep. 5 13344. (2015)
- Mino T, Fukao A, Vandenbon A, Ori D, Uehata T, Tartey S, Akira S, Suzuki Y, Vinuesa CG, Standley DM, Fujiwara T and Takeuchi O.
Regnase-1 and Roquin regulate common inflammation-related mRNAs in translation-dependent and independent manners.
Cell 161:1058-1073 (2015) - Fukao A, Mishima Y, Takizawa N, Oka S, Imataka H, Pelletier J, Sonenberg N, Thoma
C and Fujiwara T.
microRNAs trigger dissociation of eIF4AI and II from target mRNAs in humans.
Moleculae Cell56, 79-89 (2014) - Maesaki R, Satoh R, Taoka M, Kanaba T, Asano T, Fujita C, Fujiwara T, Ito Y, Isobe T, Hakoshima T, Maenaka K, Mishima M.
Efficient and cost effective production of active-form human PKB using silkworm larvae.
Sci Rep 4, 6016 (2014) - Mikami S, Kanaba T, Takizawa N, Kobayshi A, Maesaki R, Fujiwara T, Ito Y, and Mishima M.
Structural insights into the recruitment of SMRT by the co-repressor SHARP under phosphorylative regulation.
Structure 7, 35-46 (2014) - Ishii J, Oda A, Togawa S, Fukao A, Fujiwara T, Ogino C, Kondo A.
Microbial fluorescence sensing for human neurotensin receptor type 1 using Gα-engineered yeast cells.
Anal Biochem. 446, 37-43 (2014) - Takizawa N, Fujiwara T, Yamasaki M, Saito A, Fukao A, Nomoto A, Mizumoto K.
The essential role for the RNA triphosphatase Cet1p in nuclear import of the mRNA capping enzyme Cet1p-Ceg1p complex of Saccharomyces cerevisiae.
PLoS One.8, e78000. (2013) - Nishimura Y, Mieda H, Ishii J, Ogino C, Fujiwara T, Kondo A.
Targeting cancer cell-specific RNA interference by siRNA delivery using a complex carrier of affibody-displaying bio-nanocapsules and liposomes.
J Nanobiotechnology11, 19 (2013) - Kobayashi A, Kanaba T, Satoh R, Fujiwara T, Ito Y, Sugiura R, Mishima M.
Structure of the second RRM domain of Nrd1, a fission yeast MAPK target RNA binding protein, and implication for its RNA recognition and regulation.
Biochem Biophys Res Commun.437, 12-17 (2013) - Itoh S, Yokoyama R, Kamoshida G, Fujiwara T, Okada H, Takii T, Tsuji T, Fujii S, Hashizume H, Onozaki K.
Staphylococcal superantigen-like protein 10 (SSL10) inhibits blood coagulation by binding to prothrombin and factor Xa via their γ-carboxyglutamic acid (Gla) domain.
J Biol Chem.288, 21569-80 (2013) - Ishizaka A, Mizutani T, Kobayashi K, Tando T, Sakurai K, Fujiwara T, Iba H.
Double PHD finger proteins DPF3a and 3b are required as transcriptional coactivators in the SWI/SNF complex-dependent activation of the NF-κB RelA/p50 heterodimer.
J Biol Chem.287, 11924-11933 (2012) - Mishima Y, Fukao A, Kishimioto T, Sakamoto H, Fujiwara, T., Inoue K.
Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish.
Proc. Natl. Acad. Sci. USA 109, 1104-1109 (2012) - Fujiwara T, Fukao A, Sasano Y, Matsuzaki H, Kikkawa U, Imataka H, Inoue K, Endo S, Sonenberg
N, Thoma C, Sakamoto H.
Functional and direct interaction between the RNA binding protein HuD and active Akt1.
Nucleic Acids Research 40, 1944-11953 (2012) - Singh CR, Watanabe R, Zhou D, Jennings MD, Fukao A, Lee B, Ikeda Y, Chiorini JA, Campbell SG, Ashe MP, Fujiwara, T., Wek RC, Pavitt GD, Asano K.
Mechanisms of translational regulation by a human eIF5-mimic protein.
Nucleic Acids Research 39, 8314-8328 (2011) - Fujiwara Y, Kasashima K, Saito K, Fukao A, Sasano Y, Inoue K, Fujiwara T.
Microtubule association of a neuronal RNA-binding protein HuD through its binding to the light chain of MAP1B.
Biochimie 93. 817-822 (2011) - Hayashi S, Yoshida M, Fujiwara T, Maegawa S, Fukusaki E.
Single-embryo metabolomics and systematic prediction of developmental stage in zebrafish.
Z Naturforsch C. 66, 191-198 (2011) - Hokii Y, Sasano Y, Sato M, Sakamoto H, Sakata K, Shingai R, Taneda A, Oka
S, Himeno H, Muto A, Fujiwara T.
A small nucleolar RNA functions in rRNA processing in C. elegans
Nucleic Acids Research 38, 5909-5918 (2010) - Takasaki T, Fujiwara T, Strome S.
A simple yet effective method to harvest worms from a liquid culture.
THE WORM BREEDER’S GAZETTE 10, p.6, (2010) - Fukao A, Sasano Y, Imataka H, Inoue-Sakamoto H, Sonenberg N, Thoma C, Fujiwara T.
The ELAV protein HuD stimulates cap-dependent translation in a poly(A)- and eIF4A-dependent manner.
Molecular Cell 36. 1007-1017 (2009) - Takeda, Y., Mishima, Y., Fujiwara, T., Sakamoto, H., Inoue, K.
DAZL relieves miRNA-mediated repression of germline mRNAs by controlling poly(A) tail length in zebrafish.
PLoS ONE 4, e7513 (2009) - Hayashi, S., Akiyama, S., Tamaru, Y., Takeda, Y., Fujiwara, T., Inoue, K., Kobayashi, A., Maegawa, S., Fukusaki,, E.
Anovel application of metabolomics in vertebrate development .
Biochem. Biophys. Res. Commun. 386, 268-272 (2009) - Mizutani, T., Osaka, T., Fujiwara, T. and Shahidzzman, M.
Biochemical selenocysteine synthesis and the phylogenic study.
Yakugaku Zasshi 128, 989-996 (2008) - Iwanami, N., Higuchi, T., Sasano, Y., Fujiwara, T., Hoa, VQ., Okada, M., Talukder, SR., Kunimatsu, S., Li, J., Saito, F., Bhattacharya, C., Matin, A., Sasaki, T., Momoi, A., Kondoh, H., Furutani-Seiki, M. and Takahama Y.
WDR55 is a nucleolar modulator of ribosomal RNA synthesis, cell cycle progression, and teleost organ development.
PLoS Genet. 4, e1000171 (2008) - Sasano, Y., Hokii, Y., Inoue, K., Sakamoto, H., Ushida, C. and Fujiwara, T.
Distribution of U3 small nucleolar RNA and fibrillarin during early embryogenesis in Caenorhabditis elegans.
Biochimie 90, p. 898-907 (2008) - Fukumura, K., Kato, A., Jin, Y., Ideue, T., Hirose, T., Kataoka, N., Fujiwara, T., Sakamoto, H. and Inoue, K.
Tissue-specific splicing regulator Fox-1 induces exon skipping by interfering E complex formation on the downstream intron of human F1γgene.4
Nucleic Acids Research 35, 5303-5311 (2007) - Mishima, Y., Giraldez, A.J., Takeda, Y., Fujiwara, T., Sakamoto, H., Schier, A.F. and Inoue, K.
Differential regulation of germline specific mRNAs in soma and primordial germ cells by zebrafish miR-430.
Current Biology 16, 2135-2142 (2007) - Yamami, T., Ito, K., Fujiwara, T. and Nakamura, Y.
Heterologous expression of A. aeolicus ribosome recycling factor in E. coli is dominant lethal by forming a complex that lacks functional coordination for ribosome disassembly.
Molecular Microbiology 55, 150-161 (2005) - Saito, K., Fujiwara, T., Katahira, J., Inoue, K. and Sakamoto, H.
TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD.
Biochem. Biophys. Res. Commun. 321, 291-297 (2004) - Fujiwara, T., Ito, K., Yamami, T. and Nakamura, Y.
Ribosome recycling factor disassembles the posttermination ribosomal complex independent of the ribosomal translocase activity of elongation factor G.
Molecular Microbiology 53, 517-528 (2004) - Saijou, E., Fujiwara, T., Suzaki, T., Inoue, K. and Sakamoto, H.
RBD-1, a nucleolar RNA-binding protein, is essential for Caenorhabditis elegans early development through 18S ribosomal RNA processing.
Nucleic Acids Research 32, 1028-1036 (2004) - Ito, K. Fujiwara, T., Toyoda T. and Nakamura, Y.
Elongation factor G participates in ribosome disassembly by interaction with ribosome recycling factor at their tRNA-mimcry domain.
Molecular Cell 9, 1263-1272 (2002) - Nakamura, Y., Uno, M., Toyoda, T., Fujiwara, T., Ito, K.
Protein tRNA mimicry in translation termination.
Cold Spring Harbor Symp. Quant. Biol. 66, 469-475 (2002) - Fujiwara, T., Ito, K. and Nakamura, Y.
Functional mapping of ribosome-contact sites in the ribosome recycling factor : A structual view from a tRNA mimic.
RNA 7, 64-70 (2001) - Toyoda, T., Tin, OF., Ito, K., Fujiwara, T., Kumasaka, T., Yamamoto, M., Garber, MB. and Nakamura, Y.
Crystal structure combined with genetic analysis of the Thermus thermophilus ribosome recycling factor shows that a flexible hinge may act as a functional switch.
RNA 6, 1432-1444 (2000) - Mizutani, T. and Fujiwara, T.
SBP, SECIS binding protein, bind to the RNA fragment upstream of the Sec UGA codon in glutathione peroxidase mRNA.
Molecular Biology Reports 27, 99-105 (2000) - Fujiwara, T., Ito, K., Nakayashiki, T. and Nakamura, Y.
Amber mutations in ribosome recycling factors of Escherichia coli and Thermus thermophilus : evidence for C-terminal modulator element.
FEBS Letters 447, 297-302 (1999) - Mizutani, T., Watanabe, T., Kanaya, K., Nakagawa, Y. and Fujiwara, T.
Trace 5-methylaminomethyl-2-selenouridine in bovine tRNA and the selenouridine synthase activity in bovine liver.
Molecular Biology Reports 26, 167-172 (1999) - Fujiwara, T., Busch, K., Gross, HJ. and Mizutani, T.
A SECIS binding protein (SBP) is distinct from selenocysteyl-tRNA protecting factor (SePF).
Biochimie 81, 213-218 (1999) - Mizutani, T., Kanaya, K., Ikeda, S., Fujiwara, T., Yamada K. and Totsuka T.
The dual identities of mammalian tRNA(Sec) for SerRS and selenocysteine synthase.
Molecular Biology Reports 25, 211-216 (1998)
著書
- 著者名：深尾亜喜良、藤原俊伸
題 名：ヒトにおけるmicroRNAがタンパク質合成を制御する機序の解明
著書名：科学評論社「臨床免疫・アレルギー科」（印刷中）
- 著者名：深尾亜喜良、藤原俊伸
題 名：microRNA機構とRNA結合タンパク質による翻訳制御
著書名：細胞工学「パラダイムシフトする翻訳制御研究」Vol.34, p. 767-771, 2015
- 著者名：藤原俊伸
題 名：RNA結合タンパク質による翻訳制御
著書名：細胞工学「神経系の翻訳制御メカニズム」Vol.31, p. 646-654, 2012
- 著者名：深尾亜喜良、藤原俊伸
題 名：発生・分化と翻訳制御
著書名：医学のあゆみ「RNA医学・医療」Vol.238, p. 418-425, 2011
- 著者名：牛田千里、藤原俊伸
題 名：Small subunit processome、核小体タンパク質フィブリラリン
著書名：生体の科学「細胞核ー構造と機能」Vol.62, p. 418-421, 2011
- 著者名：藤原俊伸
題 名：RNA結合蛋白質HuDによる翻訳制御と神経分化
著書名：実験医学10月号
「RNAの直接解析とリボヌクレオプロテオミクス」p. 2604-2610, 2010
- 著者名：藤原俊伸、坂本博
題名：RNA結合蛋白質が主役となる神経系での転写後遺伝子発現調節
書名：蛋白質 核酸 酵素 増刊「RNA と生命」
編集者名：中村義一
出版社名：共立出版（株）
頁（年）：p.2609-2616（2007年）
- 著者名：Nakamura Y, Uno M, Toyoda T, Fujiwara T and Ito K.
題名：Protein tRNA mimicry in translation termination
書名：Cold Spring Harbor Symp. Quant. Biol.
出版社名：Cold Spring Harbor Press
頁（年）：66 : 469-475 (2002)
- 著者名：松藤千弥、藤原俊伸、中村義一
題名：セレノシステイン挿入（第4章「リコーディング」のうち、4.4.2）
書名：RNA研究の最前線
編集者名：志村令朗、渡辺公綱
出版社名：シュプリンガー・フェアラーク東京（株）
頁（年）：p.146-149（2000年）