原著論文

2024

Kamei M, Matsuo K, Yoshida Y, Shimada K, Otsuki M, Fujimoto N, Ishibashi M, Quan YS, Kamiyama F, Hara Y, Takamura S, Nakayama T. Intratumoral delivery of a highly active form of XCL1 enhances antitumor CTL responses through recruitment of CXCL9-expressing conventional type-1 dendritic cells. Int. J. Cancer, in press. Top10 Journal (2023)

Vasquez Ayala A, Hsu CY, Oles RE, Matsuo K, Loomis LR, Buzun E, Carrillo Terrazas M, Gerner RR, Lu HH, Kim S, Zhang Z, Park JH, Rivaud P, Thomson M, Lu LF, Min B, Chu H. Commensal bacteria promote type I interferon signaling to maintain immune tolerance in mice. J. Exp. Med. 2024 Jan 1;221(1):e20230063. Top10 Journal (2023)

2023

Hara Y, Honzawa T, Kitagawa M, Sano R, Matsuo K, Nakayama T. Aggravation of lipopolysaccharide-induced depressive-like behavior in CCR4-deficient mice. J. Pharmacol. Sci. 2023 Nov;153(3):89-93.

Sato M, Matsuo K, Susami Y, Yamashita A, Hayasaka H, Hara Y, Nishiwaki K, Oiso K, Kawada A, Otsuka A, Nakayama T. A CCR4 antagonist attenuates atopic dermatitis-like skin inflammation by inhibiting the recruitment and expansion of Th2 cells and Th17 cells. Int. Immunol. 2023 Sep 5;35(9):437-446.

Dhanushkodi NR, Prakash S, Quadiri A, Zayou L, Srivastava R, Tran J, Dang V, Shaik AM, Chilukurri A, Suzer B, Vera P, Sun M, Nguyen P, Lee A, Salem A, Loi J, Singer M, Nakayama T, Vahed H, Nesburn AB, BenMohamed L. Mucosal CCL28 Chemokine Improves Protection against Genital Herpes through Mobilization of Antiviral Effector Memory CCR10+CD44+ CD62L-CD8+ T Cells and Memory CCR10+B220+CD27+ B Cells into the Infected Vaginal Mucosa. J Immunol. 2023 Jul 1;211(1):118-129.

Higuchi T, Hashida Y, Matsuo K, Kitahata K, Ujihara T, Murakami I, Nakayama T, Daibata M. EBV-positive pyothorax-associated lymphoma expresses CXCL9 and CXCL10 chemokines that attract cytotoxic lymphocytes via CXCR3. Cancer Sci. 2023 Jun;114(6):2622-2633.

Yamasaki A, Miyake R, Hara Y, Okuno H, Imaida T, Okita K, Okazaki S, Akiyama Y, Hirotani K, Endo Y, Masuko K, Masuko T, Tomioka Y. Dual-targeting therapy against HER3/MET in human colorectal cancers. Cancer Med. 2023 Apr;12(8):9684-9696.

2022

Madissoon E, Oliver AJ, Kleshchevnikov V, Wilbrey-Clark A, Polanski K, Richoz N, Ribeiro Orsi A, Mamanova L, Bolt L, Elmentaite R, Pett JP, Huang N, Xu C, He P, Dabrowska M, Pritchard S, Tuck L, Prigmore E, Perera S, Knights A, Oszlanczi A, Hunter A, Vieira SF, Patel M, Lindeboom RGH, Campos LS, Matsuo K, Nakayama T, Yoshida M, Worlock KB, Nikolic MZ, Georgakopoulos N, Mahbubani KT, Saeb-Parsy K, Bayraktar OA, Clatworthy MR, Stegle O, Kumasaka N, Teichmann SA, Meyer KB. A spatially resolved atlas of the human lung characterizes a gland-associated immune niche. Nat. Genet. 2022 Dec 21;55(1):66-77. Top1 Journal (2023)

Honzawa T, Matsuo K, Hosokawa S, Kamimura M, Kaibori Y, Hara Y, Nagakubo D, Oiso N, Kawada A, Otsuka A, Yoshie O, Nakayama T. CCR4 plays a pivotal role in Th17 cell recruitment and expansion in a mouse model of rheumatoid arthritis. Int. Immunol. 2022 Aug 23;34(12):635-642.

Kitahata K, Matsuo K, Sato M, Susami Y, Hara Y, Morikawa T, Oiso N, Kawada A, Otsuka A, Nakayama T. Anti-allergic effect of ascorbic acid derivative DDH-1 in a mouse model of atopic dermatitis. Exp. Dermatol. 2022 Aug;31(8):1234-1242.

Machida H, Inoue S, Igarashi A, Saitoh S, Yamauchi K, Nishiwaki M, Nemoto T, Otaki Y, Sato M, Sato K, Nakano H, Yang S, Furuyama K, Murano H, Ishibashi Y, Ota T, Nakayama T, Shibata Y, Watanabe M. Role of CC Chemokine Ligand 17 in Mouse Models of Chronic Obstructive Pulmonary Disease. Am. J. Respir. Cell. Mol. Biol. 2022 Apr;66(4):428-438. Top10 Journal (2023)

2021

Matsuo K, Yoshie O, Nakayama T. Multifaceted Roles of Chemokines and Chemokine Receptors in Tumor Immunity. Cancers 2021 Dec 6;13(23):6132.

Matsuo K, Yoshie O, Kitahata K, Kamei M, Hara Y, Nakayama T. Recent Progress in Dendritic Cell-Based Cancer Immunotherapy. Cancers 2021 May 20;13(10):2495.

Matsuo K, Kitahata K, Kaibori Y, Arima Y, Iwama A, Ito M, Hara Y, Nagakubo D, Quan YS, Kamiyama F, Oiso N, Kawada A, Yoshie O, Nakayama T. CCR4 involvement in expansion of Th17 cells in a mouse model of psoriasis. J. Invest. Dermatol. 2021 Aug;141(8):1985-1994. Top10 Journal (2023)

Sakai R, Ito M, Komai K, Iizuka-Koga M, Matsuo K, Nakayama T, Yoshie O, Amano K, Nishimasu H, Nureki O, Kubo M, Yoshimura A. Kidney GATA3+ regulatory T cells play roles in the convalescence stage after antibody-mediated renal injury. Cell. Mol. Immunol. 2021 May;18(5):1249-1261. Top10 Journal (2023)

Okano J, Nakae Y, Nakagawa T, Katagi M, Terashima T, Nagakubo D, Nakayama T, Yoshie O, Suzuki Y, Kojima H. A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury. Sci. Rep. 2021 Mar 11;11(1):5653. Top10 Journal (2023)

Okita K, Hara Y, Okura H, Hayashi H, Sasaki Y, Masuko S, Kitadai E, Masuko K, Yoshimoto S, Hayashi N, Sugiura R, Endo Y, Okazaki S, Arai S, Yoshioka T, Matsumoto T, Makino Y, Komiyama H, Sakamoto K, Masuko T. Antitumor effects of novel mAbs against cationic amino acid transporter 1 (CAT1) on human CRC with amplified CAT1 gene. Cancer Sci. 2021 Feb;112(2):563-574.

Yamamoto S, Matsuo K, Sakai S, Mishima I, Hara Y, Oiso N, Kawada A, Yoshie O, Nakayama T. P2X receptor agonist enhances tumor-specific CTL responses through CD70+ DC-mediated Th17 induction. Int. Immunol. 2021 Jan 1;33(1):49-55.

2020

Kamei M, Matsuo K, Imanishi H, Hara Y, Quen YS, Kamiyama F, Oiso N, Kawada A, Okada N, Nakayama T. Transcutaneous immunization with a highly active form of XCL1 as a vaccine adjuvant using a hydrophilic gel patch elicits long-term CD8+ T cell responses. J. Pharmacol. Sci. 2020 Jul;143(3):182-187.

Hara Y, Minami Y, Yoshimoto S, Hayashi N, Yamasaki A, Ueda S, Masuko K, Masuko T. Anti-tumor effects of an antagonistic mAb against the ASCT2 amino acid transporter on KRAS-mutated human colorectal cancer cells. Cancer Med. 2020 Jan;9(1):302-312.

2019

Takamura S, Kato S, Motozono C, Shimaoka T, Ueha S, Matsuo K, Miyauchi K, Masumoto T, Katsushima A, Nakayama T, Tomura M, Matsushima K, Kubo M, Miyazaka M. Interstitial-resident memory CD8+ T cells sustain frontline epithelial memory in the lung. J. Exp. Med. 2019 Dec 2;216(12):2736-2747. Top10 Journal (2023)

Fox JC, Thomas MA, Dishman AF, Larsen O, Nakayama T, Yoshie O, Rosenkilde MM, Volkman BF. Structure-function guided modeling of chemokine-GPCR specificity for the chemokine XCL1 and its receptor XCR1. Sci. Signal. 2019 Sep 3;12(597). pii: eaat4128. Top10 Journal (2023)

Higuchi T, Matsuo K, Hashida Y, Kitahata K, Ujihara T, Taniguchi A, Yoshie O, Nakayama T, Daibata M. Epstein-Barr virus-positive pyothorax-assosiated lymphoma expresses CCL17 and CCL22 chemokines that attract CCR4-expressing regulatory T cells. Cancer Lett. 2019 Apr 3;453:184-192. Top10 Journal (2023)

Ueda S, Hayashi H, Miyamoto T, Abe S, Hirai K, Matsukura K, Yagi H, Hara Y, Yoshida K, Okazaki S, Tamura M, Abe Y, Agatsuma T, Niwa SI, Masuko K, Masuko T. Anti-tumor effects of mAb against L-type amino acid transporter 1 (LAT1) bound to human and monkey LAT1 with dual avidity modes. Cancer Sci. 2019 Feb;110(2):674-685.

Ito M, Komai K, Omata-Mise S, Iizuka-Koga M, Noguchi Y, Kondo T, Sakai R, Matsuo K, Nakayama T., Yoshie O, Nakatsukasa H, Chikuma S, Shichita T, Yoshimura A. Brain regulatory T cells supress astrogliosis and potentiate neurological recovery. Nature 2019 Jan;565(7738):246-250. Top1 Journal (2023)

Matsuo K, Hatanaka S, Kimura Y, Hara Y, Nishiwaki K, Quan YS, Kamiyama F, Oiso N, Kawada A, Kabashima K, Nakayama T. A CCR4 antagonist ameliorates atopic dermatitis-like skin lesions induced by dibutyl phthalate and a hydrogel patch containing ovalbumin. Biomed. Pharmacother. 2019 Jan;109:1437-1444. Top10 Journal (2023)

Kawase H, Ago Y, Naito M, Higuchi M, Hara Y, Hasebe S, Tsukada S, Kasai A, Nakazawa T, Mishina T, Kouji H, Takuma K, Hashimoto H. mS-11, a mimetic of the mSin3-binding helix in NRSF, ameliorates social interaction deficits in a prenatal valproic acid-induced autism mouse model. Pharmacol. Biochem. Behav. 2019 Jan;176:1-5.

2018

Matsuo K, Kitahata K, Kawabata F, Kamei M, Hara Y, Takamura S, Oiso N, Kawada A, Yoshie O, Nakayama T. A highly active form of lymphotactin/XCL1 functions as an effective adjuvant to recruit cross-presenting dendritic cells and induce effector and memory CD8+ T cell responses. Front. Immunol. 2018 Nov 27;9:2775.

Kitahata K, Matsuo K, Hara Y, Naganuma T, Oiso N, Kawada A, Nakayama T. Ascorbic acid derivative DDH-1 ameliorates psoriasis-like skin lesions in mice by suppressing inflammatory cytokine expression. J. Pharmacol. Sci. 2018 Dec;138(4):284-288.

Hara Y, Torii R, Ueda S, Kurimoto E, Ueda E, Okura H, Tatano Y, Yagi H, Ohno Y, Tanaka T, Masuko K, Masuko T. Inhibition of tumor formation and metastasis by a monoclonal antibody against lymphatic vessel endothelial hyaluronan receptor 1. Cancer Sci.2018 Oct;109(10):3171-3182.

Matsuo K, Nagakubo D, Komori Y, Fujisato S, Takeda N, Kitamatsu M, Nishiwaki K, Quan YS, Kamiyama F, Oiso N, Kawada A, Yoshie O, Nakayama T. CCR4 is critically involved in allergic skin inflammation of BALB/c mice. J. Invest. Dermatol. 2018 Aug;138(8):1764-1773. Top10 Journal (2023)

Yamamoto S, Matsuo K, Nagakubo D, Higashiyama S, Nishiwaki K, Oiso N, Kawada A, Yoshie O, Nakayama T. A CCR4 antagonist enhances DC activation and homing to the regional lymph node and shows potent vaccine adjuvant activity through the inhibition of regulatory T-cell recruitment. J. Pharmcol. Sci.2018 Mar;136(3):165-171.

Matsuo K, Nagakubo D, Yamamoto S, Shigeta A, Tomida S, Fujita M, Hirata T, Tsunoda I, Nakayama T (corresponding author), Yoshie O. CCL28-deficient mice have reduced IgA antibody-secreting cells and an altered microbiota in the colon. J. Immunol. 2018 Jan 15;200(2):800-809.

2017

Hara Y, Ago Y, Higuchi M, Hasebe S, Nakazawa T, Hashimoto H, Matsuda T, Takuma K. Oxytocin attenuates deficits in social interaction but not recognition memory in a prenatal valproic acid-induced mouse model of autism. Horm. Behav. 2017 Nov;96:130-136.

Hara Y, Ago Y, Taruta A, Hasebe S, Kawase H, Tanabe W, Tsukada S, Nakazawa T, Hashimoto H, Matsuda T, Takuma K. Risperidone and aripiprazole alleviate prenatal valproic acid-induced abnormalities in behaviors and dendritic spine density in mice. Psychopharmacology (Berl) 2017 Nov;234(21):3217-3228.

Mashud R, Nomachi A, Hayakawa A, Kubouchi K, Danno S, Hirata T, Matsuo K, Nakayama T, Sato R, Sugiura R, Abe M, Sakimura K, Wakana S, Ohsaki H, Komoshida S, Mukai H. Impaired lymphocyte trafficking in mice deficient in the activity of PKN1. Sci. Rep. 2017 Aug 9;7(1):7663. Top10 Journal (2023)

Yamaguchi H, Hara Y, Ago Y, Takano E, Hasebe S, Nakazawa T, Hashimoto H, Matsuda T, Takuma K. Environmental enrichment attenuates behavioral abnormalities in valproic acid-exposed autism model mice. Behav. Brain Res. 2017 Aug 30;333:67-73.

Hara Y, Ago Y, Takano E, Hasebe S, Nakazawa T, Hashimoto H, Matsuda T, Takuma K. Prenatal exposure to valproic acid increases miR-132 levels in the mouse embryonic brain. Mol. Autism 2017 Jun 28;8:33. Top10 Journal (2023)

Tsubaki M, Takeda T, Kino T, Sakai K, Itoh T, Imano M, Nakayama T, Nishio K, Satou T, Nishida S. Contributions of MET activation to BCR-ABL1 tyrosine kinase inhibitor resistance in chronic myeloid leukemia cells. Oncotarget 2017 Jun 13;8(24):38717-38730.

2016

Morikawa T, Hachiman I, Matsuo K, Nishida E, Ninomiya K, Hayakawa T, Yoshie O, Muraoka O, Nakayama T. Neolignanes from aril of Myristica fragrans as potent antagonists of CC chemokine eceptor 3. J. Nat. Prod. 2016 Aug 26;79(8):2005-13. Top10 Journal (2023)

Hara Y, Ago Y, Taruta A, Katashiba K, Hasebe S, Takano E, Onaka Y, Hashimoto H, Matsuda T, Takuma K. Improvement by methylphenidate and atomoxetine of social interaction deficits and recognition memory impairment in a mouse model of valproic acid-induced autism. Autism Res. 2016 Sep;9(9):926-39.

Matsuo K, Koizumi K, Fujita M, Morikawa T, Jo M, Shibahara N, Saiki I, Yoshie O, Nakayama T. Efficient use of a crude drug/herb library reveals Ephedra Herb as a specific antagonist for Th2-specific chemokine receptors CCR3, CCR4, and CCR8. Front. Cell Dev. Biol. 2016 Jun 7;4:54.

Matsuo K, Itoh T, Koyama A, Imamura R, Kawai S, Nishiwaki K, Oiso N, Kawada A, Yoshie O, Nakayama T. CCR4 is critically involved in effective antitumor immunity in mice bearing intradermal B16 melanoma. Cancer Lett. 2016 Aug;378(1):16-22. Top10 Journal (2023)

Otori T, Inoue T, Hosomi K, Nakagawa H, Takashima K, Kondo H, Takada T, Ito E, Nakayama T, Wada T, Ishiwata S, Maegawa T, Funakami Y, Nakamura S, Kubota Y, Hiraide A, Matsuyama K, Nishida S. Survey on Custom Statisfaction for Evaluation and Improvement of Physical Assessment Practical Training Seminar for Pharmacist. Jpn. J. Soc. Pharm. 2016;35(2):94-101.

Matsuo K, Hirobe S, Okada N, Nakagawa S. Analysis of skin permeability and toxicological properties of silica particles. Biol. Pharm. Bull. 2016; 39(7):1201-1205.

Matsuo K, Nishiuma S, Hasegawa S, Kawabata F, Kitahata K, Nakayama T. Vaccination with antigen combined with ab-ATP as a vaccine adjuvant enhances antigen-specific antibody production via dendritic cell activation. Biol. Pharm. Bull., 2016; 39(6): 1073-1076.

Moriguchi K, Miyamoto K, Tanaka N, Ueno R, Nakayama T, Yoshie O, Kusunoki S. C-C chemokine receptor type 4 antagonist Compound 22 ameliorates experimental autoimmune encephalomyelitis. J. Neuroimmunol., 2016 Feb 15;291:54-8.

2015

Hara Y, Takuma K, Takano E, Katashiba K, Taruta A, Higashino K, Hashimoto H, Ago Y, Matsuda T. Reduced prefrontal dopaminergic activity in valproic acid-treated mouse autism model. Behav. Brain Res. 2015 Aug 1;289:39-47.

Hirobe S, Azukizawa H, Hanafusa T, Matsuo K, Quan YS, Kamiyama F, Katayama I, Okada N, Nakagawa S. Clinical study and stability assessment of a novel transcutaneous influenza vaccination using a dissolving microneedle patch. Biomaterials, 2015 Jul;57:50-8. Top10 Journal (2023)

Wada A, Ito A, Iitsuka H, Tsuneyama K, Miyazono T, Murakami J, Shibahara N, Sakurai H, Saiki I, Nakayama T, Yoshie O, Koizumi K, Sugiyama T. Role of chemokine CX3CL1 in progression of multiple myeloma via CX3CR1 in bone microenvironments. Oncol. Rep., 2015 Jun;33(6):2935-2939.

Fox JC, Nakayama T, Tyler RC, Sander TL, Yoshie O, Volkman BF. Structural and agonist properties of XCL2, the other member of the C-chemokine subfamily. Cytokine, 2015 Feb;71(2):302-11.

2014

Kee JY, Ito A, Hojo S, Hashimoto I, Igarashi Y, Tsuneyama K, Tsukada K, Irimura T, Shibahara N, Takasaki I, Inujima A, Nakayama T, Yoshie O, Sakurai H, Saiki I, Koizumi K. CXCL16 suppresses liver metastasis of colorectal cancer by promo ing TNF-α-induced apoptosis by tumor-associated macrophages. BMC Cancer, 2014 Dec 15;14:949.

Takuma K, Hara Y, Kataoka S, Kawanai T, Maeda Y, Watanabe R, Takano E, Hayata-Takano A, Hashimoto H, Ago Y, Matsuda T. Chronic treatment with valproic acid or sodium butyrate attenuates novel object recognition deficits and hippocampal dendritic spine loss in a mouse model of autism. Pharmacol. Biochem. Behav. 2014 Nov;126:43-9.

Matsumoto M, Nakayama T, Inoue D, Takamatsu K, Itotani R, Ishitoko M, Suzuki S, Sakuramoto M, Yuba Y, Yoshie O, Takemura M, Fukui M. A pleomorphic carcinoma of the lung producing multiple cytokines and forming a rapidly progressive mass-like opacity. BMC Cancer, 2014 Aug 13;14:588.

Kato M, Oiso N, Itoh T, Sato M, Matsuo K, Nakayama T, Satou T, Kawada A. Necrobiosis lipoidica with infiltration of Th17 cells into vascular lesions. J. Dermatol., 2014 May;41(5):459-461.

Matsuo K, Okamoto H, Kawai Y, Quan YS, Kamiyama F, Hirobe S, Okada N, Nakagawa S. Vaccine efficacy of transcutaneous immunization with amyloid β using a dissolving microneedle array in a mouse model of Alzheimer's disease. J. Neuroimmunol., 2014 Jan;266(1-2):1-11.

2013

Hirobe S, Azukisawa H, Matsuo K, Zhai Y, Quan YS, Kamiyama F, Suzuki H, Katayama I, Okada N, Nakagawa S. Development and clinical study of self-dissolving microneedle patch for transcutaneous immunization device. Pharm. Res., 2013 Oct;30(10):2664-2674.

Matsuo K, Ishii Y, Kawai Y, Saiba Y, Quan YS, Kamiyama F, Hirobe S, Okada N, Nakagawa S. Analysis of transcutaneous antigenic protein delivery by a hydrogel patch formulation. J. Pharm. Sci., 2013 Jun;102(6):1936-1947.

Itoh T, Tabuchi M, Mizuguchi N, Imano M, Tsubaki M, Nishida S, Hashimoto S, Matsuo K, Nakayama T,Ito A, Munakata H, Satou T. Neuroprotective effect of (-)-epigallocatechin-3-gallate in rats when administered pre- or post-traumatic brain injury. J. Neural. Transm., 2013 May;120(5):767-83.

Higuchi T, Nakayama T, Arao T, Nishio K, Yoshie O. SOX4 is a direct target gene of FRA-2 and induces expression of HDAC8 in adult T-cell leukemia/lymphoma. Blood, 2013 May;121(18):3640-3649. Top10 Journal (2023)

Kee JY, Ito A, Hojo S, Hashimoto I, Igarashi Y, Tsukada K, Irimura T, Shibahara N, Nakayama T, Yoshie O, Sakurai H, Saiki I, Koizumi K. Chemokine CXCL16 suppresses liver metastasis of colorectal cancer via augmentation of tumor-infiltrating natural killer T cells in a murine model. Oncol. Rep., 2013 Mar;29(3):975-982.

Kataoka S, Takuma K, Hara Y, Maeda Y, Ago Y, Matsuda T. Autism-like behaviours with transient histone hyperacetylation in mice treated prenatally with valproic acid. Int. J. Neuropsychopharmacol. 2013 Feb;16(1):91-103. Top10 Journal (2023)

2012

Matsuo K, Hirobe S, Yokota Y, Ayabe Y, Seto M, Quan YS, Kamiyama F, Tougan T, Horii T, Mukai Y, Okada N, Nakagawa S. Transcutaneous immunization using a dissolving microneedle array protects against tetanus, diphtheria, malaria, and influenza. J. Control. Release, 2012 Jun;160(3):495-501. Top10 Journal (2023)

Matsuo K, Yokota Y, Zhai Y, Quan YS, Kamiyama F, Mukai Y, Okada N, Nakagawa S. A low-invasive and effective transcutaneous immunization system using a novel dissolving microneedle array for soluble and particulate antigens. J. Control. Release, 2012 Jan;161(1):10-17. Top10 Journal (2023)

Nakayama T, Higuchi T, Oiso N, Kawada A, Yoshie O. Expression and Function of FRA2/JUND in Cutaneous T-Cell Lymphomas. Anticancer Res., 2012 Apr;32(4):1367-73.

Hirobe S, Matsuo K, Quan YS, Kamiyama F, Morito H, Asada H, Takaya Y, Mukai Y, Okada N, Nakagawa S. Clinical study of transcutaneous vaccination using a hydrogel patch for tetanus and diphtheria. Vaccine, 2012 Feb;30(10):1847-1854. Top10 Journal (2023)

Hara Y, Maeda Y, Kataoka S, Ago Y, Takuma K, Matsuda T. Effect of prenatal valproic acid exposure on cortical morphology in female mice. J. Pharmacol. Sci. 2012;118(4):543-6.

2011

Matsuo K, Ishii Y, Quan YS, Kamiyama F, Asada H, Mukai Y, Okada N, Nakagawa S. Compositional optimization and safety assessment of a hydrogel patch as a transcutaneous immunization device. Biol. Pharm. Bull., 2011;34(12):1835-40.

Mukai Y, Yoshinaga T, Yoshikawa M, Matsuo K, Yoshikawa T, Matsuo K, Niki K, Yoshioka Y, Okada N, Nakagawa S. Induction of endoplasmic reticulum-endosome fusion for antigen cross-presentation induced by poly (γ-glutamic acid) nanoparticles. J. Immunol., 2011 Dec;187(12):6249-55.

Ohtani H, Nakayama T, Yoshie O. In situ expression of the CCL20-CCR6 axis in lymphocyte-rich gastric cancer and its potential role in the formation of lymphoid stroma. Pathol. Int., 2011 Nov;61(11):645-51.

Matsuo K, Ishii Y, Quan YS, Kamiyama F, Mukai Y, Okada N, Nakagawa S. Characterization of transcutaneous protein delivery by a hydrogel patch in animal, human, and tissue-engineered skin models. Biol. Pharm. Bull., 2011;34(4):586-9.

Nabeshi H, Yoshikawa T, Matsuyama K, Nakazato Y, Matsuo K, Arimori A, Isobe M, Tochigi S, Kondoh S, Hirai T, Akase T, Yamashita T, Yamashita K, Yoshida T, Nagano K, Abe Y, Yoshioka Y, Kamada H, Imazawa T, Itoh N, Nakagawa S, Mayumi T, Tsunoda S, Tsutsumi Y. Systemic distribution, nuclear entry and cytotoxicity of amorphous nanosilica following topical application. Biomaterials, 2011 Apr;32(11):2713-24. Top10 Journal (2023)

Matsuo K, Ishii Y, Quan YS, Kamiyama F, Mukai Y, Yoshioka Y, Okada N, Nakagawa S. Transcutaneous vaccination using a hydrogel patch induces effective immune responses to tetanus and diphtheria toxoid in hairless rat. J. Control. Release, 2011 Jan;149(1):15-20. Top10 Journal (2023)

2010

Matsuo K, Ishii Y, Matsuo K, Yoshinaga T, Akashi M, Mukai Y, Yoshioka Y, Okada N, Nakagawa S. The utility of poly(g-glutamic acid) nanoparticles as antigen delivery carriers in dendritic cell-based cancer immunotherapy. Biol. Pharm. Bull., 2010;33(12):2003-7.

Nakayama T, Watanabe Y, Oiso N, Higuchi T, Shigeta A, Mizuguchi N, Katou F, Hashimoto K, Kawada A, Yoshie O. Eotaxin-3/CC Chemokine Ligand 26 Is a Functional Ligand for CX3CR1. J. Immunol., 2010 Dec 1;185(11):6472-9.
本誌上位10％にランクされる論文として、“In This Issue”で紹介された

Watanabe Y, Katou F, Ohtani H, Nakayama T, Yoshie O, Hashimoto K. Tumor-infiltrating lymphocytes, particularly the balance between CD8(+) T cells and CCR4(+) regulatory T cells, affect the survival of patients with oral squamous cell carcinoma. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 2010 May;109(5):744-52.
本誌Oral medicine部門の年間最優秀論文に選出された

2009

Koizumi K, Saitoh Y, Minami T, Takeno N, Tsuneyama K, Miyahara T, Nakayama T, Sakurai H, Takano Y, Nishimura M, Imai T, Yoshie O, Saiki I. Role of CX3CL1/Fractalkine in Osteoclast Differentiation and Bone Resorption. J. Immunol., 2009 Dec 15;183(12):7825-31.

Jin Z, Nagakubo D, Shirakawa AK, Nakayama T, Shigeta A, Hieshima K, Yamada Y, Yoshie O. CXCR7 is inducible by HTLV-1 Tax and promotes growth and survival of HTLV-1-infected T cells. Int. J. Cancer, 2009 Nov 1;125(9):2229-35. Top10 Journal (2023)

Ohtani H, Jin Z, Takegawa S, Nakayama T, Yoshie O. Abundant expression of CXCL9 (MIG) by stromal cells that include dendritic cells and accumulation of CXCR3+ T cells in lymphocyte-rich gastric carcinoma. J. Pathol., 2009 Jan;217(1):21-31. Top10 Journal (2023)

2008

Nakayama T, Hieshima K, Arao T, Jin Z, Nagakubo D, Shirakawa AK, Yamada Y, Fujii M, Oiso N, Kawada A, Nishio K, Yoshie O. Aberrant expression of Fra-2 promotes CCR4 expression and cell proliferation in adult T-cell leukemia. Oncogene, 2008 May 22;27(23):3221-32. Top10 Journal (2023)

Ishii Y, Nakae T, Sakamoto F, Matsuo K, Matsuo K, Quan YS, Kamiyama F, Fujita T, Yamamoto A, Nakagawa S, Okada N. A transcutaneous vaccination system using a hydrogel patch for viral and bacterial infection. J. Control. Release, 2008 Oct;131(2):113-20. Top10 Journal (2023)

Poole E, Atkins E, Nakayama T, Yoshie O, Groves I, Alcami A, Sinclair J. NF-kappaB-mediated activation of the chemokine CCL22 by the product of the human cytomegalovirus gene UL144 escapes regulation by viral IE86. J. Virol., 2008 May;82(9):4250-6. Epub 2008 Feb 20. Top10 Journal (2023)

Yoshikawa T, Okada N, Oda A, Matsuo K, Matsuo K, Kayamuro H, Ishii Y, Yoshinaga T, Akagi T, Akashi M, Nakagawa S. Nanoparticles built by self-assembly of amphiphilic gamma-PGA can deliver antigens to antigen-presenting cells with high efficiency: a new tumor-vaccine carrier for eliciting effector T cells. Vaccine, 2008 Mar;26(10):1303-13. Top10 Journal (2023)

Yoshikawa T, Okada N, Oda A, Matsuo K, Matsuo K, Mukai Y, Yoshioka Y, Akagi T, Akashi M, Nakagawa S. Development of amphiphilic gamma-PGA-nanoparticle based tumor vaccine: potential of the nanoparticulate cytosolic protein delivery carrier. Biochem. Biophys. Res. Commun., 2008 Feb;366(2):408-413.

Hieshima K, Nagakubo D, Nakayama T, Shirakawa AK, Jin Z, Yoshie O. Tax-Inducible Production of CC Chemokine Ligand 22 by Human T Cell Leukemia Virus Type 1 (HTLV-1)-Infected T Cells Promotes Preferential Transmission of HTLV-1 to CCR4-Expressing CD4+ T Cells. J Immunol., 2008 Jan 15;180(2):931-9.

Shirakawa AK, Nagakubo D, Hieshima K, Nakayama T, Jin Z, Yoshie O. 1,25-Dihydroxyvitamin D3 Induces CCR10 Expression in Terminally Differentiating Human B Cells. J. Immunol., 2008 Mar 1;180(5):2786-95.

Kagami S, Saeki H, Tsunemi Y, Nakamura K, Kuwano Y, Komine M, Nakayama T, Yoshie O, Tamaki K. CCL27-transgenic mice show enhanced contact hypersensitivity to Th2, but not Th1 stimuli. Eur. J. Immunol., 2008 Mar;38(3):647-57.

Takegawa S, Jin Z, Nakayama T, Oyama T, Hieshima K, Nagakubo D, Shirakawa AK, Tsuzuki T, Nakamura S, Yoshie O. Expression of CCL17 and CCL22 by LMP1+ tumor cells in age-related EBV+ B-cell lymphoproliferative. Cancer Sci., 2008 Feb;99(2):296-302.

2007

Katou F, Ohtani H, Watanabe Y, Nakayama T, Yoshie O. Differing phenotypes between intraepithelial and stromal lymphocytes in early-stage tongue cancer. Cancer Res., 2007 Dec 1;67(23):11195-201. Top10 Journal (2023)

Hojo S, Koizumi K, Tsuneyama K, Arita Y, Cui Z, Shinohara K, Minami T,Hashimoto I, Nakayama T, Sakurai H, Takano Y, Yoshie O, Tsukada K, Saiki I. High-level expression of chemokine CXCL16 by tumor cells correlates with a good prognosis and increased tumor-infiltrating lymphocytes in colorectal cancer. Cancer Res., 2007 May 15;67(10):4725-31. Top10 Journal (2023)

Nagakubo D, Jin Z, Hieshima K, Nakayama T, Shirakawa AK, Tanaka Y, Hasegawa H, Hayashi T, Tsukasaki K, Yamada Y, Yoshie O. Expression of CCR9 in HTLV-1(+) T cells and ATL cells expressing Tax. Int. J. Cancer, 2007 Apr 1;120(7):1591-7. Top10 Journal (2023)

2006

Harasawa H, Yamada Y, Hieshima K, Jin Z, Nakayama T, Yoshie O, Shimizu K, Hasegawa H, Hayashi T, Imaizumi Y, Ikeda S, Soda H, Soda H, Atogami S, Takasaki Y, Tsukasaki K, Tomonaga M, Murata K, Sugahara K, Tsuruda K, Kamihira S. Survey of chemokine receptor expression reveals frequent co-expression of skin-homing CCR4 and CCR10 in adult T-cell leukemia/lymphoma. Leuk. Lymphoma., 2006 Oct;47(10):2163-73.　　

Tsunemi Y, Saeki H, Nakamura K, Nagakubo D, Nakayama T, Yoshie O, Kagami S, Shimazu K, Kadono T, Sugaya M, Komine M, Matsushima K, Tamaki K. CCL17 transgenic mice show an enhanced Th2-type response to both allergic and non-allergic stimuli. Eur. J. Immunol., 2006 Aug;36(8):2116-27.

Nakayama T, Shirane J, Hieshima K, Shibano M, Watanabe M, Jin Z, Nagakubo D, Saito T, Shimomura Y, Yoshie O. Direct inactivation of HSV-1 by chemokines. Virology, 2006 Jul 5;350(2):484-92.

Nakamura ES, Koizumi K, Kobayashi M, Saitoh Y, Nakayama T, Sakurai H, Kameda Y, Yoshie O, Saiki I. RANKL-induced CCL22/macrophage-derived chemokine produced from osteoclasts potentially promotes the bone metastasis of lung cancer expressing its receptor CCR4. Clin. Exp. Metastasis, 2006;23(1):9-18.

Hasegawa H, Inoue A, Kohno M, Muraoka M, Miyazaki T, Terada M, Nakayama T, Yoshie O, Nose M, Yasukawa M. Antagonist of interferon-inducible protein 10/CXCL10 ameliorates the progression of autoimmune sialadenitis in MRL/lpr mice. Arthritis. Rheum., 2006 Mar 30;54(4):1174-1183. Top10 Journal (2023)

Yasumoto K, Koizumi K, Kawashima A, Saitoh Y, Arita Y, Shinohara K, Minami T, Nakayama T, Sakurai H, Takahashi Y, Yoshie O, Saiki I. Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer. Cancer Res., 2006 Feb 15;66(4):2181-7. Top10 Journal (2023)

Watanabe Y, Nakayama T, Nagakubo D, Hieshima K, Jin Z, Katou F, Hashimoto K, Yoshie O. Dopamine selectively induces migration and homing of naive CD8+ T cells via dopamine receptor D3. J. Immunol., 2006 Jan 15;176(2):848-56.

2005

Gao JQ, Sugita T, Kanagawa N, Iida K, Okada N, Mizuguchi H, Nakayama T, Hayakawa T, Yoshie O, Tsutsumi Y, Mayumi T, Nakagawa S. Anti-tumor responses induced by chemokine CCL19 transfected into an ovarian carcinoma model via fiber-mutant adenovirus vector. Biol. Pharm. Bull., 2005 Jun;28(6):1066-70.

Musha H, Ohtani H, Mizoi T, Kinouchi M, Nakayama T, Shiiba K, Miyagawa K, Nagura H, Yoshie O, Sasaki I. Selective infiltration of CCR5(+)CXCR3(+) T lymphocytes in human colorectal carcinoma. Int. J. Cancer, 2005 Oct 10;116(6):949-56. Top10 Journal (2023)

Okada N, Mori N, Koretomo R, Okada Y, Nakayama T, Yoshie O, Mizuguchi H, Hayakawa T, Nakagawa S, Mayumi T, Fujita T, Yamamoto A. Augmentation of the migratory ability of DC-based vaccine into regional lymph nodes by efficient CCR7 gene transduction. Gene Ther., 2005 Jan;12(2):129-39.

2004

Hieshima K, Kawasaki Y, Hanamoto H, Nakayama T, Nagakubo D, Kanamaru A, Yoshie O. CC chemokine ligands 25 and 28 play essential roles in intestinal extravasation of IgA antibody-secreting cells. J. Immunol., 2004 Sep 15;173(6):3668-75.
本誌上位10％にランクされる論文として、“In This Issue”で紹介された　

Shirane J, Nakayama T, Nagakubo D, Izawa D, Hieshima K, Shimomura Y, Yoshie O. Corneal epithelial cells and stromal keratocytes efficently produce CC chemokine-ligand 20 (CCL20) and attract cells expressing its receptor CCR6 in mouse herpetic stromal keratitis. Curr. Eye Res., 2004 May;28(5):297-306.

Nakayama T, Kato Y, Hieshima K, Nagakubo D, Kunori Y, Fujisawa T, Yoshie O. Liver-expressed chemokine/CC chemokine ligand 16 attracts eosinophils by interacting with histamine H4 receptor. J. Immunol., 2004 Aug 1;173(3):2078-83.

Shimaoka T, Nakayama T, Hieshima K, Kume N, Fukumoto N, Minami M, Hayashida K, Kita T, Yoshie O, Yonehara S. Chemokines generally exhibit scavenger receptor activity through their receptor-binding domain. J. Biol. Chem., 2004 June 25; 279(26): 26807-10.

Gao JQ, Alexandre LS, Tsuda Y, Katayama K, Eto Y, Sekiguchi F, Mizuguchi H, Hayakawa T, Nakayama T, Yoshie O, Tsutsumi Y, Mayumi T, Nakagawa S. Tumor-suppressive activities by chemokines introduced into OV-HM cells using fiber-mutant adenovirus vectors. Pharmazie, 2004 Mar;59(3):238-9.

Okada N, Gao JQ, Sasaki A, Niwa M, Okada Y, Nakayama T, Yoshie O, Mizuguchi H, Hayakawa T, Fujita T, Yamamoto A, Tsutsumi Y, Mayumi T, Nakagawa S. Anti-tumor activity of chemokine is affected by both kinds of tumors and the activation state of the host's immune system: implications for chemokine-based cancer immunotherapy. Biochem. Biophys. Res. Commun., 2004 Apr 23;317(1):68-76.

Hanamoto H, Nakayama T, Miyazato H, Takegawa S, Hieshima K, Tatsumi Y, Kanamaru A, Yoshie O. Expression of CCL28 by Reed-Sternberg cells defines a major subtype of classical Hodgkin's disease with frequent infiltration of eosinophils and/or plasma cells. Am. J. Pathol., 2004 Mar;164(3):997-1006. Top10 Journal (2023)

Nakayama T, Hieshima K, Nagakubo D, Sato E, Nakayama M, Kawa K, Yoshie O. Selective induction of Th2-attracting chemokines CCL17 and CCL22 in human B cells by latent membrane protein 1 of Epstein-Barr virus. J. Virol., 2004 Feb;78(4):1665-74. Top10 Journal (2023)

Ohtani N, Ohtani H, Nakayama T, Naganuma H, Sato E, Imai T, Nagura H, Yoshie O. Infiltration of CD8+ T cells containing RANTES/CCL5+ cytoplasmic granules in actively inflammatory lesions of human chronic gastritis. Lab. Invest., 2004 Mar;84(3):368-75. Top10 Journal (2023)

Shimaoka T, Nakayama T, Fukumoto N, Kume N, Takahashi S, Yamaguchi J, Minami M, Hayashida K, Kita T, Ohsumi J, Yoshie O, Yonehara S. Cell surface-anchored SR-PSOX/CXC chemokine ligand 16 mediates firm adhesion of CXC chemokine receptor 6-expressing cells. J. Leukoc. Biol., 2004 Feb;75(2):267-74.

2003　

Gao JQ, Tsuda Y, Katayama K, Nakayama T, Yoshie O, Hatanaka Y, Tani Y, Mizuguchi H, Hayakawa T, Tsutsumi Y, Mayumi T, Nakagawa S. Antitumor effect by interleukin-11 receptor alpha-locus chemokine/CCL27, introduced into tumor cells through a recombinant adenovirus vector. Cancer Res., 2003 Aug 1;63(15):4420-5. Top10 Journal (2023)

Shimaoka T, Nakayama T, Kume N, Takahashi S, Yamaguchi J, Minami M, Hayashida K, Kita T, Ohsumi J, Yoshie O, and Yonehara S. Cutting Edge: SR-PSOX/CXC Chemokine Ligand 16 Mediates Bacterial Phagocytosis by APCs Through its Chemokine Domain. J. Immunol., 2003 Aug 15;171(4):1647-51.

Iijima W, Ohtani H, Nakayama T, Sugawara Y, Sato E, Nagura H, Yoshie O, Sasano T. Infiltrating CD8+ T Cells in Oral Lichen Planus Predominantly Express CCR5 and CXCR3 and Carry Respective Chemokine Ligands RANTES/CCL5 and IP-10/CXCL10 in Their Cytolytic Granules: A Potential Self-Recruiting Mechanism. Am. J. Pathol., 2003 Jul;163(1):261-8. Top10 Journal (2023)

Nakayama T, Hieshima K, Izawa D, Tatsumi Y, Kanamaru A, Yoshie O. Cutting edge: profile of chemokine receptor expression on human plasma cells accounts for their efficient recruitment to target tissues. J. Immunol., 2003 Feb 1;170(3):1136-40.

Hieshima K, Ohtani H, Shibano M, Izawa D, Nakayama T, Kawasaki Y, Shiba F, Shiota M, Katou F, Saito T, Yoshie O. CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity. J. Immunol., 2003 Feb 1;170(3):1452-61.

Katou F, Ohtani H, Nakayama T, Nagura H, Yoshie O, Motegi K. Differential expression of CCL19 by DC-Lamp+ mature dendritic cells in human lymph node versus chronically inflamed skin. J. Pathol., 2003 Jan;199(1):98-106. Top10 Journal (2023)

2002

Fujisawa T, Fujisawa R, Kato Y, Nakayama T, Morita A, Katsumata H, Nishimori H, Iguchi K, Kamiya H, Gray PW, Chantry D, Suzuki R, Yoshie O. Presence of high contents of thymus and activation-regulated chemokine in platelets and elevated plasma levels of thymus and activation-regulated chemokine and macrophage-derived chemokine in patients with atopic dermatitis. J. Allergy Clin. Immunol., 2002 Jul;110(1):139-46. Top10 Journal (2023)

Horikawa T, Nakayama T, Hikita I, Yamada H, Fujisawa R, Bito T, Harada S, Fukunaga A, Chantry D, Gray PW, Morita A, Suzuki R, Tezuka T, Ichihashi M, Yoshie O. IFN-gamma-inducible expression of thymus and activation-regulated chemokine/CCL17 and macrophage-derived chemokine/CCL22 in epidermal keratinocytes and their roles in atopic dermatitis. Int. Immunol., 2002 Jul;14(7):767-773.　

Nishimura M, Umehara H, Nakayama T, Yoneda O, Hieshima K, Kakizaki M, Dohmae N, Yoshie O, and Imai T. Dual Functions of Fractalkine/CX3C Ligand 1 in Trafficking of Perforin(+)/Granzyme B(+) Cytotoxic Effector Lymphocytes That Are Defined by CX3CR1 Expression. J. Immunol., 2002 Jun 15;168(12):6173-80.

Nakayama T, Fujisawa R, Izawa D, Hieshima K, Takada K, and Yoshie O. Human B cells immortalized with Epstein-Barr virus upregulate CCR6 and CCR10 and downregulate CXCR4 and CXCR5. J. Virol., 2002 Mar;76(6):3072-7. Top10 Journal (2023)

Yoshie O, Fujisawa R, Nakayama T, Harasawa H, Tago H, Izawa D, Hieshima K, Tatsumi Y, Matsushima K, Hasegawa H, Kanamaru A, Kamihira S, and Yamada Y. Frequent expression of CCR4 in adult T-cell leukemia and HTLV-1-transformed T cells. Blood, 2002 Mar 1;99(5):1505-1511. Top10 Journal (2023)

2001

Fujiie S, Hieshima K, Izawa D, Nakayama T, Fujisawa R, Ohyanagi H, Yoshie O. Proinflammatory cytokines induce liver and activation-regulated chemokine/macrophage inflammatory protein-3 alpha/CCL20 in mucosal epithelial cells through NF-kB. Int. Immunol., 2001 Oct;13(10):1255-1263.　

Nomiyama H, Hieshima K, Nakayama T, Sakaguchi T, Fujisawa R, Tanase S, Nishiura H, Matsuno K, Takamori H, Tabira Y, Yamamoto T, Miura R, Yoshie O. Human CC chemokine liver-expressed chemokine/CCL16 is a functional ligand for CCR1, CCR2 and CCR5, and constitutively expressed by hepatocytes. Int. Immunol., 2001 Aug;13(8):1021-9.

Katou F, Ohtani H, Nakayama T, Ono K, Matsushima K, Saaristo A, Nagura H, Yoshie O, Motegi K. Macrophage-derived chemokine (MDC/CCL22) and CCR4 are involved in the formation of T lymphocyte-dendritic cell clusters in human inflamed skin and secondary lymphoid tissue. Am. J. Pathol., 2001 Apr;158(4):1263-70. Top10 Journal (2023)

Kawasaki S, Takizawa H, Yoneyama H, Nakayama T, Fujisawa R, Izumizaki M, Imai T, Yoshie O, Homma I, Yamamoto K, Matsushima K. Intervention of thymus and activation-regulated chemokine attenuates the development of allergic airway inflammation and hyperresponsiveness in mice. J. Immunol., 2001 Feb 1;166(3):2055-62.

Nakayama T, Fujisawa R, Yamada H, Horikawa T, Kawasaki H, Hieshima K, Izawa D, Fujiie S, Tezuka T, Yoshie O. Inducible expression of a CC chemokine liver- and activation-regulated chemokine (LARC)/macrophage inflammatory protein (MIP)-3 alpha/CCL20 by epidermal keratinocytes and its role in atopic dermatitis. Int. Immunol., 2001 Jan;13(1):95-103.

1999

Mayumi-Matsuda K, Kojima S, Nakayama T, Suzuki H, Sakata T. Scanning gene expression during neuronal cell death evoked by nerve growth factor depletion. Biochim. Biophys. Acta., 1999 Dec 23;1489(2-3):293-302.

Ishikawa-Mochizuki I, Kitaura M, Baba M, Nakayama T, Izawa D, Imai T, Yamada H, Hieshima K, Suzuki R, Nomiyama H, Yoshie O. Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus. FEBS Lett., 1999 Nov 5;460(3):544-8.

Yoshida T, Izawa D, Nakayama T, Nakahara K, Kakizaki M, Imai T, Suzuki R, Miyasaka M, Yoshie O. Molecular cloning of mXCR1, the murine SCM-1/lymphotactin receptor. FEBS Lett., 1999 Sep 10;458(1):37-40.

Kojima S, Nakayama T, Kuwajima G, Suzuki H, Sakata T. TrkB mutant lacking the amino-terminal half of the extracellular portion acts as a functional brain-derived neurotrophic factor receptor. Biochim. Biophys. Acta., 1999 Aug 20;1420(1-2):104-10.

Nakayama T, Yaoi T, Kuwajima G, Yoshie O, Sakata T. Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma. FEBS Lett., 1999 Jun 18;453(1-2):77-80.

Nakayama T, Yaoi T, Kuwajima G. Localization and subcellular distribution of N-copine in mouse brain. J. Neurochem., 1999 Jan;72(1):373-9.

1998

Nakayama T, Yaoi T, Yasui M, Kuwajima G. N-copine: a novel two C2-domain-containing protein with neuronal activity-regulated expression. FEBS Lett., 1998 May 22;428(1-2):80-4.

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